BindingDB logo
myBDB logout

PubMed code 19131247

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255171
PNG
((+/-)-2-amino-N-(2-(5-(isopropylamino)-2-(4-(methy...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F)NC(C)C
Show InChI InChI=1S/C27H34F3N5O3S/c1-15(2)33-18-7-11-22(35-25(37)16-4-8-19(39-3)9-5-16)23(13-18)34-24(36)14-32-26(38)20-12-17(27(28,29)30)6-10-21(20)31/h4-6,8-10,12,15,18,22-23,33H,7,11,13-14,31H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255219
PNG
((+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(CCC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H33F3N4O5S/c1-45-25-13-10-21(11-14-25)30(42)39-27-17-24(37-31(43)44-19-20-6-3-2-4-7-20)12-15-26(27)38-28(40)18-36-29(41)22-8-5-9-23(16-22)32(33,34)35/h2-11,13-14,16,24,26-27H,12,15,17-19H2,1H3,(H,36,41)(H,37,43)(H,38,40)(H,39,42)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255219
PNG
((+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(CCC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H33F3N4O5S/c1-45-25-13-10-21(11-14-25)30(42)39-27-17-24(37-31(43)44-19-20-6-3-2-4-7-20)12-15-26(27)38-28(40)18-36-29(41)22-8-5-9-23(16-22)32(33,34)35/h2-11,13-14,16,24,26-27H,12,15,17-19H2,1H3,(H,36,41)(H,37,43)(H,38,40)(H,39,42)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255738
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Show SMILES CSc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C26H33F3N4O2S/c1-33(2)20-9-12-22(23(14-20)30-15-17-7-10-21(36-3)11-8-17)32-24(34)16-31-25(35)18-5-4-6-19(13-18)26(27,28)29/h4-8,10-11,13,20,22-23,30H,9,12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255221
PNG
((+/-)-N-(2-(2-((1H-indol-5-yl)methylamino)-4-(dime...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C27H32F3N5O2/c1-35(2)21-7-9-23(24(14-21)32-15-17-6-8-22-18(12-17)10-11-31-22)34-25(36)16-33-26(37)19-4-3-5-20(13-19)27(28,29)30/h3-6,8,10-13,21,23-24,31-32H,7,9,14-16H2,1-2H3,(H,33,37)(H,34,36)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255171
PNG
((+/-)-2-amino-N-(2-(5-(isopropylamino)-2-(4-(methy...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F)NC(C)C
Show InChI InChI=1S/C27H34F3N5O3S/c1-15(2)33-18-7-11-22(35-25(37)16-4-8-19(39-3)9-5-16)23(13-18)34-24(36)14-32-26(38)20-12-17(27(28,29)30)6-10-21(20)31/h4-6,8-10,12,15,18,22-23,33H,7,11,13-14,31H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255737
PNG
((+/-)-2-amino-N-(2-(4-amino-2-(4-(methylthio)benza...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(N)CCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3S/c1-36-16-6-2-13(3-7-16)22(34)32-20-11-15(28)5-9-19(20)31-21(33)12-30-23(35)17-10-14(24(25,26)27)4-8-18(17)29/h2-4,6-8,10,15,19-20H,5,9,11-12,28-29H2,1H3,(H,30,35)(H,31,33)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.80n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255219
PNG
((+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(CCC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H33F3N4O5S/c1-45-25-13-10-21(11-14-25)30(42)39-27-17-24(37-31(43)44-19-20-6-3-2-4-7-20)12-15-26(27)38-28(40)18-36-29(41)22-8-5-9-23(16-22)32(33,34)35/h2-11,13-14,16,24,26-27H,12,15,17-19H2,1H3,(H,36,41)(H,37,43)(H,38,40)(H,39,42)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.10n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255739
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-methylbenzylami...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H33F3N4O2/c1-17-7-9-18(10-8-17)15-30-23-14-21(33(2)3)11-12-22(23)32-24(34)16-31-25(35)19-5-4-6-20(13-19)26(27,28)29/h4-10,13,21-23,30H,11-12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255737
PNG
((+/-)-2-amino-N-(2-(4-amino-2-(4-(methylthio)benza...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(N)CCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3S/c1-36-16-6-2-13(3-7-16)22(34)32-20-11-15(28)5-9-19(20)31-21(33)12-30-23(35)17-10-14(24(25,26)27)4-8-18(17)29/h2-4,6-8,10,15,19-20H,5,9,11-12,28-29H2,1H3,(H,30,35)(H,31,33)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255738
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Show SMILES CSc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C26H33F3N4O2S/c1-33(2)20-9-12-22(23(14-20)30-15-17-7-10-21(36-3)11-8-17)32-24(34)16-31-25(35)18-5-4-6-19(13-18)26(27,28)29/h4-8,10-11,13,20,22-23,30H,9,12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255799
PNG
((+/-)-N-(2-(2-(4-chlorobenzylamino)-4-(dimethylami...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C25H30ClF3N4O2/c1-33(2)20-10-11-21(22(13-20)30-14-16-6-8-19(26)9-7-16)32-23(34)15-31-24(35)17-4-3-5-18(12-17)25(27,28)29/h3-9,12,20-22,30H,10-11,13-15H2,1-2H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50255219
PNG
((+/-)-benzyl-3-(4-(methylthio)benzamido)-4-(2-(3-(...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(CCC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H33F3N4O5S/c1-45-25-13-10-21(11-14-25)30(42)39-27-17-24(37-31(43)44-19-20-6-3-2-4-7-20)12-15-26(27)38-28(40)18-36-29(41)22-8-5-9-23(16-22)32(33,34)35/h2-11,13-14,16,24,26-27H,12,15,17-19H2,1H3,(H,36,41)(H,37,43)(H,38,40)(H,39,42)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of CCR3 (unknown origin) at 10 uM

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255175
PNG
((+/-)-N-(2-(2-(4-acetamidobenzylamino)-4-(dimethyl...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C27H34F3N5O3/c1-17(36)33-21-9-7-18(8-10-21)15-31-24-14-22(35(2)3)11-12-23(24)34-25(37)16-32-26(38)19-5-4-6-20(13-19)27(28,29)30/h4-10,13,22-24,31H,11-12,14-16H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 7.70n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255798
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-methoxybenzylam...)
Show SMILES COc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C26H33F3N4O3/c1-33(2)20-9-12-22(23(14-20)30-15-17-7-10-21(36-3)11-8-17)32-24(34)16-31-25(35)18-5-4-6-19(13-18)26(27,28)29/h4-8,10-11,13,20,22-23,30H,9,12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255221
PNG
((+/-)-N-(2-(2-((1H-indol-5-yl)methylamino)-4-(dime...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C27H32F3N5O2/c1-35(2)21-7-9-23(24(14-21)32-15-17-6-8-22-18(12-17)10-11-31-22)34-25(36)16-33-26(37)19-4-3-5-20(13-19)27(28,29)30/h3-6,8,10-13,21,23-24,31-32H,7,9,14-16H2,1-2H3,(H,33,37)(H,34,36)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255739
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-methylbenzylami...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H33F3N4O2/c1-17-7-9-18(10-8-17)15-30-23-14-21(33(2)3)11-12-22(23)32-24(34)16-31-25(35)19-5-4-6-20(13-19)26(27,28)29/h4-10,13,21-23,30H,11-12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 9.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255798
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-methoxybenzylam...)
Show SMILES COc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C26H33F3N4O3/c1-33(2)20-9-12-22(23(14-20)30-15-17-7-10-21(36-3)11-8-17)32-24(34)16-31-25(35)18-5-4-6-19(13-18)26(27,28)29/h4-8,10-11,13,20,22-23,30H,9,12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 12.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255739
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-methylbenzylami...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(C)cc1
Show InChI InChI=1S/C26H33F3N4O2/c1-17-7-9-18(10-8-17)15-30-23-14-21(33(2)3)11-12-22(23)32-24(34)16-31-25(35)19-5-4-6-20(13-19)26(27,28)29/h4-10,13,21-23,30H,11-12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 12.6n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255737
PNG
((+/-)-2-amino-N-(2-(4-amino-2-(4-(methylthio)benza...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(N)CCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3S/c1-36-16-6-2-13(3-7-16)22(34)32-20-11-15(28)5-9-19(20)31-21(33)12-30-23(35)17-10-14(24(25,26)27)4-8-18(17)29/h2-4,6-8,10,15,19-20H,5,9,11-12,28-29H2,1H3,(H,30,35)(H,31,33)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 13.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255799
PNG
((+/-)-N-(2-(2-(4-chlorobenzylamino)-4-(dimethylami...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C25H30ClF3N4O2/c1-33(2)20-10-11-21(22(13-20)30-14-16-6-8-19(26)9-7-16)32-23(34)15-31-24(35)17-4-3-5-18(12-17)25(27,28)29/h3-9,12,20-22,30H,10-11,13-15H2,1-2H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255797
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-isopropylbenzyl...)
Show SMILES CC(C)c1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C28H37F3N4O2/c1-18(2)20-10-8-19(9-11-20)16-32-25-15-23(35(3)4)12-13-24(25)34-26(36)17-33-27(37)21-6-5-7-22(14-21)28(29,30)31/h5-11,14,18,23-25,32H,12-13,15-17H2,1-4H3,(H,33,37)(H,34,36)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255175
PNG
((+/-)-N-(2-(2-(4-acetamidobenzylamino)-4-(dimethyl...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C27H34F3N5O3/c1-17(36)33-21-9-7-18(8-10-21)15-31-24-14-22(35(2)3)11-12-23(24)34-25(37)16-32-26(38)19-5-4-6-20(13-19)27(28,29)30/h4-10,13,22-24,31H,11-12,14-16H2,1-3H3,(H,32,38)(H,33,36)(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 17.4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255797
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-isopropylbenzyl...)
Show SMILES CC(C)c1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C28H37F3N4O2/c1-18(2)20-10-8-19(9-11-20)16-32-25-15-23(35(3)4)12-13-24(25)34-26(36)17-33-27(37)21-6-5-7-22(14-21)28(29,30)31/h5-11,14,18,23-25,32H,12-13,15-17H2,1-4H3,(H,33,37)(H,34,36)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 19n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50255735
PNG
((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCNCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3S/c1-35-15-5-2-13(3-6-15)21(33)31-18-8-9-28-11-19(18)30-20(32)12-29-22(34)16-10-14(23(24,25)26)4-7-17(16)27/h2-7,10,18-19,28H,8-9,11-12,27H2,1H3,(H,29,34)(H,30,32)(H,31,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 19.7n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of CCR3 (unknown origin) at 10 uM

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255738
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-(methylthio)ben...)
Show SMILES CSc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C26H33F3N4O2S/c1-33(2)20-9-12-22(23(14-20)30-15-17-7-10-21(36-3)11-8-17)32-24(34)16-31-25(35)18-5-4-6-19(13-18)26(27,28)29/h4-8,10-11,13,20,22-23,30H,9,12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255221
PNG
((+/-)-N-(2-(2-((1H-indol-5-yl)methylamino)-4-(dime...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C27H32F3N5O2/c1-35(2)21-7-9-23(24(14-21)32-15-17-6-8-22-18(12-17)10-11-31-22)34-25(36)16-33-26(37)19-4-3-5-20(13-19)27(28,29)30/h3-6,8,10-13,21,23-24,31-32H,7,9,14-16H2,1-2H3,(H,33,37)(H,34,36)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255174
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(3-(trifluoromethy...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F6N4O2/c1-36(2)20-9-10-21(22(13-20)33-14-16-5-3-7-18(11-16)25(27,28)29)35-23(37)15-34-24(38)17-6-4-8-19(12-17)26(30,31)32/h3-8,11-12,20-22,33H,9-10,13-15H2,1-2H3,(H,34,38)(H,35,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 3


(Homo sapiens (Human))		BDBM50255171
PNG
((+/-)-2-amino-N-(2-(5-(isopropylamino)-2-(4-(methy...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F)NC(C)C
Show InChI InChI=1S/C27H34F3N5O3S/c1-15(2)33-18-7-11-22(35-25(37)16-4-8-19(39-3)9-5-16)23(13-18)34-24(36)14-32-26(38)20-12-17(27(28,29)30)6-10-21(20)31/h4-6,8-10,12,15,18,22-23,33H,7,11,13-14,31H2,1-3H3,(H,32,38)(H,34,36)(H,35,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 27.2n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Inhibition of CCR3 (unknown origin) at 10 uM

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255735
PNG
((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCNCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3S/c1-35-15-5-2-13(3-6-15)21(33)31-18-8-9-28-11-19(18)30-20(32)12-29-22(34)16-10-14(23(24,25)26)4-7-17(16)27/h2-7,10,18-19,28H,8-9,11-12,27H2,1H3,(H,29,34)(H,30,32)(H,31,33)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 28n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255174
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(3-(trifluoromethy...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C26H30F6N4O2/c1-36(2)20-9-10-21(22(13-20)33-14-16-5-3-7-18(11-16)25(27,28)29)35-23(37)15-34-24(38)17-6-4-8-19(12-17)26(30,31)32/h3-8,11-12,20-22,33H,9-10,13-15H2,1-2H3,(H,34,38)(H,35,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 32.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255798
PNG
((+/-)-N-(2-(4-(dimethylamino)-2-(4-methoxybenzylam...)
Show SMILES COc1ccc(CNC2CC(CCC2NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)N(C)C)cc1
Show InChI InChI=1S/C26H33F3N4O3/c1-33(2)20-9-12-22(23(14-20)30-15-17-7-10-21(36-3)11-8-17)32-24(34)16-31-25(35)18-5-4-6-19(13-18)26(27,28)29/h4-8,10-11,13,20,22-23,30H,9,12,14-16H2,1-3H3,(H,31,35)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 41.4n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255800
PNG
((+/-)-N-(2-(2-(3,4-dichlorobenzylamino)-4-(dimethy...)
Show SMILES CN(C)C1CCC(NC(=O)CNC(=O)c2cccc(c2)C(F)(F)F)C(C1)NCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C25H29Cl2F3N4O2/c1-34(2)18-7-9-21(22(12-18)31-13-15-6-8-19(26)20(27)10-15)33-23(35)14-32-24(36)16-4-3-5-17(11-16)25(28,29)30/h3-6,8,10-11,18,21-22,31H,7,9,12-14H2,1-2H3,(H,32,36)(H,33,35)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 61.5n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255735
PNG
((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCNCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3S/c1-35-15-5-2-13(3-6-15)21(33)31-18-8-9-28-11-19(18)30-20(32)12-29-22(34)16-10-14(23(24,25)26)4-7-17(16)27/h2-7,10,18-19,28H,8-9,11-12,27H2,1H3,(H,29,34)(H,30,32)(H,31,33)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 75n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human monocytes assessed as inhibition of MCP1-induced calcium influx by FLIPR

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255735
PNG
((+/-)-2-amino-N-(2-(4-(4-(methylthio)benzamido)pip...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCNCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3S/c1-35-15-5-2-13(3-6-15)21(33)31-18-8-9-28-11-19(18)30-20(32)12-29-22(34)16-10-14(23(24,25)26)4-7-17(16)27/h2-7,10,18-19,28H,8-9,11-12,27H2,1H3,(H,29,34)(H,30,32)(H,31,33)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 109n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CCR2 in human PBMCs assessed as inhibition of MCP1-induced chemotaxis

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255170
PNG
((+/-)-2-amino-N-(2-(2-(4-(methylthio)benzamido)-5-...)
Show SMILES CNC(=O)NC1CCC(NC(=O)c2ccc(SC)cc2)C(C1)NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C26H31F3N6O4S/c1-31-25(39)33-16-6-10-20(35-23(37)14-3-7-17(40-2)8-4-14)21(12-16)34-22(36)13-32-24(38)18-11-15(26(27,28)29)5-9-19(18)30/h3-5,7-9,11,16,20-21H,6,10,12-13,30H2,1-2H3,(H,32,38)(H,34,36)(H,35,37)(H2,31,33,39)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 112n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255218
PNG
((+/-)-N-(2-(5-(isopropylamino)-2-(4-(methylthio)be...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(CC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(C)C
Show InChI InChI=1S/C27H33F3N4O3S/c1-16(2)32-20-9-12-22(34-26(37)17-7-10-21(38-3)11-8-17)23(14-20)33-24(35)15-31-25(36)18-5-4-6-19(13-18)27(28,29)30/h4-8,10-11,13,16,20,22-23,32H,9,12,14-15H2,1-3H3,(H,31,36)(H,33,35)(H,34,37)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 136n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255734
PNG
((+/-)-2-amino-N-(2-(2-(4-(methylthio)benzamido)cyc...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCCCC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C24H27F3N4O3S/c1-35-16-9-6-14(7-10-16)22(33)31-20-5-3-2-4-19(20)30-21(32)13-29-23(34)17-12-15(24(25,26)27)8-11-18(17)28/h6-12,19-20H,2-5,13,28H2,1H3,(H,29,34)(H,30,32)(H,31,33)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 155n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255217
PNG
((+/-)-2-amino-N-(2-(5-amino 2-(4-(methylthio)benza...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(N)CC1NC(=O)CNC(=O)c1cc(ccc1N)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3S/c1-36-16-6-2-13(3-7-16)22(34)32-19-9-5-15(28)11-20(19)31-21(33)12-30-23(35)17-10-14(24(25,26)27)4-8-18(17)29/h2-4,6-8,10,15,19-20H,5,9,11-12,28-29H2,1H3,(H,30,35)(H,31,33)(H,32,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 168n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255220
PNG
((+/-)-N-(2-(4-amino-2-(4-(methylthio)benzamido)cyc...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CC(N)CCC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H27F3N4O3S/c1-35-18-8-5-14(6-9-18)23(34)31-20-12-17(28)7-10-19(20)30-21(32)13-29-22(33)15-3-2-4-16(11-15)24(25,26)27/h2-6,8-9,11,17,19-20H,7,10,12-13,28H2,1H3,(H,29,33)(H,30,32)(H,31,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 228n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255736
PNG
((+/-)-[2-({[5-Benzyloxycarbonylamino-2-(4-methylsu...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(CC1NC(=O)CNC(=O)c1cc(ccc1NC(=O)OC(C)(C)C)C(F)(F)F)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C37H42F3N5O7S/c1-36(2,3)52-35(50)45-28-16-12-24(37(38,39)40)18-27(28)33(48)41-20-31(46)43-30-19-25(42-34(49)51-21-22-8-6-5-7-9-22)13-17-29(30)44-32(47)23-10-14-26(53-4)15-11-23/h5-12,14-16,18,25,29-30H,13,17,19-21H2,1-4H3,(H,41,48)(H,42,49)(H,43,46)(H,44,47)(H,45,50)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 600n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
C-C chemokine receptor type 2


(Homo sapiens (Human))		BDBM50255172
PNG
((+/-)-benzyl-4-(4-(methylthio)benzamido)-3-(2-(3-(...)
Show SMILES CSc1ccc(cc1)C(=O)NC1CCC(CC1NC(=O)CNC(=O)c1cccc(c1)C(F)(F)F)NC(=O)OCc1ccccc1
Show InChI InChI=1S/C32H33F3N4O5S/c1-45-25-13-10-21(11-14-25)30(42)39-26-15-12-24(37-31(43)44-19-20-6-3-2-4-7-20)17-27(26)38-28(40)18-36-29(41)22-8-5-9-23(16-22)32(33,34)35/h2-11,13-14,16,24,26-27H,12,15,17-19H2,1H3,(H,36,41)(H,37,43)(H,38,40)(H,39,42)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.61E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Displacement of [125I]MCP1 from CCR2 in human PBMCs

Bioorg Med Chem Lett 19: 597-601 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.062
BindingDB Entry DOI: 10.7270/Q2QF8SR1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%