Affinity Data by PubMed id=18849166

PubMed code 18849166

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50293183 ((R)-4-methyl-2-(2-(5-(quinoline-8-sulfonamido)-1H-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	545	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [3H]neurotensin from human NTS1 receptor expressed in CHOK1 cells after 60 mins by beta plate liquid scintillation counter				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50293183 ((R)-4-methyl-2-(2-(5-(quinoline-8-sulfonamido)-1H-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.76	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins befo...				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50034787 (2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.79	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins befo...				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50130880 (CHEMBL407196 \| NT(1-13) \| neurotensin \| pGlu-Leu-T...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.03	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as inhibition of intracellular calcium elevation pretreated 30 mins befo...				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50293183 ((R)-4-methyl-2-(2-(5-(quinoline-8-sulfonamido)-1H-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.78E+5	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50034787 (2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-4-meth...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.16E+5	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Neurotensin receptor type 1 (Homo sapiens (Human))	BDBM50130880 (CHEMBL407196 \| NT(1-13) \| neurotensin \| pGlu-Leu-T...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	310	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonist activity at human NTS1 receptor expressed in CHOK1 cells assessed as increase in intracellular calcium level by FLIPR assay				Bioorg Med Chem Lett 18: 5789-91 (2009) Article DOI: 10.1016/j.bmcl.2008.09.075 BindingDB Entry DOI: 10.7270/Q24X57S8
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%