Found 95 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248089
(CHEMBL517469 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4F)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-21(32-16-34)25-14-20-26(40-25)24(9-10-31-20)39-23-8-7-17(13-19(23)30)33-27(37)36-12-11-35(28(36)38)22-6-4-3-5-18(22)29/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248054
(CHEMBL508395 | N-(3-fluoro-4-(2-(4-((methyl(2-(4-m...)Show SMILES CN(CCN1CCN(C)CC1)Cc1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C38H40FN7O3S/c1-42-16-19-44(20-17-42)21-18-43(2)26-27-8-10-28(11-9-27)35-25-32-36(50-35)34(14-15-40-32)49-33-13-12-29(24-31(33)39)41-37(47)46-23-22-45(38(46)48)30-6-4-3-5-7-30/h3-15,24-25H,16-23,26H2,1-2H3,(H,41,47) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248088
(CHEMBL464211 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-22(32-16-34)25-14-21-26(40-25)24(9-10-31-21)39-23-8-5-18(13-20(23)30)33-27(37)36-12-11-35(28(36)38)19-6-3-17(29)4-7-19/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248510
(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H23F2N3O5/c1-36-24-14-19-21(15-25(24)37-2)31-12-9-22(19)38-23-8-7-18(13-20(23)30)33-27(35)28(10-11-28)26(34)32-17-5-3-16(29)4-6-17/h3-9,12-15H,10-11H2,1-2H3,(H,32,34)(H,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248048
(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCCN2CCCC2)cn1 Show InChI InChI=1S/C33H32FN7O3S/c34-25-19-23(37-32(42)41-18-17-40(33(41)43)24-7-2-1-3-8-24)9-10-28(25)44-29-11-12-35-26-20-30(45-31(26)29)27-21-39(22-36-27)16-6-15-38-13-4-5-14-38/h1-3,7-12,19-22H,4-6,13-18H2,(H,37,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248053
(4-(4-(7-(2-fluoro-4-(2-oxo-3-phenylimidazolidine-1...)Show SMILES CNC(=O)N1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C36H34FN7O4S/c1-38-34(45)42-17-15-41(16-18-42)23-24-7-9-25(10-8-24)32-22-29-33(49-32)31(13-14-39-29)48-30-12-11-26(21-28(30)37)40-35(46)44-20-19-43(36(44)47)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,45)(H,40,46) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247962
(CHEMBL462232 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)37-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)36)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248558
(CHEMBL465131 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-34-15-21(31-16-34)24-14-20-25(38-24)23(9-12-30-20)37-22-8-7-18(13-19(22)29)33-27(36)28(10-11-28)26(35)32-17-5-3-2-4-6-17/h2-9,12-16H,10-11H2,1H3,(H,32,35)(H,33,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248557
(CHEMBL465130 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES CN(C(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C27H22FN5O3S/c1-32-15-21(30-16-32)24-13-20-27(37-24)23(10-11-29-20)36-22-9-8-17(12-19(22)28)31-25(34)14-26(35)33(2)18-6-4-3-5-7-18/h3-13,15-16H,14H2,1-2H3,(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248051
(CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247984
(CHEMBL453613 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-16-22(31-17-33)25-15-21-26(39-25)24(10-11-30-21)38-23-9-8-18(14-20(23)29)32-27(36)35-13-12-34(28(35)37)19-6-4-3-5-7-19/h3-11,14-17H,2,12-13H2,1H3,(H,32,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248052
(CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248091
(CHEMBL518676 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(37)34-12-11-33(27(34)35)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248046
(CHEMBL445871 | N-(4-(2-(1-(2-(dimethylamino)ethyl)...)Show SMILES CN(C)CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H28FN7O3S/c1-35(2)12-13-36-18-24(33-19-36)27-17-23-28(42-27)26(10-11-32-23)41-25-9-8-20(16-22(25)31)34-29(39)38-15-14-37(30(38)40)21-6-4-3-5-7-21/h3-11,16-19H,12-15H2,1-2H3,(H,34,39) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248090
(CHEMBL462835 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4OC)cc3F)c2s1 Show InChI InChI=1S/C29H25FN6O4S/c1-3-34-16-21(32-17-34)26-15-20-27(41-26)25(10-11-31-20)40-23-9-8-18(14-19(23)30)33-28(37)36-13-12-35(29(36)38)22-6-4-5-7-24(22)39-2/h4-11,14-17H,3,12-13H2,1-2H3,(H,33,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248556
(CHEMBL464510 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-12-19-26(36-23)22(9-10-28-19)35-21-8-7-17(11-18(21)27)31-25(34)13-24(33)30-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H,30,33)(H,31,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248602
(CHEMBL459478 | N-(3-fluoro-4-(2-(1-isopropyl-1H-im...)Show SMILES CC(C)n1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H26FN5O3S/c1-18(2)35-16-24(33-17-35)27-15-23-28(40-27)26(10-12-32-23)39-25-9-8-19(14-22(25)31)34-29(37)21-11-13-36(30(21)38)20-6-4-3-5-7-20/h3-10,12,14-18,21H,11,13H2,1-2H3,(H,34,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248053
(4-(4-(7-(2-fluoro-4-(2-oxo-3-phenylimidazolidine-1...)Show SMILES CNC(=O)N1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C36H34FN7O4S/c1-38-34(45)42-17-15-41(16-18-42)23-24-7-9-25(10-8-24)32-22-29-33(49-32)31(13-14-39-29)48-30-12-11-26(21-28(30)37)40-35(46)44-20-19-43(36(44)47)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,45)(H,40,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248047
(CHEMBL503524 | N-(3-fluoro-4-(2-(1-(2-(pyrrolidin-...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCN2CCCC2)cn1 Show InChI InChI=1S/C32H30FN7O3S/c33-24-18-22(36-31(41)40-17-16-39(32(40)42)23-6-2-1-3-7-23)8-9-27(24)43-28-10-11-34-25-19-29(44-30(25)28)26-20-38(21-35-26)15-14-37-12-4-5-13-37/h1-3,6-11,18-21H,4-5,12-17H2,(H,36,41) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248048
(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCCN2CCCC2)cn1 Show InChI InChI=1S/C33H32FN7O3S/c34-25-19-23(37-32(42)41-18-17-40(33(41)43)24-7-2-1-3-8-24)9-10-28(25)44-29-11-12-35-26-20-30(45-31(26)29)27-21-39(22-36-27)16-6-15-38-13-4-5-14-38/h1-3,7-12,19-22H,4-6,13-18H2,(H,37,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248510
(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H23F2N3O5/c1-36-24-14-19-21(15-25(24)37-2)31-12-9-22(19)38-23-8-7-18(13-20(23)30)33-27(35)28(10-11-28)26(34)32-17-5-3-16(29)4-6-17/h3-9,12-15H,10-11H2,1-2H3,(H,32,34)(H,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248089
(CHEMBL517469 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4F)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-21(32-16-34)25-14-20-26(40-25)24(9-10-31-20)39-23-8-7-17(13-19(23)30)33-27(37)36-12-11-35(28(36)38)22-6-4-3-5-18(22)29/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248051
(CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247962
(CHEMBL462232 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)37-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)36)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248056
((S)-N-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbon...)Show SMILES CN(C)[C@H]1CCN(C1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 |r| Show InChI InChI=1S/C30H29FN6O4S/c1-34(2)21-11-13-35(18-21)28(38)26-17-23-27(42-26)25(10-12-32-23)41-24-9-8-19(16-22(24)31)33-29(39)37-15-14-36(30(37)40)20-6-4-3-5-7-20/h3-10,12,16-17,21H,11,13-15,18H2,1-2H3,(H,33,39)/t21-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248050
(CHEMBL455655 | N-(4-(2-(1-ethyl-1H-imidazol-2-yl)t...)Show SMILES CCn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-13-12-31-26(33)24-17-21-25(39-24)23(10-11-30-21)38-22-9-8-18(16-20(22)29)32-27(36)35-15-14-34(28(35)37)19-6-4-3-5-7-19/h3-13,16-17H,2,14-15H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248091
(CHEMBL518676 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(37)34-12-11-33(27(34)35)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247984
(CHEMBL453613 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-16-22(31-17-33)25-15-21-26(39-25)24(10-11-30-21)38-23-9-8-18(14-20(23)29)32-27(36)35-13-12-34(28(35)37)19-6-4-3-5-7-19/h3-11,14-17H,2,12-13H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248511
(CHEMBL490965 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)NC(=O)Cc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)35-21-8-7-17(12-18(21)27)30-26(34)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248050
(CHEMBL455655 | N-(4-(2-(1-ethyl-1H-imidazol-2-yl)t...)Show SMILES CCn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-13-12-31-26(33)24-17-21-25(39-24)23(10-11-30-21)38-22-9-8-18(16-20(22)29)32-27(36)35-15-14-34(28(35)37)19-6-4-3-5-7-19/h3-13,16-17H,2,14-15H2,1H3,(H,32,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248090
(CHEMBL462835 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4OC)cc3F)c2s1 Show InChI InChI=1S/C29H25FN6O4S/c1-3-34-16-21(32-17-34)26-15-20-27(41-26)25(10-11-31-20)40-23-9-8-18(14-19(23)30)33-28(37)36-13-12-35(29(36)38)22-6-4-5-7-24(22)39-2/h4-11,14-17H,3,12-13H2,1-2H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248049
(CHEMBL510676 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-12-11-30-25(32)23-16-20-24(38-23)22(9-10-29-20)37-21-8-7-17(15-19(21)28)31-26(35)34-14-13-33(27(34)36)18-5-3-2-4-6-18/h2-12,15-16H,13-14H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM24498
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248088
(CHEMBL464211 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-22(32-16-34)25-14-21-26(40-25)24(9-10-31-21)39-23-8-5-18(13-20(23)30)33-27(37)36-12-11-35(28(36)38)19-6-3-17(29)4-7-19/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248556
(CHEMBL464510 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-12-19-26(36-23)22(9-10-28-19)35-21-8-7-17(11-18(21)27)31-25(34)13-24(33)30-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H,30,33)(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248054
(CHEMBL508395 | N-(3-fluoro-4-(2-(4-((methyl(2-(4-m...)Show SMILES CN(CCN1CCN(C)CC1)Cc1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C38H40FN7O3S/c1-42-16-19-44(20-17-42)21-18-43(2)26-27-8-10-28(11-9-27)35-25-32-36(50-35)34(14-15-40-32)49-33-13-12-29(24-31(33)39)41-37(47)46-23-22-45(38(46)48)30-6-4-3-5-7-30/h3-15,24-25H,16-23,26H2,1-2H3,(H,41,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248558
(CHEMBL465131 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-34-15-21(31-16-34)24-14-20-25(38-24)23(9-12-30-20)37-22-8-7-18(13-19(22)29)33-27(36)28(10-11-28)26(35)32-17-5-3-2-4-6-17/h2-9,12-16H,10-11H2,1H3,(H,32,35)(H,33,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248052
(CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248049
(CHEMBL510676 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-12-11-30-25(32)23-16-20-24(38-23)22(9-10-29-20)37-21-8-7-17(15-19(21)28)31-26(35)34-14-13-33(27(34)36)18-5-3-2-4-6-18/h2-12,15-16H,13-14H2,1H3,(H,31,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM24485
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248057
(CHEMBL508776 | N-(3-fluoro-4-(2-(1-methyl-1,2,3,6-...)Show SMILES CN1CCC(=CC1)c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 |c:4| Show InChI InChI=1S/C29H26FN5O3S/c1-33-13-10-19(11-14-33)26-18-23-27(39-26)25(9-12-31-23)38-24-8-7-20(17-22(24)30)32-28(36)35-16-15-34(29(35)37)21-5-3-2-4-6-21/h2-10,12,17-18H,11,13-16H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248046
(CHEMBL445871 | N-(4-(2-(1-(2-(dimethylamino)ethyl)...)Show SMILES CN(C)CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H28FN7O3S/c1-35(2)12-13-36-18-24(33-19-36)27-17-23-28(42-27)26(10-11-32-23)41-25-9-8-20(16-22(25)31)34-29(39)38-15-14-37(30(38)40)21-6-4-3-5-7-21/h3-11,16-19H,12-15H2,1-2H3,(H,34,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248047
(CHEMBL503524 | N-(3-fluoro-4-(2-(1-(2-(pyrrolidin-...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCN2CCCC2)cn1 Show InChI InChI=1S/C32H30FN7O3S/c33-24-18-22(36-31(41)40-17-16-39(32(40)42)23-6-2-1-3-7-23)8-9-27(24)43-28-10-11-34-25-19-29(44-30(25)28)26-20-38(21-35-26)15-14-37-12-4-5-13-37/h1-3,6-11,18-21H,4-5,12-17H2,(H,36,41) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248601
(CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24498
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248511
(CHEMBL490965 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)NC(=O)Cc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)35-21-8-7-17(12-18(21)27)30-26(34)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,34) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50242737
((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248601
(CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248602
(CHEMBL459478 | N-(3-fluoro-4-(2-(1-isopropyl-1H-im...)Show SMILES CC(C)n1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H26FN5O3S/c1-18(2)35-16-24(33-17-35)27-15-23-28(40-27)26(10-12-32-23)39-25-9-8-19(14-22(25)31)34-29(37)21-11-13-36(30(21)38)20-6-4-3-5-7-20/h3-10,12,14-18,21H,11,13H2,1-2H3,(H,34,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247984
(CHEMBL453613 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-16-22(31-17-33)25-15-21-26(39-25)24(10-11-30-21)38-23-9-8-18(14-20(23)29)32-27(36)35-13-12-34(28(35)37)19-6-4-3-5-7-19/h3-11,14-17H,2,12-13H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248056
((S)-N-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbon...)Show SMILES CN(C)[C@H]1CCN(C1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 |r| Show InChI InChI=1S/C30H29FN6O4S/c1-34(2)21-11-13-35(18-21)28(38)26-17-23-27(42-26)25(10-12-32-23)41-24-9-8-19(16-22(24)31)33-29(39)37-15-14-36(30(37)40)20-6-4-3-5-7-20/h3-10,12,16-17,21H,11,13-15,18H2,1-2H3,(H,33,39)/t21-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248557
(CHEMBL465130 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES CN(C(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C27H22FN5O3S/c1-32-15-21(30-16-32)24-13-20-27(37-24)23(10-11-29-20)36-22-9-8-17(12-19(22)28)31-25(34)14-26(35)33(2)18-6-4-3-5-7-18/h3-13,15-16H,14H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24498
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248088
(CHEMBL464211 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-22(32-16-34)25-14-21-26(40-25)24(9-10-31-21)39-23-8-5-18(13-20(23)30)33-27(37)36-12-11-35(28(36)38)19-6-3-17(29)4-7-19/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248600
(CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248046
(CHEMBL445871 | N-(4-(2-(1-(2-(dimethylamino)ethyl)...)Show SMILES CN(C)CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H28FN7O3S/c1-35(2)12-13-36-18-24(33-19-36)27-17-23-28(42-27)26(10-11-32-23)41-25-9-8-20(16-22(25)31)34-29(39)38-15-14-37(30(38)40)21-6-4-3-5-7-21/h3-11,16-19H,12-15H2,1-2H3,(H,34,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248558
(CHEMBL465131 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-34-15-21(31-16-34)24-14-20-25(38-24)23(9-12-30-20)37-22-8-7-18(13-19(22)29)33-27(36)28(10-11-28)26(35)32-17-5-3-2-4-6-17/h2-9,12-16H,10-11H2,1H3,(H,32,35)(H,33,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248090
(CHEMBL462835 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4OC)cc3F)c2s1 Show InChI InChI=1S/C29H25FN6O4S/c1-3-34-16-21(32-17-34)26-15-20-27(41-26)25(10-11-31-20)40-23-9-8-18(14-19(23)30)33-28(37)36-13-12-35(29(36)38)22-6-4-5-7-24(22)39-2/h4-11,14-17H,3,12-13H2,1-2H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247961
(CHEMBL462231 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4(C)CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C29H24FN5O3S/c1-29(11-13-35(28(29)37)19-6-4-3-5-7-19)27(36)33-18-8-9-23(20(30)14-18)38-24-10-12-31-21-15-25(39-26(21)24)22-16-34(2)17-32-22/h3-10,12,14-17H,11,13H2,1-2H3,(H,33,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248088
(CHEMBL464211 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-22(32-16-34)25-14-21-26(40-25)24(9-10-31-21)39-23-8-5-18(13-20(23)30)33-27(37)36-12-11-35(28(36)38)19-6-3-17(29)4-7-19/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cells |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24485
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248091
(CHEMBL518676 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(37)34-12-11-33(27(34)35)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248053
(4-(4-(7-(2-fluoro-4-(2-oxo-3-phenylimidazolidine-1...)Show SMILES CNC(=O)N1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C36H34FN7O4S/c1-38-34(45)42-17-15-41(16-18-42)23-24-7-9-25(10-8-24)32-22-29-33(49-32)31(13-14-39-29)48-30-12-11-26(21-28(30)37)40-35(46)44-20-19-43(36(44)47)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,45)(H,40,46) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248089
(CHEMBL517469 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4F)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-21(32-16-34)25-14-20-26(40-25)24(9-10-31-20)39-23-8-7-17(13-19(23)30)33-27(37)36-12-11-35(28(36)38)22-6-4-3-5-18(22)29/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248049
(CHEMBL510676 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-12-11-30-25(32)23-16-20-24(38-23)22(9-10-29-20)37-21-8-7-17(15-19(21)28)31-26(35)34-14-13-33(27(34)36)18-5-3-2-4-6-18/h2-12,15-16H,13-14H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247962
(CHEMBL462232 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)37-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)36)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248050
(CHEMBL455655 | N-(4-(2-(1-ethyl-1H-imidazol-2-yl)t...)Show SMILES CCn1ccnc1-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H23FN6O3S/c1-2-33-13-12-31-26(33)24-17-21-25(39-24)23(10-11-30-21)38-22-9-8-18(16-20(22)29)32-27(36)35-15-14-34(28(35)37)19-6-4-3-5-7-19/h3-13,16-17H,2,14-15H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248557
(CHEMBL465130 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES CN(C(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C27H22FN5O3S/c1-32-15-21(30-16-32)24-13-20-27(37-24)23(10-11-29-20)36-22-9-8-17(12-19(22)28)31-25(34)14-26(35)33(2)18-6-4-3-5-7-18/h3-13,15-16H,14H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248057
(CHEMBL508776 | N-(3-fluoro-4-(2-(1-methyl-1,2,3,6-...)Show SMILES CN1CCC(=CC1)c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 |c:4| Show InChI InChI=1S/C29H26FN5O3S/c1-33-13-10-19(11-14-33)26-18-23-27(39-26)25(9-12-31-23)38-24-8-7-20(17-22(24)30)32-28(36)35-16-15-34(29(35)37)21-5-3-2-4-6-21/h2-10,12,17-18H,11,13-16H2,1H3,(H,32,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM4814
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
PDB
Article
PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248055
(CHEMBL448993 | N-(4-(2-(3-acetylphenyl)thieno[3,2-...)Show SMILES CC(=O)c1cccc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C31H23FN4O4S/c1-19(37)20-6-5-7-21(16-20)28-18-25-29(41-28)27(12-13-33-25)40-26-11-10-22(17-24(26)32)34-30(38)36-15-14-35(31(36)39)23-8-3-2-4-9-23/h2-13,16-18H,14-15H2,1H3,(H,34,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248602
(CHEMBL459478 | N-(3-fluoro-4-(2-(1-isopropyl-1H-im...)Show SMILES CC(C)n1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H26FN5O3S/c1-18(2)35-16-24(33-17-35)27-15-23-28(40-27)26(10-12-32-23)39-25-9-8-19(14-22(25)31)34-29(37)21-11-13-36(30(21)38)20-6-4-3-5-7-20/h3-10,12,14-18,21H,11,13H2,1-2H3,(H,34,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247961
(CHEMBL462231 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4(C)CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C29H24FN5O3S/c1-29(11-13-35(28(29)37)19-6-4-3-5-7-19)27(36)33-18-8-9-23(20(30)14-18)38-24-10-12-31-21-15-25(39-26(21)24)22-16-34(2)17-32-22/h3-10,12,14-17H,11,13H2,1-2H3,(H,33,36) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248056
((S)-N-(4-(2-(3-(dimethylamino)pyrrolidine-1-carbon...)Show SMILES CN(C)[C@H]1CCN(C1)C(=O)c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 |r| Show InChI InChI=1S/C30H29FN6O4S/c1-34(2)21-11-13-35(18-21)28(38)26-17-23-27(42-26)25(10-12-32-23)41-24-9-8-19(16-22(24)31)33-29(39)37-15-14-36(30(37)40)20-6-4-3-5-7-20/h3-10,12,16-17,21H,11,13-15,18H2,1-2H3,(H,33,39)/t21-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248088
(CHEMBL464211 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)Show SMILES CCn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2s1 Show InChI InChI=1S/C28H22F2N6O3S/c1-2-34-15-22(32-16-34)25-14-21-26(40-25)24(9-10-31-21)39-23-8-5-18(13-20(23)30)33-27(37)36-12-11-35(28(36)38)19-6-3-17(29)4-7-19/h3-10,13-16H,2,11-12H2,1H3,(H,33,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met-mediated migration in HGF-stimulated human A549 cells by wound healing assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248052
(CHEMBL447616 | N-(3-fluoro-4-(2-(4-((4-methylpiper...)Show SMILES CN1CCN(Cc2ccc(cc2)-c2cc3nccc(Oc4ccc(NC(=O)N5CCN(C5=O)c5ccccc5)cc4F)c3s2)CC1 Show InChI InChI=1S/C35H33FN6O3S/c1-39-15-17-40(18-16-39)23-24-7-9-25(10-8-24)32-22-29-33(46-32)31(13-14-37-29)45-30-12-11-26(21-28(30)36)38-34(43)42-20-19-41(35(42)44)27-5-3-2-4-6-27/h2-14,21-22H,15-20,23H2,1H3,(H,38,43) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248055
(CHEMBL448993 | N-(4-(2-(3-acetylphenyl)thieno[3,2-...)Show SMILES CC(=O)c1cccc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C31H23FN4O4S/c1-19(37)20-6-5-7-21(16-20)28-18-25-29(41-28)27(12-13-33-25)40-26-11-10-22(17-24(26)32)34-30(38)36-15-14-35(31(36)39)23-8-3-2-4-9-23/h2-13,16-18H,14-15H2,1H3,(H,34,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247960
(CHEMBL462023 | N-(3-fluoro-4-(2-(1-isopropyl-1H-im...)Show SMILES CC(C)n1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CN(C(=O)C4)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H26FN5O3S/c1-18(2)35-16-24(33-17-35)27-14-23-29(40-27)26(10-11-32-23)39-25-9-8-20(13-22(25)31)34-30(38)19-12-28(37)36(15-19)21-6-4-3-5-7-21/h3-11,13-14,16-19H,12,15H2,1-2H3,(H,34,38) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248048
(CHEMBL449757 | N-(3-fluoro-4-(2-(1-(3-(pyrrolidin-...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCCN2CCCC2)cn1 Show InChI InChI=1S/C33H32FN7O3S/c34-25-19-23(37-32(42)41-18-17-40(33(41)43)24-7-2-1-3-8-24)9-10-28(25)44-29-11-12-35-26-20-30(45-31(26)29)27-21-39(22-36-27)16-6-15-38-13-4-5-14-38/h1-3,7-12,19-22H,4-6,13-18H2,(H,37,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248057
(CHEMBL508776 | N-(3-fluoro-4-(2-(1-methyl-1,2,3,6-...)Show SMILES CN1CCC(=CC1)c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 |c:4| Show InChI InChI=1S/C29H26FN5O3S/c1-33-13-10-19(11-14-33)26-18-23-27(39-26)25(9-12-31-23)38-24-8-7-20(17-22(24)30)32-28(36)35-16-15-34(29(35)37)21-5-3-2-4-6-21/h2-10,12,17-18H,11,13-16H2,1H3,(H,32,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248556
(CHEMBL464510 | N1-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)CC(=O)Nc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O3S/c1-32-14-20(29-15-32)23-12-19-26(36-23)22(9-10-28-19)35-21-8-7-17(11-18(21)27)31-25(34)13-24(33)30-16-5-3-2-4-6-16/h2-12,14-15H,13H2,1H3,(H,30,33)(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248047
(CHEMBL503524 | N-(3-fluoro-4-(2-(1-(2-(pyrrolidin-...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1cn(CCN2CCCC2)cn1 Show InChI InChI=1S/C32H30FN7O3S/c33-24-18-22(36-31(41)40-17-16-39(32(40)42)23-6-2-1-3-7-23)8-9-27(24)43-28-10-11-34-25-19-29(44-30(25)28)26-20-38(21-35-26)15-14-37-12-4-5-13-37/h1-3,6-11,18-21H,4-5,12-17H2,(H,36,41) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248601
(CHEMBL518209 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H22FN5O3S/c1-33-15-22(31-16-33)25-14-21-26(38-25)24(9-11-30-21)37-23-8-7-17(13-20(23)29)32-27(35)19-10-12-34(28(19)36)18-5-3-2-4-6-18/h2-9,11,13-16,19H,10,12H2,1H3,(H,32,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248051
(CHEMBL448276 | N-(3-fluoro-4-(2-(4-(piperazin-1-yl...)Show SMILES Fc1cc(NC(=O)N2CCN(C2=O)c2ccccc2)ccc1Oc1ccnc2cc(sc12)-c1ccc(CN2CCNCC2)cc1 Show InChI InChI=1S/C34H31FN6O3S/c35-27-20-25(38-33(42)41-19-18-40(34(41)43)26-4-2-1-3-5-26)10-11-29(27)44-30-12-13-37-28-21-31(45-32(28)30)24-8-6-23(7-9-24)22-39-16-14-36-15-17-39/h1-13,20-21,36H,14-19,22H2,(H,38,42) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50247960
(CHEMBL462023 | N-(3-fluoro-4-(2-(1-isopropyl-1H-im...)Show SMILES CC(C)n1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4CN(C(=O)C4)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C30H26FN5O3S/c1-18(2)35-16-24(33-17-35)27-14-23-29(40-27)26(10-11-32-23)39-25-9-8-20(13-22(25)31)34-30(38)19-12-28(37)36(15-19)21-6-4-3-5-7-21/h3-11,13-14,16-19H,12,15H2,1-2H3,(H,34,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248054
(CHEMBL508395 | N-(3-fluoro-4-(2-(4-((methyl(2-(4-m...)Show SMILES CN(CCN1CCN(C)CC1)Cc1ccc(cc1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C38H40FN7O3S/c1-42-16-19-44(20-17-42)21-18-43(2)26-27-8-10-28(11-9-27)35-25-32-36(50-35)34(14-15-40-32)49-33-13-12-29(24-31(33)39)41-37(47)46-23-22-45(38(46)48)30-6-4-3-5-7-30/h3-15,24-25H,16-23,26H2,1-2H3,(H,41,47) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50242737
((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 863 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of VEGFR2 (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248055
(CHEMBL448993 | N-(4-(2-(3-acetylphenyl)thieno[3,2-...)Show SMILES CC(=O)c1cccc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C31H23FN4O4S/c1-19(37)20-6-5-7-21(16-20)28-18-25-29(41-28)27(12-13-33-25)40-26-11-10-22(17-24(26)32)34-30(38)36-15-14-35(31(36)39)23-8-3-2-4-9-23/h2-13,16-18H,14-15H2,1H3,(H,34,38) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247961
(CHEMBL462231 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)C4(C)CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C29H24FN5O3S/c1-29(11-13-35(28(29)37)19-6-4-3-5-7-19)27(36)33-18-8-9-23(20(30)14-18)38-24-10-12-31-21-15-25(39-26(21)24)22-16-34(2)17-32-22/h3-10,12,14-17H,11,13H2,1-2H3,(H,33,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248600
(CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248600
(CHEMBL462667 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES CN(C(=O)C1(CC1)C(=O)Nc1ccc(Oc2ccnc3cc(sc23)-c2cn(C)cn2)c(F)c1)c1ccccc1 Show InChI InChI=1S/C29H24FN5O3S/c1-34-16-22(32-17-34)25-15-21-26(39-25)24(10-13-31-21)38-23-9-8-18(14-20(23)30)33-27(36)29(11-12-29)28(37)35(2)19-6-4-3-5-7-19/h3-10,13-17H,11-12H2,1-2H3,(H,33,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50248121
(CHEMBL464409 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=S)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)37)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assay |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248121
(CHEMBL464409 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=S)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)37)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused recombinant c-Met (unknown origin) catalytic domain expressed in baculovirus-infected Trichoplusia ni Hi5 cells after 30 mins... |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM4814
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met (unknown origin) |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248121
(CHEMBL464409 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=S)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O2S2/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)36-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)37)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of TPR-fused Met (unknown origin) phosphorylation expressed in human 293T cells by ELISA |
Bioorg Med Chem Lett 19: 1323-8 (2009)
Article DOI: 10.1016/j.bmcl.2009.01.068
BindingDB Entry DOI: 10.7270/Q23F4PHJ |
More data for this
Ligand-Target Pair | |
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