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PubMed code 19447612

Compile data set for download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258344
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(pyrrolidi...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C27H27N5O/c1-19-23-10-11-30-26(23)9-8-25(19)31-27-21(16-28)17-29-18-24(27)20-4-6-22(7-5-20)33-15-14-32-12-2-3-13-32/h4-11,17-18,30H,2-3,12-15H2,1H3,(H,29,31)
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n/an/a 4.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258795
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-fluoro-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C22H17FN4O2/c1-28-19-6-3-13(9-20(19)29-2)16-12-25-11-14(10-24)22(16)27-18-5-4-17-15(21(18)23)7-8-26-17/h3-9,11-12,26H,1-2H3,(H,25,27)
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n/an/a 5.30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258798
PNG
(5-(4-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino...)
Show SMILES COc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C22H18N4O/c1-14-18-9-10-25-21(18)8-7-20(14)26-22-16(11-23)12-24-13-19(22)15-3-5-17(27-2)6-4-15/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 5.60n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258388
PNG
(5-(4-(2-(2-(dimethylamino)ethylamino)ethoxy)phenyl...)
Show SMILES CN(C)CCNCCOc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C27H30N6O/c1-19-23-10-11-31-26(23)9-8-25(19)32-27-21(16-28)17-30-18-24(27)20-4-6-22(7-5-20)34-15-13-29-12-14-33(2)3/h4-11,17-18,29,31H,12-15H2,1-3H3,(H,30,32)
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n/an/a 5.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258384
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-methyl-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C23H20N4O2/c1-14-17-8-9-26-20(17)6-5-19(14)27-23-16(11-24)12-25-13-18(23)15-4-7-21(28-2)22(10-15)29-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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n/an/a 6.30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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n/an/a 7.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258346
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-(pyrrol...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCC(CC3)N3CCCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C32H36N6O/c1-23-28-10-13-35-31(28)9-8-30(23)36-32-25(20-33)21-34-22-29(32)24-4-6-27(7-5-24)39-19-18-37-16-11-26(12-17-37)38-14-2-3-15-38/h4-10,13,21-22,26,35H,2-3,11-12,14-19H2,1H3,(H,34,36)
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n/an/a 11n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258387
PNG
(5-(3,4-dimethoxyphenyl)-4-(6-methyl-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cc2cc[nH]c2cc1C
Show InChI InChI=1S/C23H20N4O2/c1-14-8-20-16(6-7-26-20)9-19(14)27-23-17(11-24)12-25-13-18(23)15-4-5-21(28-2)22(10-15)29-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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n/an/a 11n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258794
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-methoxy-1H-indol-5-yl...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1OC
Show InChI InChI=1S/C23H20N4O3/c1-28-20-7-4-14(10-21(20)29-2)17-13-25-12-15(11-24)22(17)27-19-6-5-18-16(8-9-26-18)23(19)30-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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n/an/a 11n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM29816
PNG
(4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 1c...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12
Show InChI InChI=1S/C22H18N4O2/c1-27-20-7-6-14(10-21(20)28-2)17-13-24-12-15(11-23)22(17)26-19-5-3-4-18-16(19)8-9-25-18/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 13n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258390
PNG
(4-(1H-indol-4-ylamino)-5-(4-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2cccc3[nH]ccc23)CC1
Show InChI InChI=1S/C27H28N6O/c1-32-11-13-33(14-12-32)15-16-34-22-7-5-20(6-8-22)24-19-29-18-21(17-28)27(24)31-26-4-2-3-25-23(26)9-10-30-25/h2-10,18-19,30H,11-16H2,1H3,(H,29,31)
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n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258345
PNG
(5-(4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)p...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCN(CCO)CC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C29H32N6O2/c1-21-25-8-9-32-28(25)7-6-27(21)33-29-23(18-30)19-31-20-26(29)22-2-4-24(5-3-22)37-17-15-35-12-10-34(11-13-35)14-16-36/h2-9,19-20,32,36H,10-17H2,1H3,(H,31,33)
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n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258388
PNG
(5-(4-(2-(2-(dimethylamino)ethylamino)ethoxy)phenyl...)
Show SMILES CN(C)CCNCCOc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C27H30N6O/c1-19-23-10-11-31-26(23)9-8-25(19)32-27-21(16-28)17-30-18-24(27)20-4-6-22(7-5-20)34-15-13-29-12-14-33(2)3/h4-11,17-18,29,31H,12-15H2,1-3H3,(H,30,32)
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n/an/a 18n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258389
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C29H32N6O/c1-21-25-10-11-32-28(25)9-8-27(21)33-29-23(18-30)19-31-20-26(29)22-4-6-24(7-5-22)36-17-3-12-35-15-13-34(2)14-16-35/h4-11,19-20,32H,3,12-17H2,1-2H3,(H,31,33)
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n/an/a 19n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258821
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-morpholino...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCOCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C27H27N5O2/c1-19-23-8-9-30-26(23)7-6-25(19)31-27-21(16-28)17-29-18-24(27)20-2-4-22(5-3-20)34-15-12-32-10-13-33-14-11-32/h2-9,17-18,30H,10-15H2,1H3,(H,29,31)
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n/an/a 20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258797
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-phenylnicotinoni...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccccc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C21H16N4/c1-14-17-9-10-24-20(17)8-7-19(14)25-21-16(11-22)12-23-13-18(21)15-5-3-2-4-6-15/h2-10,12-13,24H,1H3,(H,23,25)
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n/an/a 27n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258344
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(pyrrolidi...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C27H27N5O/c1-19-23-10-11-30-26(23)9-8-25(19)31-27-21(16-28)17-29-18-24(27)20-4-6-22(7-5-20)33-15-14-32-12-2-3-13-32/h4-11,17-18,30H,2-3,12-15H2,1H3,(H,29,31)
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n/an/a 28n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258345
PNG
(5-(4-(2-(4-(2-hydroxyethyl)piperazin-1-yl)ethoxy)p...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCN(CCO)CC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C29H32N6O2/c1-21-25-8-9-32-28(25)7-6-27(21)33-29-23(18-30)19-31-20-26(29)22-2-4-24(5-3-22)37-17-15-35-12-10-34(11-13-35)14-16-36/h2-9,19-20,32,36H,10-17H2,1H3,(H,31,33)
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n/an/a 29n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258346
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-(pyrrol...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCC(CC3)N3CCCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C32H36N6O/c1-23-28-10-13-35-31(28)9-8-30(23)36-32-25(20-33)21-34-22-29(32)24-4-6-27(7-5-24)39-19-18-37-16-11-26(12-17-37)38-14-2-3-15-38/h4-10,13,21-22,26,35H,2-3,11-12,14-19H2,1H3,(H,34,36)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258823
PNG
(4-(6-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2cc3cc[nH]c3cc2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-15-27-22(7-8-31-27)16-26(20)32-28-23(17-29)18-30-19-25(28)21-3-5-24(6-4-21)35-14-13-34-11-9-33(2)10-12-34/h3-8,15-16,18-19,31H,9-14H2,1-2H3,(H,30,32)
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n/an/a 33n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258819
PNG
(5-(3-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino...)
Show SMILES COc1cccc(c1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C22H18N4O/c1-14-18-8-9-25-21(18)7-6-20(14)26-22-16(11-23)12-24-13-19(22)15-4-3-5-17(10-15)27-2/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 36n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258390
PNG
(4-(1H-indol-4-ylamino)-5-(4-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2cccc3[nH]ccc23)CC1
Show InChI InChI=1S/C27H28N6O/c1-32-11-13-33(14-12-32)15-16-34-22-7-5-20(6-8-22)24-19-29-18-21(17-28)27(24)31-26-4-2-3-25-23(26)9-10-30-25/h2-10,18-19,30H,11-16H2,1H3,(H,29,31)
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n/an/a 41n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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n/an/a 51n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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n/an/a 54n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCepsilon by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258385
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-ethyl-1H-indol-5-ylam...)
Show SMILES CCc1c(Nc2c(cncc2-c2ccc(OC)c(OC)c2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H22N4O2/c1-4-17-18-9-10-27-20(18)6-7-21(17)28-24-16(12-25)13-26-14-19(24)15-5-8-22(29-2)23(11-15)30-3/h5-11,13-14,27H,4H2,1-3H3,(H,26,28)
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n/an/a 55n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM29816
PNG
(4-indolylamino-5-phenyl-3-pyridinecarbonitrile, 1c...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2[nH]ccc12
Show InChI InChI=1S/C22H18N4O2/c1-27-20-7-6-14(10-21(20)28-2)17-13-24-12-15(11-23)22(17)26-19-5-3-4-18-16(19)8-9-25-18/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 62n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258797
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-phenylnicotinoni...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccccc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C21H16N4/c1-14-17-9-10-24-20(17)8-7-19(14)25-21-16(11-22)12-23-13-18(21)15-5-3-2-4-6-15/h2-10,12-13,24H,1H3,(H,23,25)
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n/an/a 63n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258795
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-fluoro-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1F
Show InChI InChI=1S/C22H17FN4O2/c1-28-19-6-3-13(9-20(19)29-2)16-12-25-11-14(10-24)22(16)27-18-5-4-17-15(21(18)23)7-8-26-17/h3-9,11-12,26H,1-2H3,(H,25,27)
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n/an/a 69n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM25558
PNG
(4-arylamino-3-pyridinecarbonitrile, 4p | 5-(3,4-di...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H18N4O2/c1-27-20-6-3-14(10-21(20)28-2)18-13-24-12-16(11-23)22(18)26-17-4-5-19-15(9-17)7-8-25-19/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258391
PNG
(4-(1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C27H28N6O/c1-32-10-12-33(13-11-32)14-15-34-24-5-2-20(3-6-24)25-19-29-18-22(17-28)27(25)31-23-4-7-26-21(16-23)8-9-30-26/h2-9,16,18-19,30H,10-15H2,1H3,(H,29,31)
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n/an/a 73n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258384
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-methyl-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C23H20N4O2/c1-14-17-8-9-26-20(17)6-5-19(14)27-23-16(11-24)12-25-13-18(23)15-4-7-21(28-2)22(10-15)29-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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n/an/a 81n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258820
PNG
(5-(2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino...)
Show SMILES COc1ccccc1-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C22H18N4O/c1-14-16-9-10-25-20(16)8-7-19(14)26-22-15(11-23)12-24-13-18(22)17-5-3-4-6-21(17)27-2/h3-10,12-13,25H,1-2H3,(H,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258798
PNG
(5-(4-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino...)
Show SMILES COc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C22H18N4O/c1-14-18-9-10-25-21(18)8-7-20(14)26-22-16(11-23)12-24-13-19(22)15-3-5-17(27-2)6-4-15/h3-10,12-13,25H,1-2H3,(H,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258389
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(3-(piperazin...)
Show SMILES CN1CCN(CCCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C29H32N6O/c1-21-25-10-11-32-28(25)9-8-27(21)33-29-23(18-30)19-31-20-26(29)22-4-6-24(7-5-22)36-17-3-12-35-15-13-34(2)14-16-35/h4-11,19-20,32H,3,12-17H2,1-2H3,(H,31,33)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258386
PNG
(5-(3,4-dimethoxyphenyl)-4-(7-methyl-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cc(C)c2[nH]ccc2c1
Show InChI InChI=1S/C23H20N4O2/c1-14-8-18(9-16-6-7-26-22(14)16)27-23-17(11-24)12-25-13-19(23)15-4-5-20(28-2)21(10-15)29-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258823
PNG
(4-(6-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2cc3cc[nH]c3cc2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-15-27-22(7-8-31-27)16-26(20)32-28-23(17-29)18-30-19-25(28)21-3-5-24(6-4-21)35-14-13-34-11-9-33(2)10-12-34/h3-8,15-16,18-19,31H,9-14H2,1-2H3,(H,30,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258821
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-morpholino...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(OCCN3CCOCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C27H27N5O2/c1-19-23-8-9-30-26(23)7-6-25(19)31-27-21(16-28)17-29-18-24(27)20-2-4-22(5-3-20)34-15-12-32-10-13-33-14-11-32/h2-9,17-18,30H,10-15H2,1H3,(H,29,31)
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n/an/a 150n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258391
PNG
(4-(1H-indol-5-ylamino)-5-(4-(2-(4-methylpiperazin-...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2)CC1
Show InChI InChI=1S/C27H28N6O/c1-32-10-12-33(13-11-32)14-15-34-24-5-2-20(3-6-24)25-19-29-18-22(17-28)27(25)31-23-4-7-26-21(16-23)8-9-30-26/h2-9,16,18-19,30H,10-15H2,1H3,(H,29,31)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258819
PNG
(5-(3-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino...)
Show SMILES COc1cccc(c1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C22H18N4O/c1-14-18-8-9-25-21(18)7-6-20(14)26-22-16(11-23)12-24-13-19(22)15-4-3-5-17(10-15)27-2/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 210n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258796
PNG
(5-(3,4-dimethoxyphenyl)-4-(1,4-dimethyl-1H-indol-5...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2n(C)ccc2c1C
Show InChI InChI=1S/C24H22N4O2/c1-15-18-9-10-28(2)21(18)7-6-20(15)27-24-17(12-25)13-26-14-19(24)16-5-8-22(29-3)23(11-16)30-4/h5-11,13-14H,1-4H3,(H,26,27)
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n/an/a 260n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258341
PNG
(4-((1H-indol-5-yl)(methyl)amino)-5-(3,4-dimethoxyp...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1N(C)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C23H20N4O2/c1-27(18-5-6-20-16(10-18)8-9-26-20)23-17(12-24)13-25-14-19(23)15-4-7-21(28-2)22(11-15)29-3/h4-11,13-14,26H,1-3H3
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n/an/a 270n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258387
PNG
(5-(3,4-dimethoxyphenyl)-4-(6-methyl-1H-indol-5-yla...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cc2cc[nH]c2cc1C
Show InChI InChI=1S/C23H20N4O2/c1-14-8-20-16(6-7-26-20)9-19(14)27-23-17(11-24)12-25-13-18(23)15-4-5-21(28-2)22(10-15)29-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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n/an/a 280n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258820
PNG
(5-(2-methoxyphenyl)-4-(4-methyl-1H-indol-5-ylamino...)
Show SMILES COc1ccccc1-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C22H18N4O/c1-14-16-9-10-25-20(16)8-7-19(14)26-22-15(11-23)12-24-13-18(22)17-5-3-4-6-21(17)27-2/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 340n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258794
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-methoxy-1H-indol-5-yl...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1OC
Show InChI InChI=1S/C23H20N4O3/c1-28-20-7-4-14(10-21(20)29-2)17-13-25-12-15(11-24)22(17)27-19-6-5-18-16(8-9-26-18)23(19)30-3/h4-10,12-13,26H,1-3H3,(H,25,27)
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n/an/a 350n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM25558
PNG
(4-arylamino-3-pyridinecarbonitrile, 4p | 5-(3,4-di...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H18N4O2/c1-27-20-6-3-14(10-21(20)28-2)18-13-24-12-16(11-23)22(18)26-17-4-5-19-15(9-17)7-8-25-19/h3-10,12-13,25H,1-2H3,(H,24,26)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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n/an/a 450n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCeta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258793
PNG
(4-(1H-indol-7-ylamino)-5-(3,4-dimethoxyphenyl)nico...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1cccc2cc[nH]c12
Show InChI InChI=1S/C22H18N4O2/c1-27-19-7-6-15(10-20(19)28-2)17-13-24-12-16(11-23)21(17)26-18-5-3-4-14-8-9-25-22(14)18/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 740n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258385
PNG
(5-(3,4-dimethoxyphenyl)-4-(4-ethyl-1H-indol-5-ylam...)
Show SMILES CCc1c(Nc2c(cncc2-c2ccc(OC)c(OC)c2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H22N4O2/c1-4-17-18-9-10-27-20(18)6-7-21(17)28-24-16(12-25)13-26-14-19(24)15-5-8-22(29-2)23(11-15)30-3/h5-11,13-14,27H,4H2,1-3H3,(H,26,28)
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n/an/a 980n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258796
PNG
(5-(3,4-dimethoxyphenyl)-4-(1,4-dimethyl-1H-indol-5...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2n(C)ccc2c1C
Show InChI InChI=1S/C24H22N4O2/c1-15-18-9-10-28(2)21(18)7-6-20(15)27-24-17(12-25)13-26-14-19(24)16-5-8-22(29-3)23(11-16)30-4/h5-11,13-14H,1-4H3,(H,26,27)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258342
PNG
(4-(1H-indol-5-yloxy)-5-(3,4-dimethoxyphenyl)nicoti...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Oc1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H17N3O3/c1-26-20-6-3-14(10-21(20)27-2)18-13-24-12-16(11-23)22(18)28-17-4-5-19-15(9-17)7-8-25-19/h3-10,12-13,25H,1-2H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50258343
PNG
(5-(3,4-dimethoxyphenyl)-4-(1H-indol-5-yl)nicotinon...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C22H17N3O2/c1-26-20-6-4-14(10-21(20)27-2)18-13-24-12-17(11-23)22(18)16-3-5-19-15(9-16)7-8-25-19/h3-10,12-13,25H,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50258341
PNG
(4-((1H-indol-5-yl)(methyl)amino)-5-(3,4-dimethoxyp...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1N(C)c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C23H20N4O2/c1-27(18-5-6-20-16(10-18)8-9-26-20)23-17(12-24)13-25-14-19(23)15-4-7-21(28-2)22(11-15)29-3/h4-11,13-14,26H,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM25559
PNG
(4-arylamino-3-pyridinecarbonitrile, 4q | 5-(3,4-di...)
Show SMILES COc1ccc(cc1OC)-c1cncc(C#N)c1Nc1ccc2cc[nH]c2c1
Show InChI InChI=1S/C22H18N4O2/c1-27-20-6-4-15(9-21(20)28-2)18-13-24-12-16(11-23)22(18)26-17-5-3-14-7-8-25-19(14)10-17/h3-10,12-13,25H,1-2H3,(H,24,26)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of MK2


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of ROCK1


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCbeta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50258822
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(2-(4-methylp...)
Show SMILES CN1CCN(CCOc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C28H30N6O/c1-20-24-9-10-31-27(24)8-7-26(20)32-28-22(17-29)18-30-19-25(28)21-3-5-23(6-4-21)35-16-15-34-13-11-33(2)12-14-34/h3-10,18-19,31H,11-16H2,1-2H3,(H,30,32)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCzeta by IMAP assay


Bioorg Med Chem Lett 19: 3623-6 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.126
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%