Affinity Data by PubMed id=19121582

PubMed code 19121582

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	250	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM26994 (CHEMBL68253 \| H2NSO3H \| sulfamic acid) Show SMILES NS(O)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM26995 (CHEMBL355001 \| H2NSO2NH2 \| sulfamamide \| sulfamide...) Show SMILES NS(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM26994 (CHEMBL68253 \| H2NSO3H \| sulfamic acid) Show SMILES NS(O)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM26995 (CHEMBL355001 \| H2NSO2NH2 \| sulfamamide \| sulfamide...) Show SMILES NS(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM26994 (CHEMBL68253 \| H2NSO3H \| sulfamic acid) Show SMILES NS(O)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	3.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM26996 (CHEMBL21485 \| PhB(OH)2 \| Phenyl-boronic acid \| Phe...) Show SMILES OB(O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	8.20E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM26995 (CHEMBL355001 \| H2NSO2NH2 \| sulfamamide \| sulfamide...) Show SMILES NS(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.13E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 4 (Homo sapiens (Human))	BDBM26997 (CHEMBL364571 \| PhAsO3H2 \| benzenarsonic acid \| ben...) Show SMILES O[As](O)(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.39E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM26996 (CHEMBL21485 \| PhB(OH)2 \| Phenyl-boronic acid \| Phe...) Show SMILES OB(O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.31E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM26997 (CHEMBL364571 \| PhAsO3H2 \| benzenarsonic acid \| ben...) Show SMILES O[As](O)(=O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.17E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM26997 (CHEMBL364571 \| PhAsO3H2 \| benzenarsonic acid \| ben...) Show SMILES O[As](O)(=O)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	4.92E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM26996 (CHEMBL21485 \| PhB(OH)2 \| Phenyl-boronic acid \| Phe...) Show SMILES OB(O)c1ccccc1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.86E+7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
MC-98000 Princ Curated by ChEMBL					Assay Description Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay				Bioorg Med Chem Lett 19: 650-3 (2009) Article DOI: 10.1016/j.bmcl.2008.12.056 BindingDB Entry DOI: 10.7270/Q2D50MT8
MC-98000 Princ Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%