Found 46 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179883
((4-Isopropylphenyl)-(4-isoquinolin-5-yl-phthalazin...)Show SMILES CC(C)c1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)cc1 Show InChI InChI=1S/C26H22N4/c1-17(2)18-10-12-20(13-11-18)28-26-24-8-4-3-7-23(24)25(29-30-26)22-9-5-6-19-16-27-15-14-21(19)22/h3-17H,1-2H3,(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM21
(CHEMBL24828 | N-(4-bromo-2-fluorophenyl)-6-methoxy...)Show SMILES COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C22H24BrFN4O2/c1-28-7-5-14(6-8-28)12-30-21-11-19-16(10-20(21)29-2)22(26-13-25-19)27-18-4-3-15(23)9-17(18)24/h3-4,9-11,13-14H,5-8,12H2,1-2H3,(H,25,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179881
((4-Chlorophenyl)-(4-isoquinolin-5-yl-phthalazin-1-...)Show SMILES Clc1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)cc1 Show InChI InChI=1S/C23H15ClN4/c24-16-8-10-17(11-9-16)26-23-21-6-2-1-5-20(21)22(27-28-23)19-7-3-4-15-14-25-13-12-18(15)19/h1-14H,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179890
((4-tert-Butylphenyl)-(4-isoquinolin-5-yl-phthalazi...)Show SMILES CC(C)(C)c1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)cc1 Show InChI InChI=1S/C27H24N4/c1-27(2,3)19-11-13-20(14-12-19)29-26-24-9-5-4-8-23(24)25(30-31-26)22-10-6-7-18-17-28-16-15-21(18)22/h4-17H,1-3H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173019
(4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benz...)Show SMILES CC(C)(C)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C25H24N4O/c1-25(2,3)18-12-14-19(15-13-18)27-24-21-7-5-4-6-20(21)22(28-29-24)16-8-10-17(11-9-16)23(26)30/h4-15H,1-3H3,(H2,26,30)(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179889
(CHEMBL382818 | N-(4-(chlorodifluoromethoxy)phenyl)...)Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)cc1 Show InChI InChI=1S/C24H15ClF2N4O/c25-24(26,27)32-17-10-8-16(9-11-17)29-23-21-6-2-1-5-20(21)22(30-31-23)19-7-3-4-15-14-28-13-12-18(15)19/h1-14H,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173031
(4-(4-(4-bromophenylamino)phthalazin-1-yl)benzamide...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(Br)cc2)c2ccccc12 Show InChI InChI=1S/C21H15BrN4O/c22-15-9-11-16(12-10-15)24-21-18-4-2-1-3-17(18)19(25-26-21)13-5-7-14(8-6-13)20(23)27/h1-12H,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179888
((3,4-Dichloro-phenyl)-(4-isoquinolin-5-yl-phthalaz...)Show SMILES Clc1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)cc1Cl Show InChI InChI=1S/C23H14Cl2N4/c24-20-9-8-15(12-21(20)25)27-23-19-6-2-1-5-18(19)22(28-29-23)17-7-3-4-14-13-26-11-10-16(14)17/h1-13H,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179891
((4-Chloro-3-trifluoromethylphenyl)-(4-isoquinolin-...)Show SMILES FC(F)(F)c1cc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)ccc1Cl Show InChI InChI=1S/C24H14ClF3N4/c25-21-9-8-15(12-20(21)24(26,27)28)30-23-19-6-2-1-5-18(19)22(31-32-23)17-7-3-4-14-13-29-11-10-16(14)17/h1-13H,(H,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173045
(4-(4-(4-tert-butylphenylamino)phthalazin-1-yl)-N-m...)Show SMILES CNC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(cc2)C(C)(C)C)c2ccccc12 Show InChI InChI=1S/C26H26N4O/c1-26(2,3)19-13-15-20(16-14-19)28-24-22-8-6-5-7-21(22)23(29-30-24)17-9-11-18(12-10-17)25(31)27-4/h5-16H,1-4H3,(H,27,31)(H,28,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173049
(4-(4-(4-(chlorodifluoromethoxy)phenylamino)phthala...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C22H15ClF2N4O2/c23-22(24,25)31-16-11-9-15(10-12-16)27-21-18-4-2-1-3-17(18)19(28-29-21)13-5-7-14(8-6-13)20(26)30/h1-12H,(H2,26,30)(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179893
((4-Isoquinolin-5-yl-phthalazin-1-yl)-(2-methyl-1Hi...)Show SMILES Cc1cc2cc(Nc3nnc(-c4cccc5cnccc45)c4ccccc34)ccc2[nH]1 Show InChI InChI=1S/C26H19N5/c1-16-13-18-14-19(9-10-24(18)28-16)29-26-23-7-3-2-6-22(23)25(30-31-26)21-8-4-5-17-15-27-12-11-20(17)21/h2-15,28H,1H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179884
((4-Isoquinolin-5-yl-phthalazin-1-yl)-m-tolylamine ...)Show SMILES Cc1cccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)c1 Show InChI InChI=1S/C24H18N4/c1-16-6-4-8-18(14-16)26-24-22-10-3-2-9-21(22)23(27-28-24)20-11-5-7-17-15-25-13-12-19(17)20/h2-15H,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179894
((4-Isoquinolin-5-yl-phthalazin-1-yl)-(4-morpholin-...)Show SMILES C1CN(CCO1)c1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)cc1 Show InChI InChI=1S/C27H23N5O/c1-2-6-25-24(5-1)26(23-7-3-4-19-18-28-13-12-22(19)23)30-31-27(25)29-20-8-10-21(11-9-20)32-14-16-33-17-15-32/h1-13,18H,14-17H2,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173022
(3-(4-(4-tert-butylphenylamino)phthalazin-1-yl)benz...)Show SMILES CC(C)(C)c1ccc(Nc2nnc(-c3cccc(c3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C25H24N4O/c1-25(2,3)18-11-13-19(14-12-18)27-24-21-10-5-4-9-20(21)22(28-29-24)16-7-6-8-17(15-16)23(26)30/h4-15H,1-3H3,(H2,26,30)(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179882
((2-Fluoro-4-methylphenyl)-(4-isoquinolin-5-ylphtha...)Show SMILES Cc1ccc(Nc2nnc(-c3cccc4cnccc34)c3ccccc23)c(F)c1 Show InChI InChI=1S/C24H17FN4/c1-15-9-10-22(21(25)13-15)27-24-20-7-3-2-6-19(20)23(28-29-24)18-8-4-5-16-14-26-12-11-17(16)18/h2-14H,1H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173034
(4-(4-(3-tert-butylphenylamino)phthalazin-1-yl)benz...)Show SMILES CC(C)(C)c1cccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)c1 Show InChI InChI=1S/C25H24N4O/c1-25(2,3)18-7-6-8-19(15-18)27-24-21-10-5-4-9-20(21)22(28-29-24)16-11-13-17(14-12-16)23(26)30/h4-15H,1-3H3,(H2,26,30)(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173021
(4-{4-[4-(Chloro-difluoro-methoxy)-phenylamino]-pht...)Show SMILES COC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C23H16ClF2N3O3/c1-31-22(30)15-8-6-14(7-9-15)20-18-4-2-3-5-19(18)21(29-28-20)27-16-10-12-17(13-11-16)32-23(24,25)26/h2-13H,1H3,(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173051
(4-(4-(3,4-dichlorophenylamino)phthalazin-1-yl)benz...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(Cl)c(Cl)c2)c2ccccc12 Show InChI InChI=1S/C21H14Cl2N4O/c22-17-10-9-14(11-18(17)23)25-21-16-4-2-1-3-15(16)19(26-27-21)12-5-7-13(8-6-12)20(24)28/h1-11H,(H2,24,28)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173024
(4-(4-(4-(chlorodifluoromethoxy)phenylamino)phthala...)Show SMILES OCCNC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C24H19ClF2N4O3/c25-24(26,27)34-18-11-9-17(10-12-18)29-22-20-4-2-1-3-19(20)21(30-31-22)15-5-7-16(8-6-15)23(33)28-13-14-32/h1-12,32H,13-14H2,(H,28,33)(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173041
(3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)piperidi...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2cccc(Br)c2)c2ccccc12 Show InChI InChI=1S/C21H15BrN4O/c22-15-4-3-5-16(12-15)24-21-18-7-2-1-6-17(18)19(25-26-21)13-8-10-14(11-9-13)20(23)27/h1-12H,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173011
(4-(4-(4-chlorophenylamino)phthalazin-1-yl)benzamid...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(Cl)cc2)c2ccccc12 Show InChI InChI=1S/C21H15ClN4O/c22-15-9-11-16(12-10-15)24-21-18-4-2-1-3-17(18)19(25-26-21)13-5-7-14(8-6-13)20(23)27/h1-12H,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173029
(4-(4-(m-tolylamino)phthalazin-1-yl)benzamide | 4-(...)Show SMILES Cc1cccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)c1 Show InChI InChI=1S/C22H18N4O/c1-14-5-4-6-17(13-14)24-22-19-8-3-2-7-18(19)20(25-26-22)15-9-11-16(12-10-15)21(23)27/h2-13H,1H3,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173012
(4-(4-(3-chlorophenylamino)phthalazin-1-yl)benzamid...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2cccc(Cl)c2)c2ccccc12 Show InChI InChI=1S/C21H15ClN4O/c22-15-4-3-5-16(12-15)24-21-18-7-2-1-6-17(18)19(25-26-21)13-8-10-14(11-9-13)20(23)27/h1-12H,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173017
(4-(4-(p-tolylamino)phthalazin-1-yl)benzamide | 4-(...)Show SMILES Cc1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C22H18N4O/c1-14-6-12-17(13-7-14)24-22-19-5-3-2-4-18(19)20(25-26-22)15-8-10-16(11-9-15)21(23)27/h2-13H,1H3,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179886
((4-tert-Butylphenyl)-(4-quinolin-5-yl-phthalazin-1...)Show SMILES CC(C)(C)c1ccc(Nc2nnc(-c3cccc4ncccc34)c3ccccc23)cc1 Show InChI InChI=1S/C27H24N4/c1-27(2,3)18-13-15-19(16-14-18)29-26-23-9-5-4-8-22(23)25(30-31-26)21-10-6-12-24-20(21)11-7-17-28-24/h4-17H,1-3H3,(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173043
(4-(4-(4-methoxyphenylamino)phthalazin-1-yl)benzami...)Show SMILES COc1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C22H18N4O2/c1-28-17-12-10-16(11-13-17)24-22-19-5-3-2-4-18(19)20(25-26-22)14-6-8-15(9-7-14)21(23)27/h2-13H,1H3,(H2,23,27)(H,24,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173025
(4-[4-(4-Carbamoyl-phenyl)-phthalazin-1-ylamino]-be...)Show SMILES COC(=O)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C23H18N4O3/c1-30-23(29)16-10-12-17(13-11-16)25-22-19-5-3-2-4-18(19)20(26-27-22)14-6-8-15(9-7-14)21(24)28/h2-13H,1H3,(H2,24,28)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173013
(4-(4-(4-chlorophenylamino)phthalazin-1-yl)-N-methy...)Show SMILES CNC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(Cl)cc2)c2ccccc12 Show InChI InChI=1S/C22H17ClN4O/c1-24-22(28)15-8-6-14(7-9-15)20-18-4-2-3-5-19(18)21(27-26-20)25-17-12-10-16(23)11-13-17/h2-13H,1H3,(H,24,28)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173047
(3-(4-(4-(chlorodifluoromethoxy)phenylamino)phthala...)Show SMILES NC(=O)c1cccc(c1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C22H15ClF2N4O2/c23-22(24,25)31-16-10-8-15(9-11-16)27-21-18-7-2-1-6-17(18)19(28-29-21)13-4-3-5-14(12-13)20(26)30/h1-12H,(H2,26,30)(H,27,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173020
((4-(4-(4-(chlorodifluoromethoxy)phenylamino)phthal...)Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(-c3ccc(cc3)C(=O)N3CCOCC3)c3ccccc23)cc1 Show InChI InChI=1S/C26H21ClF2N4O3/c27-26(28,29)36-20-11-9-19(10-12-20)30-24-22-4-2-1-3-21(22)23(31-32-24)17-5-7-18(8-6-17)25(34)33-13-15-35-16-14-33/h1-12H,13-16H2,(H,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173014
(CHEMBL364974 | N-(4-(chlorodifluoromethoxy)phenyl)...)Show SMILES Cc1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C22H16ClF2N3O/c1-14-6-8-15(9-7-14)20-18-4-2-3-5-19(18)21(28-27-20)26-16-10-12-17(13-11-16)29-22(23,24)25/h2-13H,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173008
(4-(4-(4-(trifluoromethoxy)phenoxy)phthalazin-1-yl)...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Oc2ccc(OC(F)(F)F)cc2)c2ccccc12 Show InChI InChI=1S/C22H14F3N3O3/c23-22(24,25)31-16-11-9-15(10-12-16)30-21-18-4-2-1-3-17(18)19(27-28-21)13-5-7-14(8-6-13)20(26)29/h1-12H,(H2,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173016
(4-(4-(phenylamino)phthalazin-1-yl)benzamide | 4-(4...)Show InChI InChI=1S/C21H16N4O/c22-20(26)15-12-10-14(11-13-15)19-17-8-4-5-9-18(17)21(25-24-19)23-16-6-2-1-3-7-16/h1-13H,(H2,22,26)(H,23,25) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173028
(4-(4-(4-(benzyloxy)phenylamino)phthalazin-1-yl)ben...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OCc3ccccc3)cc2)c2ccccc12 Show InChI InChI=1S/C28H22N4O2/c29-27(33)21-12-10-20(11-13-21)26-24-8-4-5-9-25(24)28(32-31-26)30-22-14-16-23(17-15-22)34-18-19-6-2-1-3-7-19/h1-17H,18H2,(H2,29,33)(H,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179895
((4-Isoquinolin-5-yl-phthalazin-1-yl)-o-tolylamine ...)Show InChI InChI=1S/C24H18N4/c1-16-7-2-5-12-22(16)26-24-21-10-4-3-9-20(21)23(27-28-24)19-11-6-8-17-15-25-14-13-18(17)19/h2-15H,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173018
(CHEMBL195829 | N-(4-(chlorodifluoromethoxy)phenyl)...)Show SMILES COc1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C22H16ClF2N3O2/c1-29-16-10-6-14(7-11-16)20-18-4-2-3-5-19(18)21(28-27-20)26-15-8-12-17(13-9-15)30-22(23,24)25/h2-13H,1H3,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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UniChem
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173015
(CHEMBL196422 | N-tert-Butyl-4-{4-[4-(chloro-difluo...)Show SMILES CC(C)(C)NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C26H23ClF2N4O2/c1-25(2,3)31-24(34)17-10-8-16(9-11-17)22-20-6-4-5-7-21(20)23(33-32-22)30-18-12-14-19(15-13-18)35-26(27,28)29/h4-15H,1-3H3,(H,30,33)(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173009
(4-(4-(4-(chlorodifluoromethoxy)phenylamino)phthala...)Show SMILES CC(C)NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(OC(F)(F)Cl)cc2)c2ccccc12 Show InChI InChI=1S/C25H21ClF2N4O2/c1-15(2)29-24(33)17-9-7-16(8-10-17)22-20-5-3-4-6-21(20)23(32-31-22)30-18-11-13-19(14-12-18)34-25(26,27)28/h3-15H,1-2H3,(H,29,33)(H,30,32) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247780
(CHEMBL460724 | N-(4-(chlorodifluoromethoxy)phenyl)...)Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(-c3cccc(Cl)c3)c3ccccc23)cc1 Show InChI InChI=1S/C21H13Cl2F2N3O/c22-14-5-3-4-13(12-14)19-17-6-1-2-7-18(17)20(28-27-19)26-15-8-10-16(11-9-15)29-21(23,24)25/h1-12H,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173037
(CHEMBL195727 | N-(4-(chlorodifluoromethoxy)phenyl)...)Show SMILES FC(F)(Cl)Oc1ccc(Nc2nnc(-c3ccccc3)c3ccccc23)cc1 Show InChI InChI=1S/C21H14ClF2N3O/c22-21(23,24)28-16-12-10-15(11-13-16)25-20-18-9-5-4-8-17(18)19(26-27-20)14-6-2-1-3-7-14/h1-13H,(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
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GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50179887
((4-Chlorophenyl)-(4-quinolin-5-yl-phthalazin-1-yl)...)Show SMILES Clc1ccc(Nc2nnc(-c3cccc4ncccc34)c3ccccc23)cc1 Show InChI InChI=1S/C23H15ClN4/c24-15-10-12-16(13-11-15)26-23-20-6-2-1-5-19(20)22(27-28-23)18-7-3-9-21-17(18)8-4-14-25-21/h1-14H,(H,26,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173050
(4-(4-(4-(trifluoromethoxy)phenylthio)phthalazin-1-...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Sc2ccc(OC(F)(F)F)cc2)c2ccccc12 Show InChI InChI=1S/C22H14F3N3O2S/c23-22(24,25)30-15-9-11-16(12-10-15)31-21-18-4-2-1-3-17(18)19(27-28-21)13-5-7-14(8-6-13)20(26)29/h1-12H,(H2,26,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50173042
(4-(4-(4-carbamoylphenyl)phthalazin-1-ylamino)benza...)Show SMILES NC(=O)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C22H17N5O2/c23-20(28)14-7-5-13(6-8-14)19-17-3-1-2-4-18(17)22(27-26-19)25-16-11-9-15(10-12-16)21(24)29/h1-12H,(H2,23,28)(H2,24,29)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247683
(4-(4-(4-phenoxyphenylamino)phthalazin-1-yl)benzami...)Show SMILES NC(=O)c1ccc(cc1)-c1nnc(Nc2ccc(Oc3ccccc3)cc2)c2ccccc12 Show InChI InChI=1S/C27H20N4O2/c28-26(32)19-12-10-18(11-13-19)25-23-8-4-5-9-24(23)27(31-30-25)29-20-14-16-22(17-15-20)33-21-6-2-1-3-7-21/h1-17H,(H2,28,32)(H,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247684
(4-(4-(4-(N-methylsulfamoyl)phenylamino)phthalazin-...)Show SMILES CNS(=O)(=O)c1ccc(Nc2nnc(-c3ccc(cc3)C(N)=O)c3ccccc23)cc1 Show InChI InChI=1S/C22H19N5O3S/c1-24-31(29,30)17-12-10-16(11-13-17)25-22-19-5-3-2-4-18(19)20(26-27-22)14-6-8-15(9-7-14)21(23)28/h2-13,24H,1H3,(H2,23,28)(H,25,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
ImClone Systems, Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) by HTRF method |
Bioorg Med Chem 17: 731-40 (2009)
Article DOI: 10.1016/j.bmc.2008.11.049
BindingDB Entry DOI: 10.7270/Q2W95929 |
More data for this
Ligand-Target Pair | |
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