BindingDB logo
myBDB logout

PubMed code 19525110

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297764
PNG
((R)-5-cyano-3-(3,4-dioxo-2-(1-phenylpropylamino)cy...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(cc(C(=O)N(C)C)c2O)C#N)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H22N4O4/c1-4-16(14-8-6-5-7-9-14)25-18-19(22(30)21(18)29)26-17-11-13(12-24)10-15(20(17)28)23(31)27(2)3/h5-11,16,25-26,28H,4H2,1-3H3/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297761
PNG
((R)-6-bromo-3-(3,4-dioxo-2-(1-phenylpropylamino)cy...)
Show SMILES CC[C@@H](Nc1c(Nc2ccc(Br)c(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C22H22BrN3O4/c1-4-14(12-8-6-5-7-9-12)24-17-18(21(29)20(17)28)25-15-11-10-13(23)16(19(15)27)22(30)26(2)3/h5-11,14,24-25,27H,4H2,1-3H3/t14-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
4n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50236053
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-4-15(13-9-6-5-7-10-13)23-17-18(21(28)20(17)27)24-16-12-8-11-14(19(16)26)22(29)25(2)3/h5-12,15,23-24,26H,4H2,1-3H3/t15-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
4.40n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297740
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2c(C)ccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-5-16(14-9-7-6-8-10-14)24-18-19(22(29)21(18)28)25-17-13(2)11-12-15(20(17)27)23(30)26(3)4/h6-12,16,24-25,27H,5H2,1-4H3/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
4.5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297741
PNG
((R)-5-cyano-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propy...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(cc(C(=O)N(C)C)c2O)C#N)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C21H20N4O4S/c1-4-13(15-6-5-7-30-15)23-16-17(20(28)19(16)27)24-14-9-11(10-22)8-12(18(14)26)21(29)25(2)3/h5-9,13,23-24,26H,4H2,1-3H3/t13-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50200880
PNG
((R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(C)o1 |r|
Show InChI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50200887
PNG
((R)-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)c...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C20H21N3O4S/c1-4-12(14-9-6-10-28-14)21-15-16(19(26)18(15)25)22-13-8-5-7-11(17(13)24)20(27)23(2)3/h5-10,12,21-22,24H,4H2,1-3H3/t12-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297738
PNG
((R)-1-(3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobu...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCCC3C(O)=O)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H25N3O6/c1-2-16(14-8-4-3-5-9-14)26-19-20(23(31)22(19)30)27-17-11-6-10-15(21(17)29)24(32)28-13-7-12-18(28)25(33)34/h3-6,8-11,16,18,26-27,29H,2,7,12-13H2,1H3,(H,33,34)/t16-,18?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
5n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297755
PNG
((R)-3-(2-hydroxy-3-(pyrrolidine-1-carbonyl)phenyla...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCCC3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H25N3O4/c1-2-17(15-9-4-3-5-10-15)25-19-20(23(30)22(19)29)26-18-12-8-11-16(21(18)28)24(31)27-13-6-7-14-27/h3-5,8-12,17,25-26,28H,2,6-7,13-14H2,1H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
9n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297756
PNG
((R)-3-(2-hydroxy-3-(morpholine-4-carbonyl)phenylam...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCOCC3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H25N3O5/c1-2-17(15-7-4-3-5-8-15)25-19-20(23(30)22(19)29)26-18-10-6-9-16(21(18)28)24(31)27-11-13-32-14-12-27/h3-10,17,25-26,28H,2,11-14H2,1H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
10n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297735
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N3O4/c1-5-17(15-10-7-6-8-11-15)25-19-20(23(30)22(19)29)26-18-13-9-12-16(21(18)28)24(31)27(4)14(2)3/h6-14,17,25-26,28H,5H2,1-4H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
11n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297745
PNG
((R)-2-hydroxy-3-(2-(1-(5-methylfuran-2-yl)propylam...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(O)=O)c2O)c(=O)c1=O)c1ccc(C)o1 |r|
Show InChI InChI=1S/C19H18N2O6/c1-3-11(13-8-7-9(2)27-13)20-14-15(18(24)17(14)23)21-12-6-4-5-10(16(12)22)19(25)26/h4-8,11,20-22H,3H2,1-2H3,(H,25,26)/t11-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
12n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297736
PNG
((R)-3-(2-hydroxy-3-(4-methylpiperazine-1-carbonyl)...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCN(C)CC3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H28N4O4/c1-3-18(16-8-5-4-6-9-16)26-20-21(24(32)23(20)31)27-19-11-7-10-17(22(19)30)25(33)29-14-12-28(2)13-15-29/h4-11,18,26-27,30H,3,12-15H2,1-2H3/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
12n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297739
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2ccc(-c3ccccn3)c(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H26N4O4/c1-4-18(16-10-6-5-7-11-16)29-22-23(26(34)25(22)33)30-20-14-13-17(19-12-8-9-15-28-19)21(24(20)32)27(35)31(2)3/h5-15,18,29-30,32H,4H2,1-3H3/t18-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
15n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297763
PNG
((R)-4-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2ccc(-c3ccccc3)c(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H27N3O4/c1-4-20(18-13-9-6-10-14-18)29-23-24(27(34)26(23)33)30-21-16-15-19(17-11-7-5-8-12-17)22(25(21)32)28(35)31(2)3/h5-16,20,29-30,32H,4H2,1-3H3/t20-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
17n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297737
PNG
((R)-3-(2-hydroxy-3-((S)-3-hydroxypyrrolidine-1-car...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CC[C@H](O)C3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H25N3O5/c1-2-17(14-7-4-3-5-8-14)25-19-20(23(31)22(19)30)26-18-10-6-9-16(21(18)29)24(32)27-12-11-15(28)13-27/h3-10,15,17,25-26,28-29H,2,11-13H2,1H3/t15-,17+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
18n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297760
PNG
((R)-3-(2-hydroxy-3-(4-picolinoylpiperazine-1-carbo...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCN(CC3)C(=O)c3ccccn3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C30H29N5O5/c1-2-21(19-9-4-3-5-10-19)32-24-25(28(38)27(24)37)33-22-13-8-11-20(26(22)36)29(39)34-15-17-35(18-16-34)30(40)23-12-6-7-14-31-23/h3-14,21,32-33,36H,2,15-18H2,1H3/t21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297757
PNG
((R)-3-(2-hydroxy-3-(3-hydroxyazetidine-1-carbonyl)...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CC(O)C3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H23N3O5/c1-2-16(13-7-4-3-5-8-13)24-18-19(22(30)21(18)29)25-17-10-6-9-15(20(17)28)23(31)26-11-14(27)12-26/h3-10,14,16,24-25,27-28H,2,11-12H2,1H3/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297758
PNG
((R)-3-(2-hydroxy-3-((S)-3-(hydroxymethyl)pyrrolidi...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CC[C@H](CO)C3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H27N3O5/c1-2-18(16-7-4-3-5-8-16)26-20-21(24(32)23(20)31)27-19-10-6-9-17(22(19)30)25(33)28-12-11-15(13-28)14-29/h3-10,15,18,26-27,29-30H,2,11-14H2,1H3/t15-,18+/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
20n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297737
PNG
((R)-3-(2-hydroxy-3-((S)-3-hydroxypyrrolidine-1-car...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CC[C@H](O)C3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H25N3O5/c1-2-17(14-7-4-3-5-8-14)25-19-20(23(31)22(19)30)26-18-10-6-9-16(21(18)29)24(32)27-12-11-15(28)13-27/h3-10,15,17,25-26,28-29H,2,11-13H2,1H3/t15-,17+/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
21n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297748
PNG
((R)-3-(2-hydroxyphenylamino)-4-(1-(5-methylfuran-2...)
Show SMILES CC[C@@H](Nc1c(Nc2ccccc2O)c(=O)c1=O)c1ccc(C)o1 |r|
Show InChI InChI=1S/C18H18N2O4/c1-3-11(14-9-8-10(2)24-14)19-15-16(18(23)17(15)22)20-12-6-4-5-7-13(12)21/h4-9,11,19-21H,3H2,1-2H3/t11-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
22n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297746
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(N)=O)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C20H19N3O4/c1-2-13(11-7-4-3-5-8-11)22-15-16(19(26)18(15)25)23-14-10-6-9-12(17(14)24)20(21)27/h3-10,13,22-24H,2H2,1H3,(H2,21,27)/t13-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
25n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297759
PNG
((R)-3-(3-(4-acetylpiperazine-1-carbonyl)-2-hydroxy...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCN(CC3)C(C)=O)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C26H28N4O5/c1-3-19(17-8-5-4-6-9-17)27-21-22(25(34)24(21)33)28-20-11-7-10-18(23(20)32)26(35)30-14-12-29(13-15-30)16(2)31/h4-11,19,27-28,32H,3,12-15H2,1-2H3/t19-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
27n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297752
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)NC)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C21H21N3O4/c1-3-14(12-8-5-4-6-9-12)23-16-17(20(27)19(16)26)24-15-11-7-10-13(18(15)25)21(28)22-2/h4-11,14,23-25H,3H2,1-2H3,(H,22,28)/t14-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
28n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297738
PNG
((R)-1-(3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobu...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCCC3C(O)=O)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H25N3O6/c1-2-16(14-8-4-3-5-9-14)26-19-20(23(31)22(19)30)27-17-11-6-10-15(21(17)29)24(32)28-13-7-12-18(28)25(33)34/h3-6,8-11,16,18,26-27,29H,2,7,12-13H2,1H3,(H,33,34)/t16-,18?/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
30n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297754
PNG
((R)-N-cyclopropyl-3-(3,4-dioxo-2-(1-phenylpropylam...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)NC3CC3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H23N3O4/c1-2-16(13-7-4-3-5-8-13)25-18-19(22(29)21(18)28)26-17-10-6-9-15(20(17)27)23(30)24-14-11-12-14/h3-10,14,16,25-27H,2,11-12H2,1H3,(H,24,30)/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
34n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50236053
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C22H23N3O4/c1-4-15(13-9-6-5-7-10-13)23-17-18(21(28)20(17)27)24-16-12-8-11-14(19(16)26)22(29)25(2)3/h5-12,15,23-24,26H,4H2,1-3H3/t15-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
40n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297736
PNG
((R)-3-(2-hydroxy-3-(4-methylpiperazine-1-carbonyl)...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N3CCN(C)CC3)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H28N4O4/c1-3-18(16-8-5-4-6-9-16)26-20-21(24(32)23(20)31)27-19-11-7-10-17(22(19)30)25(33)29-14-12-28(2)13-15-29/h4-11,18,26-27,30H,3,12-15H2,1-2H3/t18-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
41n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297742
PNG
((R)-5-chloro-3-(3,4-dioxo-2-(1-(thiophen-2-yl)prop...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(Cl)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C20H20ClN3O4S/c1-4-12(14-6-5-7-29-14)22-15-16(19(27)18(15)26)23-13-9-10(21)8-11(17(13)25)20(28)24(2)3/h5-9,12,22-23,25H,4H2,1-3H3/t12-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
50n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297741
PNG
((R)-5-cyano-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propy...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(cc(C(=O)N(C)C)c2O)C#N)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C21H20N4O4S/c1-4-13(15-6-5-7-30-15)23-16-17(20(28)19(16)27)24-14-9-11(10-22)8-12(18(14)26)21(29)25(2)3/h5-9,13,23-24,26H,4H2,1-3H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
54n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297743
PNG
((R)-5-bromo-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propy...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(Br)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C20H20BrN3O4S/c1-4-12(14-6-5-7-29-14)22-15-16(19(27)18(15)26)23-13-9-10(21)8-11(17(13)25)20(28)24(2)3/h5-9,12,22-23,25H,4H2,1-3H3/t12-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
61n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297744
PNG
((R)-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)c...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(C)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C21H23N3O4S/c1-5-13(15-7-6-8-29-15)22-16-17(20(27)19(16)26)23-14-10-11(2)9-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
76n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297735
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N3O4/c1-5-17(15-10-7-6-8-11-15)25-19-20(23(30)22(19)29)26-18-13-9-12-16(21(18)28)24(31)27(4)14(2)3/h6-14,17,25-26,28H,5H2,1-4H3/t17-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
123n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297762
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(C)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-5-16(14-9-7-6-8-10-14)24-18-19(22(29)21(18)28)25-17-12-13(2)11-15(20(17)27)23(30)26(3)4/h6-12,16,24-25,27H,5H2,1-4H3/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
203n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50200887
PNG
((R)-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)c...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C20H21N3O4S/c1-4-12(14-9-6-10-28-14)21-15-16(19(26)18(15)25)22-13-8-5-7-11(17(13)24)20(27)23(2)3/h5-10,12,21-22,24H,4H2,1-3H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
210n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297753
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)NC(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-4-16(14-9-6-5-7-10-14)25-18-19(22(29)21(18)28)26-17-12-8-11-15(20(17)27)23(30)24-13(2)3/h5-13,16,25-27H,4H2,1-3H3,(H,24,30)/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
219n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297750
PNG
((R)-2-hydroxy-N,N-dimethyl-3-(2-(methyl(1-phenylpr...)
Show SMILES CC[C@@H](N(C)c1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-5-17(14-10-7-6-8-11-14)26(4)19-18(21(28)22(19)29)24-16-13-9-12-15(20(16)27)23(30)25(2)3/h6-13,17,24,27H,5H2,1-4H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>270n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297747
PNG
((R)-4-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(N2CCOc3c2cccc3C(=O)N(C)C)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H25N3O4/c1-4-17(15-9-6-5-7-10-15)25-19-20(22(29)21(19)28)27-13-14-31-23-16(24(30)26(2)3)11-8-12-18(23)27/h5-12,17,25H,4,13-14H2,1-3H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>270n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297749
PNG
((R)-2-hydroxy-N,N-dimethyl-3-(methyl(2-(methyl(1-p...)
Show SMILES CC[C@@H](N(C)c1c(N(C)c2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N3O4/c1-6-17(15-11-8-7-9-12-15)26(4)19-20(23(30)22(19)29)27(5)18-14-10-13-16(21(18)28)24(31)25(2)3/h7-14,17,28H,6H2,1-5H3/t17-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>270n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297751
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cccc(C(=O)N(C)C)c2OC)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-5-16(14-10-7-6-8-11-14)24-18-19(21(28)20(18)27)25-17-13-9-12-15(22(17)30-4)23(29)26(2)3/h6-13,16,24-25H,5H2,1-4H3/t16-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>270n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297740
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2c(C)ccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N3O4/c1-5-16(14-9-7-6-8-10-14)24-18-19(22(29)21(18)28)25-17-13(2)11-12-15(20(17)27)23(30)26(3)4/h6-12,16,24-25,27H,5H2,1-4H3/t16-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
381n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297739
PNG
((R)-3-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2ccc(-c3ccccn3)c(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H26N4O4/c1-4-18(16-10-6-5-7-11-16)29-22-23(26(34)25(22)33)30-20-14-13-17(19-12-8-9-15-28-19)21(24(20)32)27(35)31(2)3/h5-15,18,29-30,32H,4H2,1-3H3/t18-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>1.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297742
PNG
((R)-5-chloro-3-(3,4-dioxo-2-(1-(thiophen-2-yl)prop...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(Cl)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C20H20ClN3O4S/c1-4-12(14-6-5-7-29-14)22-15-16(19(27)18(15)26)23-13-9-10(21)8-11(17(13)25)20(28)24(2)3/h5-9,12,22-23,25H,4H2,1-3H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
1.22E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50297765
PNG
((R)-5-(3,4-dioxo-2-(1-phenylpropylamino)cyclobut-1...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(cc(C(=O)N(C)C)c2O)-c2ccccc2)c(=O)c1=O)c1ccccc1 |r|
Show InChI InChI=1S/C28H27N3O4/c1-4-21(18-13-9-6-10-14-18)29-23-24(27(34)26(23)33)30-22-16-19(17-11-7-5-8-12-17)15-20(25(22)32)28(35)31(2)3/h5-16,21,29-30,32H,4H2,1-3H3/t21-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
>2.00E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR2


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297743
PNG
((R)-5-bromo-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propy...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(Br)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C20H20BrN3O4S/c1-4-12(14-6-5-7-29-14)22-15-16(19(27)18(15)26)23-13-9-10(21)8-11(17(13)25)20(28)24(2)3/h5-9,12,22-23,25H,4H2,1-3H3/t12-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
2.07E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50297744
PNG
((R)-3-(3,4-dioxo-2-(1-(thiophen-2-yl)propylamino)c...)
Show SMILES CC[C@@H](Nc1c(Nc2cc(C)cc(C(=O)N(C)C)c2O)c(=O)c1=O)c1cccs1 |r|
Show InChI InChI=1S/C21H23N3O4S/c1-5-13(15-7-6-8-29-15)22-16-17(20(27)19(16)26)23-14-10-11(2)9-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
2.80E+3n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Displacement of human [125I]IL-8 from human CXCR1


Bioorg Med Chem Lett 19: 4446-9 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.049
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%