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PubMed code 19027197

Compile data set for download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50291990
PNG
((R)-2-Amino-N-(2,6-dimethyl-phenyl)-propionamide(t...)
Show SMILES C[C@@H](N)C(=O)Nc1c(C)cccc1C |r|
Show InChI InChI=1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14)/t9-/m1/s1
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n/an/an/an/a 2.75E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135885
PNG
((R)-2-(4-Chloro-2-methyl-phenoxy)-1-phenyl-ethylam...)
Show SMILES Cc1cc(Cl)ccc1OC[C@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C15H16ClNO/c1-11-9-13(16)7-8-15(11)18-10-14(17)12-5-3-2-4-6-12/h2-9,14H,10,17H2,1H3/t14-/m0/s1
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n/an/an/an/a 1.51E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413850
PNG
(CHEMBL485002)
Show SMILES CN(C(=O)[C@@H]1CCCN1C)c1c(C)cccc1C |r|
Show InChI InChI=1S/C15H22N2O/c1-11-7-5-8-12(2)14(11)17(4)15(18)13-9-6-10-16(13)3/h5,7-8,13H,6,9-10H2,1-4H3/t13-/m0/s1
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n/an/an/an/a 2.00E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413854
PNG
(CHEMBL486721)
Show SMILES Cc1cccc(C)c1NC(=O)[C@H]1CCN(Cc2ccccc2)C1 |r|
Show InChI InChI=1S/C20H24N2O/c1-15-7-6-8-16(2)19(15)21-20(23)18-11-12-22(14-18)13-17-9-4-3-5-10-17/h3-10,18H,11-14H2,1-2H3,(H,21,23)/t18-/m0/s1
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n/an/an/an/a 2.29E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413855
PNG
(CHEMBL501346)
Show SMILES Cc1cccc(C)c1N1CN2CCC[C@@H]2C1=O |r|
Show InChI InChI=1S/C14H18N2O/c1-10-5-3-6-11(2)13(10)16-9-15-8-4-7-12(15)14(16)17/h3,5-6,12H,4,7-9H2,1-2H3/t12-/m1/s1
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n/an/an/an/a 5.01E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135881
PNG
((R)-2-(4-Chloro-phenoxy)-1-phenyl-ethylamine | (R)...)
Show SMILES N[C@@H](COc1ccc(Cl)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C14H14ClNO/c15-12-6-8-13(9-7-12)17-10-14(16)11-4-2-1-3-5-11/h1-9,14H,10,16H2/t14-/m0/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413864
PNG
(CHEMBL2021481)
Show SMILES C[C@H](O)COc1ccccc1 |r|
Show InChI InChI=1S/C9H12O2/c1-8(10)7-11-9-5-3-2-4-6-9/h2-6,8,10H,7H2,1H3/t8-/m0/s1
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n/an/an/an/a 2.34E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413867
PNG
(CHEMBL483784)
Show SMILES Cc1cccc(C)c1SC[C@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C16H19NS/c1-12-7-6-8-13(2)16(12)18-11-15(17)14-9-4-3-5-10-14/h3-10,15H,11,17H2,1-2H3/t15-/m0/s1
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n/an/an/an/a 7.08E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413868
PNG
(CHEMBL452986)
Show SMILES Cc1cccc(C)c1SC[C@@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C16H19NS/c1-12-7-6-8-13(2)16(12)18-11-15(17)14-9-4-3-5-10-14/h3-10,15H,11,17H2,1-2H3/t15-/m1/s1
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n/an/an/an/a 4.68E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413853
PNG
(CHEMBL485004)
Show SMILES Cc1cccc(C)c1NC(=O)[C@@H]1CCN(Cc2ccccc2)C1 |r|
Show InChI InChI=1S/C20H24N2O/c1-15-7-6-8-16(2)19(15)21-20(23)18-11-12-22(14-18)13-17-9-4-3-5-10-17/h3-10,18H,11-14H2,1-2H3,(H,21,23)/t18-/m1/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413858
PNG
(CHEMBL487338)
Show SMILES Cc1cccc(C)c1OC[C@H](N)Cc1ccccc1 |r|
Show InChI InChI=1S/C17H21NO/c1-13-7-6-8-14(2)17(13)19-12-16(18)11-15-9-4-3-5-10-15/h3-10,16H,11-12,18H2,1-2H3/t16-/m1/s1
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n/an/an/an/a 2.40E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413861
PNG
(CHEMBL486414)
Show SMILES Cc1cc(Cl)ccc1OCC(N)Cc1ccccc1
Show InChI InChI=1S/C16H18ClNO/c1-12-9-14(17)7-8-16(12)19-11-15(18)10-13-5-3-2-4-6-13/h2-9,15H,10-11,18H2,1H3
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Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135878
PNG
((R)-1-Phenyl-2-o-tolyloxy-ethylamine | (R)-1-pheny...)
Show SMILES Cc1ccccc1OC[C@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C15H17NO/c1-12-7-5-6-10-15(12)17-11-14(16)13-8-3-2-4-9-13/h2-10,14H,11,16H2,1H3/t14-/m0/s1
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Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413862
PNG
(CHEMBL486528)
Show SMILES Cc1ccccc1OCC(N)Cc1ccccc1
Show InChI InChI=1S/C16H19NO/c1-13-7-5-6-10-16(13)18-12-15(17)11-14-8-3-2-4-9-14/h2-10,15H,11-12,17H2,1H3
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n/an/an/an/a 3.02E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135879
PNG
((S)-2-Phenoxy-1-phenyl-ethylamine | (S)-2-phenoxy-...)
Show SMILES N[C@H](COc1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C14H15NO/c15-14(12-7-3-1-4-8-12)11-16-13-9-5-2-6-10-13/h1-10,14H,11,15H2/t14-/m1/s1
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n/an/an/an/a 1.58E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413865
PNG
(CHEMBL468775)
Show SMILES C[C@H](CN)COc1c(C)cccc1C |r|
Show InChI InChI=1S/C12H19NO/c1-9(7-13)8-14-12-10(2)5-4-6-11(12)3/h4-6,9H,7-8,13H2,1-3H3/t9-/m1/s1
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n/an/an/an/a 2.34E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413869
PNG
(CHEMBL448542)
Show SMILES C[C@H](CN)CSc1c(C)cccc1C |r|
Show InChI InChI=1S/C12H19NS/c1-9(7-13)8-14-12-10(2)5-4-6-11(12)3/h4-6,9H,7-8,13H2,1-3H3/t9-/m1/s1
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n/an/an/an/a 2.69E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413857
PNG
(CHEMBL474672)
Show SMILES CC(C)[C@H](N)COc1c(C)cccc1C |r|
Show InChI InChI=1S/C13H21NO/c1-9(2)12(14)8-15-13-10(3)6-5-7-11(13)4/h5-7,9,12H,8,14H2,1-4H3/t12-/m1/s1
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n/an/an/an/a 5.75E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135877
PNG
((R)-2-(4-Chloro-2,6-dimethyl-phenoxy)-1-phenyl-eth...)
Show SMILES Cc1cc(Cl)cc(C)c1OC[C@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C16H18ClNO/c1-11-8-14(17)9-12(2)16(11)19-10-15(18)13-6-4-3-5-7-13/h3-9,15H,10,18H2,1-2H3/t15-/m0/s1
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n/an/an/an/a 1.95E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413860
PNG
(CHEMBL501561)
Show SMILES C[C@@H](CN)COc1c(C)cc(Cl)cc1C |r|
Show InChI InChI=1S/C12H18ClNO/c1-8(6-14)7-15-12-9(2)4-11(13)5-10(12)3/h4-5,8H,6-7,14H2,1-3H3/t8-/m0/s1
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n/an/an/an/a 2.88E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135873
PNG
((S)-2-(4-Chloro-phenoxy)-1-phenyl-ethylamine | (S)...)
Show SMILES N[C@H](COc1ccc(Cl)cc1)c1ccccc1 |r|
Show InChI InChI=1S/C14H14ClNO/c15-12-6-8-13(9-7-12)17-10-14(16)11-4-2-1-3-5-11/h1-9,14H,10,16H2/t14-/m1/s1
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n/an/an/an/a 3.02E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50291989
PNG
((S)-2-Amino-N-(2,6-dimethyl-phenyl)-propionamide(t...)
Show SMILES C[C@H](N)C(=O)Nc1c(C)cccc1C |r|
Show InChI InChI=1S/C11H16N2O/c1-7-5-4-6-8(2)10(7)13-11(14)9(3)12/h4-6,9H,12H2,1-3H3,(H,13,14)/t9-/m0/s1
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n/an/an/an/a 2.24E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135883
PNG
((2R)-1-(2,6-dimethylphenoxy)propan-2-amine | (R)-1...)
Show SMILES C[C@@H](N)COc1c(C)cccc1C |r|
Show InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3/t10-/m1/s1
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n/an/an/an/a 2.29E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413866
PNG
(CHEMBL485647)
Show SMILES C[C@@H](CN)COc1c(C)cccc1C |r|
Show InChI InChI=1S/C12H19NO/c1-9(7-13)8-14-12-10(2)5-4-6-11(12)3/h4-6,9H,7-8,13H2,1-3H3/t9-/m0/s1
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n/an/an/an/a 1.74E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413845
PNG
(CHEMBL473705)
Show SMILES CN1CCC[C@@H]1C(=O)Nc1c(C)cccc1C |r|
Show InChI InChI=1S/C14H20N2O/c1-10-6-4-7-11(2)13(10)15-14(17)12-8-5-9-16(12)3/h4,6-7,12H,5,8-9H2,1-3H3,(H,15,17)/t12-/m1/s1
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n/an/an/an/a 6.76E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135884
PNG
((S)-1-(2,6-dimethylphenoxy)propan-2-amine | (S)-2-...)
Show SMILES C[C@H](N)COc1c(C)cccc1C |r|
Show InChI InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3/t10-/m0/s1
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n/an/an/an/a 2.69E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135882
PNG
((S)-2-(4-Chloro-2,6-dimethyl-phenoxy)-1-phenyl-eth...)
Show SMILES Cc1cc(Cl)cc(C)c1OC[C@@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C16H18ClNO/c1-11-8-14(17)9-12(2)16(11)19-10-15(18)13-6-4-3-5-7-13/h3-9,15H,10,18H2,1-2H3/t15-/m1/s1
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n/an/an/an/a 7.94E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413844
PNG
(CHEMBL473499)
Show SMILES Cc1cccc(C)c1NC(=O)[C@@H]1CCCN1 |r|
Show InChI InChI=1S/C13H18N2O/c1-9-5-3-6-10(2)12(9)15-13(16)11-7-4-8-14-11/h3,5-6,11,14H,4,7-8H2,1-2H3,(H,15,16)/t11-/m0/s1
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n/an/an/an/a 4.07E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413847
PNG
(CHEMBL484981)
Show SMILES CN(C(=O)[C@H]1CCCN1)c1c(C)cccc1C |r|
Show InChI InChI=1S/C14H20N2O/c1-10-6-4-7-11(2)13(10)16(3)14(17)12-8-5-9-15-12/h4,6-7,12,15H,5,8-9H2,1-3H3/t12-/m1/s1
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n/an/an/an/a 2.19E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413848
PNG
(CHEMBL484996)
Show SMILES CN(C(=O)[C@@H]1CCCN1)c1c(C)cccc1C |r|
Show InChI InChI=1S/C14H20N2O/c1-10-6-4-7-11(2)13(10)16(3)14(17)12-8-5-9-15-12/h4,6-7,12,15H,5,8-9H2,1-3H3/t12-/m0/s1
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n/an/an/an/a 6.76E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413851
PNG
(CHEMBL519199)
Show SMILES Cc1cccc(C)c1NC(=O)[C@H]1CCCN1Cc1ccccc1 |r|
Show InChI InChI=1S/C20H24N2O/c1-15-8-6-9-16(2)19(15)21-20(23)18-12-7-13-22(18)14-17-10-4-3-5-11-17/h3-6,8-11,18H,7,12-14H2,1-2H3,(H,21,23)/t18-/m1/s1
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n/an/an/an/a 3.16E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413852
PNG
(CHEMBL485003)
Show SMILES Cc1cccc(C)c1NC(=O)[C@@H]1CCCN1Cc1ccccc1 |r|
Show InChI InChI=1S/C20H24N2O/c1-15-8-6-9-16(2)19(15)21-20(23)18-12-7-13-22(18)14-17-10-4-3-5-11-17/h3-6,8-11,18H,7,12-14H2,1-2H3,(H,21,23)/t18-/m0/s1
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n/an/an/an/a 1.00E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135880
PNG
((S)-2-(2,6-Dimethyl-phenoxy)-1-phenyl-ethylamine |...)
Show SMILES Cc1cccc(C)c1OC[C@@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C16H19NO/c1-12-7-6-8-13(2)16(12)18-11-15(17)14-9-4-3-5-10-14/h3-10,15H,11,17H2,1-2H3/t15-/m1/s1
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n/an/an/an/a 3.02E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413856
PNG
(CHEMBL446777)
Show SMILES CC(C)[C@@H](N)COc1c(C)cccc1C |r|
Show InChI InChI=1S/C13H21NO/c1-9(2)12(14)8-15-13-10(3)6-5-7-11(13)4/h5-7,9,12H,8,14H2,1-4H3/t12-/m0/s1
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n/an/an/an/a 5.75E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413863
PNG
(CHEMBL2021482)
Show SMILES C[C@@H](O)COc1ccccc1 |r|
Show InChI InChI=1S/C9H12O2/c1-8(10)7-11-9-5-3-2-4-6-9/h2-6,8,10H,7H2,1H3/t8-/m1/s1
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n/an/an/an/a 2.09E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135874
PNG
((R)-2-Phenoxy-1-phenyl-ethylamine | (R)-2-phenoxy-...)
Show SMILES N[C@@H](COc1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C14H15NO/c15-14(12-7-3-1-4-8-12)11-16-13-9-5-2-6-10-13/h1-10,14H,11,15H2/t14-/m0/s1
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n/an/an/an/a 3.98E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413846
PNG
(CHEMBL473706)
Show SMILES CN1CCC[C@H]1C(=O)Nc1c(C)cccc1C |r|
Show InChI InChI=1S/C14H20N2O/c1-10-6-4-7-11(2)13(10)15-14(17)12-8-5-9-16(12)3/h4,6-7,12H,5,8-9H2,1-3H3,(H,15,17)/t12-/m0/s1
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n/an/an/an/a 2.82E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50135886
PNG
((R)-2-(2,6-Dimethyl-phenoxy)-1-phenyl-ethylamine |...)
Show SMILES Cc1cccc(C)c1OC[C@H](N)c1ccccc1 |r|
Show InChI InChI=1S/C16H19NO/c1-12-7-6-8-13(2)16(12)18-11-15(17)14-9-4-3-5-10-14/h3-10,15H,11,17H2,1-2H3/t15-/m0/s1
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n/an/an/an/a 3.02E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413859
PNG
(CHEMBL486315)
Show SMILES C[C@H](CN)COc1c(C)cc(Cl)cc1C |r|
Show InChI InChI=1S/C12H18ClNO/c1-8(6-14)7-15-12-9(2)4-11(13)5-10(12)3/h4-5,8H,6-7,14H2,1-3H3/t8-/m1/s1
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n/an/an/an/a 3.72E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413870
PNG
(CHEMBL444700)
Show SMILES C[C@@H](CN)CSc1c(C)cccc1C |r|
Show InChI InChI=1S/C12H19NS/c1-9(7-13)8-14-12-10(2)5-4-6-11(12)3/h4-6,9H,7-8,13H2,1-3H3/t9-/m0/s1
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n/an/an/an/a 1.91E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413841
PNG
(CHEMBL472884)
Show SMILES C[C@@H](NCc1ccccc1)C(=O)Nc1c(C)cccc1C |r|
Show InChI InChI=1S/C18H22N2O/c1-13-8-7-9-14(2)17(13)20-18(21)15(3)19-12-16-10-5-4-6-11-16/h4-11,15,19H,12H2,1-3H3,(H,20,21)/t15-/m1/s1
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n/an/an/an/a 1.12E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413842
PNG
(CHEMBL473498)
Show SMILES C[C@H](NCc1ccccc1)C(=O)Nc1c(C)cccc1C |r|
Show InChI InChI=1S/C18H22N2O/c1-13-8-7-9-14(2)17(13)20-18(21)15(3)19-12-16-10-5-4-6-11-16/h4-11,15,19H,12H2,1-3H3,(H,20,21)/t15-/m0/s1
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n/an/an/an/a 9.12E+3n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413843
PNG
(CHEMBL502686)
Show SMILES Cc1cccc(C)c1NC(=O)[C@H]1CCCN1 |r|
Show InChI InChI=1S/C13H18N2O/c1-9-5-3-6-10(2)12(9)15-13(16)11-7-4-8-14-11/h3,5-6,11,14H,4,7-8H2,1-2H3,(H,15,16)/t11-/m1/s1
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n/an/an/an/a 1.20E+4n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
Voltage-gated sodium channel subunit alpha Nav1.4 (Nav1.4)


(Homo sapiens (Human))
BDBM50413849
PNG
(CHEMBL484833)
Show SMILES CN(C(=O)[C@H]1CCCN1C)c1c(C)cccc1C |r|
Show InChI InChI=1S/C15H22N2O/c1-11-7-5-8-12(2)14(11)17(4)15(18)13-9-6-10-16(13)3/h5,7-8,13H,6,9-10H2,1-4H3/t13-/m1/s1
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n/an/an/an/a 5.01E+5n/an/an/an/a



Universit£ degli Studi di Bari

Curated by ChEMBL


Assay Description
Inhibition of Nav1.4 ion channel assessed as reduction in cumulative sodium current


Eur J Med Chem 44: 1477-85 (2009)


Article DOI: 10.1016/j.ejmech.2008.10.005
BindingDB Entry DOI: 10.7270/Q2M61MGC
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%