Found 4 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Protein kinase C-like 1
(Candida albicans) | BDBM50256734
((-)-Cercosporamide | CHEMBL475816)Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6| Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1 | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Candida albicans Pkc1 expressed in insect Sf9 cells by scintillation proximity assay |
Bioorg Med Chem Lett 19: 724-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.035 BindingDB Entry DOI: 10.7270/Q2H41R95 |
More data for this Ligand-Target Pair | |
Protein kinase C beta type
(Homo sapiens (Human)) | BDBM50256734
((-)-Cercosporamide | CHEMBL475816)Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6| Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of human PKCbeta by scintillation proximity assay |
Bioorg Med Chem Lett 19: 724-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.035 BindingDB Entry DOI: 10.7270/Q2H41R95 |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50256734
((-)-Cercosporamide | CHEMBL475816)Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6| Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of human PKCalpha by scintillation proximity assay |
Bioorg Med Chem Lett 19: 724-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.035 BindingDB Entry DOI: 10.7270/Q2H41R95 |
More data for this Ligand-Target Pair | |
Protein kinase C gamma type
(Homo sapiens (Human)) | BDBM50256734
((-)-Cercosporamide | CHEMBL475816)Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6| Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Sankyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of human PKCgamma by scintillation proximity assay |
Bioorg Med Chem Lett 19: 724-6 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.035 BindingDB Entry DOI: 10.7270/Q2H41R95 |
More data for this Ligand-Target Pair | |