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PubMed code 19433357

Compile data set for download or QSAR
Found 88 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32488
PNG
(aryl piperidine, 9d)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cl)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C19H21ClN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23)
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n/an/a 40n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32487
PNG
(aryl piperidine, 9b)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C19H21BrN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23)
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n/an/a 60n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32488
PNG
(aryl piperidine, 9d)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cl)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C19H21ClN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23)
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n/an/a 80n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32487
PNG
(aryl piperidine, 9b)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C19H21BrN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23)
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n/an/a 90n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32470
PNG
(piperazine amide, 4q)
Show SMILES Fc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1
Show InChI InChI=1S/C18H17BrFN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32494
PNG
(aryl piperidine, 9j)
Show SMILES CC#Cc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C22H24N2O4/c1-3-5-17-8-9-19(28-17)21(25)23-18-7-4-6-16(2)20(18)24-12-10-22(11-13-24)26-14-15-27-22/h4,6-9H,10-15H2,1-2H3,(H,23,25)
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n/an/a 110n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32494
PNG
(aryl piperidine, 9j)
Show SMILES CC#Cc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C22H24N2O4/c1-3-5-17-8-9-19(28-17)21(25)23-18-7-4-6-16(2)20(18)24-12-10-22(11-13-24)26-14-15-27-22/h4,6-9H,10-15H2,1-2H3,(H,23,25)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32460
PNG
(piperazine amide, 4g)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1
Show InChI InChI=1S/C18H17BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24)
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n/an/a 140n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32460
PNG
(piperazine amide, 4g)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1
Show InChI InChI=1S/C18H17BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24)
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n/an/a 160n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32461
PNG
(piperazine amide, 4h)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)C1CC1
Show InChI InChI=1S/C18H19BrClN3O2/c19-16-7-6-15(25-16)18(24)21-14-3-1-2-13(20)17(14)23-10-8-22(9-11-23)12-4-5-12/h1-3,6-7,12H,4-5,8-11H2,(H,21,24)
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n/an/a 180n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32469
PNG
(piperazine amide, 4p)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H22BrN3O2/c1-3-9-22-10-12-23(13-11-22)18-14(2)5-4-6-15(18)21-19(24)16-7-8-17(20)25-16/h3-8H,1,9-13H2,2H3,(H,21,24)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32469
PNG
(piperazine amide, 4p)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H22BrN3O2/c1-3-9-22-10-12-23(13-11-22)18-14(2)5-4-6-15(18)21-19(24)16-7-8-17(20)25-16/h3-8H,1,9-13H2,2H3,(H,21,24)
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n/an/a 200n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32490
PNG
(aryl piperidine, 9f)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)C#N)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H21N3O4/c1-14-3-2-4-16(22-19(24)17-6-5-15(13-21)27-17)18(14)23-9-7-20(8-10-23)25-11-12-26-20/h2-6H,7-12H2,1H3,(H,22,24)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32489
PNG
(aryl piperidine, 9e)
Show SMILES Cc1cccc(NC(=O)c2ccc(F)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C19H21FN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32490
PNG
(aryl piperidine, 9f)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)C#N)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H21N3O4/c1-14-3-2-4-16(22-19(24)17-6-5-15(13-21)27-17)18(14)23-9-7-20(8-10-23)25-11-12-26-20/h2-6H,7-12H2,1H3,(H,22,24)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32458
PNG
(piperazine amide, 4e | piperazine amide, 6a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32462
PNG
(piperazine amide, 4i)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccco2)CC1
Show InChI InChI=1S/C20H19BrClN3O3/c21-18-7-6-17(28-18)20(26)23-16-5-1-4-15(22)19(16)25-10-8-24(9-11-25)13-14-3-2-12-27-14/h1-7,12H,8-11,13H2,(H,23,26)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32492
PNG
(aryl piperidine, 9h)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)C(F)F)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H22F2N2O4/c1-13-3-2-4-14(23-19(25)16-6-5-15(28-16)18(21)22)17(13)24-9-7-20(8-10-24)26-11-12-27-20/h2-6,18H,7-12H2,1H3,(H,23,25)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32462
PNG
(piperazine amide, 4i)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccco2)CC1
Show InChI InChI=1S/C20H19BrClN3O3/c21-18-7-6-17(28-18)20(26)23-16-5-1-4-15(22)19(16)25-10-8-24(9-11-25)13-14-3-2-12-27-14/h1-7,12H,8-11,13H2,(H,23,26)
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The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32470
PNG
(piperazine amide, 4q)
Show SMILES Fc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1
Show InChI InChI=1S/C18H17BrFN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32476
PNG
(piperazine amide, 6b)
Show SMILES Clc1cccc(NC(=O)c2cnc(Br)s2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)21-16(24)14-11-20-17(18)25-14/h2-5,11H,1,6-10H2,(H,21,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32491
PNG
(aryl piperidine, 9g)
Show SMILES Cc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H24N2O4/c1-14-4-3-5-16(21-19(23)17-7-6-15(2)26-17)18(14)22-10-8-20(9-11-22)24-12-13-25-20/h3-7H,8-13H2,1-2H3,(H,21,23)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32458
PNG
(piperazine amide, 4e | piperazine amide, 6a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32476
PNG
(piperazine amide, 6b)
Show SMILES Clc1cccc(NC(=O)c2cnc(Br)s2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)21-16(24)14-11-20-17(18)25-14/h2-5,11H,1,6-10H2,(H,21,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32492
PNG
(aryl piperidine, 9h)
Show SMILES Cc1cccc(NC(=O)c2ccc(o2)C(F)F)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H22F2N2O4/c1-13-3-2-4-14(23-19(25)16-6-5-15(28-16)18(21)22)17(13)24-9-7-20(8-10-24)26-11-12-27-20/h2-6,18H,7-12H2,1H3,(H,23,25)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32454
PNG
(piperazine amide, 4b)
Show SMILES CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C16H17BrClN3O2/c1-20-7-9-21(10-8-20)15-11(18)3-2-4-12(15)19-16(22)13-5-6-14(17)23-13/h2-6H,7-10H2,1H3,(H,19,22)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32455
PNG
(cid_979869 | piperazine amide, 1)
Show SMILES CCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H19BrClN3O2/c1-2-21-8-10-22(11-9-21)16-12(19)4-3-5-13(16)20-17(23)14-6-7-15(18)24-14/h3-7H,2,8-11H2,1H3,(H,20,23)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32458
PNG
(piperazine amide, 4e | piperazine amide, 6a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32459
PNG
(piperazine amide, 4f)
Show SMILES CC(=C)CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C19H21BrClN3O2/c1-13(2)12-23-8-10-24(11-9-23)18-14(21)4-3-5-15(18)22-19(25)16-6-7-17(20)26-16/h3-7H,1,8-12H2,2H3,(H,22,25)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32489
PNG
(aryl piperidine, 9e)
Show SMILES Cc1cccc(NC(=O)c2ccc(F)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C19H21FN2O4/c1-13-3-2-4-14(21-18(23)15-5-6-16(20)26-15)17(13)22-9-7-19(8-10-22)24-11-12-25-19/h2-6H,7-12H2,1H3,(H,21,23)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32496
PNG
(aryl piperidine, 9l)
Show SMILES COc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H24N2O5/c1-14-4-3-5-15(21-19(23)16-6-7-17(24-2)27-16)18(14)22-10-8-20(9-11-22)25-12-13-26-20/h3-7H,8-13H2,1-2H3,(H,21,23)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32491
PNG
(aryl piperidine, 9g)
Show SMILES Cc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H24N2O4/c1-14-4-3-5-16(21-19(23)17-7-6-15(2)26-17)18(14)22-10-8-20(9-11-22)24-12-13-25-20/h3-7H,8-13H2,1-2H3,(H,21,23)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32459
PNG
(piperazine amide, 4f)
Show SMILES CC(=C)CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C19H21BrClN3O2/c1-13(2)12-23-8-10-24(11-9-23)18-14(21)4-3-5-15(18)22-19(25)16-6-7-17(20)26-16/h3-7H,1,8-12H2,2H3,(H,22,25)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32466
PNG
(piperazine amide, 4m)
Show SMILES CC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H17BrClN3O3/c1-11(23)21-7-9-22(10-8-21)16-12(19)3-2-4-13(16)20-17(24)14-5-6-15(18)25-14/h2-6H,7-10H2,1H3,(H,20,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32496
PNG
(aryl piperidine, 9l)
Show SMILES COc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C20H24N2O5/c1-14-4-3-5-15(21-19(23)16-6-7-17(24-2)27-16)18(14)22-10-8-20(9-11-22)25-12-13-26-20/h3-7H,8-13H2,1-2H3,(H,21,23)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32456
PNG
(piperazine amide, 4c)
Show SMILES CCCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C18H21BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7H,2,8-12H2,1H3,(H,21,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32466
PNG
(piperazine amide, 4m)
Show SMILES CC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H17BrClN3O3/c1-11(23)21-7-9-22(10-8-21)16-12(19)3-2-4-13(16)20-17(24)14-5-6-15(18)25-14/h2-6H,7-10H2,1H3,(H,20,24)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32463
PNG
(piperazine amide, 4j)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H21BrClN3O2/c23-20-10-9-19(29-20)22(28)25-18-8-4-7-17(24)21(18)27-13-11-26(12-14-27)15-16-5-2-1-3-6-16/h1-10H,11-15H2,(H,25,28)
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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32456
PNG
(piperazine amide, 4c)
Show SMILES CCCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C18H21BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7H,2,8-12H2,1H3,(H,21,24)
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n/an/a 900n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32464
PNG
(piperazine amide, 4k)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H23BrClN3O2/c24-21-10-9-20(30-21)23(29)26-19-8-4-7-18(25)22(19)28-15-13-27(14-16-28)12-11-17-5-2-1-3-6-17/h1-10H,11-16H2,(H,26,29)
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n/an/a 900n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32461
PNG
(piperazine amide, 4h)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)C1CC1
Show InChI InChI=1S/C18H19BrClN3O2/c19-16-7-6-15(25-16)18(24)21-14-3-1-2-13(20)17(14)23-10-8-22(9-11-23)12-4-5-12/h1-3,6-7,12H,4-5,8-11H2,(H,21,24)
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n/an/a 960n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32493
PNG
(aryl piperidine, 9i)
Show SMILES CCc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C21H26N2O4/c1-3-16-7-8-18(27-16)20(24)22-17-6-4-5-15(2)19(17)23-11-9-21(10-12-23)25-13-14-26-21/h4-8H,3,9-14H2,1-2H3,(H,22,24)
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n/an/a 1.00E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32465
PNG
(piperazine amide, 4l)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H18BrClN4O2/c21-17-8-7-16(28-17)20(27)24-15-5-3-4-14(22)19(15)26-12-10-25(11-13-26)18-6-1-2-9-23-18/h1-9H,10-13H2,(H,24,27)
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n/an/a 1.00E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32455
PNG
(cid_979869 | piperazine amide, 1)
Show SMILES CCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H19BrClN3O2/c1-2-21-8-10-22(11-9-21)16-12(19)4-3-5-13(16)20-17(23)14-6-7-15(18)24-14/h3-7H,2,8-11H2,1H3,(H,20,23)
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n/an/a 1.10E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32463
PNG
(piperazine amide, 4j)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H21BrClN3O2/c23-20-10-9-19(29-20)22(28)25-18-8-4-7-17(24)21(18)27-13-11-26(12-14-27)15-16-5-2-1-3-6-16/h1-10H,11-15H2,(H,25,28)
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n/an/a 1.10E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32454
PNG
(piperazine amide, 4b)
Show SMILES CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C16H17BrClN3O2/c1-20-7-9-21(10-8-20)15-11(18)3-2-4-12(15)19-16(22)13-5-6-14(17)23-13/h2-6H,7-10H2,1H3,(H,19,22)
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n/an/a 1.20E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32465
PNG
(piperazine amide, 4l)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H18BrClN4O2/c21-17-8-7-16(28-17)20(27)24-15-5-3-4-14(22)19(15)26-12-10-25(11-13-26)18-6-1-2-9-23-18/h1-9H,10-13H2,(H,24,27)
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n/an/a 1.20E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32458
PNG
(piperazine amide, 4e | piperazine amide, 6a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24)
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n/an/a 1.26E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32464
PNG
(piperazine amide, 4k)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H23BrClN3O2/c24-21-10-9-20(30-21)23(29)26-19-8-4-7-18(25)22(19)28-15-13-27(14-16-28)12-11-17-5-2-1-3-6-17/h1-10H,11-16H2,(H,26,29)
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n/an/a 1.40E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32493
PNG
(aryl piperidine, 9i)
Show SMILES CCc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C21H26N2O4/c1-3-16-7-8-18(27-16)20(24)22-17-6-4-5-15(2)19(17)23-11-9-21(10-12-23)25-13-14-26-21/h4-8H,3,9-14H2,1-2H3,(H,22,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32457
PNG
(piperazine amide, 4d)
Show SMILES CC(C)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C18H21BrClN3O2/c1-12(2)22-8-10-23(11-9-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7,12H,8-11H2,1-2H3,(H,21,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32477
PNG
(piperazine amide, 6c)
Show SMILES Clc1cccc(NC(=O)c2nc(Br)cs2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)20-16(24)17-21-14(18)11-25-17/h2-5,11H,1,6-10H2,(H,20,24)
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n/an/a 1.80E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32483
PNG
(piperazine amide, 6j)
Show SMILES Cc1cccc(n1)C(=O)Nc1cccc(Cl)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C20H23ClN4O/c1-3-10-24-11-13-25(14-12-24)19-16(21)7-5-8-17(19)23-20(26)18-9-4-6-15(2)22-18/h3-9H,1,10-14H2,2H3,(H,23,26)
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32477
PNG
(piperazine amide, 6c)
Show SMILES Clc1cccc(NC(=O)c2nc(Br)cs2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)20-16(24)17-21-14(18)11-25-17/h2-5,11H,1,6-10H2,(H,20,24)
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n/an/a 1.80E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32482
PNG
(piperazine amide, 6i)
Show SMILES Clc1cccc(NC(=O)c2cccc(Br)n2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H20BrClN4O/c1-2-9-24-10-12-25(13-11-24)18-14(21)5-3-6-15(18)23-19(26)16-7-4-8-17(20)22-16/h2-8H,1,9-13H2,(H,23,26)
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n/an/a 2.00E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32483
PNG
(piperazine amide, 6j)
Show SMILES Cc1cccc(n1)C(=O)Nc1cccc(Cl)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C20H23ClN4O/c1-3-10-24-11-13-25(14-12-24)19-16(21)7-5-8-17(19)23-20(26)18-9-4-6-15(2)22-18/h3-9H,1,10-14H2,2H3,(H,23,26)
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n/an/a 2.00E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32457
PNG
(piperazine amide, 4d)
Show SMILES CC(C)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C18H21BrClN3O2/c1-12(2)22-8-10-23(11-9-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7,12H,8-11H2,1-2H3,(H,21,24)
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n/an/a 2.20E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32478
PNG
(piperazine amide, 6d)
Show SMILES Clc1cccc(NC(=O)c2cscn2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H19ClN4OS/c1-2-6-21-7-9-22(10-8-21)16-13(18)4-3-5-14(16)20-17(23)15-11-24-12-19-15/h2-5,11-12H,1,6-10H2,(H,20,23)
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n/an/a 2.30E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32495
PNG
(aryl piperidine, 9k)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cc3ccccc3)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C26H28N2O4/c1-19-6-5-9-22(24(19)28-14-12-26(13-15-28)30-16-17-31-26)27-25(29)23-11-10-21(32-23)18-20-7-3-2-4-8-20/h2-11H,12-18H2,1H3,(H,27,29)
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n/an/a 3.20E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32453
PNG
(piperazine amide, 4a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCNCC1
Show InChI InChI=1S/C15H15BrClN3O2/c16-13-5-4-12(22-13)15(21)19-11-3-1-2-10(17)14(11)20-8-6-18-7-9-20/h1-5,18H,6-9H2,(H,19,21)
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n/an/a 4.10E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32480
PNG
(piperazine amide, 6g)
Show SMILES Clc1cccc(NC(=O)c2ccc[nH]2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H21ClN4O/c1-2-9-22-10-12-23(13-11-22)17-14(19)5-3-6-15(17)21-18(24)16-7-4-8-20-16/h2-8,20H,1,9-13H2,(H,21,24)
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n/an/a 4.50E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32495
PNG
(aryl piperidine, 9k)
Show SMILES Cc1cccc(NC(=O)c2ccc(Cc3ccccc3)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C26H28N2O4/c1-19-6-5-9-22(24(19)28-14-12-26(13-15-28)30-16-17-31-26)27-25(29)23-11-10-21(32-23)18-20-7-3-2-4-8-20/h2-11H,12-18H2,1H3,(H,27,29)
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n/an/a 4.80E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32479
PNG
(piperazine amide, 6f)
Show SMILES Clc1cccc(NC(=O)c2ccno2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H19ClN4O2/c1-2-8-21-9-11-22(12-10-21)16-13(18)4-3-5-14(16)20-17(23)15-6-7-19-24-15/h2-7H,1,8-12H2,(H,20,23)
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n/an/a 5.00E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32497
PNG
(aryl piperidine, 9m)
Show SMILES CC(=O)Nc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C21H25N3O5/c1-14-4-3-5-16(23-20(26)17-6-7-18(29-17)22-15(2)25)19(14)24-10-8-21(9-11-24)27-12-13-28-21/h3-7H,8-13H2,1-2H3,(H,22,25)(H,23,26)
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n/an/a 5.80E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32481
PNG
(piperazine amide, 6h)
Show SMILES Cc1nc(cs1)C(=O)Nc1cccc(Cl)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H21ClN4OS/c1-3-7-22-8-10-23(11-9-22)17-14(19)5-4-6-15(17)21-18(24)16-12-25-13(2)20-16/h3-6,12H,1,7-11H2,2H3,(H,21,24)
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n/an/a 5.80E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32468
PNG
(piperazine amide, 4o)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C20H23BrClN3O4/c1-20(2,3)29-19(27)25-11-9-24(10-12-25)17-13(22)5-4-6-14(17)23-18(26)15-7-8-16(21)28-15/h4-8H,9-12H2,1-3H3,(H,23,26)
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n/an/a 6.30E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32484
PNG
(piperazine amide, 6k)
Show SMILES Clc1cccc(NC(=O)c2cccc(Br)c2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C20H21BrClN3O/c1-2-9-24-10-12-25(13-11-24)19-17(22)7-4-8-18(19)23-20(26)15-5-3-6-16(21)14-15/h2-8,14H,1,9-13H2,(H,23,26)
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n/an/a 6.40E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32484
PNG
(piperazine amide, 6k)
Show SMILES Clc1cccc(NC(=O)c2cccc(Br)c2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C20H21BrClN3O/c1-2-9-24-10-12-25(13-11-24)19-17(22)7-4-8-18(19)23-20(26)15-5-3-6-16(21)14-15/h2-8,14H,1,9-13H2,(H,23,26)
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n/an/a 7.10E+3n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32480
PNG
(piperazine amide, 6g)
Show SMILES Clc1cccc(NC(=O)c2ccc[nH]2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H21ClN4O/c1-2-9-22-10-12-23(13-11-22)17-14(19)5-3-6-15(17)21-18(24)16-7-4-8-20-16/h2-8,20H,1,9-13H2,(H,21,24)
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n/an/a 8.90E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32453
PNG
(piperazine amide, 4a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCNCC1
Show InChI InChI=1S/C15H15BrClN3O2/c16-13-5-4-12(22-13)15(21)19-11-3-1-2-10(17)14(11)20-8-6-18-7-9-20/h1-5,18H,6-9H2,(H,19,21)
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n/an/a 9.90E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32497
PNG
(aryl piperidine, 9m)
Show SMILES CC(=O)Nc1ccc(o1)C(=O)Nc1cccc(C)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C21H25N3O5/c1-14-4-3-5-16(23-20(26)17-6-7-18(29-17)22-15(2)25)19(14)24-10-8-21(9-11-24)27-12-13-28-21/h3-7H,8-13H2,1-2H3,(H,22,25)(H,23,26)
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n/an/a 1.10E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32485
PNG
(piperazine amide, 6l)
Show SMILES Clc1cccc(NC(=O)c2ncccn2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-2-9-23-10-12-24(13-11-23)16-14(19)5-3-6-15(16)22-18(25)17-20-7-4-8-21-17/h2-8H,1,9-13H2,(H,22,25)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32472
PNG
(piperazine amide, 4s)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H19BrF3N3O2/c1-2-8-25-9-11-26(12-10-25)17-13(19(21,22)23)4-3-5-14(17)24-18(27)15-6-7-16(20)28-15/h2-7H,1,8-12H2,(H,24,27)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32467
PNG
(piperazine amide, 4n)
Show SMILES FC(F)(F)C(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H14BrClF3N3O3/c18-13-5-4-12(28-13)15(26)23-11-3-1-2-10(19)14(11)24-6-8-25(9-7-24)16(27)17(20,21)22/h1-5H,6-9H2,(H,23,26)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32498
PNG
(aryl piperidine, 9n)
Show SMILES Cc1cccc(NC(=O)c2ccc(Nc3ccccc3)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C25H27N3O4/c1-18-6-5-9-20(23(18)28-14-12-25(13-15-28)30-16-17-31-25)27-24(29)21-10-11-22(32-21)26-19-7-3-2-4-8-19/h2-11,26H,12-17H2,1H3,(H,27,29)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32473
PNG
(piperazine amide, 4t)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(-c2ccccc2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C24H24BrN3O2/c1-2-13-27-14-16-28(17-15-27)23-19(18-7-4-3-5-8-18)9-6-10-20(23)26-24(29)21-11-12-22(25)30-21/h2-12H,1,13-17H2,(H,26,29)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32472
PNG
(piperazine amide, 4s)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H19BrF3N3O2/c1-2-8-25-9-11-26(12-10-25)17-13(19(21,22)23)4-3-5-14(17)24-18(27)15-6-7-16(20)28-15/h2-7H,1,8-12H2,(H,24,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32474
PNG
(piperazine amide, 4u)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C24H25BrN4O2/c1-2-13-28-14-16-29(17-15-28)23-19(26-18-7-4-3-5-8-18)9-6-10-20(23)27-24(30)21-11-12-22(25)31-21/h2-12,26H,1,13-17H2,(H,27,30)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32486
PNG
(piperazine amide, 6m)
Show SMILES Clc1cccc(NC(=O)c2ccc(cn2)C#N)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C20H20ClN5O/c1-2-8-25-9-11-26(12-10-25)19-16(21)4-3-5-17(19)24-20(27)18-7-6-15(13-22)14-23-18/h2-7,14H,1,8-12H2,(H,24,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32474
PNG
(piperazine amide, 4u)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C24H25BrN4O2/c1-2-13-28-14-16-29(17-15-28)23-19(26-18-7-4-3-5-8-18)9-6-10-20(23)27-24(30)21-11-12-22(25)31-21/h2-12,26H,1,13-17H2,(H,27,30)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32471
PNG
(piperazine amide, 4r)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Br)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19Br2N3O2/c1-2-8-22-9-11-23(12-10-22)17-13(19)4-3-5-14(17)21-18(24)15-6-7-16(20)25-15/h2-7H,1,8-12H2,(H,21,24)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32486
PNG
(piperazine amide, 6m)
Show SMILES Clc1cccc(NC(=O)c2ccc(cn2)C#N)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C20H20ClN5O/c1-2-8-25-9-11-26(12-10-25)19-16(21)4-3-5-17(19)24-20(27)18-7-6-15(13-22)14-23-18/h2-7,14H,1,8-12H2,(H,24,27)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32498
PNG
(aryl piperidine, 9n)
Show SMILES Cc1cccc(NC(=O)c2ccc(Nc3ccccc3)o2)c1N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C25H27N3O4/c1-18-6-5-9-20(23(18)28-14-12-25(13-15-28)30-16-17-31-25)27-24(29)21-10-11-22(32-21)26-19-7-3-2-4-8-19/h2-11,26H,12-17H2,1H3,(H,27,29)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM32467
PNG
(piperazine amide, 4n)
Show SMILES FC(F)(F)C(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H14BrClF3N3O3/c18-13-5-4-12(28-13)15(26)23-11-3-1-2-10(19)14(11)24-6-8-25(9-7-24)16(27)17(20,21)22/h1-5H,6-9H2,(H,23,26)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32473
PNG
(piperazine amide, 4t)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(-c2ccccc2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C24H24BrN3O2/c1-2-13-27-14-16-28(17-15-27)23-19(18-7-4-3-5-8-18)9-6-10-20(23)26-24(29)21-11-12-22(25)30-21/h2-12H,1,13-17H2,(H,26,29)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32471
PNG
(piperazine amide, 4r)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Br)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19Br2N3O2/c1-2-8-22-9-11-23(12-10-22)17-13(19)4-3-5-14(17)21-18(24)15-6-7-16(20)25-15/h2-7H,1,8-12H2,(H,21,24)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32468
PNG
(piperazine amide, 4o)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C20H23BrClN3O4/c1-20(2,3)29-19(27)25-11-9-24(10-12-25)17-13(22)5-4-6-14(17)23-18(26)15-7-8-16(21)28-15/h4-8H,9-12H2,1-3H3,(H,23,26)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Isoform Alpha-1 of Mitogen-activated protein kinase 10 (Alpha-1) 9-402]


(Homo sapiens (Human))		BDBM32485
PNG
(piperazine amide, 6l)
Show SMILES Clc1cccc(NC(=O)c2ncccn2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-2-9-23-10-12-24(13-11-23)16-14(19)5-3-6-15(16)22-18(25)17-20-7-4-8-21-17/h2-8H,1,9-13H2,(H,22,25)
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n/an/a>2.00E+4n/an/an/an/an/an/a



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...

Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%