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PubMed code 19109017

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C-like 1


(Candida albicans)
BDBM50256734
PNG
((-)-Cercosporamide | CHEMBL475816)
Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6|
Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1
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PubMed
n/an/a 44n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of Candida albicans Pkc1 expressed in insect Sf9 cells by scintillation proximity assay


Bioorg Med Chem Lett 19: 724-6 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.035
BindingDB Entry DOI: 10.7270/Q2H41R95
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM50256734
PNG
((-)-Cercosporamide | CHEMBL475816)
Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6|
Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1
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PubMed
n/an/a 350n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PKCbeta by scintillation proximity assay


Bioorg Med Chem Lett 19: 724-6 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.035
BindingDB Entry DOI: 10.7270/Q2H41R95
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50256734
PNG
((-)-Cercosporamide | CHEMBL475816)
Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6|
Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1
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PubMed
n/an/a 1.02E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PKCalpha by scintillation proximity assay


Bioorg Med Chem Lett 19: 724-6 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.035
BindingDB Entry DOI: 10.7270/Q2H41R95
More data for this
Ligand-Target Pair
Protein kinase C, gamma


(Homo sapiens (Human))
BDBM50256734
PNG
((-)-Cercosporamide | CHEMBL475816)
Show SMILES CC(=O)C1C(=O)C=C2Oc3c(c(O)cc(O)c3C(N)=O)[C@]2(C)C1=O |r,t:6|
Show InChI InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,10,19,21H,1-2H3,(H2,17,23)/t10?,16-/m1/s1
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PubMed
n/an/a 5.80E+3n/an/an/an/an/an/a



Daiichi Sankyo Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of human PKCgamma by scintillation proximity assay


Bioorg Med Chem Lett 19: 724-6 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.035
BindingDB Entry DOI: 10.7270/Q2H41R95
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%