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PubMed code 19398205

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM20321
PNG
(3-[(4-tert-butylphenyl)methyl]-1-[(3-fluoro-4-meth...)
Show SMILES CC(C)(C)c1ccc(CNC(=S)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O2S2/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(27)23-13-15-7-10-18(17(21)11-15)24-28(4,25)26/h5-11,24H,12-13H2,1-4H3,(H2,22,23,27)
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n/an/a 37n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258505
PNG
(CHEMBL468512 | N-(3-Cyano-5-fluoro-4-(methylsulfon...)
Show SMILES CC1(C)CCC(C)(C)c2cc(CCC(=O)NCc3cc(F)c(NS(C)(=O)=O)c(c3)C#N)ccc12
Show InChI InChI=1S/C26H32FN3O3S/c1-25(2)10-11-26(3,4)21-13-17(6-8-20(21)25)7-9-23(31)29-16-18-12-19(15-28)24(22(27)14-18)30-34(5,32)33/h6,8,12-14,30H,7,9-11,16H2,1-5H3,(H,29,31)
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n/an/a 57n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258476
PNG
(3-(4-tert-Butylphenyl)-N-(3-cyano-5-fluoro-4-(meth...)
Show SMILES CC(C)(C)c1ccc(CCC(=O)NCc2cc(F)c(NS(C)(=O)=O)c(c2)C#N)cc1
Show InChI InChI=1S/C22H26FN3O3S/c1-22(2,3)18-8-5-15(6-9-18)7-10-20(27)25-14-16-11-17(13-24)21(19(23)12-16)26-30(4,28)29/h5-6,8-9,11-12,26H,7,10,14H2,1-4H3,(H,25,27)
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n/an/a 85n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258840
PNG
(3-(4-tert-Butylphenyl)-N-(3-fluoro-4-(methylsulfon...)
Show SMILES CC(C)(C)c1ccc(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C21H27FN2O3S/c1-21(2,3)17-9-5-15(6-10-17)8-12-20(25)23-14-16-7-11-19(18(22)13-16)24-28(4,26)27/h5-7,9-11,13,24H,8,12,14H2,1-4H3,(H,23,25)
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n/an/a 170n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258415
PNG
(CHEMBL493769 | N-(3-Fluoro-4-(methylsulfonamido)be...)
Show SMILES CC1(C)CCC(C)(C)c2cc(CCC(=O)NCc3ccc(NS(C)(=O)=O)c(F)c3)ccc12
Show InChI InChI=1S/C25H33FN2O3S/c1-24(2)12-13-25(3,4)20-14-17(6-9-19(20)24)8-11-23(29)27-16-18-7-10-22(21(26)15-18)28-32(5,30)31/h6-7,9-10,14-15,28H,8,11-13,16H2,1-5H3,(H,27,29)
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n/an/a 180n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258314
PNG
(3-(3,5-Di-tert-butylphenyl)-N-(3-fluoro-4-(methyls...)
Show SMILES CC(C)(C)c1cc(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc(c1)C(C)(C)C
Show InChI InChI=1S/C25H35FN2O3S/c1-24(2,3)19-12-17(13-20(15-19)25(4,5)6)9-11-23(29)27-16-18-8-10-22(21(26)14-18)28-32(7,30)31/h8,10,12-15,28H,9,11,16H2,1-7H3,(H,27,29)
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n/an/a 200n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258504
PNG
(CHEMBL512461 | N-(3-Cyano-5-fluoro-4-(methylsulfon...)
Show SMILES CC1(CC1)c1ccc(CCC(=O)NCc2cc(F)c(NS(C)(=O)=O)c(c2)C#N)cc1
Show InChI InChI=1S/C22H24FN3O3S/c1-22(9-10-22)18-6-3-15(4-7-18)5-8-20(27)25-14-16-11-17(13-24)21(19(23)12-16)26-30(2,28)29/h3-4,6-7,11-12,26H,5,8-10,14H2,1-2H3,(H,25,27)
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n/an/a 210n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258446
PNG
(3-(6-tert-Butylchroman-8-yl)-N-(3-fluoro-4-(methyl...)
Show SMILES CC(C)(C)c1cc(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)c2OCCCc2c1
Show InChI InChI=1S/C24H31FN2O4S/c1-24(2,3)19-13-17-6-5-11-31-23(17)18(14-19)8-10-22(28)26-15-16-7-9-21(20(25)12-16)27-32(4,29)30/h7,9,12-14,27H,5-6,8,10-11,15H2,1-4H3,(H,26,28)
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n/an/a 280n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258414
PNG
((E)-N-(3-Fluoro-4-(methylsulfonamido)benzyl)-3-(5,...)
Show SMILES CC1(C)CCC(C)(C)c2cc(\C=C\C(=O)NCc3ccc(NS(C)(=O)=O)c(F)c3)ccc12
Show InChI InChI=1S/C25H31FN2O3S/c1-24(2)12-13-25(3,4)20-14-17(6-9-19(20)24)8-11-23(29)27-16-18-7-10-22(21(26)15-18)28-32(5,30)31/h6-11,14-15,28H,12-13,16H2,1-5H3,(H,27,29)/b11-8+
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n/an/a 340n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258270
PNG
(CHEMBL492800 | N-(3-Fluoro-4-(methylsulfonamido)be...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)CCc2ccc(CC3CC3)cc2)cc1F
Show InChI InChI=1S/C21H25FN2O3S/c1-28(26,27)24-20-10-8-18(13-19(20)22)14-23-21(25)11-9-15-2-4-16(5-3-15)12-17-6-7-17/h2-5,8,10,13,17,24H,6-7,9,11-12,14H2,1H3,(H,23,25)
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n/an/a 360n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258269
PNG
((E)-N-(3-Fluoro-4-(methylsulfonamido)benzyl)-3-(4-...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)\C=C\c2ccc(CC3CC3)cc2)cc1F
Show InChI InChI=1S/C21H23FN2O3S/c1-28(26,27)24-20-10-8-18(13-19(20)22)14-23-21(25)11-9-15-2-4-16(5-3-15)12-17-6-7-17/h2-5,8-11,13,17,24H,6-7,12,14H2,1H3,(H,23,25)/b11-9+
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n/an/a 390n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258839
PNG
((E)-3-(4-tert-Butylphenyl)-N-(3-fluoro-4-(methylsu...)
Show SMILES CC(C)(C)c1ccc(\C=C\C(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C21H25FN2O3S/c1-21(2,3)17-9-5-15(6-10-17)8-12-20(25)23-14-16-7-11-19(18(22)13-16)24-28(4,26)27/h5-13,24H,14H2,1-4H3,(H,23,25)/b12-8+
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n/an/a 490n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258841
PNG
(3-(4-sec-Butylphenyl)-N-(3-fluoro-4-(methylsulfona...)
Show SMILES CC(C)Cc1ccc(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C21H27FN2O3S/c1-15(2)12-17-6-4-16(5-7-17)9-11-21(25)23-14-18-8-10-20(19(22)13-18)24-28(3,26)27/h4-8,10,13,15,24H,9,11-12,14H2,1-3H3,(H,23,25)
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n/an/a 640n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50172598
PNG
(CHEMBL197781 | N-(4-[({4-tert-Butylbenzyl}aminocar...)
Show SMILES CC(C)(C)c1ccc(CNC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H26FN3O3S/c1-20(2,3)16-8-5-14(6-9-16)12-22-19(25)23-13-15-7-10-18(17(21)11-15)24-28(4,26)27/h5-11,24H,12-13H2,1-4H3,(H2,22,23,25)
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n/an/a 710n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258445
PNG
((E)-3-(6-tert-Butylchroman-8-yl)-N-(3-fluoro-4-(me...)
Show SMILES CC(C)(C)c1cc2CCCOc2c(\C=C\C(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)c1
Show InChI InChI=1S/C24H29FN2O4S/c1-24(2,3)19-13-17-6-5-11-31-23(17)18(14-19)8-10-22(28)26-15-16-7-9-21(20(25)12-16)27-32(4,29)30/h7-10,12-14,27H,5-6,11,15H2,1-4H3,(H,26,28)/b10-8+
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n/an/a 920n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258474
PNG
((E)-3-(2,2-Dimethylchroman-6-yl)-N-(3-fluoro-4-(me...)
Show SMILES CC1(C)CCc2cc(\C=C\C(=O)NCc3ccc(NS(C)(=O)=O)c(F)c3)ccc2O1
Show InChI InChI=1S/C22H25FN2O4S/c1-22(2)11-10-17-12-15(5-8-20(17)29-22)6-9-21(26)24-14-16-4-7-19(18(23)13-16)25-30(3,27)28/h4-9,12-13,25H,10-11,14H2,1-3H3,(H,24,26)/b9-6+
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n/an/a 1.40E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258416
PNG
((E)-3-(5-tert-Butyl-2,3-dihydrobenzofuran-7-yl)-N-...)
Show SMILES CC(C)(C)c1cc2CCOc2c(\C=C\C(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)c1
Show InChI InChI=1S/C23H27FN2O4S/c1-23(2,3)18-12-16(22-17(13-18)9-10-30-22)6-8-21(27)25-14-15-5-7-20(19(24)11-15)26-31(4,28)29/h5-8,11-13,26H,9-10,14H2,1-4H3,(H,25,27)/b8-6+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258413
PNG
(3-(3,5-Bis(trifluoromethyl)phenyl)-N-(3-fluoro-4-(...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)CCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)cc1F
Show InChI InChI=1S/C19H17F7N2O3S/c1-32(30,31)28-16-4-2-12(8-15(16)20)10-27-17(29)5-3-11-6-13(18(21,22)23)9-14(7-11)19(24,25)26/h2,4,6-9,28H,3,5,10H2,1H3,(H,27,29)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258803
PNG
(CHEMBL466622 | N-(4-tert-Butylbenzyl)-3-[3-fluoro-...)
Show SMILES CC(C)(C)c1ccc(CNC(=O)CCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C21H27FN2O3S/c1-21(2,3)17-9-5-16(6-10-17)14-23-20(25)12-8-15-7-11-19(18(22)13-15)24-28(4,26)27/h5-7,9-11,13,24H,8,12,14H2,1-4H3,(H,23,25)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258447
PNG
((E)-3-(2,2-Dimethyl-2,3-dihydrobenzofuran-5-yl)-N-...)
Show SMILES CC1(C)Cc2cc(\C=C\C(=O)NCc3ccc(NS(C)(=O)=O)c(F)c3)ccc2O1
Show InChI InChI=1S/C21H23FN2O4S/c1-21(2)12-16-10-14(5-8-19(16)28-21)6-9-20(25)23-13-15-4-7-18(17(22)11-15)24-29(3,26)27/h4-11,24H,12-13H2,1-3H3,(H,23,25)/b9-6+
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n/an/a 4.30E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258271
PNG
(CHEMBL492801 | N-(3-Fluoro-4-(methylsulfonamido)be...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)CCc2ccc(cc2)C(F)(F)F)cc1F
Show InChI InChI=1S/C18H18F4N2O3S/c1-28(26,27)24-16-8-4-13(10-15(16)19)11-23-17(25)9-5-12-2-6-14(7-3-12)18(20,21)22/h2-4,6-8,10,24H,5,9,11H2,1H3,(H,23,25)
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n/an/a 4.60E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258444
PNG
(3-(5-tert-Butyl-2,3-dihydrobenzofuran-7-yl)-N-(3-f...)
Show SMILES CC(C)(C)c1cc2CCOc2c(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)c1
Show InChI InChI=1S/C23H29FN2O4S/c1-23(2,3)18-12-16(22-17(13-18)9-10-30-22)6-8-21(27)25-14-15-5-7-20(19(24)11-15)26-31(4,28)29/h5,7,11-13,26H,6,8-10,14H2,1-4H3,(H,25,27)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258475
PNG
(3-(2,2-Dimethylchroman-6-yl)-N-(3-fluoro-4-(methyl...)
Show SMILES CC1(C)CCc2cc(CCC(=O)NCc3ccc(NS(C)(=O)=O)c(F)c3)ccc2O1
Show InChI InChI=1S/C22H27FN2O4S/c1-22(2)11-10-17-12-15(5-8-20(17)29-22)6-9-21(26)24-14-16-4-7-19(18(23)13-16)25-30(3,27)28/h4-5,7-8,12-13,25H,6,9-11,14H2,1-3H3,(H,24,26)
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n/an/a 7.20E+3n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258473
PNG
(3-(2,2-Dimethyl-2,3-dihydrobenzofuran-5-yl)-N-(3-f...)
Show SMILES CC1(C)Cc2cc(CCC(=O)NCc3ccc(NS(C)(=O)=O)c(F)c3)ccc2O1
Show InChI InChI=1S/C21H25FN2O4S/c1-21(2)12-16-10-14(5-8-19(16)28-21)6-9-20(25)23-13-15-4-7-18(17(22)11-15)24-29(3,26)27/h4-5,7-8,10-11,24H,6,9,12-13H2,1-3H3,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258837
PNG
(3-(4-Bromophenyl)-N-(3-fluoro-4-(methylsulfonamido...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)CCc2ccc(Br)cc2)cc1F
Show InChI InChI=1S/C17H18BrFN2O3S/c1-25(23,24)21-16-8-4-13(10-15(16)19)11-20-17(22)9-5-12-2-6-14(18)7-3-12/h2-4,6-8,10,21H,5,9,11H2,1H3,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258838
PNG
((E)-N-(3-Fluoro-4-(methylsulfonamido)benzyl)-3-(4-...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)\C=C\c2ccc(I)cc2)cc1F
Show InChI InChI=1S/C17H16FIN2O3S/c1-25(23,24)21-16-8-4-13(10-15(16)18)11-20-17(22)9-5-12-2-6-14(19)7-3-12/h2-10,21H,11H2,1H3,(H,20,22)/b9-5+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258273
PNG
(3-(4-tert-Butoxyphenyl)-N-(3-fluoro-4-(methylsulfo...)
Show SMILES CC(C)(C)Oc1ccc(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C21H27FN2O4S/c1-21(2,3)28-17-9-5-15(6-10-17)8-12-20(25)23-14-16-7-11-19(18(22)13-16)24-29(4,26)27/h5-7,9-11,13,24H,8,12,14H2,1-4H3,(H,23,25)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258804
PNG
(CHEMBL466827 | N-(3-Fluoro-4-(methylsulfonamido)be...)
Show SMILES CS(=O)(=O)Nc1ccc(CNC(=O)CCc2ccccc2)cc1F
Show InChI InChI=1S/C17H19FN2O3S/c1-24(22,23)20-16-9-7-14(11-15(16)18)12-19-17(21)10-8-13-5-3-2-4-6-13/h2-7,9,11,20H,8,10,12H2,1H3,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50258272
PNG
(CHEMBL495006 | N-(3-Fluoro-4-(methylsulfonamido)be...)
Show SMILES CC(C)Oc1ccc(CCC(=O)NCc2ccc(NS(C)(=O)=O)c(F)c2)cc1
Show InChI InChI=1S/C20H25FN2O4S/c1-14(2)27-17-8-4-15(5-9-17)7-11-20(24)22-13-16-6-10-19(18(21)12-16)23-28(3,25)26/h4-6,8-10,12,14,23H,7,11,13H2,1-3H3,(H,22,24)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Seoul National University

Curated by ChEMBL


Assay Description
Antagonist activity at TRPV1 in Sprague-Dawley rat DRG neuron assessed as reduction of capsaicin-stimulated 45Ca2+ uptake

Bioorg Med Chem 17: 3557-67 (2009)


Article DOI: 10.1016/j.bmc.2009.04.010
BindingDB Entry DOI: 10.7270/Q2V124QJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%