Found 8 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274366
(2-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-N-(4-(2-...)Show SMILES Cn1nc(cc1C(=O)C(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C26H32N4O4/c1-26(2,3)23-17-21(29(4)28-23)24(31)25(32)27-20-9-10-22(19-8-6-5-7-18(19)20)34-16-13-30-11-14-33-15-12-30/h5-10,17H,11-16H2,1-4H3,(H,27,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274368
(2-(5-tert-butyl-2-methylfuran-3-yl)-N-(4-(6-(morph...)Show SMILES Cc1oc(cc1C(=O)C(=O)Nc1ccc(-c2ccc(CN3CCOCC3)nc2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C31H33N3O4/c1-20-26(17-28(38-20)31(2,3)4)29(35)30(36)33-27-12-11-23(24-7-5-6-8-25(24)27)21-9-10-22(32-18-21)19-34-13-15-37-16-14-34/h5-12,17-18H,13-16,19H2,1-4H3,(H,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha phosphorylation |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274367
(2-(5-tert-butyl-2-methylfuran-3-yl)-N-(4-(2-morpho...)Show SMILES Cc1oc(cc1C(=O)C(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C27H32N2O5/c1-18-21(17-24(34-18)27(2,3)4)25(30)26(31)28-22-9-10-23(20-8-6-5-7-19(20)22)33-16-13-29-11-14-32-15-12-29/h5-10,17H,11-16H2,1-4H3,(H,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274364
(2-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-2-(hydr...)Show SMILES Cc1cccc(c1)-n1nc(cc1C(N=O)C(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H37N5O4/c1-22-8-7-9-23(20-22)37-27(21-29(34-37)32(2,3)4)30(35-39)31(38)33-26-12-13-28(25-11-6-5-10-24(25)26)41-19-16-36-14-17-40-18-15-36/h5-13,20-21,30H,14-19H2,1-4H3,(H,33,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274368
(2-(5-tert-butyl-2-methylfuran-3-yl)-N-(4-(6-(morph...)Show SMILES Cc1oc(cc1C(=O)C(=O)Nc1ccc(-c2ccc(CN3CCOCC3)nc2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C31H33N3O4/c1-20-26(17-28(38-20)31(2,3)4)29(35)30(36)33-27-12-11-23(24-7-5-6-8-25(24)27)21-9-10-22(32-18-21)19-34-13-15-37-16-14-34/h5-12,17-18H,13-16,19H2,1-4H3,(H,33,36) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274366
(2-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-N-(4-(2-...)Show SMILES Cn1nc(cc1C(=O)C(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C26H32N4O4/c1-26(2,3)23-17-21(29(4)28-23)24(31)25(32)27-20-9-10-22(19-8-6-5-7-18(19)20)34-16-13-30-11-14-33-15-12-30/h5-10,17H,11-16H2,1-4H3,(H,27,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha phosphorylation |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274364
(2-(3-tert-butyl-1-m-tolyl-1H-pyrazol-5-yl)-2-(hydr...)Show SMILES Cc1cccc(c1)-n1nc(cc1C(N=O)C(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C32H37N5O4/c1-22-8-7-9-23(20-22)37-27(21-29(34-37)32(2,3)4)30(35-39)31(38)33-26-12-13-28(25-11-6-5-10-24(25)26)41-19-16-36-14-17-40-18-15-36/h5-13,20-21,30H,14-19H2,1-4H3,(H,33,38) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha phosphorylation |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50274367
(2-(5-tert-butyl-2-methylfuran-3-yl)-N-(4-(2-morpho...)Show SMILES Cc1oc(cc1C(=O)C(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C27H32N2O5/c1-18-21(17-24(34-18)27(2,3)4)25(30)26(31)28-22-9-10-23(20-8-6-5-7-19(20)22)33-16-13-29-11-14-32-15-12-29/h5-10,17H,11-16H2,1-4H3,(H,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Kemia, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human p38alpha phosphorylation |
Bioorg Med Chem Lett 18: 5456-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.09.028 BindingDB Entry DOI: 10.7270/Q2154GWM |
More data for this Ligand-Target Pair | |