Affinity Data by PubMed id=19170619

PubMed code 19170619

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10882 (6-ethoxy-1,3-benzothiazole-2-sulfonamide \| CHEMBL1...) Show SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10882 (6-ethoxy-1,3-benzothiazole-2-sulfonamide \| CHEMBL1...) Show SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM10875 (5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide...) Show SMILES NS(=O)(=O)c1nnc(s1)-c1ccccc1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10875 (5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide...) Show SMILES NS(=O)(=O)c1nnc(s1)-c1ccccc1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10875 (5-(2-chlorophenyl)-1,3,4-thiadiazole-2-sulfonamide...) Show SMILES NS(=O)(=O)c1nnc(s1)-c1ccccc1Cl Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	4.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50108567 (5-Phenylmethanesulfonylamino-[1,3,4]thiadiazole-2-...) Show SMILES NS(=O)(=O)c1nnc(NS(=O)(=O)Cc2ccccc2)s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50108567 (5-Phenylmethanesulfonylamino-[1,3,4]thiadiazole-2-...) Show SMILES NS(=O)(=O)c1nnc(NS(=O)(=O)Cc2ccccc2)s1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	8.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM92939 (Methazolamide, MZM) Show SMILES CC1N=C(S\C1=N\C(C)=O)S(N)(=O)=O \|c:2\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50108567 (5-Phenylmethanesulfonylamino-[1,3,4]thiadiazole-2-...) Show SMILES NS(=O)(=O)c1nnc(NS(=O)(=O)Cc2ccccc2)s1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article PubMed	9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM10880 (AZA \| AZA2 \| AZM acetazolamide \| Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	10.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair				3D Structure (crystal)
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM92939 (Methazolamide, MZM) Show SMILES CC1N=C(S\C1=N\C(C)=O)S(N)(=O)=O \|c:2\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	11.4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM92939 (Methazolamide, MZM) Show SMILES CC1N=C(S\C1=N\C(C)=O)S(N)(=O)=O \|c:2\| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	11.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida					Assay Description Inhibition assay using carbonic anhydrases.				Biochemistry 48: 1322-31 (2009) Article DOI: 10.1021/bi802035f BindingDB Entry DOI: 10.7270/Q2HX1B94
University of Florida					More data for this Ligand-Target Pair

* indicates data uncertainty>20%