Found 41 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293525
(5-methyl-2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)...)Show InChI InChI=1S/C18H15N5S/c1-11-10-24-18-15(11)17(21-13-6-8-19-9-7-13)22-16(23-18)14-5-3-4-12(2)20-14/h3-10H,1-2H3,(H,19,21,22,23) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293515
(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)Show InChI InChI=1S/C17H13N5S/c1-11-10-23-17(19-11)16-21-14-5-3-2-4-13(14)15(22-16)20-12-6-8-18-9-7-12/h2-10H,1H3,(H,18,20,21,22) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293526
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)thieno[3,...)Show InChI InChI=1S/C17H13N5S/c1-11-3-2-4-14(19-11)16-21-13-7-10-23-15(13)17(22-16)20-12-5-8-18-9-6-12/h2-10H,1H3,(H,18,20,21,22) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293527
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinolin-...)Show InChI InChI=1S/C20H16N4/c1-14-5-4-8-18(22-14)20-13-19(23-15-9-11-21-12-10-15)16-6-2-3-7-17(16)24-20/h2-13H,1H3,(H,21,23,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293516
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazoli...)Show InChI InChI=1S/C19H15N5/c1-13-5-4-8-17(21-13)19-23-16-7-3-2-6-15(16)18(24-19)22-14-9-11-20-12-10-14/h2-12H,1H3,(H,20,22,23,24) | PDB
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MMDB
PC cid
PC sid
PDB
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Similars
| PDB
Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293520
(CHEMBL537968 | N-(1H-indazol-5-yl)-2-(6-methylpyri...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 Show InChI InChI=1S/C21H16N6/c1-13-5-4-8-19(23-13)21-25-18-7-3-2-6-16(18)20(26-21)24-15-9-10-17-14(11-15)12-22-27-17/h2-12H,1H3,(H,22,27)(H,24,25,26) | PDB
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PC cid
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| PDB
Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293519
(2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazo...)Show InChI InChI=1S/C18H14N6/c1-12-5-4-8-15(21-12)18-22-14-7-3-2-6-13(14)17(24-18)23-16-9-10-19-11-20-16/h2-11H,1H3,(H,19,20,22,23,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293514
(2-(3-chlorophenyl)-N-(pyridin-4-yl)quinazolin-4-am...)Show InChI InChI=1S/C19H13ClN4/c20-14-5-3-4-13(12-14)18-23-17-7-2-1-6-16(17)19(24-18)22-15-8-10-21-11-9-15/h1-12H,(H,21,22,23,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293527
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinolin-...)Show InChI InChI=1S/C20H16N4/c1-14-5-4-8-18(22-14)20-13-19(23-15-9-11-21-12-10-15)16-6-2-3-7-17(16)24-20/h2-13H,1H3,(H,21,23,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293526
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)thieno[3,...)Show InChI InChI=1S/C17H13N5S/c1-11-3-2-4-14(19-11)16-21-13-7-10-23-15(13)17(22-16)20-12-5-8-18-9-6-12/h2-10H,1H3,(H,18,20,21,22) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293519
(2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazo...)Show InChI InChI=1S/C18H14N6/c1-12-5-4-8-15(21-12)18-22-14-7-3-2-6-13(14)17(24-18)23-16-9-10-19-11-20-16/h2-11H,1H3,(H,19,20,22,23,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293520
(CHEMBL537968 | N-(1H-indazol-5-yl)-2-(6-methylpyri...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 Show InChI InChI=1S/C21H16N6/c1-13-5-4-8-19(23-13)21-25-18-7-3-2-6-16(18)20(26-21)24-15-9-10-17-14(11-15)12-22-27-17/h2-12H,1H3,(H,22,27)(H,24,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293524
(6-methyl-2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)...)Show InChI InChI=1S/C16H15N5/c1-11-4-3-5-14(18-11)16-19-12(2)10-15(21-16)20-13-6-8-17-9-7-13/h3-10H,1-2H3,(H,17,19,20,21) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293516
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazoli...)Show InChI InChI=1S/C19H15N5/c1-13-5-4-8-17(21-13)19-23-16-7-3-2-6-15(16)18(24-19)22-14-9-11-20-12-10-14/h2-12H,1H3,(H,20,22,23,24) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
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| Purchase
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
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Similars
| PDB
Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293513
(2-phenyl-N-(pyridin-4-yl)quinazolin-4-amine | CHEM...)Show InChI InChI=1S/C19H14N4/c1-2-6-14(7-3-1)18-22-17-9-5-4-8-16(17)19(23-18)21-15-10-12-20-13-11-15/h1-13H,(H,20,21,22,23) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
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CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 194 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293517
(2-(6-methylpyridin-2-yl)-N-(2-methylpyridin-4-yl)q...)Show InChI InChI=1S/C20H17N5/c1-13-6-5-9-18(22-13)20-24-17-8-4-3-7-16(17)19(25-20)23-15-10-11-21-14(2)12-15/h3-12H,1-2H3,(H,21,23,24,25) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293518
(3-(2-(6-methylpyridin-2-yl)quinazolin-4-ylamino)be...)Show SMILES Cc1cccc(n1)-c1nc(Nc2cccc(c2)C(N)=O)c2ccccc2n1 Show InChI InChI=1S/C21H17N5O/c1-13-6-4-11-18(23-13)21-25-17-10-3-2-9-16(17)20(26-21)24-15-8-5-7-14(12-15)19(22)27/h2-12H,1H3,(H2,22,27)(H,24,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 263 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293525
(5-methyl-2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)...)Show InChI InChI=1S/C18H15N5S/c1-11-10-24-18-15(11)17(21-13-6-8-19-9-7-13)22-16(23-18)14-5-3-4-12(2)20-14/h3-10H,1-2H3,(H,19,21,22,23) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 318 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293515
(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)Show InChI InChI=1S/C17H13N5S/c1-11-10-23-17(19-11)16-21-14-5-3-2-4-13(14)15(22-16)20-12-6-8-18-9-7-12/h2-10H,1H3,(H,18,20,21,22) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 342 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293518
(3-(2-(6-methylpyridin-2-yl)quinazolin-4-ylamino)be...)Show SMILES Cc1cccc(n1)-c1nc(Nc2cccc(c2)C(N)=O)c2ccccc2n1 Show InChI InChI=1S/C21H17N5O/c1-13-6-4-11-18(23-13)21-25-17-10-3-2-9-16(17)20(26-21)24-15-8-5-7-14(12-15)19(22)27/h2-12H,1H3,(H2,22,27)(H,24,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 545 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293521
(CHEMBL550482 | N-(1-methyl-1H-indazol-5-yl)-2-(6-m...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3n(C)ncc3c2)c2ccccc2n1 Show InChI InChI=1S/C22H18N6/c1-14-6-5-9-19(24-14)22-26-18-8-4-3-7-17(18)21(27-22)25-16-10-11-20-15(12-16)13-23-28(20)2/h3-13H,1-2H3,(H,25,26,27) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 588 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293522
(CHEMBL550483 | N-(2-(6-methylpyridin-2-yl)quinazol...)Show InChI InChI=1S/C21H15N5S/c1-13-5-4-8-18(23-13)21-25-16-7-3-2-6-15(16)20(26-21)24-14-9-10-17-19(11-14)27-12-22-17/h2-12H,1H3,(H,24,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 646 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293524
(6-methyl-2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)...)Show InChI InChI=1S/C16H15N5/c1-11-4-3-5-14(18-11)16-19-12(2)10-15(21-16)20-13-6-8-17-9-7-13/h3-10H,1-2H3,(H,17,19,20,21) | PDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 745 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293521
(CHEMBL550482 | N-(1-methyl-1H-indazol-5-yl)-2-(6-m...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3n(C)ncc3c2)c2ccccc2n1 Show InChI InChI=1S/C22H18N6/c1-14-6-5-9-19(24-14)22-26-18-8-4-3-7-17(18)21(27-22)25-16-10-11-20-15(12-16)13-23-28(20)2/h3-13H,1-2H3,(H,25,26,27) | PDB
MMDB
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B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293517
(2-(6-methylpyridin-2-yl)-N-(2-methylpyridin-4-yl)q...)Show InChI InChI=1S/C20H17N5/c1-13-6-5-9-18(22-13)20-24-17-8-4-3-7-16(17)19(25-20)23-15-10-11-21-14(2)12-15/h3-12H,1-2H3,(H,21,23,24,25) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293513
(2-phenyl-N-(pyridin-4-yl)quinazolin-4-amine | CHEM...)Show InChI InChI=1S/C19H14N4/c1-2-6-14(7-3-1)18-22-17-9-5-4-8-16(17)19(23-18)21-15-10-12-20-13-11-15/h1-13H,(H,20,21,22,23) | PDB
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293514
(2-(3-chlorophenyl)-N-(pyridin-4-yl)quinazolin-4-am...)Show InChI InChI=1S/C19H13ClN4/c20-14-5-3-4-13(12-14)18-23-17-7-2-1-6-16(17)19(24-18)22-15-8-10-21-11-9-15/h1-12H,(H,21,22,23,24) | PDB
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B.MOAD
antibodypedia
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293513
(2-phenyl-N-(pyridin-4-yl)quinazolin-4-amine | CHEM...)Show InChI InChI=1S/C19H14N4/c1-2-6-14(7-3-1)18-22-17-9-5-4-8-16(17)19(23-18)21-15-10-12-20-13-11-15/h1-13H,(H,20,21,22,23) | PDB
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PC sid
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| Article
PubMed
| n/a | n/a | 2.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293523
(CHEMBL563207 | N-(1H-benzo[d][1,2,3]triazol-6-yl)-...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3nn[nH]c3c2)c2ccccc2n1 Show InChI InChI=1S/C20H15N7/c1-12-5-4-8-17(21-12)20-23-15-7-3-2-6-14(15)19(24-20)22-13-9-10-16-18(11-13)26-27-25-16/h2-11H,1H3,(H,22,23,24)(H,25,26,27) | PDB
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B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of human ALK5 kinase expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293523
(CHEMBL563207 | N-(1H-benzo[d][1,2,3]triazol-6-yl)-...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3nn[nH]c3c2)c2ccccc2n1 Show InChI InChI=1S/C20H15N7/c1-12-5-4-8-17(21-12)20-23-15-7-3-2-6-14(15)19(24-20)22-13-9-10-16-18(11-13)26-27-25-16/h2-11H,1H3,(H,22,23,24)(H,25,26,27) | PDB
MMDB
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antibodypedia
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293522
(CHEMBL550483 | N-(2-(6-methylpyridin-2-yl)quinazol...)Show InChI InChI=1S/C21H15N5S/c1-13-5-4-8-18(23-13)21-25-16-7-3-2-6-15(16)20(26-21)24-14-9-10-17-19(11-14)27-12-22-17/h2-12H,1H3,(H,24,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of TGFbeta-induced ALK5 in human HepG2 cells by luciferase assay |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293516
(2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazoli...)Show InChI InChI=1S/C19H15N5/c1-13-5-4-8-17(21-13)19-23-16-7-3-2-6-15(16)18(24-19)22-14-9-11-20-12-10-14/h2-12H,1H3,(H,20,22,23,24) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 6.72E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293521
(CHEMBL550482 | N-(1-methyl-1H-indazol-5-yl)-2-(6-m...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3n(C)ncc3c2)c2ccccc2n1 Show InChI InChI=1S/C22H18N6/c1-14-6-5-9-19(24-14)22-26-18-8-4-3-7-17(18)21(27-22)25-16-10-11-20-15(12-16)13-23-28(20)2/h3-13H,1-2H3,(H,25,26,27) | PDB
MMDB
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B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293523
(CHEMBL563207 | N-(1H-benzo[d][1,2,3]triazol-6-yl)-...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3nn[nH]c3c2)c2ccccc2n1 Show InChI InChI=1S/C20H15N7/c1-12-5-4-8-17(21-12)20-23-15-7-3-2-6-14(15)19(24-20)22-13-9-10-16-18(11-13)26-27-25-16/h2-11H,1H3,(H,22,23,24)(H,25,26,27) | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293520
(CHEMBL537968 | N-(1H-indazol-5-yl)-2-(6-methylpyri...)Show SMILES Cc1cccc(n1)-c1nc(Nc2ccc3[nH]ncc3c2)c2ccccc2n1 Show InChI InChI=1S/C21H16N6/c1-13-5-4-8-19(23-13)21-25-18-7-3-2-6-16(18)20(26-21)24-15-9-10-17-14(11-15)12-22-27-17/h2-12H,1H3,(H,22,27)(H,24,25,26) | PDB
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| PDB
Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293518
(3-(2-(6-methylpyridin-2-yl)quinazolin-4-ylamino)be...)Show SMILES Cc1cccc(n1)-c1nc(Nc2cccc(c2)C(N)=O)c2ccccc2n1 Show InChI InChI=1S/C21H17N5O/c1-13-6-4-11-18(23-13)21-25-17-10-3-2-9-16(17)20(26-21)24-15-8-5-7-14(12-15)19(22)27/h2-12H,1H3,(H2,22,27)(H,24,25,26) | PDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293517
(2-(6-methylpyridin-2-yl)-N-(2-methylpyridin-4-yl)q...)Show InChI InChI=1S/C20H17N5/c1-13-6-5-9-18(22-13)20-24-17-8-4-3-7-16(17)19(25-20)23-15-10-11-21-14(2)12-15/h3-12H,1-2H3,(H,21,23,24,25) | PDB
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antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293522
(CHEMBL550483 | N-(2-(6-methylpyridin-2-yl)quinazol...)Show InChI InChI=1S/C21H15N5S/c1-13-5-4-8-18(23-13)21-25-16-7-3-2-6-15(16)20(26-21)24-14-9-10-17-19(11-14)27-12-22-17/h2-12H,1H3,(H,24,25,26) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293519
(2-(6-methylpyridin-2-yl)-N-(pyrimidin-4-yl)quinazo...)Show InChI InChI=1S/C18H14N6/c1-12-5-4-8-15(21-12)18-22-14-7-3-2-6-13(14)17(24-18)23-16-9-10-19-11-20-16/h2-11H,1H3,(H,19,20,22,23,24) | PDB
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B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293514
(2-(3-chlorophenyl)-N-(pyridin-4-yl)quinazolin-4-am...)Show InChI InChI=1S/C19H13ClN4/c20-14-5-3-4-13(12-14)18-23-17-7-2-1-6-16(17)19(24-18)22-15-8-10-21-11-9-15/h1-12H,(H,21,22,23,24) | PDB
MMDB
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B.MOAD
antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
TGF-beta receptor type-1
(Homo sapiens (Human)) | BDBM50293515
(2-(4-methylthiazol-2-yl)-N-(pyridin-4-yl)quinazoli...)Show InChI InChI=1S/C17H13N5S/c1-11-10-23-17(19-11)16-21-14-5-3-2-4-13(14)15(22-16)20-12-6-8-18-9-7-12/h2-10H,1H3,(H,18,20,21,22) | PDB
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B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Inhibition of GST-fused p38alpha |
Bioorg Med Chem Lett 19: 2277-81 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.087
BindingDB Entry DOI: 10.7270/Q2K07497 |
More data for this
Ligand-Target Pair | |
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