Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346031 (6-{4-Cyano-3-[(R)-2-hydroxy-3-(2-indan-2-yl-1,1-di...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346032 (6-[2-((R)-1-{(R)-3-[2-(3-Chloro-4-methyl-phenyl)-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50161093 ((R)-2-chloro-6-(2-hydroxy-3-(2-methyl-1-(naphthale...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346033 (6-(4-Cyano-3-{(R)-3-[2-(3-fluoro-4-methyl-phenyl)-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50318873 ((1S,2S,3R,4R,5S)-6-{2-[(1R)-1-[(2R)-3-{[1-(3-fluor...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346034 (6-[2-((R)-1-{(R)-3-[2-(4-Chloro-2-fluoro-phenyl)-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346035 (6-{3,4-Difluoro-5-[(R)-2-hydroxy-3-(2-indan-2-yl-1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346036 (CHEMBL1198855 | Ronacaleret) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346037 (6-(4-Fluoro-3-{(R)-3-[2-(3-fluoro-4-methyl-phenyl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Rattus norvegicus) | BDBM50346036 (CHEMBL1198855 | Ronacaleret) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at rat calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346038 (6-(4-Cyano-3-{(R)-3-[1,1-dimethyl-2-(1-oxo-1,3-dih...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346039 (6-{3-[(R)-2-Hydroxy-3-(2-indan-2-yl-1,1-dimethyl-e...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346041 (6-(2-{(R)-1-[(R)-2-Hydroxy-3-(2-indan-2-yl-1,1-dim...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Extracellular calcium-sensing receptor (Homo sapiens (Human)) | BDBM50346040 (6-(3-{(R)-3-[2-(3-Fluoro-4-methyl-phenyl)-1,1-dime...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Negative allosteric modulator activity at human recombinant calcium sensing receptor expressed in HEK cells | Bioorg Med Chem Lett 19: 3328-32 (2009) Article DOI: 10.1016/j.bmcl.2009.04.044 BindingDB Entry DOI: 10.7270/Q2K937V7 | |||||||||||
More data for this Ligand-Target Pair |