Found 8 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50414250
(CHEMBL457077)Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.35E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of LCK SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50133496
((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of c-SRC SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50414250
(CHEMBL457077)Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1\C=C\c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of c-SRC SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50414251
(SALVIANOLIC ACID B)Show SMILES OC(OC(Cc1ccc(O)c(O)c1)C(O)=O)C1C(Oc2cc(O)cc(\C=C\C(=O)OC(Cc3ccc(O)c(O)c3)C(O)=O)c12)c1ccc(O)c(O)c1 Show InChI InChI=1S/C36H32O16/c37-20-13-18(4-8-30(44)50-28(34(45)46)11-16-1-5-21(38)24(41)9-16)31-27(15-20)51-33(19-3-7-23(40)26(43)14-19)32(31)36(49)52-29(35(47)48)12-17-2-6-22(39)25(42)10-17/h1-10,13-15,28-29,32-33,36-43,49H,11-12H2,(H,45,46)(H,47,48)/b8-4+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of LCK SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50133496
((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)Show SMILES OC(=O)[C@@H](Cc1ccc(O)c(O)c1)OC(=O)\C=C\c1ccc(O)c(O)c1 |r| Show InChI InChI=1S/C18H16O8/c19-12-4-1-10(7-14(12)21)3-6-17(23)26-16(18(24)25)9-11-2-5-13(20)15(22)8-11/h1-8,16,19-22H,9H2,(H,24,25)/b6-3+/t16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of LCK SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50414249
(CAFTARIC ACID)Show SMILES OC(C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H12O9/c14-7-3-1-6(5-8(7)15)2-4-9(16)22-11(13(20)21)10(17)12(18)19/h1-5,10-11,14-15,17H,(H,18,19)(H,20,21)/b4-2+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of c-SRC SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50414251
(SALVIANOLIC ACID B)Show SMILES OC(OC(Cc1ccc(O)c(O)c1)C(O)=O)C1C(Oc2cc(O)cc(\C=C\C(=O)OC(Cc3ccc(O)c(O)c3)C(O)=O)c12)c1ccc(O)c(O)c1 Show InChI InChI=1S/C36H32O16/c37-20-13-18(4-8-30(44)50-28(34(45)46)11-16-1-5-21(38)24(41)9-16)31-27(15-20)51-33(19-3-7-23(40)26(43)14-19)32(31)36(49)52-29(35(47)48)12-17-2-6-22(39)25(42)10-17/h1-10,13-15,28-29,32-33,36-43,49H,11-12H2,(H,45,46)(H,47,48)/b8-4+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of c-SRC SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50414249
(CAFTARIC ACID)Show SMILES OC(C(OC(=O)\C=C\c1ccc(O)c(O)c1)C(O)=O)C(O)=O Show InChI InChI=1S/C13H12O9/c14-7-3-1-6(5-8(7)15)2-4-9(16)22-11(13(20)21)10(17)12(18)19/h1-5,10-11,14-15,17H,(H,18,19)(H,20,21)/b4-2+ | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Max Planck Institute of Biochemistry
Curated by ChEMBL
| Assay Description Inhibition of LCK SH2 domain |
Bioorg Med Chem Lett 19: 3305-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.083 BindingDB Entry DOI: 10.7270/Q29P32WX |
More data for this Ligand-Target Pair | |