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PubMed code 19524438

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414505
PNG
(CHEMBL552399)
Show SMILES CCCC(C)Nc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C9H15N3O2/c1-3-4-6(2)10-8-5-7(9(13)14)11-12-8/h5-6H,3-4H2,1-2H3,(H,13,14)(H2,10,11,12)
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n/an/an/an/a 6.76E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414507
PNG
(CHEMBL551191)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccoc1)Cc1ccsc1
Show InChI InChI=1S/C14H13N3O3S/c18-14(19)12-5-13(16-15-12)17(6-10-1-3-20-8-10)7-11-2-4-21-9-11/h1-5,8-9H,6-7H2,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414500
PNG
(CHEMBL557298)
Show SMILES OC(=O)c1cc([nH]n1)N(CCc1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C20H21N3O2/c24-20(25)18-15-19(22-21-18)23(13-11-16-7-3-1-4-8-16)14-12-17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,21,22)(H,24,25)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414503
PNG
(CHEMBL553912)
Show SMILES CCCCCCN(CCCCCC)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C16H29N3O2/c1-3-5-7-9-11-19(12-10-8-6-4-2)15-13-14(16(20)21)17-18-15/h13H,3-12H2,1-2H3,(H,17,18)(H,20,21)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM23515
PNG
(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Show SMILES OC(=O)c1cccnc1
Show InChI InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
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n/an/an/an/a 27n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414504
PNG
(CHEMBL560254)
Show SMILES CCCN(CCC)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C10H17N3O2/c1-3-5-13(6-4-2)9-7-8(10(14)15)11-12-9/h7H,3-6H2,1-2H3,(H,11,12)(H,14,15)
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n/an/an/an/a 8.32E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414509
PNG
(CHEMBL552114)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccc(Br)s1)Cc1ccc(Br)s1
Show InChI InChI=1S/C14H11Br2N3O2S2/c15-11-3-1-8(22-11)6-19(7-9-2-4-12(16)23-9)13-5-10(14(20)21)17-18-13/h1-5H,6-7H2,(H,17,18)(H,20,21)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414499
PNG
(CHEMBL561920)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c22-18(23)16-11-17(20-19-16)21(12-14-7-3-1-4-8-14)13-15-9-5-2-6-10-15/h1-11H,12-13H2,(H,19,20)(H,22,23)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414504
PNG
(CHEMBL560254)
Show SMILES CCCN(CCC)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C10H17N3O2/c1-3-5-13(6-4-2)9-7-8(10(14)15)11-12-9/h7H,3-6H2,1-2H3,(H,11,12)(H,14,15)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414500
PNG
(CHEMBL557298)
Show SMILES OC(=O)c1cc([nH]n1)N(CCc1ccccc1)CCc1ccccc1
Show InChI InChI=1S/C20H21N3O2/c24-20(25)18-15-19(22-21-18)23(13-11-16-7-3-1-4-8-16)14-12-17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,21,22)(H,24,25)
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n/an/an/an/a 5.62E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414498
PNG
(CHEMBL550563)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccccc1F)Cc1ccccc1F
Show InChI InChI=1S/C18H15F2N3O2/c19-14-7-3-1-5-12(14)10-23(11-13-6-2-4-8-15(13)20)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a 8.71E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414496
PNG
(CHEMBL564907)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccc(F)cc1)Cc1ccc(F)cc1
Show InChI InChI=1S/C18H15F2N3O2/c19-14-5-1-12(2-6-14)10-23(11-13-3-7-15(20)8-4-13)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1 |c:3|
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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n/an/an/an/a 1.30E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at N-terminal HA-tagged GPR109a receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414494
PNG
(CHEMBL564300)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccsc1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-5-13(16-15-12)17(6-10-1-3-20-8-10)7-11-2-4-21-9-11/h1-5,8-9H,6-7H2,(H,15,16)(H,18,19)
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n/an/an/an/a 9.12E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50208138
PNG
((+)-acifran | (-)-acifran | 5-Methyl-4-oxo-5-pheny...)
Show SMILES CC1(OC(=CC1=O)C(O)=O)c1ccccc1 |c:3|
Show InChI InChI=1S/C12H10O4/c1-12(8-5-3-2-4-6-8)10(13)7-9(16-12)11(14)15/h2-7H,1H3,(H,14,15)
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n/an/an/an/a 4.20E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at N-terminal HA-tagged GPR109b receptor transfected in forskolin-stimulated cells assessed as cAMP accumulation by flashplate assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414497
PNG
(CHEMBL564064)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1cccc(F)c1)Cc1cccc(F)c1
Show InChI InChI=1S/C18H15F2N3O2/c19-14-5-1-3-12(7-14)10-23(11-13-4-2-6-15(20)8-13)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414490
PNG
(CHEMBL550153)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccco1
Show InChI InChI=1S/C14H13N3O3S/c18-14(19)12-6-13(16-15-12)17(7-10-3-5-21-9-10)8-11-2-1-4-20-11/h1-6,9H,7-8H2,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414491
PNG
(CHEMBL559204)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-6-13(16-15-12)17(7-10-3-5-20-9-10)8-11-2-1-4-21-11/h1-6,9H,7-8H2,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414508
PNG
(CHEMBL560853)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccc(F)cc1
Show InChI InChI=1S/C16H14FN3O2S/c17-13-3-1-11(2-4-13)8-20(9-12-5-6-23-10-12)15-7-14(16(21)22)18-19-15/h1-7,10H,8-9H2,(H,18,19)(H,21,22)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414510
PNG
(CHEMBL564511)
Show SMILES Cc1ccc(CN(Cc2ccc(C)s2)c2cc(n[nH]2)C(O)=O)s1
Show InChI InChI=1S/C16H17N3O2S2/c1-10-3-5-12(22-10)8-19(9-13-6-4-11(2)23-13)15-7-14(16(20)21)17-18-15/h3-7H,8-9H2,1-2H3,(H,17,18)(H,20,21)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414512
PNG
(CHEMBL553435)
Show SMILES OC(=O)c1cc(NCc2ccccc2)[nH]n1
Show InChI InChI=1S/C11H11N3O2/c15-11(16)9-6-10(14-13-9)12-7-8-4-2-1-3-5-8/h1-6H,7H2,(H,15,16)(H2,12,13,14)
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n/an/an/an/a 120n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414493
PNG
(CHEMBL565055)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccoc1)Cc1ccoc1
Show InChI InChI=1S/C14H13N3O4/c18-14(19)12-5-13(16-15-12)17(6-10-1-3-20-8-10)7-11-2-4-21-9-11/h1-5,8-9H,6-7H2,(H,15,16)(H,18,19)
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n/an/an/an/a 8.91E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414501
PNG
(CHEMBL562933)
Show SMILES CC(C)CCN(CCC(C)C)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C14H25N3O2/c1-10(2)5-7-17(8-6-11(3)4)13-9-12(14(18)19)15-16-13/h9-11H,5-8H2,1-4H3,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414503
PNG
(CHEMBL553912)
Show SMILES CCCCCCN(CCCCCC)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C16H29N3O2/c1-3-5-7-9-11-19(12-10-8-6-4-2)15-13-14(16(20)21)17-18-15/h13H,3-12H2,1-2H3,(H,17,18)(H,20,21)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414497
PNG
(CHEMBL564064)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1cccc(F)c1)Cc1cccc(F)c1
Show InChI InChI=1S/C18H15F2N3O2/c19-14-5-1-3-12(7-14)10-23(11-13-4-2-6-15(20)8-13)17-9-16(18(24)25)21-22-17/h1-9H,10-11H2,(H,21,22)(H,24,25)
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n/an/an/an/a 9.33E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414492
PNG
(CHEMBL564914)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccccc1
Show InChI InChI=1S/C16H15N3O2S/c20-16(21)14-8-15(18-17-14)19(10-13-6-7-22-11-13)9-12-4-2-1-3-5-12/h1-8,11H,9-10H2,(H,17,18)(H,20,21)
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n/an/an/an/a 14n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414491
PNG
(CHEMBL559204)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-6-13(16-15-12)17(7-10-3-5-20-9-10)8-11-2-1-4-21-11/h1-6,9H,7-8H2,(H,15,16)(H,18,19)
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n/an/an/an/a 141n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414506
PNG
(CHEMBL553415)
Show SMILES CCC(C)Nc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C8H13N3O2/c1-3-5(2)9-7-4-6(8(12)13)10-11-7/h4-5H,3H2,1-2H3,(H,12,13)(H2,9,10,11)
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n/an/an/an/a 4.47E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414501
PNG
(CHEMBL562933)
Show SMILES CC(C)CCN(CCC(C)C)c1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C14H25N3O2/c1-10(2)5-7-17(8-6-11(3)4)13-9-12(14(18)19)15-16-13/h9-11H,5-8H2,1-4H3,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414513
PNG
(CHEMBL394468)
Show SMILES OC(=O)c1ccc(NCC=C)nc1
Show InChI InChI=1S/C9H10N2O2/c1-2-5-10-8-4-3-7(6-11-8)9(12)13/h2-4,6H,1,5H2,(H,10,11)(H,12,13)
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n/an/an/an/a 42n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414495
PNG
(CHEMBL562675)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1cccs1)Cc1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-7-13(16-15-12)17(8-10-3-1-5-20-10)9-11-4-2-6-21-11/h1-7H,8-9H2,(H,15,16)(H,18,19)
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n/an/an/an/a 257n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414495
PNG
(CHEMBL562675)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1cccs1)Cc1cccs1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-7-13(16-15-12)17(8-10-3-1-5-20-10)9-11-4-2-6-21-11/h1-7H,8-9H2,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414511
PNG
(CHEMBL552463)
Show SMILES OC(=O)c1cc([nH]n1)N(CC1CCCCC1)CC1CCCCC1
Show InChI InChI=1S/C18H29N3O2/c22-18(23)16-11-17(20-19-16)21(12-14-7-3-1-4-8-14)13-15-9-5-2-6-10-15/h11,14-15H,1-10,12-13H2,(H,19,20)(H,22,23)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414490
PNG
(CHEMBL550153)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccco1
Show InChI InChI=1S/C14H13N3O3S/c18-14(19)12-6-13(16-15-12)17(7-10-3-5-21-9-10)8-11-2-1-4-20-11/h1-6,9H,7-8H2,(H,15,16)(H,18,19)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414502
PNG
(CHEMBL561720)
Show SMILES OC(=O)c1cc([nH]n1)N(CC1CC1)CC1CC1
Show InChI InChI=1S/C12H17N3O2/c16-12(17)10-5-11(14-13-10)15(6-8-1-2-8)7-9-3-4-9/h5,8-9H,1-4,6-7H2,(H,13,14)(H,16,17)
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n/an/an/an/a 3.98E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414494
PNG
(CHEMBL564300)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccsc1
Show InChI InChI=1S/C14H13N3O2S2/c18-14(19)12-5-13(16-15-12)17(6-10-1-3-20-8-10)7-11-2-4-21-9-11/h1-5,8-9H,6-7H2,(H,15,16)(H,18,19)
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n/an/an/an/a 3.20n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 3


(Homo sapiens (Human))		BDBM50414499
PNG
(CHEMBL561920)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccccc1)Cc1ccccc1
Show InChI InChI=1S/C18H17N3O2/c22-18(23)16-11-17(20-19-16)21(12-14-7-3-1-4-8-14)13-15-9-5-2-6-10-15/h1-11H,12-13H2,(H,19,20)(H,22,23)
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n/an/an/an/a 851n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109b receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))		BDBM50414492
PNG
(CHEMBL564914)
Show SMILES OC(=O)c1cc([nH]n1)N(Cc1ccsc1)Cc1ccccc1
Show InChI InChI=1S/C16H15N3O2S/c20-16(21)14-8-15(18-17-14)19(10-13-6-7-22-11-13)9-12-4-2-1-3-5-12/h1-8,11H,9-10H2,(H,17,18)(H,20,21)
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n/an/an/an/a<1.00E+4n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at GPR109a receptor transfected in CHOK1 cells assessed as inhibition of forskolin-induced cAMP generation by HTRF assay

Bioorg Med Chem Lett 19: 4207-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.108
BindingDB Entry DOI: 10.7270/Q2GF0TJJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%