Affinity Data by PubMed id=19527031

PubMed code 19527031

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293820 (2-(2-(2-amino-6-oxo-1,6,7,8-tetrahydropurin-9-yl)e...) Show SMILES Nc1nc2N(CCOCCP(O)(O)=O)CNc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293821 (2-(2-(6-oxo-1,6,7,8-tetrahydropurin-9-yl)ethoxy)et...) Show SMILES OP(O)(=O)CCOCCN1CNc2c1nc[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293826 ((2-(4-oxo-2,3,4,5-tetrahydropyrazolo[3,4-d]pyrimid...) Show SMILES OP(O)(=O)COCCN1NCc2c1nc[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293819 (((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1,6,7,8-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293818 (((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6,7,8-tetrahydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293830 (CHEMBL561493 \| RS-(3-(2-amino-6-oxo-1,6,7,8-tetrah...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293835 ((R)-5-(2-Amino-6-oxo-1,6,7,8-tetrahydro-purin-9-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.23E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 8.5 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293831 ((S)-(1-(5-amino-7-oxo-1,2,6,7-tetrahydro-[1,2,3]tr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293835 ((R)-5-(2-Amino-6-oxo-1,6,7,8-tetrahydro-purin-9-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293836 (CHEMBL541006 \| RS-(1-(2-amino-6-oxo-7,8-dihydro-1H...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.27E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 8.5 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50225188 ((2-(2-amino-6-oxo-1,6,7,8-tetrahydropurin-9-yl)eth...) Show SMILES Nc1nc2N(CCOCP(O)(O)=O)CNc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293833 (((R)-1-(2-amino-8-bromo-6-oxo-1,6,7,8-tetrahydropu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50225188 ((2-(2-amino-6-oxo-1,6,7,8-tetrahydropurin-9-yl)eth...) Show SMILES Nc1nc2N(CCOCP(O)(O)=O)CNc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	5.59E+4	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 8.5 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293824 ((2-(2-amino-8-hydroxy-6-oxo-1,6,7,8-tetrahydropuri...) Show SMILES Nc1nc2N(CCOCP(O)(O)=O)C(O)Nc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.80E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293834 ((S)-5-(2-Amino-6-oxo-1,6,7,8-tetrahydro-purin-9-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293834 ((S)-5-(2-Amino-6-oxo-1,6,7,8-tetrahydro-purin-9-yl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.15E+5	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 8.5 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293828 (CHEMBL560759 \| isopropyl(2-(2-amino-6-oxo-1,6,7,8-...) Show SMILES CC(C)OP(O)(=O)COCCN1CNc2c1nc(N)[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.40E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293823 ((2-(5-amino-7-oxo-1,2,6,7-tetrahydro-[1,2,3]triazo...) Show SMILES Nc1nc2N(CCOCP(O)(O)=O)NNc2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.75E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293837 ((S)-9-[3-hydroxy-2-(phosphonomethoxy)propyl]guanin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.77E+5	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 8.5 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293838 ((2-(6-oxo-1,6,7,8-tetrahydropurin-9-yl)ethoxy)meth...) Show SMILES OP(O)(=O)COCCN1CNc2c1nc[nH]c2=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.82E+5	n/a	n/a	n/a	n/a	n/a	n/a	8.5	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 8.5 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293832 (((S)-1-(2-amino-8-bromo-6-oxo-1,6,7,8-tetrahydropu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293825 ((2-(2-amino-8-bromo-6-oxo-1,6,7,8-tetrahydropurin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>4.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293827 ((2-(2-amino-6-thioxo-1,6,7,8-tetrahydropurin-9-yl)...) Show SMILES Nc1nc2N(CCOCP(O)(O)=O)CNc2c(=S)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair
Hypoxanthine-guanine phosphoribosyltransferase (Homo sapiens (Human))	BDBM50293829 (6-methylheptyl(2-(2-amino-6-oxo-1,6,7,8-tetrahydro...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of human recombinant HGPRT at pH 7.4 by spectrophotometric assay				J Med Chem 52: 4391-9 (2009) Article DOI: 10.1021/jm900267n BindingDB Entry DOI: 10.7270/Q27M0809
The University of Queensland Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)

* indicates data uncertainty>20%