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PubMed code 19317445

Compile data set for download or QSAR
Found 53 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413500
PNG
(CHEMBL471724 | UR-PI287)
Show SMILES CC(C)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-8(2)10(17)16-11(12)14-5-3-4-9-6-13-7-15-9/h6-8H,3-5H2,1-2H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 1.40n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413499
PNG
(CHEMBL465170 | UR-PI295)
Show SMILES CCCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-2-4-10(17)16-11(12)14-6-3-5-9-7-13-8-15-9/h7-8H,2-6H2,1H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 141n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413500
PNG
(CHEMBL471724 | UR-PI287)
Show SMILES CC(C)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-8(2)10(17)16-11(12)14-5-3-4-9-6-13-7-15-9/h6-8H,3-5H2,1-2H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 110n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413503
PNG
(CHEMBL514641 | UR-PI141)
Show SMILES NC(NC(=O)CCc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1 |w:16.18|
Show InChI InChI=1S/C18H22N6O/c19-18(21-9-3-4-14-11-20-12-23-14)24-17(25)8-7-13-10-22-16-6-2-1-5-15(13)16/h1-2,5-6,10-12,22H,3-4,7-9H2,(H,20,23)(H3,19,21,24,25)
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n/an/an/an/a 7.10n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413506
PNG
(CHEMBL474617 | UR-PI147)
Show SMILES CN(CCC(=O)NC(N)=NCCCc1cnc[nH]1)C(=O)c1cc2ccccc2[nH]1 |w:9.9|
Show InChI InChI=1S/C20H25N7O2/c1-27(19(29)17-11-14-5-2-3-7-16(14)25-17)10-8-18(28)26-20(21)23-9-4-6-15-12-22-13-24-15/h2-3,5,7,11-13,25H,4,6,8-10H2,1H3,(H,22,24)(H3,21,23,26,28)
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n/an/an/an/a 3.55E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413507
PNG
(CHEMBL475620 | UR-PI182)
Show SMILES NC(NC(=O)CCCNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C20H25N7O2/c21-20(24-10-3-6-15-12-22-13-25-15)27-18(28)8-4-9-23-19(29)17-11-14-5-1-2-7-16(14)26-17/h1-2,5,7,11-13,26H,3-4,6,8-10H2,(H,22,25)(H,23,29)(H3,21,24,27,28)
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n/an/an/an/a 490n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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n/an/an/an/a 110n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50413500
PNG
(CHEMBL471724 | UR-PI287)
Show SMILES CC(C)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-8(2)10(17)16-11(12)14-5-3-4-9-6-13-7-15-9/h6-8H,3-5H2,1-2H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 2.57E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 68n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413504
PNG
(CHEMBL474449)
Show SMILES NC(NC(=O)CNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C18H21N7O2/c19-18(21-7-3-5-13-9-20-11-23-13)25-16(26)10-22-17(27)15-8-12-4-1-2-6-14(12)24-15/h1-2,4,6,8-9,11,24H,3,5,7,10H2,(H,20,23)(H,22,27)(H3,19,21,25,26)
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n/an/an/an/a 955n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)|
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
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n/an/an/an/a 7.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413500
PNG
(CHEMBL471724 | UR-PI287)
Show SMILES CC(C)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-8(2)10(17)16-11(12)14-5-3-4-9-6-13-7-15-9/h6-8H,3-5H2,1-2H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 3.70n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413498
PNG
(CHEMBL475621 | UR-PI294)
Show SMILES CCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:7.7|
Show InChI InChI=1S/C10H17N5O/c1-2-9(16)15-10(11)13-5-3-4-8-6-12-7-14-8/h6-7H,2-5H2,1H3,(H,12,14)(H3,11,13,15,16)
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n/an/an/an/a 3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413503
PNG
(CHEMBL514641 | UR-PI141)
Show SMILES NC(NC(=O)CCc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1 |w:16.18|
Show InChI InChI=1S/C18H22N6O/c19-18(21-9-3-4-14-11-20-12-23-14)24-17(25)8-7-13-10-22-16-6-2-1-5-15(13)16/h1-2,5-6,10-12,22H,3-4,7-9H2,(H,20,23)(H3,19,21,24,25)
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n/an/an/an/a 78n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 2.5n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413499
PNG
(CHEMBL465170 | UR-PI295)
Show SMILES CCCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-2-4-10(17)16-11(12)14-6-3-5-9-7-13-8-15-9/h7-8H,2-6H2,1H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 2.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413498
PNG
(CHEMBL475621 | UR-PI294)
Show SMILES CCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:7.7|
Show InChI InChI=1S/C10H17N5O/c1-2-9(16)15-10(11)13-5-3-4-8-6-12-7-14-8/h6-7H,2-5H2,1H3,(H,12,14)(H3,11,13,15,16)
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n/an/an/an/a 372n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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n/an/an/an/a 98n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 25n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413500
PNG
(CHEMBL471724 | UR-PI287)
Show SMILES CC(C)C(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-8(2)10(17)16-11(12)14-5-3-4-9-6-13-7-15-9/h6-8H,3-5H2,1-2H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 110n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413502
PNG
(CHEMBL474447 | UR-PI104)
Show SMILES NC(NC(=O)Cc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1 |w:15.17|
Show InChI InChI=1S/C17H20N6O/c18-17(20-7-3-4-13-10-19-11-22-13)23-16(24)8-12-9-21-15-6-2-1-5-14(12)15/h1-2,5-6,9-11,21H,3-4,7-8H2,(H,19,22)(H3,18,20,23,24)
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n/an/an/an/a 19n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 15n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)|
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
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n/an/an/an/a 8.10n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413497
PNG
(CHEMBL443896 | UR-PI288)
Show SMILES CC(=O)NC(N)=NCCCc1cnc[nH]1 |w:6.6|
Show InChI InChI=1S/C9H15N5O/c1-7(15)14-9(10)12-4-2-3-8-5-11-6-13-8/h5-6H,2-4H2,1H3,(H,11,13)(H3,10,12,14,15)
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n/an/an/an/a 724n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413499
PNG
(CHEMBL465170 | UR-PI295)
Show SMILES CCCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-2-4-10(17)16-11(12)14-6-3-5-9-7-13-8-15-9/h7-8H,2-6H2,1H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 186n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413505
PNG
(CHEMBL515428)
Show SMILES NC(NC(=O)CCNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C19H23N7O2/c20-19(23-8-3-5-14-11-21-12-24-14)26-17(27)7-9-22-18(28)16-10-13-4-1-2-6-15(13)25-16/h1-2,4,6,10-12,25H,3,5,7-9H2,(H,21,24)(H,22,28)(H3,20,23,26,27)
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n/an/an/an/a 83n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413497
PNG
(CHEMBL443896 | UR-PI288)
Show SMILES CC(=O)NC(N)=NCCCc1cnc[nH]1 |w:6.6|
Show InChI InChI=1S/C9H15N5O/c1-7(15)14-9(10)12-4-2-3-8-5-11-6-13-8/h5-6H,2-4H2,1H3,(H,11,13)(H3,10,12,14,15)
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n/an/an/an/a 813n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413504
PNG
(CHEMBL474449)
Show SMILES NC(NC(=O)CNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C18H21N7O2/c19-18(21-7-3-5-13-9-20-11-23-13)25-16(26)10-22-17(27)15-8-12-4-1-2-6-14(12)24-15/h1-2,4,6,8-9,11,24H,3,5,7,10H2,(H,20,23)(H,22,27)(H3,19,21,25,26)
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n/an/an/an/a 16n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 16n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413507
PNG
(CHEMBL475620 | UR-PI182)
Show SMILES NC(NC(=O)CCCNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:20.22|
Show InChI InChI=1S/C20H25N7O2/c21-20(24-10-3-6-15-12-22-13-25-15)27-18(28)8-4-9-23-19(29)17-11-14-5-1-2-7-16(14)26-17/h1-2,5,7,11-13,26H,3-4,6,8-10H2,(H,22,25)(H,23,29)(H3,21,24,27,28)
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n/an/an/an/a 30n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 191n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413498
PNG
(CHEMBL475621 | UR-PI294)
Show SMILES CCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:7.7|
Show InChI InChI=1S/C10H17N5O/c1-2-9(16)15-10(11)13-5-3-4-8-6-12-7-14-8/h6-7H,2-5H2,1H3,(H,12,14)(H3,11,13,15,16)
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n/an/an/an/a 302n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)|
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
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n/an/an/an/a 2.57E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50413499
PNG
(CHEMBL465170 | UR-PI295)
Show SMILES CCCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-2-4-10(17)16-11(12)14-6-3-5-9-7-13-8-15-9/h7-8H,2-6H2,1H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 2.19E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413502
PNG
(CHEMBL474447 | UR-PI104)
Show SMILES NC(NC(=O)Cc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1 |w:15.17|
Show InChI InChI=1S/C17H20N6O/c18-17(20-7-3-4-13-10-19-11-22-13)23-16(24)8-12-9-21-15-6-2-1-5-14(12)15/h1-2,5-6,9-11,21H,3-4,7-8H2,(H,19,22)(H3,18,20,23,24)
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n/an/an/an/a 36n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50413498
PNG
(CHEMBL475621 | UR-PI294)
Show SMILES CCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:7.7|
Show InChI InChI=1S/C10H17N5O/c1-2-9(16)15-10(11)13-5-3-4-8-6-12-7-14-8/h6-7H,2-5H2,1H3,(H,12,14)(H3,11,13,15,16)
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n/an/an/an/a 3.47E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50413497
PNG
(CHEMBL443896 | UR-PI288)
Show SMILES CC(=O)NC(N)=NCCCc1cnc[nH]1 |w:6.6|
Show InChI InChI=1S/C9H15N5O/c1-7(15)14-9(10)12-4-2-3-8-5-11-6-13-8/h5-6H,2-4H2,1H3,(H,11,13)(H3,10,12,14,15)
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n/an/an/an/a 1.29E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50413502
PNG
(CHEMBL474447 | UR-PI104)
Show SMILES NC(NC(=O)Cc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1 |w:15.17|
Show InChI InChI=1S/C17H20N6O/c18-17(20-7-3-4-13-10-19-11-22-13)23-16(24)8-12-9-21-15-6-2-1-5-14(12)15/h1-2,5-6,9-11,21H,3-4,7-8H2,(H,19,22)(H3,18,20,23,24)
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n/an/an/an/a 182n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 1.00E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413504
PNG
(CHEMBL474449)
Show SMILES NC(NC(=O)CNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:18.20|
Show InChI InChI=1S/C18H21N7O2/c19-18(21-7-3-5-13-9-20-11-23-13)25-16(26)10-22-17(27)15-8-12-4-1-2-6-14(12)24-15/h1-2,4,6,8-9,11,24H,3,5,7,10H2,(H,20,23)(H,22,27)(H3,19,21,25,26)
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n/an/an/an/a 28n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413497
PNG
(CHEMBL443896 | UR-PI288)
Show SMILES CC(=O)NC(N)=NCCCc1cnc[nH]1 |w:6.6|
Show InChI InChI=1S/C9H15N5O/c1-7(15)14-9(10)12-4-2-3-8-5-11-6-13-8/h5-6H,2-4H2,1H3,(H,11,13)(H3,10,12,14,15)
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n/an/an/an/a 3.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50413508
PNG
(CHEMBL474448)
Show SMILES NC(NC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:14.16|
Show InChI InChI=1S/C16H18N6O/c17-16(19-7-3-5-12-9-18-10-20-12)22-15(23)14-8-11-4-1-2-6-13(11)21-14/h1-2,4,6,8-10,21H,3,5,7H2,(H,18,20)(H3,17,19,22,23)
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n/an/an/an/a 1.70E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H1 receptor expressed in insect Sf9 cells co-expressing RGS4 assessed as gamma[32P]GTP binding by liquid scintillation coun...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413505
PNG
(CHEMBL515428)
Show SMILES NC(NC(=O)CCNC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:19.21|
Show InChI InChI=1S/C19H23N7O2/c20-19(23-8-3-5-14-11-21-12-24-14)26-17(27)7-9-22-18(28)16-10-13-4-1-2-6-15(13)25-16/h1-2,4,6,10-12,25H,3,5,7-9H2,(H,21,24)(H,22,28)(H3,20,23,26,27)
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n/an/an/an/a 33n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413499
PNG
(CHEMBL465170 | UR-PI295)
Show SMILES CCCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:8.8|
Show InChI InChI=1S/C11H19N5O/c1-2-4-10(17)16-11(12)14-6-3-5-9-7-13-8-15-9/h7-8H,2-6H2,1H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 1.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413498
PNG
(CHEMBL475621 | UR-PI294)
Show SMILES CCC(=O)NC(N)=NCCCc1cnc[nH]1 |w:7.7|
Show InChI InChI=1S/C10H17N5O/c1-2-9(16)15-10(11)13-5-3-4-8-6-12-7-14-8/h6-7H,2-5H2,1H3,(H,12,14)(H3,11,13,15,16)
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n/an/an/an/a 1.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50413506
PNG
(CHEMBL474617 | UR-PI147)
Show SMILES CN(CCC(=O)NC(N)=NCCCc1cnc[nH]1)C(=O)c1cc2ccccc2[nH]1 |w:9.9|
Show InChI InChI=1S/C20H25N7O2/c1-27(19(29)17-11-14-5-2-3-7-16(14)25-17)10-8-18(28)26-20(21)23-9-4-6-15-12-22-13-24-15/h2-3,5,7,11-13,25H,4,6,8-10H2,1H3,(H,22,24)(H3,21,23,26,28)
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n/an/an/an/a 11n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H3 receptor expressed in insect Sf9 cells co-expressing Gialpha2, Gbeta1gamma2 and RGS4 assessed as gamma[32P]GTP binding b...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 12n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413506
PNG
(CHEMBL474617 | UR-PI147)
Show SMILES CN(CCC(=O)NC(N)=NCCCc1cnc[nH]1)C(=O)c1cc2ccccc2[nH]1 |w:9.9|
Show InChI InChI=1S/C20H25N7O2/c1-27(19(29)17-11-14-5-2-3-7-16(14)25-17)10-8-18(28)26-20(21)23-9-4-6-15-12-22-13-24-15/h2-3,5,7,11-13,25H,4,6,8-10H2,1H3,(H,22,24)(H3,21,23,26,28)
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n/an/an/an/a 151n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413506
PNG
(CHEMBL474617 | UR-PI147)
Show SMILES CN(CCC(=O)NC(N)=NCCCc1cnc[nH]1)C(=O)c1cc2ccccc2[nH]1 |w:9.9|
Show InChI InChI=1S/C20H25N7O2/c1-27(19(29)17-11-14-5-2-3-7-16(14)25-17)10-8-18(28)26-20(21)23-9-4-6-15-12-22-13-24-15/h2-3,5,7,11-13,25H,4,6,8-10H2,1H3,(H,22,24)(H3,21,23,26,28)
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n/an/an/an/a 347n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413508
PNG
(CHEMBL474448)
Show SMILES NC(NC(=O)c1cc2ccccc2[nH]1)=NCCCc1cnc[nH]1 |w:14.16|
Show InChI InChI=1S/C16H18N6O/c17-16(19-7-3-5-12-9-18-10-20-12)22-15(23)14-8-11-4-1-2-6-13(11)21-14/h1-2,4,6,8-10,21H,3,5,7H2,(H,18,20)(H3,17,19,22,23)
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n/an/an/an/a 288n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50413503
PNG
(CHEMBL514641 | UR-PI141)
Show SMILES NC(NC(=O)CCc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1 |w:16.18|
Show InChI InChI=1S/C18H22N6O/c19-18(21-9-3-4-14-11-20-12-23-14)24-17(25)8-7-13-10-22-16-6-2-1-5-15(13)16/h1-2,5-6,10-12,22H,3-4,7-9H2,(H,20,23)(H3,19,21,24,25)
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n/an/an/an/a 81n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50413497
PNG
(CHEMBL443896 | UR-PI288)
Show SMILES CC(=O)NC(N)=NCCCc1cnc[nH]1 |w:6.6|
Show InChI InChI=1S/C9H15N5O/c1-7(15)14-9(10)12-4-2-3-8-5-11-6-13-8/h5-6H,2-4H2,1H3,(H,11,13)(H3,10,12,14,15)
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n/an/an/an/a 4.90n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 1.20E+3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...


J Med Chem 52: 2623-7 (2009)


Article DOI: 10.1021/jm9000693
BindingDB Entry DOI: 10.7270/Q2P270BN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%