Found 23 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278651
(CHEMBL470219 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES Fc1ccc(Nc2ncnc3nc(Nc4ccc(CN5CCCC5)cc4)sc23)cc1Cl Show InChI InChI=1S/C22H20ClFN6S/c23-17-11-16(7-8-18(17)24)27-20-19-21(26-13-25-20)29-22(31-19)28-15-5-3-14(4-6-15)12-30-9-1-2-10-30/h3-8,11,13H,1-2,9-10,12H2,(H2,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278702
(CHEMBL471058 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES CCc1nccn1Cc1ccc(Nc2nc3ncnc(Nc4ccc(F)c(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C23H19ClFN7S/c1-2-19-26-9-10-32(19)12-14-3-5-15(6-4-14)30-23-31-22-20(33-23)21(27-13-28-22)29-16-7-8-18(25)17(24)11-16/h3-11,13H,2,12H2,1H3,(H2,27,28,29,30,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278535
(4-(7-(3-chlorophenylamino)thiazolo[4,5-d]pyrimidin...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4cccc(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C17H13ClN6O2S2/c18-10-2-1-3-12(8-10)22-15-14-16(21-9-20-15)24-17(27-14)23-11-4-6-13(7-5-11)28(19,25)26/h1-9H,(H2,19,25,26)(H2,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278537
(4-(7-(3-chloro-4-fluorophenylamino)thiazolo[4,5-d]...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4ccc(F)c(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C17H12ClFN6O2S2/c18-12-7-10(3-6-13(12)19)23-15-14-16(22-8-21-15)25-17(28-14)24-9-1-4-11(5-2-9)29(20,26)27/h1-8H,(H2,20,26,27)(H2,21,22,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278704
(CHEMBL503418 | N7-(3-chloro-4-(3-fluorobenzyloxy)p...)Show SMILES CN1CCN(Cc2ccc(Nc3nc4ncnc(Nc5ccc(OCc6cccc(F)c6)c(Cl)c5)c4s3)cc2)CC1 Show InChI InChI=1S/C30H29ClFN7OS/c1-38-11-13-39(14-12-38)17-20-5-7-23(8-6-20)36-30-37-29-27(41-30)28(33-19-34-29)35-24-9-10-26(25(31)16-24)40-18-21-3-2-4-22(32)15-21/h2-10,15-16,19H,11-14,17-18H2,1H3,(H2,33,34,35,36,37) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278536
(4-(7-(3-bromophenylamino)thiazolo[4,5-d]pyrimidin-...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4cccc(Br)c4)c3s2)cc1 Show InChI InChI=1S/C17H13BrN6O2S2/c18-10-2-1-3-12(8-10)22-15-14-16(21-9-20-15)24-17(27-14)23-11-4-6-13(7-5-11)28(19,25)26/h1-9H,(H2,19,25,26)(H2,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278609
(CHEMBL470011 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES Fc1ccc(Nc2ncnc3nc(Nc4ccc(CN5CCCCC5)cc4)sc23)cc1Cl Show InChI InChI=1S/C23H22ClFN6S/c24-18-12-17(8-9-19(18)25)28-21-20-22(27-14-26-21)30-23(32-20)29-16-6-4-15(5-7-16)13-31-10-2-1-3-11-31/h4-9,12,14H,1-3,10-11,13H2,(H2,26,27,28,29,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278701
((S)-(1-(4-(7-(3-chloro-4-fluorophenylamino)thiazol...)Show SMILES OC[C@@H]1CCCN1Cc1ccc(Nc2nc3ncnc(Nc4ccc(F)c(Cl)c4)c3s2)cc1 |r| Show InChI InChI=1S/C23H22ClFN6OS/c24-18-10-16(7-8-19(18)25)28-21-20-22(27-13-26-21)30-23(33-20)29-15-5-3-14(4-6-15)11-31-9-1-2-17(31)12-32/h3-8,10,13,17,32H,1-2,9,11-12H2,(H2,26,27,28,29,30)/t17-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278649
(CHEMBL513208 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES CN(C)Cc1ccc(Nc2nc3ncnc(Nc4ccc(F)c(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C20H18ClFN6S/c1-28(2)10-12-3-5-13(6-4-12)26-20-27-19-17(29-20)18(23-11-24-19)25-14-7-8-16(22)15(21)9-14/h3-9,11H,10H2,1-2H3,(H2,23,24,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278652
(CHEMBL511637 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES Fc1ccc(Nc2ncnc3nc(Nc4ccc(CN5CCOCC5)cc4)sc23)cc1Cl Show InChI InChI=1S/C22H20ClFN6OS/c23-17-11-16(5-6-18(17)24)27-20-19-21(26-13-25-20)29-22(32-19)28-15-3-1-14(2-4-15)12-30-7-9-31-10-8-30/h1-6,11,13H,7-10,12H2,(H2,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278650
(CHEMBL470218 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES CN(C)CCc1ccc(Nc2nc3ncnc(Nc4ccc(F)c(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C21H20ClFN6S/c1-29(2)10-9-13-3-5-14(6-4-13)27-21-28-20-18(30-21)19(24-12-25-20)26-15-7-8-17(23)16(22)11-15/h3-8,11-12H,9-10H2,1-2H3,(H2,24,25,26,27,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278538
(4-(7-(m-tolylamino)thiazolo[4,5-d]pyrimidin-2-ylam...)Show SMILES Cc1cccc(Nc2ncnc3nc(Nc4ccc(cc4)S(N)(=O)=O)sc23)c1 Show InChI InChI=1S/C18H16N6O2S2/c1-11-3-2-4-13(9-11)22-16-15-17(21-10-20-16)24-18(27-15)23-12-5-7-14(8-6-12)28(19,25)26/h2-10H,1H3,(H2,19,25,26)(H2,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278610
(CHEMBL470012 | N7-(3-chloro-4-fluorophenyl)-N2-(4-...)Show SMILES Fc1ccc(Nc2ncnc3nc(Nc4ccc(CCN5CCOCC5)cc4)sc23)cc1Cl Show InChI InChI=1S/C23H22ClFN6OS/c24-18-13-17(5-6-19(18)25)28-21-20-22(27-14-26-21)30-23(33-20)29-16-3-1-15(2-4-16)7-8-31-9-11-32-12-10-31/h1-6,13-14H,7-12H2,(H2,26,27,28,29,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278607
(4-(7-(3-chloro-4-fluorophenylamino)thiazolo[4,5-d]...)Show SMILES COCCN(CCOC)S(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4ccc(F)c(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C23H24ClFN6O4S2/c1-34-11-9-31(10-12-35-2)37(32,33)17-6-3-15(4-7-17)29-23-30-22-20(36-23)21(26-14-27-22)28-16-5-8-19(25)18(24)13-16/h3-8,13-14H,9-12H2,1-2H3,(H2,26,27,28,29,30) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278573
(CHEMBL470003 | N7-(3-chlorophenyl)-N2-phenylthiazo...)Show InChI InChI=1S/C17H12ClN5S/c18-11-5-4-8-13(9-11)21-15-14-16(20-10-19-15)23-17(24-14)22-12-6-2-1-3-7-12/h1-10H,(H2,19,20,21,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278703
(CHEMBL470391 | N7-(3-ethynylphenyl)-N2-(4-(morphol...)Show SMILES C#Cc1cccc(Nc2ncnc3nc(Nc4ccc(CN5CCOCC5)cc4)sc23)c1 Show InChI InChI=1S/C24H22N6OS/c1-2-17-4-3-5-20(14-17)27-22-21-23(26-16-25-22)29-24(32-21)28-19-8-6-18(7-9-19)15-30-10-12-31-13-11-30/h1,3-9,14,16H,10-13,15H2,(H2,25,26,27,28,29) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278571
(CHEMBL469997 | N7-(3-chloro-4-fluorophenyl)-N2-phe...)Show InChI InChI=1S/C17H11ClFN5S/c18-12-8-11(6-7-13(12)19)22-15-14-16(21-9-20-15)24-17(25-14)23-10-4-2-1-3-5-10/h1-9H,(H2,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278500
(4-(7-(phenylamino)thiazolo[4,5-d]pyrimidin-2-ylami...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4ccccc4)c3s2)cc1 Show InChI InChI=1S/C17H14N6O2S2/c18-27(24,25)13-8-6-12(7-9-13)22-17-23-16-14(26-17)15(19-10-20-16)21-11-4-2-1-3-5-11/h1-10H,(H2,18,24,25)(H2,19,20,21,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278499
(4-(7-(2,6-difluorophenylamino)thiazolo[4,5-d]pyrim...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4c(F)cccc4F)c3s2)cc1 Show InChI InChI=1S/C17H12F2N6O2S2/c18-11-2-1-3-12(19)13(11)24-15-14-16(22-8-21-15)25-17(28-14)23-9-4-6-10(7-5-9)29(20,26)27/h1-8H,(H2,20,26,27)(H2,21,22,23,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 187 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278608
(CHEMBL511623 | N7-(3-chloro-4-fluorophenyl)-N2-(2-...)Show InChI InChI=1S/C17H18ClFN6OS/c18-12-9-11(1-2-13(12)19)23-15-14-16(22-10-21-15)24-17(27-14)20-3-4-25-5-7-26-8-6-25/h1-2,9-10H,3-8H2,(H2,20,21,22,23,24) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 918 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278570
(4-(7-(3-chloro-4-morpholinophenylamino)thiazolo[4,...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4ccc(N5CCOCC5)c(Cl)c4)c3s2)cc1 Show InChI InChI=1S/C21H20ClN7O3S2/c22-16-11-14(3-6-17(16)29-7-9-32-10-8-29)26-19-18-20(25-12-24-19)28-21(33-18)27-13-1-4-15(5-2-13)34(23,30)31/h1-6,11-12H,7-10H2,(H2,23,30,31)(H2,24,25,26,27,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50278572
(4-(7-(4-morpholinophenylamino)thiazolo[4,5-d]pyrim...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4ccc(cc4)N4CCOCC4)c3s2)cc1 Show InChI InChI=1S/C21H21N7O3S2/c22-33(29,30)17-7-3-15(4-8-17)26-21-27-20-18(32-21)19(23-13-24-20)25-14-1-5-16(6-2-14)28-9-11-31-12-10-28/h1-8,13H,9-12H2,(H2,22,29,30)(H2,23,24,25,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.79E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of EGFR (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50278499
(4-(7-(2,6-difluorophenylamino)thiazolo[4,5-d]pyrim...)Show SMILES NS(=O)(=O)c1ccc(Nc2nc3ncnc(Nc4c(F)cccc4F)c3s2)cc1 Show InChI InChI=1S/C17H12F2N6O2S2/c18-11-2-1-3-12(19)13(11)24-15-14-16(22-8-21-15)25-17(28-14)23-9-4-6-10(7-5-9)29(20,26)27/h1-8H,(H2,20,26,27)(H2,21,22,23,24,25) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development LLC
Curated by ChEMBL
| Assay Description Inhibition of CDK1 (unknown origin) |
Bioorg Med Chem Lett 19: 2333-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3 |
More data for this Ligand-Target Pair | |