BindingDB logo
myBDB logout

PubMed code 19183043

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50208999
PNG
((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O |r|
Show InChI InChI=1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.5n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50208999
PNG
((R)-1-(2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-...)
Show SMILES C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1NC(N)=O |r|
Show InChI InChI=1S/C21H24ClFN4O3/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29)/t14-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 5.5n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293055
PNG
((R)-N2-(4-Chlorobenzyl)-N1-[2,6-dimethyl-4-(triflu...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1c(C)cc(cc1C)C(F)(F)F |r|
Show InChI InChI=1S/C23H25ClF3N3O2/c1-14-11-17(23(25,26)27)12-15(2)20(14)28-22(32)30-10-4-5-19(30)21(31)29(3)13-16-6-8-18(24)9-7-16/h6-9,11-12,19H,4-5,10,13H2,1-3H3,(H,28,32)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 6n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293055
PNG
((R)-N2-(4-Chlorobenzyl)-N1-[2,6-dimethyl-4-(triflu...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1c(C)cc(cc1C)C(F)(F)F |r|
Show InChI InChI=1S/C23H25ClF3N3O2/c1-14-11-17(23(25,26)27)12-15(2)20(14)28-22(32)30-10-4-5-19(30)21(31)29(3)13-16-6-8-18(24)9-7-16/h6-9,11-12,19H,4-5,10,13H2,1-3H3,(H,28,32)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293054
PNG
((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[2-methyl-4-(...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1C)C(F)(F)F |r|
Show InChI InChI=1S/C22H23ClF3N3O2/c1-14-12-16(22(24,25)26)7-10-18(14)27-21(31)29-11-3-4-19(29)20(30)28(2)13-15-5-8-17(23)9-6-15/h5-10,12,19H,3-4,11,13H2,1-2H3,(H,27,31)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293051
PNG
((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21ClF3N3O2/c1-27(13-14-4-8-16(22)9-5-14)19(29)18-3-2-12-28(18)20(30)26-17-10-6-15(7-11-17)21(23,24)25/h4-11,18H,2-3,12-13H2,1H3,(H,26,30)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293053
PNG
((R)-N2-(4-Chlorobenzyl)-N1-[2-fluoro-4-(trifluorom...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1F)C(F)(F)F |r|
Show InChI InChI=1S/C21H20ClF4N3O2/c1-28(12-13-4-7-15(22)8-5-13)19(30)18-3-2-10-29(18)20(31)27-17-9-6-14(11-16(17)23)21(24,25)26/h4-9,11,18H,2-3,10,12H2,1H3,(H,27,31)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293053
PNG
((R)-N2-(4-Chlorobenzyl)-N1-[2-fluoro-4-(trifluorom...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1F)C(F)(F)F |r|
Show InChI InChI=1S/C21H20ClF4N3O2/c1-28(12-13-4-7-15(22)8-5-13)19(30)18-3-2-10-29(18)20(31)27-17-9-6-14(11-16(17)23)21(24,25)26/h4-9,11,18H,2-3,10,12H2,1H3,(H,27,31)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293052
PNG
((R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluorom...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C21H20Cl2F3N3O2/c1-28(12-13-4-7-15(22)8-5-13)19(30)18-3-2-10-29(18)20(31)27-17-9-6-14(11-16(17)23)21(24,25)26/h4-9,11,18H,2-3,10,12H2,1H3,(H,27,31)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293054
PNG
((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[2-methyl-4-(...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1C)C(F)(F)F |r|
Show InChI InChI=1S/C22H23ClF3N3O2/c1-14-12-16(22(24,25)26)7-10-18(14)27-21(31)29-11-3-4-19(29)20(30)28(2)13-15-5-8-17(23)9-6-15/h5-10,12,19H,3-4,11,13H2,1-2H3,(H,27,31)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293052
PNG
((R)-N2-(4-Chlorobenzyl)-N1-[2-chloro-4-(trifluorom...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C21H20Cl2F3N3O2/c1-28(12-13-4-7-15(22)8-5-13)19(30)18-3-2-10-29(18)20(31)27-17-9-6-14(11-16(17)23)21(24,25)26/h4-9,11,18H,2-3,10,12H2,1H3,(H,27,31)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 120n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293051
PNG
((1S)-N1-(4-chlorobenzyl)-N1-methyl-N2-(4-(trifluor...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21ClF3N3O2/c1-27(13-14-4-8-16(22)9-5-14)19(29)18-3-2-12-28(18)20(30)26-17-10-6-15(7-11-17)21(23,24)25/h4-11,18H,2-3,12-13H2,1H3,(H,26,30)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293035
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-met...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C20H21Cl2N3O2/c1-24(13-14-4-6-15(21)7-5-14)19(26)18-3-2-12-25(18)20(27)23-17-10-8-16(22)9-11-17/h4-11,18H,2-3,12-13H2,1H3,(H,23,27)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 270n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293034
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-eth...)
Show SMILES CCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O2/c1-2-25(14-15-5-7-16(22)8-6-15)20(27)19-4-3-13-26(19)21(28)24-18-11-9-17(23)10-12-18/h5-12,19H,2-4,13-14H2,1H3,(H,24,28)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 270n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293049
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-methoxyphenyl)-N2-me...)
Show SMILES COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O3/c1-24(14-15-5-7-16(22)8-6-15)20(26)19-4-3-13-25(19)21(27)23-17-9-11-18(28-2)12-10-17/h5-12,19H,3-4,13-14H2,1-2H3,(H,23,27)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 290n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293049
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-methoxyphenyl)-N2-me...)
Show SMILES COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O3/c1-24(14-15-5-7-16(22)8-6-15)20(26)19-4-3-13-25(19)21(27)23-17-9-11-18(28-2)12-10-17/h5-12,19H,3-4,13-14H2,1-2H3,(H,23,27)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 440n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 3 hrs

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293059
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-...)
Show SMILES OCCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O3/c22-16-5-3-15(4-6-16)14-25(12-13-27)20(28)19-2-1-11-26(19)21(29)24-18-9-7-17(23)8-10-18/h3-10,19,27H,1-2,11-14H2,(H,24,29)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 540n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293046
PNG
((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-p-tolylpyrrol...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O2/c1-15-5-11-18(12-6-15)23-21(27)25-13-3-4-19(25)20(26)24(2)14-16-7-9-17(22)10-8-16/h5-12,19H,3-4,13-14H2,1-2H3,(H,23,27)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 680n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293047
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-fluorophenyl)-N2-met...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(F)cc1 |r|
Show InChI InChI=1S/C20H21ClFN3O2/c1-24(13-14-4-6-15(21)7-5-14)19(26)18-3-2-12-25(18)20(27)23-17-10-8-16(22)9-11-17/h4-11,18H,2-3,12-13H2,1H3,(H,23,27)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 700n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293048
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-cyanophenyl)-N2-meth...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(cc1)C#N |r|
Show InChI InChI=1S/C21H21ClN4O2/c1-25(14-16-4-8-17(22)9-5-16)20(27)19-3-2-12-26(19)21(28)24-18-10-6-15(13-23)7-11-18/h4-11,19H,2-3,12,14H2,1H3,(H,24,28)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 720n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293041
PNG
((R)-N2-(4-Fluorobenzyl)-N1-(4-chlorophenyl)-N2-met...)
Show SMILES CN(Cc1ccc(F)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C20H21ClFN3O2/c1-24(13-14-4-8-16(22)9-5-14)19(26)18-3-2-12-25(18)20(27)23-17-10-6-15(21)7-11-17/h4-11,18H,2-3,12-13H2,1H3,(H,23,27)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.30E+3n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293050
PNG
((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-(3-(trifluoro...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21ClF3N3O2/c1-27(13-14-7-9-16(22)10-8-14)19(29)18-6-3-11-28(18)20(30)26-17-5-2-4-15(12-17)21(23,24)25/h2,4-5,7-10,12,18H,3,6,11,13H2,1H3,(H,26,30)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 2.95E+3n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293033
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-pro...)
Show SMILES CCCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H25Cl2N3O2/c1-2-13-26(15-16-5-7-17(23)8-6-16)21(28)20-4-3-14-27(20)22(29)25-19-11-9-18(24)10-12-19/h5-12,20H,2-4,13-15H2,1H3,(H,25,29)/t20-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.60E+3n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293044
PNG
((R)-N2-(4-Chloro-3-methylbenzyl)-N1-(4-chloropheny...)
Show SMILES CN(Cc1ccc(Cl)c(C)c1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O2/c1-14-12-15(5-10-18(14)23)13-25(2)20(27)19-4-3-11-26(19)21(28)24-17-8-6-16(22)7-9-17/h5-10,12,19H,3-4,11,13H2,1-2H3,(H,24,28)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.00E+3n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293045
PNG
((2R)-N1-(4-Chlorophenyl)-N2-[1-(4-chlorophenyl)eth...)
Show SMILES CC(N(C)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O2/c1-14(15-5-7-16(22)8-6-15)25(2)20(27)19-4-3-13-26(19)21(28)24-18-11-9-17(23)10-12-18/h5-12,14,19H,3-4,13H2,1-2H3,(H,24,28)/t14?,19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.70E+3n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293042
PNG
((R)-N2-(4-Methylbenzyl)-N1-(4-chlorophenyl)-N2-met...)
Show SMILES CN(Cc1ccc(C)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O2/c1-15-5-7-16(8-6-15)14-24(2)20(26)19-4-3-13-25(19)21(27)23-18-11-9-17(22)10-12-18/h5-12,19H,3-4,13-14H2,1-2H3,(H,23,27)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.70E+3n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293038
PNG
((R)-N2-(4-Cyanobenzyl)-N1-(4-chlorophenyl)-N2-meth...)
Show SMILES CN(Cc1ccc(cc1)C#N)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H21ClN4O2/c1-25(14-16-6-4-15(13-23)5-7-16)20(27)19-3-2-12-26(19)21(28)24-18-10-8-17(22)9-11-18/h4-11,19H,2-3,12,14H2,1H3,(H,24,28)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.30E+4n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293058
PNG
((S)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[4-(trifluoro...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@@H]1CCCN1C(=O)Nc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C21H21ClF3N3O2/c1-27(13-14-4-8-16(22)9-5-14)19(29)18-3-2-12-28(18)20(30)26-17-10-6-15(7-11-17)21(23,24)25/h4-11,18H,2-3,12-13H2,1H3,(H,26,30)/t18-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>2.80E+4n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293056
PNG
(CHEMBL515927 | N2-(4-Chlorobenzyl)-N2-methyl-N1-[4...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)C1CCCCN1C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C22H23ClF3N3O2/c1-28(14-15-5-9-17(23)10-6-15)20(30)19-4-2-3-13-29(19)21(31)27-18-11-7-16(8-12-18)22(24,25)26/h5-12,19H,2-4,13-14H2,1H3,(H,27,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>2.80E+4n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293036
PNG
((R)-N2-(2-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-...)
Show SMILES OCCN(Cc1ccccc1Cl)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O3/c22-16-7-9-17(10-8-16)24-21(29)26-11-3-6-19(26)20(28)25(12-13-27)14-15-4-1-2-5-18(15)23/h1-2,4-5,7-10,19,27H,3,6,11-14H2,(H,24,29)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.30E+4n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293032
PNG
((R)-N2-(4-Chlorobenzyl)-N1-(4-chlorophenyl)pyrroli...)
Show SMILES Clc1ccc(CNC(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C19H19Cl2N3O2/c20-14-5-3-13(4-6-14)12-22-18(25)17-2-1-11-24(17)19(26)23-16-9-7-15(21)8-10-16/h3-10,17H,1-2,11-12H2,(H,22,25)(H,23,26)/t17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>7.50E+4n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293039
PNG
((R)-N2-(4-Methoxybenzyl)-N1-(4-chlorophenyl)-N2-me...)
Show SMILES COc1ccc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)cc1 |r|
Show InChI InChI=1S/C21H24ClN3O3/c1-24(14-15-5-11-18(28-2)12-6-15)20(26)19-4-3-13-25(19)21(27)23-17-9-7-16(22)8-10-17/h5-12,19H,3-4,13-14H2,1-2H3,(H,23,27)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>7.70E+4n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293057
PNG
((R)-N2-(4-Chlorobenzyl)-N2-methyl-N1-[4-(trifluoro...)
Show SMILES CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCN1C(=O)Nc1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C20H19ClF3N3O2/c1-26(12-13-2-6-15(21)7-3-13)18(28)17-10-11-27(17)19(29)25-16-8-4-14(5-9-16)20(22,23)24/h2-9,17H,10-12H2,1H3,(H,25,29)/t17-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293037
PNG
((R)-N2-(3-Chlorobenzyl)-N1-(4-chlorophenyl)-N2-(2-...)
Show SMILES OCCN(Cc1cccc(Cl)c1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O3/c22-16-6-8-18(9-7-16)24-21(29)26-10-2-5-19(26)20(28)25(11-12-27)14-15-3-1-4-17(23)13-15/h1,3-4,6-9,13,19,27H,2,5,10-12,14H2,(H,24,29)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293040
PNG
((R)-N2-[4-(Trifluoromethyl)benzyl]-N1-(4-chlorophe...)
Show SMILES CN(Cc1ccc(cc1)C(F)(F)F)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H21ClF3N3O2/c1-27(13-14-4-6-15(7-5-14)21(23,24)25)19(29)18-3-2-12-28(18)20(30)26-17-10-8-16(22)9-11-17/h4-11,18H,2-3,12-13H2,1H3,(H,26,30)/t18-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
C-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM50293043
PNG
((R)-N2-(4-Chloro-2-methylbenzyl)-N1-(4-chloropheny...)
Show SMILES CN(Cc1ccc(Cl)cc1C)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H23Cl2N3O2/c1-14-12-17(23)6-5-15(14)13-25(2)20(27)19-4-3-11-26(19)21(28)24-18-9-7-16(22)8-10-18/h5-10,12,19H,3-4,11,13H2,1-2H3,(H,24,28)/t19-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Pharmacopeia, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells

J Med Chem 52: 1295-301 (2010)


Article DOI: 10.1021/jm801416q
BindingDB Entry DOI: 10.7270/Q25X28Z3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%