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PubMed code 19303774

Compile data set for download or QSAR
Found 87 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50172920
PNG
(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Show SMILES Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1
Show InChI InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31)
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n/an/a 1.26n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50172920
PNG
(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Show SMILES Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1
Show InChI InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31)
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n/an/a 3.98n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50178832
PNG
(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Show SMILES O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1
Show InChI InChI=1S/C21H20N4O2/c26-21(17-8-11-27-14-17)25-20-13-16(7-10-23-20)15-6-9-22-19(12-15)24-18-4-2-1-3-5-18/h1-7,9-10,12-13,17H,8,11,14H2,(H,22,24)(H,23,25,26)
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n/an/a 6.31n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a 50.1n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged human full length JNK3 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50172920
PNG
(3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(pip...)
Show SMILES Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1
Show InChI InChI=1S/C25H24ClN5O/c26-21-6-1-2-7-22(21)28-19-8-9-20-23(15-19)30-31-24(20)16-4-3-5-17(14-16)25(32)29-18-10-12-27-13-11-18/h1-9,14-15,18,27-28H,10-13H2,(H,29,32)(H,30,31)
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n/an/a 79.4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK1 by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 126n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged human full length JNK3 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50178832
PNG
(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Show SMILES O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1
Show InChI InChI=1S/C21H20N4O2/c26-21(17-8-11-27-14-17)25-20-13-16(7-10-23-20)15-6-9-22-19(12-15)24-18-4-2-1-3-5-18/h1-7,9-10,12-13,17H,8,11,14H2,(H,22,24)(H,23,25,26)
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n/an/a 200n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of p38alpha by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 251n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a 316n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50178832
PNG
(CHEMBL203535 | N-(2'-(phenylamino)-4,4'-bipyridin-...)
Show SMILES O=C(Nc1cc(ccn1)-c1ccnc(Nc2ccccc2)c1)C1CCOC1
Show InChI InChI=1S/C21H20N4O2/c26-21(17-8-11-27-14-17)25-20-13-16(7-10-23-20)15-6-9-22-19(12-15)24-18-4-2-1-3-5-18/h1-7,9-10,12-13,17H,8,11,14H2,(H,22,24)(H,23,25,26)
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n/an/a 398n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK1 by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415612
PNG
(CHEMBL1083185)
Show SMILES COc1cc2CCN=C(c3cccc(Br)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13BrClNO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 398n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415624
PNG
(CHEMBL1077129)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3F)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl2FNO/c1-21-14-7-9-5-6-20-16(11(9)8-13(14)18)10-3-2-4-12(17)15(10)19/h2-4,7-8H,5-6H2,1H3
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n/an/a 631n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a 794n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged human full length JNK2-alpha-2 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415614
PNG
(CHEMBL1088053)
Show SMILES COc1cc2CCN=C(c3ccc4ccccc4c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C20H16ClNO/c1-23-19-11-15-8-9-22-20(17(15)12-18(19)21)16-7-6-13-4-2-3-5-14(13)10-16/h2-7,10-12H,8-9H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 1.26E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged human full length JNK2-alpha-2 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415621
PNG
(CHEMBL1088634)
Show SMILES COc1cc2CCN=C(c3cccc(C)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C17H16ClNO/c1-11-4-3-5-13(8-11)17-14-10-15(18)16(20-2)9-12(14)6-7-19-17/h3-5,8-10H,6-7H2,1-2H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415606
PNG
(CHEMBL1084664)
Show SMILES COc1cc2CCN=C(c3cccc(F)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)17)11-3-2-4-12(18)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 3.98E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415608
PNG
(CHEMBL1082866)
Show SMILES COc1cc2CCN=C(c3ccc(F)cc3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-8-11-6-7-19-16(13(11)9-14(15)17)10-2-4-12(18)5-3-10/h2-5,8-9H,6-7H2,1H3
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n/an/a 5.01E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415618
PNG
(CHEMBL1077132)
Show SMILES COc1cc2CCN=C(c3ccccc3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H14ClNO/c1-19-15-9-12-7-8-18-16(13(12)10-14(15)17)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3
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n/an/a 6.31E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415610
PNG
(CHEMBL1086653)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H15Cl2NO2/c1-21-15-8-10-5-6-20-17(12(10)9-16(15)22-2)11-3-4-13(18)14(19)7-11/h3-4,7-9H,5-6H2,1-2H3
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n/an/a 6.31E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 7.94E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a 7.94E+3n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of B-Raf


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of c-Fms


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of SGK1


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of IKKalpha


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of PLK1


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of IKK-beta


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of ROCK1


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of SGK1


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PLK1


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of PLK1


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of IKK-beta


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of ErbB2


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of ErbB2


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of MLK3


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of c-Fms


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
RAF serine/threonine protein kinase


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of B-Raf


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415613
PNG
(CHEMBL1077137)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1cccc(Br)c1 |c:5|
Show InChI InChI=1S/C16H13BrClNO/c1-20-15-9-13-10(8-14(15)18)5-6-19-16(13)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of CDK2


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 11


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of MLK3


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of LCK


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Inhibitor of NF-kappa-B kinase (IKK)


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of IKKalpha


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of ROCK1


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415625
PNG
(CHEMBL1077118)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H16ClNO2/c1-20-15-9-11-6-7-19-17(14(11)10-16(15)21-2)12-4-3-5-13(18)8-12/h3-5,8-10H,6-7H2,1-2H3
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n/an/a 1.00E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of JNK3 by high throughput screening


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415624
PNG
(CHEMBL1077129)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3F)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl2FNO/c1-21-14-7-9-5-6-20-16(11(9)8-13(14)18)10-3-2-4-12(17)15(10)19/h2-4,7-8H,5-6H2,1H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415612
PNG
(CHEMBL1083185)
Show SMILES COc1cc2CCN=C(c3cccc(Br)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13BrClNO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415604
PNG
(CHEMBL1077116)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1cccc(Cl)c1 |c:5|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-9-13-10(8-14(15)18)5-6-19-16(13)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a 1.26E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415609
PNG
(CHEMBL1082867)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccc(F)cc1 |c:5|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-9-13-11(8-14(15)17)6-7-19-16(13)10-2-4-12(18)5-3-10/h2-5,8-9H,6-7H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415619
PNG
(CHEMBL1088632)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccccc1 |c:5|
Show InChI InChI=1S/C16H14ClNO/c1-19-15-10-13-12(9-14(15)17)7-8-18-16(13)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415615
PNG
(CHEMBL1087420)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccc2ccccc2c1 |c:5|
Show InChI InChI=1S/C20H16ClNO/c1-23-19-12-17-15(11-18(19)21)8-9-22-20(17)16-7-6-13-4-2-3-5-14(13)10-16/h2-7,10-12H,8-9H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415603
PNG
(CHEMBL1086785)
Show SMILES COc1cccc(c1)C1=NCCc2cc(OC)c(OC)cc12 |t:9|
Show InChI InChI=1S/C18H19NO3/c1-20-14-6-4-5-13(9-14)18-15-11-17(22-3)16(21-2)10-12(15)7-8-19-18/h4-6,9-11H,7-8H2,1-3H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415605
PNG
(CHEMBL1084663)
Show SMILES Clc1cccc(c1)C1=NCCc2ccccc12 |t:8|
Show InChI InChI=1S/C15H12ClN/c16-13-6-3-5-12(10-13)15-14-7-2-1-4-11(14)8-9-17-15/h1-7,10H,8-9H2
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415606
PNG
(CHEMBL1084664)
Show SMILES COc1cc2CCN=C(c3cccc(F)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)17)11-3-2-4-12(18)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415613
PNG
(CHEMBL1077137)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1cccc(Br)c1 |c:5|
Show InChI InChI=1S/C16H13BrClNO/c1-20-15-9-13-10(8-14(15)18)5-6-19-16(13)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415603
PNG
(CHEMBL1086785)
Show SMILES COc1cccc(c1)C1=NCCc2cc(OC)c(OC)cc12 |t:9|
Show InChI InChI=1S/C18H19NO3/c1-20-14-6-4-5-13(9-14)18-15-11-17(22-3)16(21-2)10-12(15)7-8-19-18/h4-6,9-11H,7-8H2,1-3H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415617
PNG
(CHEMBL1087544)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccc(Cl)c(Cl)c1 |c:5|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-8-11-9(6-14(15)19)4-5-20-16(11)10-2-3-12(17)13(18)7-10/h2-3,6-8H,4-5H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415614
PNG
(CHEMBL1088053)
Show SMILES COc1cc2CCN=C(c3ccc4ccccc4c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C20H16ClNO/c1-23-19-11-15-8-9-22-20(17(15)12-18(19)21)16-7-6-13-4-2-3-5-14(13)10-16/h2-7,10-12H,8-9H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415605
PNG
(CHEMBL1084663)
Show SMILES Clc1cccc(c1)C1=NCCc2ccccc12 |t:8|
Show InChI InChI=1S/C15H12ClN/c16-13-6-3-5-12(10-13)15-14-7-2-1-4-11(14)8-9-17-15/h1-7,10H,8-9H2
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415608
PNG
(CHEMBL1082866)
Show SMILES COc1cc2CCN=C(c3ccc(F)cc3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-8-11-6-7-19-16(13(11)9-14(15)17)10-2-4-12(18)5-3-10/h2-5,8-9H,6-7H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415619
PNG
(CHEMBL1088632)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccccc1 |c:5|
Show InChI InChI=1S/C16H14ClNO/c1-19-15-10-13-12(9-14(15)17)7-8-18-16(13)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415607
PNG
(CHEMBL1082865)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1cccc(F)c1 |c:5|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-9-13-10(8-14(15)17)5-6-19-16(13)11-3-2-4-12(18)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415602
PNG
(CHEMBL1086783)
Show SMILES COc1cc2CCN=C(c3ccccc3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H17NO2/c1-19-15-10-13-8-9-18-17(12-6-4-3-5-7-12)14(13)11-16(15)20-2/h3-7,10-11H,8-9H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415607
PNG
(CHEMBL1082865)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1cccc(F)c1 |c:5|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-9-13-10(8-14(15)17)5-6-19-16(13)11-3-2-4-12(18)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415609
PNG
(CHEMBL1082867)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccc(F)cc1 |c:5|
Show InChI InChI=1S/C16H13ClFNO/c1-20-15-9-13-11(8-14(15)17)6-7-19-16(13)10-2-4-12(18)5-3-10/h2-5,8-9H,6-7H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415610
PNG
(CHEMBL1086653)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H15Cl2NO2/c1-21-15-8-10-5-6-20-17(12(10)9-16(15)22-2)11-3-4-13(18)14(19)7-11/h3-4,7-9H,5-6H2,1-2H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415618
PNG
(CHEMBL1077132)
Show SMILES COc1cc2CCN=C(c3ccccc3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H14ClNO/c1-19-15-9-12-7-8-18-16(13(12)10-14(15)17)11-5-3-2-4-6-11/h2-6,9-10H,7-8H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415621
PNG
(CHEMBL1088634)
Show SMILES COc1cc2CCN=C(c3cccc(C)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C17H16ClNO/c1-11-4-3-5-13(8-11)17-14-10-15(18)16(20-2)9-12(14)6-7-19-17/h3-5,8-10H,6-7H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415623
PNG
(CHEMBL1087810)
Show SMILES CCC1=NCCc2cc(OC)c(Cl)cc12 |t:2|
Show InChI InChI=1S/C12H14ClNO/c1-3-11-9-7-10(13)12(15-2)6-8(9)4-5-14-11/h6-7H,3-5H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415622
PNG
(CHEMBL1087694)
Show SMILES COc1cc2CCN=C(Cc3ccccc3)c2cc1Cl |t:7|
Show InChI InChI=1S/C17H16ClNO/c1-20-17-10-13-7-8-19-16(14(13)11-15(17)18)9-12-5-3-2-4-6-12/h2-6,10-11H,7-9H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415617
PNG
(CHEMBL1087544)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccc(Cl)c(Cl)c1 |c:5|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-8-11-9(6-14(15)19)4-5-20-16(11)10-2-3-12(17)13(18)7-10/h2-3,6-8H,4-5H2,1H3
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n/an/a 1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415622
PNG
(CHEMBL1087694)
Show SMILES COc1cc2CCN=C(Cc3ccccc3)c2cc1Cl |t:7|
Show InChI InChI=1S/C17H16ClNO/c1-20-17-10-13-7-8-19-16(14(13)11-15(17)18)9-12-5-3-2-4-6-12/h2-6,10-11H,7-9H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415602
PNG
(CHEMBL1086783)
Show SMILES COc1cc2CCN=C(c3ccccc3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H17NO2/c1-19-15-10-13-8-9-18-17(12-6-4-3-5-7-12)14(13)11-16(15)20-2/h3-7,10-11H,8-9H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415604
PNG
(CHEMBL1077116)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1cccc(Cl)c1 |c:5|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-9-13-10(8-14(15)18)5-6-19-16(13)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of histidine-tagged human recombinant p38alpha after 120 mins by TR-FRET assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (Human))
BDBM50415611
PNG
(CHEMBL1086784)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)cc3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H16ClNO2/c1-20-15-9-12-7-8-19-17(14(12)10-16(15)21-2)11-3-5-13(18)6-4-11/h3-6,9-10H,7-8H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged p38alpha expressed in Escherichia coli by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415615
PNG
(CHEMBL1087420)
Show SMILES COc1cc2C(=NCCc2cc1Cl)c1ccc2ccccc2c1 |c:5|
Show InChI InChI=1S/C20H16ClNO/c1-23-19-12-17-15(11-18(19)21)8-9-22-20(17)16-7-6-13-4-2-3-5-14(13)10-16/h2-7,10-12H,8-9H2,1H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415623
PNG
(CHEMBL1087810)
Show SMILES CCC1=NCCc2cc(OC)c(Cl)cc12 |t:2|
Show InChI InChI=1S/C12H14ClNO/c1-3-11-9-7-10(13)12(15-2)6-8(9)4-5-14-11/h6-7H,3-5H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (Human))
BDBM50415611
PNG
(CHEMBL1086784)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)cc3)c2cc1OC |t:7|
Show InChI InChI=1S/C17H16ClNO2/c1-20-15-9-12-7-8-19-17(14(12)10-16(15)21-2)11-3-5-13(18)6-4-11/h3-6,9-10H,7-8H2,1-2H3
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n/an/a>1.58E+4n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal His(6)-tagged truncated human JNK3 transfected in baculovirus expression system by fluorescence anisotropy


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged human full length JNK1-alpha-1 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50415620
PNG
(CHEMBL1088633)
Show SMILES COc1cc2CCN=C(c3cccc(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H13Cl2NO/c1-20-15-8-10-5-6-19-16(13(10)9-14(15)18)11-3-2-4-12(17)7-11/h2-4,7-9H,5-6H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length Erk2 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a 1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal histidine-tagged human full length JNK1-alpha-1 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50415616
PNG
(CHEMBL1087421)
Show SMILES COc1cc2CCN=C(c3ccc(Cl)c(Cl)c3)c2cc1Cl |t:7|
Show InChI InChI=1S/C16H12Cl3NO/c1-21-15-7-9-4-5-20-16(11(9)8-14(15)19)10-2-3-12(17)13(18)6-10/h2-3,6-8H,4-5H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



GlaxoSmithKline R&D

Curated by ChEMBL


Assay Description
Inhibition of N-terminal GST-tagged human full length Erk2 by radiometric filter binding assay


Bioorg Med Chem Lett 19: 2230-4 (2009)


Article DOI: 10.1016/j.bmcl.2009.02.098
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%