BindingDB logo
myBDB logout

PubMed code 19233646

Compile data set for download or QSAR
Found 7 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM50029593
PNG
(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1OC1CCCCC1)[N+]([O-])=O
Show InChI InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM50140257
PNG
(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)
Show SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1
Show InChI InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.07E+3n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50257785
PNG
(5,7-diacetylflavone | CHEMBL493969)
Show SMILES CC(=O)c1cc(C(C)=O)c2c(c1)oc(cc2=O)-c1ccccc1
Show InChI InChI=1S/C19H14O4/c1-11(20)14-8-15(12(2)21)19-16(22)10-17(23-18(19)9-14)13-6-4-3-5-7-13/h3-10H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.70E+3n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2 (unknown origin)

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM50257725
PNG
(2,3-dimethoxy-2'-hydroxychalcone | CHEMBL492959)
Show SMILES COc1cccc(\C=C\C(=O)c2ccccc2O)c1OC
Show InChI InChI=1S/C17H16O4/c1-20-16-9-5-6-12(17(16)21-2)10-11-15(19)13-7-3-4-8-14(13)18/h3-11,18H,1-2H3/b11-10+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.80E+3n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM50241204
PNG
((E)-3-(4-(benzyloxy)phenyl)-1-(2-hydroxyphenyl)pro...)
Show SMILES Oc1ccccc1C(=O)\C=C\c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H18O3/c23-21-9-5-4-8-20(21)22(24)15-12-17-10-13-19(14-11-17)25-16-18-6-2-1-3-7-18/h1-15,23H,16H2/b15-12+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.10E+3n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM50257724
PNG
(3,4-dibenzyloxy-2'-hydroxychalcone | CHEMBL492554)
Show SMILES Oc1ccccc1C(=O)\C=C\c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1
Show InChI InChI=1S/C29H24O4/c30-26-14-8-7-13-25(26)27(31)17-15-22-16-18-28(32-20-23-9-3-1-4-10-23)29(19-22)33-21-24-11-5-2-6-12-24/h1-19,30H,20-21H2/b17-15+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 4.60E+3n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair
Prostaglandin G/H synthase 2


(Mus musculus (Mouse))		BDBM50257726
PNG
(2'-hydroxy-3,4,5-trimethoxychalcone | CHEMBL521653)
Show SMILES COc1cc(\C=C\C(=O)c2ccccc2O)cc(OC)c1OC
Show InChI InChI=1S/C18H18O5/c1-21-16-10-12(11-17(22-2)18(16)23-3)8-9-15(20)13-6-4-5-7-14(13)19/h4-11,19H,1-3H3/b9-8+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 6.20E+3n/an/an/an/an/an/a



University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL


Assay Description
Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassay

Bioorg Med Chem Lett 19: 1650-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.001
BindingDB Entry DOI: 10.7270/Q28052HJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%