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PubMed code 19359173

Compile data set for download or QSAR
Found 51 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 2.60n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 6n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 18n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC3 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 20n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 23n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC3 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 83n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 140n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 140n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC5 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 150n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 180n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 220n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC4 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 220n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC4 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 220n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC7 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 240n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 240n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 250n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 260n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC3 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 311n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC5 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 340n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 350n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC3 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 410n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC11 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 420n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC7 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 430n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC11 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50297445
PNG
(CHEMBL561483 | N-hydroxy-7,7-bis(7-methoxy-1H-indo...)
Show SMILES COc1cccc2c(c[nH]c12)C(CCCCCC(=O)NO)c1c[nH]c2c(OC)cccc12
Show InChI InChI=1S/C25H29N3O4/c1-31-21-11-6-9-17-19(14-26-24(17)21)16(8-4-3-5-13-23(29)28-30)20-15-27-25-18(20)10-7-12-22(25)32-2/h6-7,9-12,14-16,26-27,30H,3-5,8,13H2,1-2H3,(H,28,29)
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n/an/a 440n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC2 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 3


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 440n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC3 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 530n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC7 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 590n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC2 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 590n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC5 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50297446
PNG
(CHEMBL561604 | N-hydroxy-7,7-bis(5-nitro-1H-indol-...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccc(cc12)[N+]([O-])=O)c1c[nH]c2ccc(cc12)[N+]([O-])=O
Show InChI InChI=1S/C23H23N5O6/c29-23(26-30)5-3-1-2-4-16(19-12-24-21-8-6-14(27(31)32)10-17(19)21)20-13-25-22-9-7-15(28(33)34)11-18(20)22/h6-13,16,24-25,30H,1-5H2,(H,26,29)
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n/an/a 600n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 640n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 730n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 730n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 870n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC2 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC4 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50297444
PNG
(CHEMBL564876 | N-hydroxy-7,7-di(1H-indol-3-yl)hept...)
Show SMILES ONC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H25N3O2/c27-23(26-28)13-3-1-2-8-16(19-14-24-21-11-6-4-9-17(19)21)20-15-25-22-12-7-5-10-18(20)22/h4-7,9-12,14-16,24-25,28H,1-3,8,13H2,(H,26,27)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC2 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 3.30E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 2


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 3.90E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC2 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 7


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 4.20E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC7 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 4.70E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 4.80E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC4 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 4.80E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 4.90E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC5 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 6


(Homo sapiens (Human))
BDBM50297447
PNG
(3-(4-(di(1H-indol-3-yl)methyl)phenyl)-N-hydroxyacr...)
Show SMILES ONC(=O)\C=C\c1ccc(cc1)C(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C26H21N3O2/c30-25(29-31)14-11-17-9-12-18(13-10-17)26(21-15-27-23-7-3-1-5-19(21)23)22-16-28-24-8-4-2-6-20(22)24/h1-16,26-28,31H,(H,29,30)/b14-11+
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n/an/a 4.90E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC6 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 11


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 5.80E+3n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC11 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 5


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 2.80E+4n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC5 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 5.00E+4n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC9 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone Deacetylase 10 (HDAC10)


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 7.30E+4n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC10 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 8


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 7.40E+4n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC8 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
Histone deacetylase 4


(Homo sapiens (Human))
BDBM50297448
PNG
(CHEMBL564916 | N-(2-aminophenyl)-7,7-di(1H-indol-3...)
Show SMILES Nc1ccccc1NC(=O)CCCCCC(c1c[nH]c2ccccc12)c1c[nH]c2ccccc12
Show InChI InChI=1S/C29H30N4O/c30-25-13-6-9-16-28(25)33-29(34)17-3-1-2-10-20(23-18-31-26-14-7-4-11-21(23)26)24-19-32-27-15-8-5-12-22(24)27/h4-9,11-16,18-20,31-32H,1-3,10,17,30H2,(H,33,34)
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n/an/a 1.50E+5n/an/an/an/an/an/a



Sigma-Tau Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human HDAC4 by fluroimetry


Bioorg Med Chem Lett 19: 2840-3 (2009)

Checked by Author
Article DOI: 10.1016/j.bmcl.2009.03.101
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%