Found 28 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278141
((S)-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C27H30N4O2/c1-20(29-25(32)23-12-11-21-7-5-6-8-22(21)17-23)18-30-15-13-27(14-16-30)26(33)28-19-31(27)24-9-3-2-4-10-24/h2-12,17,20H,13-16,18-19H2,1H3,(H,28,33)(H,29,32)/t20-/m0/s1 | PDB
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| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM87188
(CHEMBL471257 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cc2ccccc2s1 Show InChI InChI=1S/C24H26N4O2S/c29-22(21-16-18-6-4-5-9-20(18)31-21)25-12-15-27-13-10-24(11-14-27)23(30)26-17-28(24)19-7-2-1-3-8-19/h1-9,16H,10-15,17H2,(H,25,29)(H,26,30) | PDB
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PC sid
UniChem
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PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278138
(CHEMBL471054 | N-(2-(4-oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2n1 Show InChI InChI=1S/C25H27N5O2/c31-23(22-11-10-19-6-4-5-9-21(19)28-22)26-14-17-29-15-12-25(13-16-29)24(32)27-18-30(25)20-7-2-1-3-8-20/h1-11H,12-18H2,(H,26,31)(H,27,32) | PDB
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| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278167
(CHEMBL511475 | N-(2-(4-Oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32) | PDB
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278141
((S)-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C27H30N4O2/c1-20(29-25(32)23-12-11-21-7-5-6-8-22(21)17-23)18-30-15-13-27(14-16-30)26(33)28-19-31(27)24-9-3-2-4-10-24/h2-12,17,20H,13-16,18-19H2,1H3,(H,28,33)(H,29,32)/t20-/m0/s1 | PDB
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| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM87188
(CHEMBL471257 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cc2ccccc2s1 Show InChI InChI=1S/C24H26N4O2S/c29-22(21-16-18-6-4-5-9-20(18)31-21)25-12-15-27-13-10-24(11-14-27)23(30)26-17-28(24)19-7-2-1-3-8-19/h1-9,16H,10-15,17H2,(H,25,29)(H,26,30) | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278143
((S)-3,4-difluoro-N-(1-(4-oxo-1-phenyl-1,3,8-triaza...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C23H26F2N4O2/c1-16(27-21(30)17-7-8-19(24)20(25)13-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)18-5-3-2-4-6-18/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278143
((S)-3,4-difluoro-N-(1-(4-oxo-1-phenyl-1,3,8-triaza...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C23H26F2N4O2/c1-16(27-21(30)17-7-8-19(24)20(25)13-17)14-28-11-9-23(10-12-28)22(31)26-15-29(23)18-5-3-2-4-6-18/h2-8,13,16H,9-12,14-15H2,1H3,(H,26,31)(H,27,30)/t16-/m0/s1 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278138
(CHEMBL471054 | N-(2-(4-oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2n1 Show InChI InChI=1S/C25H27N5O2/c31-23(22-11-10-19-6-4-5-9-21(19)28-22)26-14-17-29-15-12-25(13-16-29)24(32)27-18-30(25)20-7-2-1-3-8-20/h1-11H,12-18H2,(H,26,31)(H,27,32) | PDB
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| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD2 (unknown origin) by biochemical assay |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM87185
(4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triaz...)Show SMILES COc1cc(ccc1N)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H29N5O3/c1-31-20-15-17(7-8-19(20)24)21(29)25-11-14-27-12-9-23(10-13-27)22(30)26-16-28(23)18-5-3-2-4-6-18/h2-8,15H,9-14,16,24H2,1H3,(H,25,29)(H,26,30) | PDB
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| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM87187
(CHEMBL471258 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C1CCc2ccccc2C1 Show InChI InChI=1S/C26H32N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-9,22H,10-19H2,(H,27,31)(H,28,32) | PDB
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| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278167
(CHEMBL511475 | N-(2-(4-Oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2c1 Show InChI InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32) | PDB
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CHEMBL
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM87186
(CHEMBL471055 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C#Cc1ccccc1 Show InChI InChI=1S/C24H26N4O2/c29-22(12-11-20-7-3-1-4-8-20)25-15-18-27-16-13-24(14-17-27)23(30)26-19-28(24)21-9-5-2-6-10-21/h1-10H,13-19H2,(H,25,29)(H,26,30) | PDB
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| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278138
(CHEMBL471054 | N-(2-(4-oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2n1 Show InChI InChI=1S/C25H27N5O2/c31-23(22-11-10-19-6-4-5-9-21(19)28-22)26-14-17-29-15-12-25(13-16-29)24(32)27-18-30(25)20-7-2-1-3-8-20/h1-11H,12-18H2,(H,26,31)(H,27,32) | PDB
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| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM87186
(CHEMBL471055 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C#Cc1ccccc1 Show InChI InChI=1S/C24H26N4O2/c29-22(12-11-20-7-3-1-4-8-20)25-15-18-27-16-13-24(14-17-27)23(30)26-19-28(24)21-9-5-2-6-10-21/h1-10H,13-19H2,(H,25,29)(H,26,30) | PDB
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| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278142
((trans)-N-((S)-1-(4-oxo-1-phenyl-1,3,8-triazaspiro...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C26H32N4O2/c1-19(28-24(31)23-16-22(23)20-8-4-2-5-9-20)17-29-14-12-26(13-15-29)25(32)27-18-30(26)21-10-6-3-7-11-21/h2-11,19,22-23H,12-18H2,1H3,(H,27,32)(H,28,31)/t19-,22+,23-/m0/s1 | PDB
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| n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278172
((S)-3-methyl-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspir...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cccc(C)c1 |r| Show InChI InChI=1S/C24H30N4O2/c1-18-7-6-8-20(15-18)22(29)26-19(2)16-27-13-11-24(12-14-27)23(30)25-17-28(24)21-9-4-3-5-10-21/h3-10,15,19H,11-14,16-17H2,1-2H3,(H,25,30)(H,26,29)/t19-/m0/s1 | PDB
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PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50106393
(1-(pyridin-4-yl)piperazine | 1-Pyridin-4-yl-pipera...)Show InChI InChI=1S/C9H13N3/c1-3-10-4-2-9(1)12-7-5-11-6-8-12/h1-4,11H,5-8H2 | PDB
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| Article
PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50026634
(1-(2-pyridyl)piperazine | 1-(pyridin-2-yl)piperazi...)Show InChI InChI=1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2 | PDB
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PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM87187
(CHEMBL471258 | N-[2-(4-keto-1-phenyl-1,3,8-triazas...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)C1CCc2ccccc2C1 Show InChI InChI=1S/C26H32N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-9,22H,10-19H2,(H,27,31)(H,28,32) | PDB
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| n/a | n/a | 4.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM87185
(4-amino-3-methoxy-N-[2-(4-oxo-1-phenyl-1,3,8-triaz...)Show SMILES COc1cc(ccc1N)C(=O)NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1 Show InChI InChI=1S/C23H29N5O3/c1-31-20-15-17(7-8-19(20)24)21(29)25-11-14-27-12-9-23(10-13-27)22(30)26-16-28(23)18-5-3-2-4-6-18/h2-8,15H,9-14,16,24H2,1H3,(H,25,29)(H,26,30) | PDB
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| n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278138
(CHEMBL471054 | N-(2-(4-oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1ccc2ccccc2n1 Show InChI InChI=1S/C25H27N5O2/c31-23(22-11-10-19-6-4-5-9-21(19)28-22)26-14-17-29-15-12-25(13-16-29)24(32)27-18-30(25)20-7-2-1-3-8-20/h1-11H,12-18H2,(H,26,31)(H,27,32) | PDB
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 (unknown origin) by biochemical assay |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278171
(CHEMBL471463 | N-(2-(4-oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cnc2ccccc2n1 Show InChI InChI=1S/C24H26N6O2/c31-22(21-16-26-19-8-4-5-9-20(19)28-21)25-12-15-29-13-10-24(11-14-29)23(32)27-17-30(24)18-6-2-1-3-7-18/h1-9,16H,10-15,17H2,(H,25,31)(H,27,32) | PDB
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278137
((trans)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C25H30N4O2/c30-23(22-17-21(22)19-7-3-1-4-8-19)26-13-16-28-14-11-25(12-15-28)24(31)27-18-29(25)20-9-5-2-6-10-20/h1-10,21-22H,11-18H2,(H,26,30)(H,27,31)/t21-,22+/m1/s1 | PDB
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278137
((trans)-N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C25H30N4O2/c30-23(22-17-21(22)19-7-3-1-4-8-19)26-13-16-28-14-11-25(12-15-28)24(31)27-18-29(25)20-9-5-2-6-10-20/h1-10,21-22H,11-18H2,(H,26,30)(H,27,31)/t21-,22+/m1/s1 | PDB
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D1
(Homo sapiens (Human)) | BDBM50278171
(CHEMBL471463 | N-(2-(4-oxo-1-phenyl-1,3,8-triazasp...)Show SMILES O=C(NCCN1CCC2(CC1)N(CNC2=O)c1ccccc1)c1cnc2ccccc2n1 Show InChI InChI=1S/C24H26N6O2/c31-22(21-16-26-19-8-4-5-9-20(19)28-21)25-12-15-29-13-10-24(11-14-29)23(32)27-17-30(24)18-6-2-1-3-7-18/h1-9,16H,10-15,17H2,(H,25,31)(H,27,32) | PDB
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of PLD1 in human Calu1 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278172
((S)-3-methyl-N-(1-(4-oxo-1-phenyl-1,3,8-triazaspir...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)c1cccc(C)c1 |r| Show InChI InChI=1S/C24H30N4O2/c1-18-7-6-8-20(15-18)22(29)26-19(2)16-27-13-11-24(12-14-27)23(30)25-17-28(24)21-9-4-3-5-10-21/h3-10,15,19H,11-14,16-17H2,1-2H3,(H,25,30)(H,26,29)/t19-/m0/s1 | PDB
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| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
Phospholipase D2
(Homo sapiens (Human)) | BDBM50278142
((trans)-N-((S)-1-(4-oxo-1-phenyl-1,3,8-triazaspiro...)Show SMILES C[C@@H](CN1CCC2(CC1)N(CNC2=O)c1ccccc1)NC(=O)[C@H]1C[C@@H]1c1ccccc1 |r| Show InChI InChI=1S/C26H32N4O2/c1-19(28-24(31)23-16-22(23)20-8-4-2-5-9-20)17-29-14-12-26(13-15-29)25(32)27-18-30(26)21-10-6-3-7-11-21/h2-11,19,22-23H,12-18H2,1H3,(H,27,32)(H,28,31)/t19-,22+,23-/m0/s1 | PDB
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| n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Inhibition of GFP-labeled PLD2 in human HEK293 cells |
Bioorg Med Chem Lett 19: 2240-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.02.125
BindingDB Entry DOI: 10.7270/Q2F76CG5 |
More data for this
Ligand-Target Pair | |
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