Found 30 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142158
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-i...)Show SMILES NC1=NCCN1Cc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1C(=O)Nc1ccc(Cl)cn1 |t:1| Show InChI InChI=1S/C23H20Cl2N6O2/c24-16-5-7-19(18(11-16)22(33)30-20-8-6-17(25)12-28-20)29-21(32)15-3-1-14(2-4-15)13-31-10-9-27-23(31)26/h1-8,11-12H,9-10,13H2,(H2,26,27)(H,29,32)(H,28,30,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50249295
(CHEMBL471725 | N-(5-chloropyridin-2-yl)-2-(4-(N,N-...)Show SMILES CN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20ClN5O2/c1-28(2)20(24)14-7-9-15(10-8-14)21(29)26-18-6-4-3-5-17(18)22(30)27-19-12-11-16(23)13-25-19/h3-13,24H,1-2H3,(H,26,29)(H,25,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278121
(CHEMBL511643 | N-(5-chloropyridin-2-yl)-2-(4-(imin...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCCCC2)nc1 Show InChI InChI=1S/C25H24ClN5O2/c26-19-12-13-22(28-16-19)30-25(33)20-6-2-3-7-21(20)29-24(32)18-10-8-17(9-11-18)23(27)31-14-4-1-5-15-31/h2-3,6-13,16,27H,1,4-5,14-15H2,(H,29,32)(H,28,30,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278729
(2-(4-carbamimidoylbenzamido)-N-(5-chloropyridin-2-...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C20H16ClN5O2/c21-14-9-10-17(24-11-14)26-20(28)15-3-1-2-4-16(15)25-19(27)13-7-5-12(6-8-13)18(22)23/h1-11H,(H3,22,23)(H,25,27)(H,24,26,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142163
(5-Chloro-N-(5-chloro-pyridin-2-yl)-2-[4-(2-imino-o...)Show SMILES Clc1ccc(NC(=O)c2cc(Cl)ccc2NC(=O)c2ccc(CN3CCOC3=N)cc2)nc1 Show InChI InChI=1S/C23H19Cl2N5O3/c24-16-5-7-19(18(11-16)22(32)29-20-8-6-17(25)12-27-20)28-21(31)15-3-1-14(2-4-15)13-30-9-10-33-23(30)26/h1-8,11-12,26H,9-10,13H2,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278806
(CHEMBL496895 | N-(5-chloropyridin-2-yl)-2-(4-(N-et...)Show SMILES CCN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C23H22ClN5O2/c1-3-29(2)21(25)15-8-10-16(11-9-15)22(30)27-19-7-5-4-6-18(19)23(31)28-20-13-12-17(24)14-26-20/h4-14,25H,3H2,1-2H3,(H,27,30)(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50142093
(2'-Sulfamoyl-biphenyl-4-carboxylic acid [2-(5-chlo...)Show SMILES NS(=O)(=O)c1ccccc1-c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C25H19ClN4O4S/c26-18-13-14-23(28-15-18)30-25(32)20-6-1-3-7-21(20)29-24(31)17-11-9-16(10-12-17)19-5-2-4-8-22(19)35(27,33)34/h1-15H,(H,29,31)(H2,27,33,34)(H,28,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278122
(CHEMBL471039 | N-(5-chloropyridin-2-yl)-2-(4-(imin...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCOCC2)nc1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-9-10-21(27-15-18)29-24(32)19-3-1-2-4-20(19)28-23(31)17-7-5-16(6-8-17)22(26)30-11-13-33-14-12-30/h1-10,15,26H,11-14H2,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278861
(CHEMBL497077 | N-(5-chloropyridin-2-yl)-2-(4-(imin...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCCC2)nc1 Show InChI InChI=1S/C24H22ClN5O2/c25-18-11-12-21(27-15-18)29-24(32)19-5-1-2-6-20(19)28-23(31)17-9-7-16(8-10-17)22(26)30-13-3-4-14-30/h1-2,5-12,15,26H,3-4,13-14H2,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278860
(2-(4-(azetidin-1-yl(imino)methyl)benzamido)-N-(5-c...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCC2)nc1 Show InChI InChI=1S/C23H20ClN5O2/c24-17-10-11-20(26-14-17)28-23(31)18-4-1-2-5-19(18)27-22(30)16-8-6-15(7-9-16)21(25)29-12-3-13-29/h1-2,4-11,14,25H,3,12-13H2,(H,27,30)(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278858
(CHEMBL522407 | N-(5-chloropyridin-2-yl)-2-(4-(N-me...)Show SMILES CCCN(C)C(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24ClN5O2/c1-3-14-30(2)22(26)16-8-10-17(11-9-16)23(31)28-20-7-5-4-6-19(20)24(32)29-21-13-12-18(25)15-27-21/h4-13,15,26H,3,14H2,1-2H3,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278859
(CHEMBL497247 | N-(5-chloropyridin-2-yl)-2-(4-(N,N-...)Show SMILES CCN(CC)C(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C24H24ClN5O2/c1-3-30(4-2)22(26)16-9-11-17(12-10-16)23(31)28-20-8-6-5-7-19(20)24(32)29-21-14-13-18(25)15-27-21/h5-15,26H,3-4H2,1-2H3,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278123
(CHEMBL471040 | N-(5-chloropyridin-2-yl)-2-(4-(imin...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCSCC2)nc1 Show InChI InChI=1S/C24H22ClN5O2S/c25-18-9-10-21(27-15-18)29-24(32)19-3-1-2-4-20(19)28-23(31)17-7-5-16(6-8-17)22(26)30-11-13-33-14-12-30/h1-10,15,26H,11-14H2,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278240
(CHEMBL471457 | N-(5-chloropyridin-2-yl)-2-(4-(1-me...)Show SMILES CN1CCN=C1c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 |c:4| Show InChI InChI=1S/C23H20ClN5O2/c1-29-13-12-25-21(29)15-6-8-16(9-7-15)22(30)27-19-5-3-2-4-18(19)23(31)28-20-11-10-17(24)14-26-20/h2-11,14H,12-13H2,1H3,(H,27,30)(H,26,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278804
(CHEMBL523081 | N-(5-chloropyridin-2-yl)-2-(4-(N-me...)Show SMILES CNC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18ClN5O2/c1-24-19(23)13-6-8-14(9-7-13)20(28)26-17-5-3-2-4-16(17)21(29)27-18-11-10-15(22)12-25-18/h2-12H,1H3,(H2,23,24)(H,26,28)(H,25,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278732
(CHEMBL470397 | N-(5-chloropyridin-2-yl)-2-(4-(hydr...)Show SMILES NNC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C20H17ClN6O2/c21-14-9-10-17(24-11-14)26-20(29)15-3-1-2-4-16(15)25-19(28)13-7-5-12(6-8-13)18(22)27-23/h1-11H,23H2,(H2,22,27)(H,25,28)(H,24,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278733
(CHEMBL470398 | N-(5-chloropyridin-2-yl)-2-(4-((2,2...)Show SMILES CN(C)NC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H21ClN6O2/c1-29(2)28-20(24)14-7-9-15(10-8-14)21(30)26-18-6-4-3-5-17(18)22(31)27-19-12-11-16(23)13-25-19/h3-13H,1-2H3,(H2,24,28)(H,26,30)(H,25,27,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278730
(CHEMBL511804 | N-(5-chloropyridin-2-yl)-2-(4-(N-hy...)Show SMILES ONC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C20H16ClN5O3/c21-14-9-10-17(23-11-14)25-20(28)15-3-1-2-4-16(15)24-19(27)13-7-5-12(6-8-13)18(22)26-29/h1-11,29H,(H2,22,26)(H,24,27)(H,23,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278159
(CHEMBL511277 | N-(5-chloropyridin-2-yl)-2-(4-(imin...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCNCC2)nc1 Show InChI InChI=1S/C24H23ClN6O2/c25-18-9-10-21(28-15-18)30-24(33)19-3-1-2-4-20(19)29-23(32)17-7-5-16(6-8-17)22(26)31-13-11-27-12-14-31/h1-10,15,26-27H,11-14H2,(H,29,32)(H,28,30,33) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278241
(CHEMBL471458 | N-(5-chloropyridin-2-yl)-2-(4-(1-et...)Show SMILES CCN1CCN=C1c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 |c:5| Show InChI InChI=1S/C24H22ClN5O2/c1-2-30-14-13-26-22(30)16-7-9-17(10-8-16)23(31)28-20-6-4-3-5-19(20)24(32)29-21-12-11-18(25)15-27-21/h3-12,15H,2,13-14H2,1H3,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278298
(CHEMBL471874 | N-(5-chloropyridin-2-yl)-2-(4-(1-me...)Show SMILES CN1CCCN=C1c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 |c:5| Show InChI InChI=1S/C24H22ClN5O2/c1-30-14-4-13-26-22(30)16-7-9-17(10-8-16)23(31)28-20-6-3-2-5-19(20)24(32)29-21-12-11-18(25)15-27-21/h2-3,5-12,15H,4,13-14H2,1H3,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278805
(CHEMBL497916 | N-(5-chloropyridin-2-yl)-2-(4-(N-et...)Show SMILES CCNC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C22H20ClN5O2/c1-2-25-20(24)14-7-9-15(10-8-14)21(29)27-18-6-4-3-5-17(18)22(30)28-19-12-11-16(23)13-26-19/h3-13H,2H2,1H3,(H2,24,25)(H,27,29)(H,26,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278297
(CHEMBL471670 | N-(5-chloropyridin-2-yl)-2-(4-(1,4,...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C2=NCCCN2)nc1 |t:25| Show InChI InChI=1S/C23H20ClN5O2/c24-17-10-11-20(27-14-17)29-23(31)18-4-1-2-5-19(18)28-22(30)16-8-6-15(7-9-16)21-25-12-3-13-26-21/h1-2,4-11,14H,3,12-13H2,(H,25,26)(H,28,30)(H,27,29,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278124
(CHEMBL470406 | N-{2-[(5-chloropyridin-2-yl)carbamo...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C(=N)N2CCS(=O)(=O)CC2)nc1 Show InChI InChI=1S/C24H22ClN5O4S/c25-18-9-10-21(27-15-18)29-24(32)19-3-1-2-4-20(19)28-23(31)17-7-5-16(6-8-17)22(26)30-11-13-35(33,34)14-12-30/h1-10,15,26H,11-14H2,(H,28,31)(H,27,29,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 256 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278731
(CHEMBL470186 | N-(5-chloropyridin-2-yl)-2-(4-(N-me...)Show SMILES CONC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C21H18ClN5O3/c1-30-27-19(23)13-6-8-14(9-7-13)20(28)25-17-5-3-2-4-16(17)21(29)26-18-11-10-15(22)12-24-18/h2-12H,1H3,(H2,23,27)(H,25,28)(H,24,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278239
(CHEMBL512884 | N-(5-chloropyridin-2-yl)-2-(4-(4,5-...)Show SMILES Clc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)C2=NCCN2)nc1 |t:25| Show InChI InChI=1S/C22H18ClN5O2/c23-16-9-10-19(26-13-16)28-22(30)17-3-1-2-4-18(17)27-21(29)15-7-5-14(6-8-15)20-24-11-12-25-20/h1-10,13H,11-12H2,(H,24,25)(H,27,29)(H,26,28,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Coagulation factor X
(Homo sapiens (Human)) | BDBM50278238
(CHEMBL471456 | N-(5-chloropyridin-2-yl)-2-(4-(imin...)Show SMILES CN1CCN(CC1)C(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C25H25ClN6O2/c1-31-12-14-32(15-13-31)23(27)17-6-8-18(9-7-17)24(33)29-21-5-3-2-4-20(21)25(34)30-22-11-10-19(26)16-28-22/h2-11,16,27H,12-15H2,1H3,(H,29,33)(H,28,30,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 714 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Factor 10a (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Prothrombin
(Homo sapiens (Human)) | BDBM50278729
(2-(4-carbamimidoylbenzamido)-N-(5-chloropyridin-2-...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C20H16ClN5O2/c21-14-9-10-17(24-11-14)26-20(28)15-3-1-2-4-16(15)25-19(27)13-7-5-12(6-8-13)18(22)23/h1-11H,(H3,22,23)(H,25,27)(H,24,26,28) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of thrombin (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Tissue-type plasminogen activator
(Homo sapiens (Human)) | BDBM50278729
(2-(4-carbamimidoylbenzamido)-N-(5-chloropyridin-2-...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C20H16ClN5O2/c21-14-9-10-17(24-11-14)26-20(28)15-3-1-2-4-16(15)25-19(27)13-7-5-12(6-8-13)18(22)23/h1-11H,(H3,22,23)(H,25,27)(H,24,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of tissue plasminogen activator (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |
Plasminogen
(Homo sapiens (Human)) | BDBM50278729
(2-(4-carbamimidoylbenzamido)-N-(5-chloropyridin-2-...)Show SMILES NC(=N)c1ccc(cc1)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cn1 Show InChI InChI=1S/C20H16ClN5O2/c21-14-9-10-17(24-11-14)26-20(28)15-3-1-2-4-16(15)25-19(27)13-7-5-12(6-8-13)18(22)23/h1-11H,(H3,22,23)(H,25,27)(H,24,26,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of plasmin (unknown origin) |
Bioorg Med Chem Lett 19: 2186-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.114 BindingDB Entry DOI: 10.7270/Q2Z60NZS |
More data for this Ligand-Target Pair | |