Affinity Data by PubMed id=18977148

PubMed code 18977148

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50273972 (CHEMBL461462 \| Lissoclinidine B) Show SMILES NCCc1c2SCOc2c2[nH]ccc3c4ccccc4nc1c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute-Frederick Curated by ChEMBL					Assay Description Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assay				Bioorg Med Chem 16: 10022-8 (2008) Article DOI: 10.1016/j.bmc.2008.10.024 BindingDB Entry DOI: 10.7270/Q2RB74F1
National Cancer Institute-Frederick Curated by ChEMBL					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50273917 (CHEMBL462089 \| Isolissoclinotoxin B) Show SMILES COc1cc(CCN(C)C)c2SSSSSc2c1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.86E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute-Frederick Curated by ChEMBL					Assay Description Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assay				Bioorg Med Chem 16: 10022-8 (2008) Article DOI: 10.1016/j.bmc.2008.10.024 BindingDB Entry DOI: 10.7270/Q2RB74F1
National Cancer Institute-Frederick Curated by ChEMBL					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50273919 (CHEMBL513108 \| Diplamine B) Show SMILES CSc1c(O)c2nccc3c4ccccc4[nH]c(c1CC=N)c23 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute-Frederick Curated by ChEMBL					Assay Description Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assay				Bioorg Med Chem 16: 10022-8 (2008) Article DOI: 10.1016/j.bmc.2008.10.024 BindingDB Entry DOI: 10.7270/Q2RB74F1
National Cancer Institute-Frederick Curated by ChEMBL					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50273918 (CHEMBL462090 \| N,N-dimethyl-5-methylvaracin) Show SMILES COc1c(C)c(CCN(C)C)c2SSSSSc2c1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.21E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute-Frederick Curated by ChEMBL					Assay Description Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assay				Bioorg Med Chem 16: 10022-8 (2008) Article DOI: 10.1016/j.bmc.2008.10.024 BindingDB Entry DOI: 10.7270/Q2RB74F1
National Cancer Institute-Frederick Curated by ChEMBL					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50240848 (2-(3,4-Dimethoxy-5,6,7,8,9-pentathia-benzocyclohep...) Show SMILES COc1cc(CCN)c2SSSSSc2c1OC Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute-Frederick Curated by ChEMBL					Assay Description Inhibition of GST fused human Hdm2 assessed as polyubiquitylation by electrochemiluminescence assay				Bioorg Med Chem 16: 10022-8 (2008) Article DOI: 10.1016/j.bmc.2008.10.024 BindingDB Entry DOI: 10.7270/Q2RB74F1
National Cancer Institute-Frederick Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%