Found 116 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254766
(2-(3-(2,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)cc3Cl)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-10-4-5-15(11(22)6-10)31-16-8-25-13-2-1-3-14(19(13)16)30-9-17(27)26-33(28,29)18-7-12(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254687
(CHEMBL464032 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C24H16Cl2N2O4S3/c25-17-11-22(34-24(17)26)35(30,31)28-21(29)13-32-19-7-3-6-18-23(19)20(12-27-18)33-16-9-8-14-4-1-2-5-15(14)10-16/h1-12,27H,13H2,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254841
(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-11-5-4-10(6-12(11)22)31-16-8-25-14-2-1-3-15(19(14)16)30-9-17(27)26-33(28,29)18-7-13(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assay |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254883
(CHEMBL479434 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1 Show InChI InChI=1S/C21H16Cl2N2O5S3/c1-29-12-5-7-13(8-6-12)31-17-10-24-15-3-2-4-16(20(15)17)30-11-18(26)25-33(27,28)19-9-14(22)21(23)32-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254520
(CHEMBL466184 | N-(3,4-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18F2N2O4S2/c27-20-11-10-19(13-21(20)28)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-18-9-8-16-4-1-2-5-17(16)12-18/h1-14,29H,15H2,(H,30,31) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254728
(CHEMBL465947 | N-(4-methoxyphenylsulfonyl)-2-(3-(n...)Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C27H22N2O5S2/c1-33-20-10-13-22(14-11-20)36(31,32)29-26(30)17-34-24-8-4-7-23-27(24)25(16-28-23)35-21-12-9-18-5-2-3-6-19(18)15-21/h2-16,28H,17H2,1H3,(H,29,30) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254647
(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-11-5-4-10(6-12(11)22)34(28,29)16-8-25-14-2-1-3-15(19(14)16)32-9-17(27)26-35(30,31)18-7-13(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Antagonist activity at human EP3 receptor assessed as cAMP production by cell-based assay |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254841
(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-11-5-4-10(6-12(11)22)31-16-8-25-14-2-1-3-15(19(14)16)30-9-17(27)26-33(28,29)18-7-13(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254640
(CHEMBL482379 | N-(2,5-dimethoxyphenylsulfonyl)-2-(...)Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H24N2O6S2/c1-34-20-11-13-23(35-2)26(15-20)38(32,33)30-27(31)17-36-24-9-5-8-22-28(24)25(16-29-22)37-21-12-10-18-6-3-4-7-19(18)14-21/h3-16,29H,17H2,1-2H3,(H,30,31) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254768
(CHEMBL518396 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c(C)c1 Show InChI InChI=1S/C22H18Cl2N2O4S3/c1-12-6-7-17(13(2)8-12)31-18-10-25-15-4-3-5-16(21(15)18)30-11-19(27)26-33(28,29)20-9-14(23)22(24)32-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254841
(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-11-5-4-10(6-12(11)22)31-16-8-25-14-2-1-3-15(19(14)16)30-9-17(27)26-33(28,29)18-7-13(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254641
(CHEMBL482380 | N-(2-chlorophenylsulfonyl)-2-(3-(na...)Show SMILES Clc1ccccc1S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H19ClN2O4S2/c27-20-8-3-4-11-24(20)35(31,32)29-25(30)16-33-22-10-5-9-21-26(22)23(15-28-21)34-19-13-12-17-6-1-2-7-18(17)14-19/h1-15,28H,16H2,(H,29,30) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254880
(CHEMBL520741 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1OC Show InChI InChI=1S/C22H18Cl2N2O6S3/c1-30-15-7-6-12(8-17(15)31-2)33-18-10-25-14-4-3-5-16(21(14)18)32-11-19(27)26-35(28,29)20-9-13(23)22(24)34-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255058
(CHEMBL479427 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C24H16Cl2N2O6S3/c25-17-11-22(35-24(17)26)37(32,33)28-21(29)13-34-19-7-3-6-18-23(19)20(12-27-18)36(30,31)16-9-8-14-4-1-2-5-15(14)10-16/h1-12,27H,13H2,(H,28,29) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254797
(2-(3-(2-chloro-4-fluorophenylthio)-1H-indol-4-ylox...)Show SMILES Fc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c(Cl)c1 Show InChI InChI=1S/C20H12Cl3FN2O4S3/c21-11-6-10(24)4-5-15(11)31-16-8-25-13-2-1-3-14(19(13)16)30-9-17(27)26-33(28,29)18-7-12(22)20(23)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254767
(CHEMBL464271 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Fc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c(F)c1 Show InChI InChI=1S/C20H12Cl2F2N2O4S3/c21-11-7-18(32-20(11)22)33(28,29)26-17(27)9-30-14-3-1-2-13-19(14)16(8-25-13)31-15-5-4-10(23)6-12(15)24/h1-8,25H,9H2,(H,26,27) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254686
(CHEMBL464031 | N-(3-chlorophenylsulfonyl)-2-(3-(na...)Show SMILES Clc1cccc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H19ClN2O4S2/c27-19-7-3-8-21(14-19)35(31,32)29-25(30)16-33-23-10-4-9-22-26(23)24(15-28-22)34-20-12-11-17-5-1-2-6-18(17)13-20/h1-15,28H,16H2,(H,29,30) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254520
(CHEMBL466184 | N-(3,4-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18F2N2O4S2/c27-20-11-10-19(13-21(20)28)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-18-9-8-16-4-1-2-5-17(16)12-18/h1-14,29H,15H2,(H,30,31) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Mus musculus (Mouse)) | BDBM50254647
(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-11-5-4-10(6-12(11)22)34(28,29)16-8-25-14-2-1-3-15(19(14)16)32-9-17(27)26-35(30,31)18-7-13(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254730
(2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)-N-(ph...)Show SMILES O=C(COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C26H20N2O4S2/c29-25(28-34(30,31)21-9-2-1-3-10-21)17-32-23-12-6-11-22-26(23)24(16-27-22)33-20-14-13-18-7-4-5-8-19(18)15-20/h1-16,27H,17H2,(H,28,29) | PDB
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254686
(CHEMBL464031 | N-(3-chlorophenylsulfonyl)-2-(3-(na...)Show SMILES Clc1cccc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H19ClN2O4S2/c27-19-7-3-8-21(14-19)35(31,32)29-25(30)16-33-23-10-4-9-22-26(23)24(15-28-22)34-20-12-11-17-5-1-2-6-18(17)13-20/h1-15,28H,16H2,(H,29,30) | PDB
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| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254643
(CHEMBL481589 | N-(3,5-dichlorophenylsulfonyl)-2-(3...)Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18Cl2N2O4S2/c27-18-11-19(28)13-21(12-18)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254924
(CHEMBL465923 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cn1c(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)nc2ccccc12 Show InChI InChI=1S/C22H16Cl2N4O4S3/c1-28-15-7-3-2-5-13(15)26-22(28)33-17-10-25-14-6-4-8-16(20(14)17)32-11-18(29)27-35(30,31)19-9-12(23)21(24)34-19/h2-10,25H,11H2,1H3,(H,27,29) | PDB
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254797
(2-(3-(2-chloro-4-fluorophenylthio)-1H-indol-4-ylox...)Show SMILES Fc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c(Cl)c1 Show InChI InChI=1S/C20H12Cl3FN2O4S3/c21-11-6-10(24)4-5-15(11)31-16-8-25-13-2-1-3-14(19(13)16)30-9-17(27)26-33(28,29)18-7-12(22)20(23)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254838
(CHEMBL481582 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccccn3)c12 Show InChI InChI=1S/C19H13Cl2N3O4S3/c20-11-8-17(30-19(11)21)31(26,27)24-15(25)10-28-13-5-3-4-12-18(13)14(9-23-12)29-16-6-1-2-7-22-16/h1-9,23H,10H2,(H,24,25) | PDB
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PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254642
(2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)-N-(th...)Show SMILES O=C(COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cccs1 Show InChI InChI=1S/C24H18N2O4S3/c27-22(26-33(28,29)23-9-4-12-31-23)15-30-20-8-3-7-19-24(20)21(14-25-19)32-18-11-10-16-5-1-2-6-17(16)13-18/h1-14,25H,15H2,(H,26,27) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254473
(4,5-Dichlorothiophene-2-sulfonic Acid[2-(3-Naphtha...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C25H18Cl2N2O4S2/c26-19-12-23(34-25(19)27)35(31,32)29-22(30)14-33-21-7-3-6-20-24(21)18(13-28-20)11-15-8-9-16-4-1-2-5-17(16)10-15/h1-10,12-13,28H,11,14H2,(H,29,30) | PDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254882
(2-(3-(4-chlorophenylthio)-1H-indol-4-yloxy)-N-(4,5...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)cc3)c12 Show InChI InChI=1S/C20H13Cl3N2O4S3/c21-11-4-6-12(7-5-11)30-16-9-24-14-2-1-3-15(19(14)16)29-10-17(26)25-32(27,28)18-8-13(22)20(23)31-18/h1-9,24H,10H2,(H,25,26) | PDB
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254643
(CHEMBL481589 | N-(3,5-dichlorophenylsulfonyl)-2-(3...)Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18Cl2N2O4S2/c27-18-11-19(28)13-21(12-18)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254729
(CHEMBL517165 | N-(5-chlorothiophen-2-ylsulfonyl)-2...)Show SMILES Clc1ccc(s1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C24H17ClN2O4S3/c25-21-10-11-23(33-21)34(29,30)27-22(28)14-31-19-7-3-6-18-24(19)20(13-26-18)32-17-9-8-15-4-1-2-5-16(15)12-17/h1-13,26H,14H2,(H,27,28) | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254964
(CHEMBL517180 | N-(3,4-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H18F2N2O6S2/c27-20-11-10-19(13-21(20)28)38(34,35)30-25(31)15-36-23-7-3-6-22-26(23)24(14-29-22)37(32,33)18-9-8-16-4-1-2-5-17(16)12-18/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254881
(2-(3-(4-(2-amino-2-oxoethyl)phenylthio)-1H-indol-4...)Show SMILES NC(=O)Cc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1 Show InChI InChI=1S/C22H17Cl2N3O5S3/c23-14-9-20(34-22(14)24)35(30,31)27-19(29)11-32-16-3-1-2-15-21(16)17(10-26-15)33-13-6-4-12(5-7-13)8-18(25)28/h1-7,9-10,26H,8,11H2,(H2,25,28)(H,27,29) | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254647
(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-11-5-4-10(6-12(11)22)34(28,29)16-8-25-14-2-1-3-15(19(14)16)32-9-17(27)26-35(30,31)18-7-13(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254839
(CHEMBL520933 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4n3)c12 Show InChI InChI=1S/C23H15Cl2N3O4S3/c24-14-10-21(34-23(14)25)35(30,31)28-19(29)12-32-17-7-3-6-16-22(17)18(11-26-16)33-20-9-8-13-4-1-2-5-15(13)27-20/h1-11,26H,12H2,(H,28,29) | PDB
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| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255026
(CHEMBL480992 | N-(3,5-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H18F2N2O6S2/c27-18-11-19(28)13-21(12-18)38(34,35)30-25(31)15-36-23-7-3-6-22-26(23)24(14-29-22)37(32,33)20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254882
(2-(3-(4-chlorophenylthio)-1H-indol-4-yloxy)-N-(4,5...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)cc3)c12 Show InChI InChI=1S/C20H13Cl3N2O4S3/c21-11-4-6-12(7-5-11)30-16-9-24-14-2-1-3-15(19(14)16)29-10-17(26)25-32(27,28)18-8-13(22)20(23)31-18/h1-9,24H,10H2,(H,25,26) | PDB
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| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254684
(CHEMBL481004 | N-(3,5-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18F2N2O4S2/c27-18-11-19(28)13-21(12-18)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254729
(CHEMBL517165 | N-(5-chlorothiophen-2-ylsulfonyl)-2...)Show SMILES Clc1ccc(s1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C24H17ClN2O4S3/c25-21-10-11-23(33-21)34(29,30)27-22(28)14-31-19-7-3-6-18-24(19)20(13-26-18)32-17-9-8-15-4-1-2-5-16(15)12-17/h1-13,26H,14H2,(H,27,28) | PDB
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| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254647
(2-(3-(3,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-11-5-4-10(6-12(11)22)34(28,29)16-8-25-14-2-1-3-15(19(14)16)32-9-17(27)26-35(30,31)18-7-13(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254839
(CHEMBL520933 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4n3)c12 Show InChI InChI=1S/C23H15Cl2N3O4S3/c24-14-10-21(34-23(14)25)35(30,31)28-19(29)12-32-17-7-3-6-16-22(17)18(11-26-16)33-20-9-8-13-4-1-2-5-15(13)27-20/h1-11,26H,12H2,(H,28,29) | PDB
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| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254689
(2-(3-(4-(2-amino-2-oxoethyl)phenylsulfonyl)-1H-ind...)Show SMILES NC(=O)Cc1ccc(cc1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H17Cl2N3O7S3/c23-14-9-20(35-22(14)24)37(32,33)27-19(29)11-34-16-3-1-2-15-21(16)17(10-26-15)36(30,31)13-6-4-12(5-7-13)8-18(25)28/h1-7,9-10,26H,8,11H2,(H2,25,28)(H,27,29) | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254923
(CHEMBL518110 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccccc3)c12 Show InChI InChI=1S/C20H14Cl2N2O4S3/c21-13-9-18(30-20(13)22)31(26,27)24-17(25)11-28-15-8-4-7-14-19(15)16(10-23-14)29-12-5-2-1-3-6-12/h1-10,23H,11H2,(H,24,25) | PDB
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| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254768
(CHEMBL518396 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c(C)c1 Show InChI InChI=1S/C22H18Cl2N2O4S3/c1-12-6-7-17(13(2)8-12)31-18-10-25-15-4-3-5-16(21(15)18)30-11-19(27)26-33(28,29)20-9-14(23)22(24)32-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255092
(2-(3-(2,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-10-4-5-15(11(22)6-10)34(28,29)16-8-25-13-2-1-3-14(19(13)16)32-9-17(27)26-35(30,31)18-7-12(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255094
(CHEMBL518109 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H18Cl2N2O6S3/c1-12-6-7-17(13(2)8-12)34(28,29)18-10-25-15-4-3-5-16(21(15)18)32-11-19(27)26-35(30,31)20-9-14(23)22(24)33-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254684
(CHEMBL481004 | N-(3,5-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H18F2N2O4S2/c27-18-11-19(28)13-21(12-18)36(32,33)30-25(31)15-34-23-7-3-6-22-26(23)24(14-29-22)35-20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254798
(2-(3-(2-chlorophenylthio)-1H-indol-4-yloxy)-N-(4,5...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccccc3Cl)c12 Show InChI InChI=1S/C20H13Cl3N2O4S3/c21-11-4-1-2-7-15(11)30-16-9-24-13-5-3-6-14(19(13)16)29-10-17(26)25-32(27,28)18-8-12(22)20(23)31-18/h1-9,24H,10H2,(H,25,26) | PDB
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255028
(CHEMBL520425 | N-(3-chlorophenylsulfonyl)-2-(3-(na...)Show SMILES Clc1cccc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H19ClN2O6S2/c27-19-7-3-8-21(14-19)37(33,34)29-25(30)16-35-23-10-4-9-22-26(23)24(15-28-22)36(31,32)20-12-11-17-5-1-2-6-18(17)13-20/h1-15,28H,16H2,(H,29,30) | PDB
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| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254475
(CHEMBL466595 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H18Cl2N2O8S3/c1-32-12-6-7-15(33-2)17(8-12)36(28,29)18-10-25-14-4-3-5-16(21(14)18)34-11-19(27)26-37(30,31)20-9-13(23)22(24)35-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254796
(2-(3-(benzo[d]thiazol-2-ylthio)-1H-indol-4-yloxy)-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3nc4ccccc4s3)c12 Show InChI InChI=1S/C21H13Cl2N3O4S4/c22-11-8-18(33-20(11)23)34(28,29)26-17(27)10-30-14-6-3-5-13-19(14)16(9-24-13)32-21-25-12-4-1-2-7-15(12)31-21/h1-9,24H,10H2,(H,26,27) | PDB
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| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254476
(2-(3-(benzo[d]thiazol-2-ylsulfonyl)-1H-indol-4-ylo...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1nc2ccccc2s1 Show InChI InChI=1S/C21H13Cl2N3O6S4/c22-11-8-18(34-20(11)23)36(30,31)26-17(27)10-32-14-6-3-5-13-19(14)16(9-24-13)35(28,29)21-25-12-4-1-2-7-15(12)33-21/h1-9,24H,10H2,(H,26,27) | PDB
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| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254475
(CHEMBL466595 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H18Cl2N2O8S3/c1-32-12-6-7-15(33-2)17(8-12)36(28,29)18-10-25-14-4-3-5-16(21(14)18)34-11-19(27)26-37(30,31)20-9-13(23)22(24)35-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254922
(CHEMBL481984 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cn1nnnc1Sc1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C16H12Cl2N6O4S3/c1-24-16(20-22-23-24)29-11-6-19-9-3-2-4-10(14(9)11)28-7-12(25)21-31(26,27)13-5-8(17)15(18)30-13/h2-6,19H,7H2,1H3,(H,21,25) | PDB
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| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254996
(CHEMBL516708 | N-(3,5-dichlorophenylsulfonyl)-2-(3...)Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H18Cl2N2O6S2/c27-18-11-19(28)13-21(12-18)38(34,35)30-25(31)15-36-23-7-3-6-22-26(23)24(14-29-22)37(32,33)20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255060
(CHEMBL481782 | N-(5-chlorothiophen-2-ylsulfonyl)-2...)Show SMILES Clc1ccc(s1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C24H17ClN2O6S3/c25-21-10-11-23(34-21)36(31,32)27-22(28)14-33-19-7-3-6-18-24(19)20(13-26-18)35(29,30)17-9-8-15-4-1-2-5-16(15)12-17/h1-13,26H,14H2,(H,27,28) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 9.20 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254880
(CHEMBL520741 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1OC Show InChI InChI=1S/C22H18Cl2N2O6S3/c1-30-15-7-6-12(8-17(15)31-2)33-18-10-25-14-4-3-5-16(21(14)18)32-11-19(27)26-35(28,29)20-9-13(23)22(24)34-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254963
(CHEMBL464059 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1cccc(c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O7S3/c1-31-12-4-2-5-13(8-12)34(27,28)17-10-24-15-6-3-7-16(20(15)17)32-11-18(26)25-35(29,30)19-9-14(22)21(23)33-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254687
(CHEMBL464032 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C24H16Cl2N2O4S3/c25-17-11-22(34-24(17)26)35(30,31)28-21(29)13-32-19-7-3-6-18-23(19)20(12-27-18)33-16-9-8-14-4-1-2-5-15(14)10-16/h1-12,27H,13H2,(H,28,29) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 9.70 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254796
(2-(3-(benzo[d]thiazol-2-ylthio)-1H-indol-4-yloxy)-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3nc4ccccc4s3)c12 Show InChI InChI=1S/C21H13Cl2N3O4S4/c22-11-8-18(33-20(11)23)34(28,29)26-17(27)10-30-14-6-3-5-13-19(14)16(9-24-13)32-21-25-12-4-1-2-7-15(12)31-21/h1-9,24H,10H2,(H,26,27) | PDB
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UniChem
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PubMed
| n/a | n/a | 9.80 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254730
(2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)-N-(ph...)Show SMILES O=C(COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C26H20N2O4S2/c29-25(28-34(30,31)21-9-2-1-3-10-21)17-32-23-12-6-11-22-26(23)24(16-27-22)33-20-14-13-18-7-4-5-8-19(18)15-20/h1-16,27H,17H2,(H,28,29) | PDB
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 10.1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254924
(CHEMBL465923 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cn1c(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)nc2ccccc12 Show InChI InChI=1S/C22H16Cl2N4O4S3/c1-28-15-7-3-2-5-13(15)26-22(28)33-17-10-25-14-6-4-8-16(20(14)17)32-11-18(29)27-35(30,31)19-9-12(23)21(24)34-19/h2-10,25H,11H2,1H3,(H,27,29) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254477
(2-(3-(2-chloro-4-fluorophenylsulfonyl)-1H-indol-4-...)Show SMILES Fc1ccc(c(Cl)c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C20H12Cl3FN2O6S3/c21-11-6-10(24)4-5-15(11)34(28,29)16-8-25-13-2-1-3-14(19(13)16)32-9-17(27)26-35(30,31)18-7-12(22)20(23)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254688
(CHEMBL516686 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H18Cl2N2O8S3/c1-32-15-7-6-12(8-17(15)33-2)36(28,29)18-10-25-14-4-3-5-16(21(14)18)34-11-19(27)26-37(30,31)20-9-13(23)22(24)35-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 11.4 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254645
(CHEMBL521103 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H15Cl2N3O6S3/c24-14-10-21(35-23(14)25)37(32,33)28-19(29)12-34-17-7-3-6-16-22(17)18(11-26-16)36(30,31)20-9-8-13-4-1-2-5-15(13)27-20/h1-11,26H,12H2,(H,28,29) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 11.6 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254532
(CHEMBL512993 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccccc1S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O7S3/c1-31-14-6-2-3-8-16(14)34(27,28)17-10-24-13-5-4-7-15(20(13)17)32-11-18(26)25-35(29,30)19-9-12(22)21(23)33-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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PubMed
| n/a | n/a | 11.9 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255058
(CHEMBL479427 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C24H16Cl2N2O6S3/c25-17-11-22(35-24(17)26)37(32,33)28-21(29)13-34-19-7-3-6-18-23(19)20(12-27-18)36(30,31)16-9-8-14-4-1-2-5-15(14)10-16/h1-12,27H,13H2,(H,28,29) | PDB
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UniChem
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PubMed
| n/a | n/a | 12.9 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254799
(CHEMBL482177 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccccc1Sc1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O5S3/c1-29-14-6-2-3-8-16(14)31-17-10-24-13-5-4-7-15(20(13)17)30-11-18(26)25-33(27,28)19-9-12(22)21(23)32-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 13.2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254798
(2-(3-(2-chlorophenylthio)-1H-indol-4-yloxy)-N-(4,5...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccccc3Cl)c12 Show InChI InChI=1S/C20H13Cl3N2O4S3/c21-11-4-1-2-7-15(11)30-16-9-24-13-5-3-6-14(19(13)16)29-10-17(26)25-32(27,28)18-8-12(22)20(23)31-18/h1-9,24H,10H2,(H,25,26) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 13.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255093
(CHEMBL465915 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C20H12Cl2F2N2O6S3/c21-11-7-18(33-20(11)22)35(30,31)26-17(27)9-32-14-3-1-2-13-19(14)16(8-25-13)34(28,29)15-5-4-10(23)6-12(15)24/h1-8,25H,9H2,(H,26,27) | PDB
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PubMed
| n/a | n/a | 13.8 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255061
(2-(3-(naphthalen-2-ylsulfonyl)-1H-indol-4-yloxy)-N...)Show SMILES O=C(COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C26H20N2O6S2/c29-25(28-36(32,33)20-9-2-1-3-10-20)17-34-23-12-6-11-22-26(23)24(16-27-22)35(30,31)21-14-13-18-7-4-5-8-19(18)15-21/h1-16,27H,17H2,(H,28,29) | PDB
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PubMed
| n/a | n/a | 13.9 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254690
(2-(3-(4-chlorophenylsulfonyl)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H13Cl3N2O6S3/c21-11-4-6-12(7-5-11)33(27,28)16-9-24-14-2-1-3-15(19(14)16)31-10-17(26)25-34(29,30)18-8-13(22)20(23)32-18/h1-9,24H,10H2,(H,25,26) | PDB
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PubMed
| n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254996
(CHEMBL516708 | N-(3,5-dichlorophenylsulfonyl)-2-(3...)Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H18Cl2N2O6S2/c27-18-11-19(28)13-21(12-18)38(34,35)30-25(31)15-36-23-7-3-6-22-26(23)24(14-29-22)37(32,33)20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 14.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Mus musculus (Mouse)) | BDBM50254841
(2-(3-(3,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)c(Cl)c3)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-11-5-4-10(6-12(11)22)31-16-8-25-14-2-1-3-15(19(14)16)30-9-17(27)26-33(28,29)18-7-13(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 15.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from mouse EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254964
(CHEMBL517180 | N-(3,4-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1ccc(cc1F)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H18F2N2O6S2/c27-20-11-10-19(13-21(20)28)38(34,35)30-25(31)15-36-23-7-3-6-22-26(23)24(14-29-22)37(32,33)18-9-8-16-4-1-2-5-17(16)12-18/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 16.3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254733
(CHEMBL464074 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H14Cl2N2O6S3/c21-13-9-18(31-20(13)22)33(28,29)24-17(25)11-30-15-8-4-7-14-19(15)16(10-23-14)32(26,27)12-5-2-1-3-6-12/h1-10,23H,11H2,(H,24,25) | PDB
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| n/a | n/a | 16.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254767
(CHEMBL464271 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Fc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c(F)c1 Show InChI InChI=1S/C20H12Cl2F2N2O4S3/c21-11-7-18(32-20(11)22)33(28,29)26-17(27)9-30-14-3-1-2-13-19(14)16(8-25-13)31-15-5-4-10(23)6-12(15)24/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 18.3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254645
(CHEMBL521103 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2n1 Show InChI InChI=1S/C23H15Cl2N3O6S3/c24-14-10-21(35-23(14)25)37(32,33)28-19(29)12-34-17-7-3-6-16-22(17)18(11-26-16)36(30,31)20-9-8-13-4-1-2-5-15(13)27-20/h1-11,26H,12H2,(H,28,29) | PDB
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| n/a | n/a | 18.8 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254965
(CHEMBL464237 | N-(2,5-dimethoxyphenylsulfonyl)-2-(...)Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C28H24N2O8S2/c1-36-20-11-13-23(37-2)25(15-20)40(34,35)30-27(31)17-38-24-9-5-8-22-28(24)26(16-29-22)39(32,33)21-12-10-18-6-3-4-7-19(18)14-21/h3-16,29H,17H2,1-2H3,(H,30,31) | PDB
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| n/a | n/a | 18.8 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254532
(CHEMBL512993 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccccc1S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O7S3/c1-31-14-6-2-3-8-16(14)34(27,28)17-10-24-13-5-4-7-15(20(13)17)32-11-18(26)25-35(29,30)19-9-12(22)21(23)33-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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| n/a | n/a | 19.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254477
(2-(3-(2-chloro-4-fluorophenylsulfonyl)-1H-indol-4-...)Show SMILES Fc1ccc(c(Cl)c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C20H12Cl3FN2O6S3/c21-11-6-10(24)4-5-15(11)34(28,29)16-8-25-13-2-1-3-14(19(13)16)32-9-17(27)26-35(30,31)18-7-12(22)20(23)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 20.2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254883
(CHEMBL479434 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1 Show InChI InChI=1S/C21H16Cl2N2O5S3/c1-29-12-5-7-13(8-6-12)31-17-10-24-15-3-2-4-16(20(15)17)30-11-18(26)25-33(27,28)19-9-14(22)21(23)32-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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| n/a | n/a | 22.6 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254799
(CHEMBL482177 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccccc1Sc1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O5S3/c1-29-14-6-2-3-8-16(14)31-17-10-24-13-5-4-7-15(20(13)17)30-11-18(26)25-33(27,28)19-9-12(22)21(23)32-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254769
(CHEMBL464270 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(OC)c(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c1 Show InChI InChI=1S/C22H18Cl2N2O6S3/c1-30-12-6-7-15(31-2)17(8-12)33-18-10-25-14-4-3-5-16(21(14)18)32-11-19(27)26-35(28,29)20-9-13(23)22(24)34-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 24.1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254769
(CHEMBL464270 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(OC)c(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)c1 Show InChI InChI=1S/C22H18Cl2N2O6S3/c1-30-12-6-7-15(31-2)17(8-12)33-18-10-25-14-4-3-5-16(21(14)18)32-11-19(27)26-35(28,29)20-9-13(23)22(24)34-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 24.6 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255026
(CHEMBL480992 | N-(3,5-difluorophenylsulfonyl)-2-(3...)Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H18F2N2O6S2/c27-18-11-19(28)13-21(12-18)38(34,35)30-25(31)15-36-23-7-3-6-22-26(23)24(14-29-22)37(32,33)20-9-8-16-4-1-2-5-17(16)10-20/h1-14,29H,15H2,(H,30,31) | PDB
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| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254642
(2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)-N-(th...)Show SMILES O=C(COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cccs1 Show InChI InChI=1S/C24H18N2O4S3/c27-22(26-33(28,29)23-9-4-12-31-23)15-30-20-8-3-7-19-24(20)21(14-25-19)32-18-11-10-16-5-1-2-6-17(16)13-18/h1-14,25H,15H2,(H,26,27) | PDB
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| n/a | n/a | 27.5 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254766
(2-(3-(2,4-dichlorophenylthio)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc(Cl)cc3Cl)c12 Show InChI InChI=1S/C20H12Cl4N2O4S3/c21-10-4-5-15(11(22)6-10)31-16-8-25-13-2-1-3-14(19(13)16)30-9-17(27)26-33(28,29)18-7-12(23)20(24)32-18/h1-8,25H,9H2,(H,26,27) | PDB
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| n/a | n/a | 27.6 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254689
(2-(3-(4-(2-amino-2-oxoethyl)phenylsulfonyl)-1H-ind...)Show SMILES NC(=O)Cc1ccc(cc1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H17Cl2N3O7S3/c23-14-9-20(35-22(14)24)37(32,33)27-19(29)11-34-16-3-1-2-15-21(16)17(10-26-15)36(30,31)13-6-4-12(5-7-13)8-18(25)28/h1-7,9-10,26H,8,11H2,(H2,25,28)(H,27,29) | PDB
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| n/a | n/a | 27.8 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254691
(CHEMBL464906 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1ccc(cc1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O7S3/c1-31-12-5-7-13(8-6-12)34(27,28)17-10-24-15-3-2-4-16(20(15)17)32-11-18(26)25-35(29,30)19-9-14(22)21(23)33-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254690
(2-(3-(4-chlorophenylsulfonyl)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H13Cl3N2O6S3/c21-11-4-6-12(7-5-11)33(27,28)16-9-24-14-2-1-3-15(19(14)16)31-10-17(26)25-34(29,30)18-8-13(22)20(23)32-18/h1-9,24H,10H2,(H,25,26) | PDB
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| n/a | n/a | 31.3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255094
(CHEMBL518109 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C22H18Cl2N2O6S3/c1-12-6-7-17(13(2)8-12)34(28,29)18-10-25-15-4-3-5-16(21(15)18)32-11-19(27)26-35(30,31)20-9-14(23)22(24)33-20/h3-10,25H,11H2,1-2H3,(H,26,27) | PDB
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| n/a | n/a | 33.2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254963
(CHEMBL464059 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES COc1cccc(c1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C21H16Cl2N2O7S3/c1-31-12-4-2-5-13(8-12)34(27,28)17-10-24-15-6-3-7-16(20(15)17)32-11-18(26)25-35(29,30)19-9-14(22)21(23)33-19/h2-10,24H,11H2,1H3,(H,25,26) | PDB
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| n/a | n/a | 33.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254923
(CHEMBL518110 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccccc3)c12 Show InChI InChI=1S/C20H14Cl2N2O4S3/c21-13-9-18(30-20(13)22)31(26,27)24-17(25)11-28-15-8-4-7-14-19(15)16(10-23-14)29-12-5-2-1-3-6-12/h1-10,23H,11H2,(H,24,25) | PDB
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| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254731
(CHEMBL517316 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cc1nnc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)s1 Show InChI InChI=1S/C17H12Cl2N4O4S4/c1-8-21-22-17(28-8)29-12-6-20-10-3-2-4-11(15(10)12)27-7-13(24)23-31(25,26)14-5-9(18)16(19)30-14/h2-6,20H,7H2,1H3,(H,23,24) | PDB
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| n/a | n/a | 36.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254840
(2-(3-(1H-1,2,4-triazol-3-ylthio)-1H-indol-4-yloxy)...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3nnc[nH]3)c12 Show InChI InChI=1S/C16H11Cl2N5O4S3/c17-8-4-13(29-15(8)18)30(25,26)23-12(24)6-27-10-3-1-2-9-14(10)11(5-19-9)28-16-20-7-21-22-16/h1-5,7,19H,6H2,(H,23,24)(H,20,21,22) | PDB
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| n/a | n/a | 37.9 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254995
(2-(3-(naphthalen-2-ylsulfonyl)-1H-indol-4-yloxy)-N...)Show SMILES O=C(COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1)NS(=O)(=O)c1cccs1 Show InChI InChI=1S/C24H18N2O6S3/c27-22(26-35(30,31)23-9-4-12-33-23)15-32-20-8-3-7-19-24(20)21(14-25-19)34(28,29)18-11-10-16-5-1-2-6-17(16)13-18/h1-14,25H,15H2,(H,26,27) | PDB
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| n/a | n/a | 40.2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255060
(CHEMBL481782 | N-(5-chlorothiophen-2-ylsulfonyl)-2...)Show SMILES Clc1ccc(s1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C24H17ClN2O6S3/c25-21-10-11-23(34-21)36(31,32)27-22(28)14-33-19-7-3-6-18-24(19)20(13-26-18)35(29,30)17-9-8-15-4-1-2-5-16(15)12-17/h1-13,26H,14H2,(H,27,28) | PDB
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| n/a | n/a | 40.3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255027
(CHEMBL481183 | N-(3,5-dimethylisoxazol-4-ylsulfony...)Show SMILES Cc1noc(C)c1S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C25H21N3O7S2/c1-15-25(16(2)35-27-15)37(32,33)28-23(29)14-34-21-9-5-8-20-24(21)22(13-26-20)36(30,31)19-11-10-17-6-3-4-7-18(17)12-19/h3-13,26H,14H2,1-2H3,(H,28,29) | PDB
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| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254478
(2-(3-(2-chlorophenylsulfonyl)-1H-indol-4-yloxy)-N-...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccccc1Cl Show InChI InChI=1S/C20H13Cl3N2O6S3/c21-11-4-1-2-7-15(11)33(27,28)16-9-24-13-5-3-6-14(19(13)16)31-10-17(26)25-34(29,30)18-8-12(22)20(23)32-18/h1-9,24H,10H2,(H,25,26) | PDB
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| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254881
(2-(3-(4-(2-amino-2-oxoethyl)phenylthio)-1H-indol-4...)Show SMILES NC(=O)Cc1ccc(Sc2c[nH]c3cccc(OCC(=O)NS(=O)(=O)c4cc(Cl)c(Cl)s4)c23)cc1 Show InChI InChI=1S/C22H17Cl2N3O5S3/c23-14-9-20(34-22(14)24)35(30,31)27-19(29)11-32-16-3-1-2-15-21(16)17(10-26-15)33-13-6-4-12(5-7-13)8-18(25)28/h1-7,9-10,26H,8,11H2,(H2,25,28)(H,27,29) | PDB
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| n/a | n/a | 43.2 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254476
(2-(3-(benzo[d]thiazol-2-ylsulfonyl)-1H-indol-4-ylo...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1nc2ccccc2s1 Show InChI InChI=1S/C21H13Cl2N3O6S4/c22-11-8-18(34-20(11)23)36(30,31)26-17(27)10-32-14-6-3-5-13-19(14)16(9-24-13)35(28,29)21-25-12-4-1-2-7-15(12)33-21/h1-9,24H,10H2,(H,26,27) | PDB
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PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255092
(2-(3-(2,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)cc1Cl Show InChI InChI=1S/C20H12Cl4N2O6S3/c21-10-4-5-15(11(22)6-10)34(28,29)16-8-25-13-2-1-3-14(19(13)16)32-9-17(27)26-35(30,31)18-7-12(23)20(24)33-18/h1-8,25H,9H2,(H,26,27) | PDB
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PubMed
| n/a | n/a | 44.8 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254641
(CHEMBL482380 | N-(2-chlorophenylsulfonyl)-2-(3-(na...)Show SMILES Clc1ccccc1S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C26H19ClN2O4S2/c27-20-8-3-4-11-24(20)35(31,32)29-25(30)16-33-22-10-5-9-21-26(22)23(15-28-21)34-19-13-12-17-6-1-2-7-18(17)14-19/h1-15,28H,16H2,(H,29,30) | PDB
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| n/a | n/a | 48.7 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255061
(2-(3-(naphthalen-2-ylsulfonyl)-1H-indol-4-yloxy)-N...)Show SMILES O=C(COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1)NS(=O)(=O)c1ccccc1 Show InChI InChI=1S/C26H20N2O6S2/c29-25(28-36(32,33)20-9-2-1-3-10-20)17-34-23-12-6-11-22-26(23)24(16-27-22)35(30,31)21-14-13-18-7-4-5-8-19(18)15-21/h1-16,27H,17H2,(H,28,29) | PDB
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| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254922
(CHEMBL481984 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cn1nnnc1Sc1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C16H12Cl2N6O4S3/c1-24-16(20-22-23-24)29-11-6-19-9-3-2-4-10(14(9)11)28-7-12(25)21-31(26,27)13-5-8(17)15(18)30-13/h2-6,19H,7H2,1H3,(H,21,25) | PDB
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| n/a | n/a | 58.3 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254925
(2-(3-(1H-imidazol-2-ylthio)-1H-indol-4-yloxy)-N-(4...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ncc[nH]3)c12 Show InChI InChI=1S/C17H12Cl2N4O4S3/c18-9-6-14(29-16(9)19)30(25,26)23-13(24)8-27-11-3-1-2-10-15(11)12(7-22-10)28-17-20-4-5-21-17/h1-7,22H,8H2,(H,20,21)(H,23,24) | PDB
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| n/a | n/a | 66.1 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254994
(CHEMBL465297 | N-(2-chlorophenylsulfonyl)-2-(3-(na...)Show SMILES Clc1ccccc1S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H19ClN2O6S2/c27-20-8-3-4-11-23(20)37(33,34)29-25(30)16-35-22-10-5-9-21-26(22)24(15-28-21)36(31,32)19-13-12-17-6-1-2-7-18(17)14-19/h1-15,28H,16H2,(H,29,30) | PDB
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| Article
PubMed
| n/a | n/a | 79.6 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254732
(CHEMBL464073 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cn1nnnc1S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C16H12Cl2N6O6S3/c1-24-16(20-22-23-24)32(26,27)11-6-19-9-3-2-4-10(14(9)11)30-7-12(25)21-33(28,29)13-5-8(17)15(18)31-13/h2-6,19H,7H2,1H3,(H,21,25) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 88.4 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254644
(CHEMBL481590 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccccn1 Show InChI InChI=1S/C19H13Cl2N3O6S3/c20-11-8-17(31-19(11)21)33(28,29)24-15(25)10-30-13-5-3-4-12-18(13)14(9-23-12)32(26,27)16-6-1-2-7-22-16/h1-9,23H,10H2,(H,24,25) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254685
(CHEMBL520757 | N-(3,5-dimethylisoxazol-4-ylsulfony...)Show SMILES Cc1noc(C)c1S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C25H21N3O5S2/c1-15-25(16(2)33-27-15)35(30,31)28-23(29)14-32-21-9-5-8-20-24(21)22(13-26-20)34-19-11-10-17-6-3-4-7-18(17)12-19/h3-13,26H,14H2,1-2H3,(H,28,29) | PDB
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| Article
PubMed
| n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254640
(CHEMBL482379 | N-(2,5-dimethoxyphenylsulfonyl)-2-(...)Show SMILES COc1ccc(OC)c(c1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C28H24N2O6S2/c1-34-20-11-13-23(35-2)26(15-20)38(32,33)30-27(31)17-36-24-9-5-8-22-28(24)25(16-29-22)37-21-12-10-18-6-3-4-7-19(18)14-21/h3-16,29H,17H2,1-2H3,(H,30,31) | PDB
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| Article
PubMed
| n/a | n/a | 134 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255091
(CHEMBL480416 | N-(4,5-dichlorothiophen-2-ylsulfony...)Show SMILES Cc1nnc(s1)S(=O)(=O)c1c[nH]c2cccc(OCC(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)c12 Show InChI InChI=1S/C17H12Cl2N4O6S4/c1-8-21-22-17(30-8)32(25,26)12-6-20-10-3-2-4-11(15(10)12)29-7-13(24)23-33(27,28)14-5-9(18)16(19)31-14/h2-6,20H,7H2,1H3,(H,23,24) | PDB
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| Article
PubMed
| n/a | n/a | 198 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254646
(2-(3-(1H-1,2,4-triazol-3-ylsulfonyl)-1H-indol-4-yl...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1nnc[nH]1 Show InChI InChI=1S/C16H11Cl2N5O6S3/c17-8-4-13(30-15(8)18)32(27,28)23-12(24)6-29-10-3-1-2-9-14(10)11(5-19-9)31(25,26)16-20-7-21-22-16/h1-5,7,19H,6H2,(H,23,24)(H,20,21,22) | PDB
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| Article
PubMed
| n/a | n/a | 236 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50255059
(CHEMBL520108 | N-(4-methoxyphenylsulfonyl)-2-(3-(n...)Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C27H22N2O7S2/c1-35-20-10-13-21(14-11-20)38(33,34)29-26(30)17-36-24-8-4-7-23-27(24)25(16-28-23)37(31,32)22-12-9-18-5-2-3-6-19(18)15-22/h2-16,28H,17H2,1H3,(H,29,30) | PDB
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PubMed
| n/a | n/a | 544 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254474
(2-(3-(2-naphthoyl)-1H-indol-4-yloxy)-N-(4,5-dichlo...)Show SMILES Clc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(C(=O)c3ccc4ccccc4c3)c12 Show InChI InChI=1S/C25H16Cl2N2O5S2/c26-18-11-22(35-25(18)27)36(32,33)29-21(30)13-34-20-7-3-6-19-23(20)17(12-28-19)24(31)16-9-8-14-4-1-2-5-15(14)10-16/h1-12,28H,13H2,(H,29,30) | PDB
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| Article
PubMed
| n/a | n/a | 545 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human)) | BDBM50254728
(CHEMBL465947 | N-(4-methoxyphenylsulfonyl)-2-(3-(n...)Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12 Show InChI InChI=1S/C27H22N2O5S2/c1-33-20-10-13-22(14-11-20)36(31,32)29-26(30)17-34-24-8-4-7-23-27(24)25(16-28-23)35-21-12-9-18-5-2-3-6-19(18)15-21/h2-16,28H,17H2,1H3,(H,29,30) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 651 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE Chemistry, Inc
Curated by ChEMBL
| Assay Description
Displacement of [3H]PGE2 from human EP3 receptor in presence of 10% human serum |
Bioorg Med Chem Lett 19: 123-6 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.007
BindingDB Entry DOI: 10.7270/Q2JH3M1S |
More data for this
Ligand-Target Pair | |
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