Affinity Data by PubMed id=19168355

PubMed code 19168355

Found 7 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276627 (4-(5-(4-ethoxyphenyl)-1,2,3-thiadiazol-4-yl)-6-eth...) Show SMILES CCOc1ccc(cc1)-c1snnc1-c1cc(CC)c(O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276571 (4-(5-chloro-2,4-dihydroxyphenyl)-5-(4-ethoxyphenyl...) Show SMILES CCOc1ccc(cc1)-c1snnc1-c1cc(Cl)c(O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276572 (4-chloro-6-(5-p-tolyl-1,2,3-thiadiazol-4-yl)benzen...) Show SMILES Cc1ccc(cc1)-c1snnc1-c1cc(Cl)c(O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276628 (2,4-dichloro-6-(5-(4-methoxyphenyl)-1,2,3-thiadiaz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276629 (2-chloro-4-(5-(4-ethoxyphenyl)-1,2,3-thiadiazol-4-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276570 (4-chloro-6-(5-(4-methoxyphenyl)-1,2,3-thiadiazol-4...) Show SMILES COc1ccc(cc1)-c1snnc1-c1cc(Cl)c(O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Heat shock protein HSP 90-alpha (Homo sapiens (Human))	BDBM50276573 (4-chloro-6-(5-(3,4-dimethoxyphenyl)-1,2,3-thiadiaz...) Show SMILES COc1ccc(cc1OC)-c1snnc1-c1cc(Cl)c(O)cc1O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a
Fermentas UAB Curated by ChEMBL					Assay Description Binding affinity to human full length Histidine6-tagged Hsp90alpha expressed in Escherichia coli BL21 DE3 by ITC				Bioorg Med Chem Lett 19: 1089-92 (2009) Article DOI: 10.1016/j.bmcl.2009.01.003 BindingDB Entry DOI: 10.7270/Q27944KP
Fermentas UAB Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%