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PubMed code 19091563

Compile data set for download or QSAR
Found 79 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277100
PNG
(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Show SMILES FC(F)(F)c1ccc2Sc3ccccc3N(CCCN3CCN(CCOC(=O)c4ccc(OCCCN5CCCCC5)cc4)CC3)c2c1
Show InChI InChI=1S/C37H45F3N4O3S/c38-37(39,40)30-12-15-35-33(28-30)44(32-8-2-3-9-34(32)48-35)20-6-18-42-21-23-43(24-22-42)25-27-47-36(45)29-10-13-31(14-11-29)46-26-7-19-41-16-4-1-5-17-41/h2-3,8-15,28H,1,4-7,16-27H2
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 0.0420n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277045
PNG
(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H42N2O/c1-35(27-28-16-20-31(21-17-28)37-26-10-25-36-23-7-2-8-24-36)22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 0.25n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277046
PNG
(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Show SMILES CN(CCCC12CCC(c3ccccc13)c1ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C35H44N2O/c1-36(27-28-15-17-29(18-16-28)38-26-10-25-37-23-7-2-8-24-37)22-9-20-35-21-19-30(31-11-3-5-13-33(31)35)32-12-4-6-14-34(32)35/h3-6,11-18,30H,2,7-10,19-27H2,1H3
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 0.358n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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 1.12n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277076
PNG
(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Show SMILES CN(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H38ClN3OS/c1-33(24-25-11-14-27(15-12-25)36-22-8-20-34-18-5-2-6-19-34)17-7-21-35-28-9-3-4-10-30(28)37-31-16-13-26(32)23-29(31)35/h3-4,9-16,23H,2,5-8,17-22,24H2,1H3
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 1.21n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM78433
PNG
(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Show SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
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 1.44n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277077
PNG
(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Show SMILES CN(CC\C=C1/c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H37ClN2OS/c1-34(24-25-12-15-27(16-13-25)36-22-8-21-35-19-5-2-6-20-35)18-7-10-28-29-9-3-4-11-31(29)37-32-17-14-26(33)23-30(28)32/h3-4,9-17,23H,2,5-8,18-22,24H2,1H3/b28-10+
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 1.54n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM35228
PNG
(CHEMBL21731 | Dibencycladine | Ludiomil | maprotil...)
Show SMILES CNCCCC12CCC(c3ccccc13)c1ccccc21 |TLB:10:9:6.7:20.15,16:15:6.7:14.9,THB:13:14:6.7:20.15,19:20:6.7:14.9|
Show InChI InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3
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 1.67n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 2.38n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50240514
PNG
((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Show SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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 2.96n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM78433
PNG
(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Show SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
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 3.21n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277099
PNG
(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |c:13|
Show InChI InChI=1S/C32H38ClN5O/c33-26-11-14-30-31(23-26)35-32(28-7-2-3-8-29(28)34-30)38-20-18-37(19-21-38)24-25-9-12-27(13-10-25)39-22-6-17-36-15-4-1-5-16-36/h2-3,7-14,23,34H,1,4-6,15-22,24H2
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 3.27n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50277044
PNG
(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H40N2O2/c1-35(34(37)29-18-20-30(21-19-29)38-26-10-25-36-23-7-2-8-24-36)22-9-15-33-31-13-5-3-11-27(31)16-17-28-12-4-6-14-32(28)33/h3-6,11-15,18-21H,2,7-10,16-17,22-26H2,1H3
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 3.5n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50240514
PNG
((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Show SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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 3.75n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 4.06n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 4.25n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50240514
PNG
((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Show SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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 4.56n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50276977
PNG
(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C35H42N2O2/c1-36(22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34)35(38)27-28-16-20-31(21-17-28)39-26-10-25-37-23-7-2-8-24-37/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 4.90n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 6.90n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50240514
PNG
((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Show SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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 9n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277100
PNG
(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Show SMILES FC(F)(F)c1ccc2Sc3ccccc3N(CCCN3CCN(CCOC(=O)c4ccc(OCCCN5CCCCC5)cc4)CC3)c2c1
Show InChI InChI=1S/C37H45F3N4O3S/c38-37(39,40)30-12-15-35-33(28-30)44(32-8-2-3-9-34(32)48-35)20-6-18-42-21-23-43(24-22-42)25-27-47-36(45)29-10-13-31(14-11-29)46-26-7-19-41-16-4-1-5-17-41/h2-3,8-15,28H,1,4-7,16-27H2
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 15n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50240514
PNG
((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Show SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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 18n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM78433
PNG
(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Show SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
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 21n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM78433
PNG
(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Show SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
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 40n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277046
PNG
(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Show SMILES CN(CCCC12CCC(c3ccccc13)c1ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C35H44N2O/c1-36(27-28-15-17-29(18-16-28)38-26-10-25-37-23-7-2-8-24-37)22-9-20-35-21-19-30(31-11-3-5-13-33(31)35)32-12-4-6-14-34(32)35/h3-6,11-18,30H,2,7-10,19-27H2,1H3
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 40n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277076
PNG
(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Show SMILES CN(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H38ClN3OS/c1-33(24-25-11-14-27(15-12-25)36-22-8-20-34-18-5-2-6-19-34)17-7-21-35-28-9-3-4-10-30(28)37-31-16-13-26(32)23-29(31)35/h3-4,9-16,23H,2,5-8,17-22,24H2,1H3
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 41n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277100
PNG
(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Show SMILES FC(F)(F)c1ccc2Sc3ccccc3N(CCCN3CCN(CCOC(=O)c4ccc(OCCCN5CCCCC5)cc4)CC3)c2c1
Show InChI InChI=1S/C37H45F3N4O3S/c38-37(39,40)30-12-15-35-33(28-30)44(32-8-2-3-9-34(32)48-35)20-6-18-42-21-23-43(24-22-42)25-27-47-36(45)29-10-13-31(14-11-29)46-26-7-19-41-16-4-1-5-17-41/h2-3,8-15,28H,1,4-7,16-27H2
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 47n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277077
PNG
(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Show SMILES CN(CC\C=C1/c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H37ClN2OS/c1-34(24-25-12-15-27(16-13-25)36-22-8-21-35-19-5-2-6-20-35)18-7-10-28-29-9-3-4-11-31(29)37-32-17-14-26(33)23-30(28)32/h3-4,9-17,23H,2,5-8,18-22,24H2,1H3/b28-10+
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 50n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277076
PNG
(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Show SMILES CN(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H38ClN3OS/c1-33(24-25-11-14-27(15-12-25)36-22-8-20-34-18-5-2-6-19-34)17-7-21-35-28-9-3-4-10-30(28)37-31-16-13-26(32)23-29(31)35/h3-4,9-16,23H,2,5-8,17-22,24H2,1H3
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 50n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277077
PNG
(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Show SMILES CN(CC\C=C1/c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H37ClN2OS/c1-34(24-25-12-15-27(16-13-25)36-22-8-21-35-19-5-2-6-20-35)18-7-10-28-29-9-3-4-11-31(29)37-32-17-14-26(33)23-30(28)32/h3-4,9-17,23H,2,5-8,18-22,24H2,1H3/b28-10+
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 52n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277045
PNG
(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H42N2O/c1-35(27-28-16-20-31(21-17-28)37-26-10-25-36-23-7-2-8-24-36)22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 67n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277045
PNG
(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H42N2O/c1-35(27-28-16-20-31(21-17-28)37-26-10-25-36-23-7-2-8-24-36)22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 79n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 83n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 89n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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 89n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 96n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277045
PNG
(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H42N2O/c1-35(27-28-16-20-31(21-17-28)37-26-10-25-36-23-7-2-8-24-36)22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 101n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277046
PNG
(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Show SMILES CN(CCCC12CCC(c3ccccc13)c1ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C35H44N2O/c1-36(27-28-15-17-29(18-16-28)38-26-10-25-37-23-7-2-8-24-37)22-9-20-35-21-19-30(31-11-3-5-13-33(31)35)32-12-4-6-14-34(32)35/h3-6,11-18,30H,2,7-10,19-27H2,1H3
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 146n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277046
PNG
(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Show SMILES CN(CCCC12CCC(c3ccccc13)c1ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C35H44N2O/c1-36(27-28-15-17-29(18-16-28)38-26-10-25-37-23-7-2-8-24-37)22-9-20-35-21-19-30(31-11-3-5-13-33(31)35)32-12-4-6-14-34(32)35/h3-6,11-18,30H,2,7-10,19-27H2,1H3
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 149n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277076
PNG
(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Show SMILES CN(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H38ClN3OS/c1-33(24-25-11-14-27(15-12-25)36-22-8-20-34-18-5-2-6-19-34)17-7-21-35-28-9-3-4-10-30(28)37-31-16-13-26(32)23-29(31)35/h3-4,9-16,23H,2,5-8,17-22,24H2,1H3
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 153n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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 170n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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 172n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM78433
PNG
(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Show SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
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 179n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277099
PNG
(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |c:13|
Show InChI InChI=1S/C32H38ClN5O/c33-26-11-14-30-31(23-26)35-32(28-7-2-3-8-29(28)34-30)38-20-18-37(19-21-38)24-25-9-12-27(13-10-25)39-22-6-17-36-15-4-1-5-16-36/h2-3,7-14,23,34H,1,4-6,15-22,24H2
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 190n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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 196n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 198n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277100
PNG
(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Show SMILES FC(F)(F)c1ccc2Sc3ccccc3N(CCCN3CCN(CCOC(=O)c4ccc(OCCCN5CCCCC5)cc4)CC3)c2c1
Show InChI InChI=1S/C37H45F3N4O3S/c38-37(39,40)30-12-15-35-33(28-30)44(32-8-2-3-9-34(32)48-35)20-6-18-42-21-23-43(24-22-42)25-27-47-36(45)29-10-13-31(14-11-29)46-26-7-19-41-16-4-1-5-17-41/h2-3,8-15,28H,1,4-7,16-27H2
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 203n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277046
PNG
(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Show SMILES CN(CCCC12CCC(c3ccccc13)c1ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C35H44N2O/c1-36(27-28-15-17-29(18-16-28)38-26-10-25-37-23-7-2-8-24-37)22-9-20-35-21-19-30(31-11-3-5-13-33(31)35)32-12-4-6-14-34(32)35/h3-6,11-18,30H,2,7-10,19-27H2,1H3
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 203n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277076
PNG
(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Show SMILES CN(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H38ClN3OS/c1-33(24-25-11-14-27(15-12-25)36-22-8-20-34-18-5-2-6-19-34)17-7-21-35-28-9-3-4-10-30(28)37-31-16-13-26(32)23-29(31)35/h3-4,9-16,23H,2,5-8,17-22,24H2,1H3
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 205n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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 206n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277099
PNG
(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |c:13|
Show InChI InChI=1S/C32H38ClN5O/c33-26-11-14-30-31(23-26)35-32(28-7-2-3-8-29(28)34-30)38-20-18-37(19-21-38)24-25-9-12-27(13-10-25)39-22-6-17-36-15-4-1-5-16-36/h2-3,7-14,23,34H,1,4-6,15-22,24H2
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 223n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277076
PNG
(CHEMBL459373 | [3-(2-Chloro-phenothiazin-10-yl)-pr...)
Show SMILES CN(CCCN1c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C31H38ClN3OS/c1-33(24-25-11-14-27(15-12-25)36-22-8-20-34-18-5-2-6-19-34)17-7-21-35-28-9-3-4-10-30(28)37-31-16-13-26(32)23-29(31)35/h3-4,9-16,23H,2,5-8,17-22,24H2,1H3
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 232n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50277044
PNG
(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H40N2O2/c1-35(34(37)29-18-20-30(21-19-29)38-26-10-25-36-23-7-2-8-24-36)22-9-15-33-31-13-5-3-11-27(31)16-17-28-12-4-6-14-32(28)33/h3-6,11-15,18-21H,2,7-10,16-17,22-26H2,1H3
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 243n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277077
PNG
(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Show SMILES CN(CC\C=C1/c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H37ClN2OS/c1-34(24-25-12-15-27(16-13-25)36-22-8-21-35-19-5-2-6-20-35)18-7-10-28-29-9-3-4-11-31(29)37-32-17-14-26(33)23-30(28)32/h3-4,9-17,23H,2,5-8,18-22,24H2,1H3/b28-10+
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 248n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277046
PNG
(CHEMBL517244 | methyl({4-[3-(piperidin-1-yl)propox...)
Show SMILES CN(CCCC12CCC(c3ccccc13)c1ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C35H44N2O/c1-36(27-28-15-17-29(18-16-28)38-26-10-25-37-23-7-2-8-24-37)22-9-20-35-21-19-30(31-11-3-5-13-33(31)35)32-12-4-6-14-34(32)35/h3-6,11-18,30H,2,7-10,19-27H2,1H3
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 265n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277100
PNG
(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Show SMILES FC(F)(F)c1ccc2Sc3ccccc3N(CCCN3CCN(CCOC(=O)c4ccc(OCCCN5CCCCC5)cc4)CC3)c2c1
Show InChI InChI=1S/C37H45F3N4O3S/c38-37(39,40)30-12-15-35-33(28-30)44(32-8-2-3-9-34(32)48-35)20-6-18-42-21-23-43(24-22-42)25-27-47-36(45)29-10-13-31(14-11-29)46-26-7-19-41-16-4-1-5-17-41/h2-3,8-15,28H,1,4-7,16-27H2
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 265n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277045
PNG
(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H42N2O/c1-35(27-28-16-20-31(21-17-28)37-26-10-25-36-23-7-2-8-24-36)22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 273n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277099
PNG
(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |c:13|
Show InChI InChI=1S/C32H38ClN5O/c33-26-11-14-30-31(23-26)35-32(28-7-2-3-8-29(28)34-30)38-20-18-37(19-21-38)24-25-9-12-27(13-10-25)39-22-6-17-36-15-4-1-5-16-36/h2-3,7-14,23,34H,1,4-6,15-22,24H2
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 285n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277077
PNG
(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Show SMILES CN(CC\C=C1/c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H37ClN2OS/c1-34(24-25-12-15-27(16-13-25)36-22-8-21-35-19-5-2-6-20-35)18-7-10-28-29-9-3-4-11-31(29)37-32-17-14-26(33)23-30(28)32/h3-4,9-17,23H,2,5-8,18-22,24H2,1H3/b28-10+
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 295n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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 295n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277077
PNG
(CHEMBL517407 | {3-[2-Chloro-thioxanthenylidene]-pr...)
Show SMILES CN(CC\C=C1/c2ccccc2Sc2ccc(Cl)cc12)Cc1ccc(OCCCN2CCCCC2)cc1
Show InChI InChI=1S/C32H37ClN2OS/c1-34(24-25-12-15-27(16-13-25)36-22-8-21-35-19-5-2-6-20-35)18-7-10-28-29-9-3-4-11-31(29)37-32-17-14-26(33)23-30(28)32/h3-4,9-17,23H,2,5-8,18-22,24H2,1H3/b28-10+
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 297n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277045
PNG
(CHEMBL459350 | [3-(10,11-Dihydro-dibenzo[a,d]cyclo...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H42N2O/c1-35(27-28-16-20-31(21-17-28)37-26-10-25-36-23-7-2-8-24-36)22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 305n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50276977
PNG
(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C35H42N2O2/c1-36(22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34)35(38)27-28-16-20-31(21-17-28)39-26-10-25-37-23-7-2-8-24-37/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 326n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D3 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277100
PNG
(4-(3-Piperidin-1-yl-propoxy)-benzoic acid 2-{4-[3-...)
Show SMILES FC(F)(F)c1ccc2Sc3ccccc3N(CCCN3CCN(CCOC(=O)c4ccc(OCCCN5CCCCC5)cc4)CC3)c2c1
Show InChI InChI=1S/C37H45F3N4O3S/c38-37(39,40)30-12-15-35-33(28-30)44(32-8-2-3-9-34(32)48-35)20-6-18-42-21-23-43(24-22-42)25-27-47-36(45)29-10-13-31(14-11-29)46-26-7-19-41-16-4-1-5-17-41/h2-3,8-15,28H,1,4-7,16-27H2
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 390n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50276977
PNG
(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C35H42N2O2/c1-36(22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34)35(38)27-28-16-20-31(21-17-28)39-26-10-25-37-23-7-2-8-24-37/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 559n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))		BDBM50277044
PNG
(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H40N2O2/c1-35(34(37)29-18-20-30(21-19-29)38-26-10-25-36-23-7-2-8-24-36)22-9-15-33-31-13-5-3-11-27(31)16-17-28-12-4-6-14-32(28)33/h3-6,11-15,18-21H,2,7-10,16-17,22-26H2,1H3
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 686n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277099
PNG
(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |c:13|
Show InChI InChI=1S/C32H38ClN5O/c33-26-11-14-30-31(23-26)35-32(28-7-2-3-8-29(28)34-30)38-20-18-37(19-21-38)24-25-9-12-27(13-10-25)39-22-6-17-36-15-4-1-5-16-36/h2-3,7-14,23,34H,1,4-6,15-22,24H2
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 866n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50276977
PNG
(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C35H42N2O2/c1-36(22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34)35(38)27-28-16-20-31(21-17-28)39-26-10-25-37-23-7-2-8-24-37/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 879n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50276977
PNG
(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C35H42N2O2/c1-36(22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34)35(38)27-28-16-20-31(21-17-28)39-26-10-25-37-23-7-2-8-24-37/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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 904n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277099
PNG
(8-Chloro-11-{4-[4-(3-piperidin-1-yl-propoxy)-benzy...)
Show SMILES Clc1ccc2Nc3ccccc3C(=Nc2c1)N1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |c:13|
Show InChI InChI=1S/C32H38ClN5O/c33-26-11-14-30-31(23-26)35-32(28-7-2-3-8-29(28)34-30)38-20-18-37(19-21-38)24-25-9-12-27(13-10-25)39-22-6-17-36-15-4-1-5-16-36/h2-3,7-14,23,34H,1,4-6,15-22,24H2
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 921n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50001888
PNG
((chloropromazine) [3-(2-Chloro-phenothiazin-10-yl)...)
Show SMILES CN(C)CCCN1c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C17H19ClN2S/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50020712
PNG
(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12
Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50277044
PNG
(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H40N2O2/c1-35(34(37)29-18-20-30(21-19-29)38-26-10-25-36-23-7-2-8-24-36)22-9-15-33-31-13-5-3-11-27(31)16-17-28-12-4-6-14-32(28)33/h3-6,11-15,18-21H,2,7-10,16-17,22-26H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1A) dopamine receptor


(Homo sapiens (Human))		BDBM50277044
PNG
(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H40N2O2/c1-35(34(37)29-18-20-30(21-19-29)38-26-10-25-36-23-7-2-8-24-36)22-9-15-33-31-13-5-3-11-27(31)16-17-28-12-4-6-14-32(28)33/h3-6,11-15,18-21H,2,7-10,16-17,22-26H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))		BDBM50277044
PNG
(CHEMBL460402 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C34H40N2O2/c1-35(34(37)29-18-20-30(21-19-29)38-26-10-25-36-23-7-2-8-24-36)22-9-15-33-31-13-5-3-11-27(31)16-17-28-12-4-6-14-32(28)33/h3-6,11-15,18-21H,2,7-10,16-17,22-26H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine D2 receptor expressed in CHO cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM50240514
PNG
((3Z)-3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dim...)
Show SMILES CN(C)CC\C=C1\c2ccccc2Sc2ccc(Cl)cc12
Show InChI InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50276977
PNG
(CHEMBL457957 | N-[3-(10,11-Dihydro-dibenzo[a,d]cyc...)
Show SMILES [#6]-[#7](-[#6]-[#6]\[#6]=[#6]-1/c2ccccc2-[#6]-[#6]-c2ccccc-12)-[#6](=O)-[#6]-c1ccc(-[#8]-[#6]-[#6]-[#6]-[#7]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)cc1
Show InChI InChI=1S/C35H42N2O2/c1-36(22-9-15-34-32-13-5-3-11-29(32)18-19-30-12-4-6-14-33(30)34)35(38)27-28-16-20-31(21-17-28)39-26-10-25-37-23-7-2-8-24-37/h3-6,11-17,20-21H,2,7-10,18-19,22-27H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Homo sapiens (Human))		BDBM78433
PNG
(2-[4-[3-[2-(trifluoromethyl)-10-phenothiazinyl]pro...)
Show SMILES OCCN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1
Show InChI InChI=1S/C22H26F3N3OS/c23-22(24,25)17-6-7-21-19(16-17)28(18-4-1-2-5-20(18)30-21)9-3-8-26-10-12-27(13-11-26)14-15-29/h1-2,4-7,16,29H,3,8-15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe Universit£t

Curated by ChEMBL


Assay Description
Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in CHO/HEK293 cells

Bioorg Med Chem Lett 19: 538-42 (2008)


Article DOI: 10.1016/j.bmcl.2008.09.012
BindingDB Entry DOI: 10.7270/Q25H7H6W
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%