Affinity Data by PubMed id=19329325

PubMed code 19329325

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H3 receptor (GUINEA PIG)	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Antagonist activity at human histamine H3 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50378000 (CHEMBL1202078) Show SMILES CC(C)(C)c1ccc(OCCCOCCCN2CCCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in CHO-K1 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in rat C6 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377994 (CHEMBL1202072) Show SMILES COc1cccc(OCCCOCCCN2CCCCCC2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377996 (CHEMBL1202074) Show SMILES CC1CCN(CCCOCCCOc2ccc(Cl)cc2)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377990 (CHEMBL1202068) Show SMILES COc1cccc(OCCOCCCN2CCC(C)CC2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377999 (CHEMBL1202077) Show SMILES CC1CCN(CCCOCCCOc2ccc(cc2)C(C)(C)C)CC1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377989 (CHEMBL1202067) Show SMILES COc1cccc(OCCOCCCN2CCCC(C)C2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377997 (CHEMBL1202075) Show SMILES CC1CCCCN(CCCOCCCOc2ccc(Cl)cc2)C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	14.8	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Binding affinity to histamine H3 receptor in rat cerebral cortex				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377993 (CHEMBL1202071) Show SMILES COc1cccc(OCCCOCCCN2CCC(C)CC2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	18.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377991 (CHEMBL1202069) Show SMILES CC1CCCN(CCCOCCOc2ccc(cc2)C(C)(C)C)C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	27.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377995 (CHEMBL1202073) Show SMILES CC1CCCN(CCCOCCCOc2ccc(Cl)cc2)C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	27.9	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377992 (CHEMBL1202070) Show SMILES COc1cccc(OCCCOCCCN2CCCC(C)C2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50377998 (CHEMBL1202076) Show SMILES CC1CCCN(CCCOCCCOc2ccc(cc2)C(C)(C)C)C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	51	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50267431 (1-(3-(2-(3-methoxyphenoxy)ethoxy)propyl)azepane \| ...) Show SMILES COc1cccc(OCCOCCCN2CCCCCC2)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	62	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Displacement of [125I]Iodoproxyfran from human histamine H3 receptor expressed in HEK293 cells				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Antagonist activity at human histamine H3 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H3 receptor (GUINEA PIG)	BDBM50247053 (1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...) Show SMILES Clc1ccc(CCCOCCCN2CCCCC2)cc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	5.62	n/a	n/a	n/a	n/a	n/a
Jagiellonian University Medical College Curated by ChEMBL					Assay Description Antagonist activity at histamine H3 receptor in isolated guinea pig ileum				Bioorg Med Chem 17: 3037-42 (2009) Article DOI: 10.1016/j.bmc.2009.03.014 BindingDB Entry DOI: 10.7270/Q2SF2X3H
Jagiellonian University Medical College Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%