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PubMed code 19560921

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interleukin-8


(Homo sapiens (Human))		BDBM13066
PNG
(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)
Show SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
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n/an/a 8n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295276
PNG
(2-(2-(2-fluorophenylamino)phenyl)acetic acid | CHE...)
Show SMILES OC(=O)Cc1ccccc1Nc1ccccc1F
Show InChI InChI=1S/C14H12FNO2/c15-11-6-2-4-8-13(11)16-12-7-3-1-5-10(12)9-14(17)18/h1-8,16H,9H2,(H,17,18)
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n/an/a 9n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295266
PNG
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanoic a...)
Show SMILES CC(C(O)=O)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C15H13Cl2NO2/c1-9(15(19)20)10-5-2-3-8-13(10)18-14-11(16)6-4-7-12(14)17/h2-9,18H,1H3,(H,19,20)
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n/an/a 10n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
C-X-C chemokine receptor type 1


(Homo sapiens (Human))		BDBM13066
PNG
(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)
Show SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
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n/an/a 12n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of wild type CXCR1 transfected in mouse L1.2 cells assessed as inhibition of CXCL8-induced cell migration pretreated for 15 mins measured ...

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295267
PNG
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}propanamide...)
Show SMILES CC(C(N)=O)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C15H14Cl2N2O/c1-9(15(18)20)10-5-2-3-8-13(10)19-14-11(16)6-4-7-12(14)17/h2-9,19H,1H3,(H2,18,20)
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n/an/a 12n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295281
PNG
(2-(2-(2-fluorophenoxy)phenyl)acetic acid | CHEMBL2...)
Show SMILES OC(=O)Cc1ccccc1Oc1ccccc1F
Show InChI InChI=1S/C14H11FO3/c15-11-6-2-4-8-13(11)18-12-7-3-1-5-10(12)9-14(16)17/h1-8H,9H2,(H,16,17)
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n/an/a 13n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295268
PNG
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(methyls...)
Show SMILES CC(C(=O)NS(C)(=O)=O)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H16Cl2N2O3S/c1-10(16(21)20-24(2,22)23)11-6-3-4-9-14(11)19-15-12(17)7-5-8-13(15)18/h3-10,19H,1-2H3,(H,20,21)
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n/an/a 13n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295270
PNG
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(2-hydro...)
Show SMILES CC(C(=O)NCCO)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H18Cl2N2O2/c1-11(17(23)20-9-10-22)12-5-2-3-8-15(12)21-16-13(18)6-4-7-14(16)19/h2-8,11,21-22H,9-10H2,1H3,(H,20,23)
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n/an/a 20n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50169048
PNG
((R)-2-(3-Benzoyl-phenyl)-propionic acid | (R)-2-(3...)
Show SMILES C[C@@H](C(O)=O)c1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)/t11-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295269
PNG
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N,N'-[3,3-...)
Show SMILES CC(C(=O)NCCCN(C)C)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C20H25Cl2N3O/c1-14(20(26)23-12-7-13-25(2)3)15-8-4-5-11-18(15)24-19-16(21)9-6-10-17(19)22/h4-6,8-11,14,24H,7,12-13H2,1-3H3,(H,23,26)
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n/an/a 25n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50090679
PNG
(2-(2-(2,5-dichlorophenylamino)phenyl)acetic acid |...)
Show SMILES OC(=O)Cc1ccccc1Nc1cc(Cl)ccc1Cl
Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-6-11(16)13(8-10)17-12-4-2-1-3-9(12)7-14(18)19/h1-6,8,17H,7H2,(H,18,19)
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n/an/a 25n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295283
PNG
(2-[2-(2-Fluorophenoxy)phenyl]-N-(methylsulfonyl)ac...)
Show SMILES CS(=O)(=O)NC(=O)Cc1ccccc1Oc1ccccc1F
Show InChI InChI=1S/C15H14FNO4S/c1-22(19,20)17-15(18)10-11-6-2-4-8-13(11)21-14-9-5-3-7-12(14)16/h2-9H,10H2,1H3,(H,17,18)
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n/an/a 50n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM17638
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1
Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)
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Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50169044
PNG
((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...)
Show SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1
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Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295287
PNG
(2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)ace...)
Show SMILES Cc1ccc(cc1)C(=O)c1ccc(CC(O)=O)n1C
Show InChI InChI=1S/C15H15NO3/c1-10-3-5-11(6-4-10)15(19)13-8-7-12(16(13)2)9-14(17)18/h3-8H,9H2,1-2H3,(H,17,18)
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Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295275
PNG
(2-(2-(2-chlorophenylamino)phenyl)acetic acid | CHE...)
Show SMILES OC(=O)Cc1ccccc1Nc1ccccc1Cl
Show InChI InChI=1S/C14H12ClNO2/c15-11-6-2-4-8-13(11)16-12-7-3-1-5-10(12)9-14(17)18/h1-8,16H,9H2,(H,17,18)
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n/an/a 400n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295274
PNG
(2-(2-(2,6-dichloro-3-methylphenylamino)phenyl)acet...)
Show SMILES Cc1ccc(Cl)c(Nc2ccccc2CC(O)=O)c1Cl
Show InChI InChI=1S/C15H13Cl2NO2/c1-9-6-7-11(16)15(14(9)17)18-12-5-3-2-4-10(12)8-13(19)20/h2-7,18H,8H2,1H3,(H,19,20)
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n/an/a 500n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295282
PNG
(2-(2-(2-chlorophenoxy)phenyl)acetic acid | CHEMBL3...)
Show SMILES OC(=O)Cc1ccccc1Oc1ccccc1Cl
Show InChI InChI=1S/C14H11ClO3/c15-11-6-2-4-8-13(11)18-12-7-3-1-5-10(12)9-14(16)17/h1-8H,9H2,(H,16,17)
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Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295271
PNG
(2-{2-[(2,6-Dichlorophenyl)amino]phenyl}-N-(2,6-dim...)
Show SMILES CC(C(=O)Nc1c(C)cccc1C)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C23H22Cl2N2O/c1-14-8-6-9-15(2)21(14)27-23(28)16(3)17-10-4-5-13-20(17)26-22-18(24)11-7-12-19(22)25/h4-13,16,26H,1-3H3,(H,27,28)
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Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295272
PNG
(CHEMBL549975 | N-(tert-Butyl)-2-{2-[(2,6-dichlorop...)
Show SMILES CC(C(=O)NC(C)(C)C)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C19H22Cl2N2O/c1-12(18(24)23-19(2,3)4)13-8-5-6-11-16(13)22-17-14(20)9-7-10-15(17)21/h5-12,22H,1-4H3,(H,23,24)
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Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295277
PNG
((2-Phenylamino-phenyl)-acetic acid | 2-(2-(phenyla...)
Show SMILES OC(=O)Cc1ccccc1Nc1ccccc1
Show InChI InChI=1S/C14H13NO2/c16-14(17)10-11-6-4-5-9-13(11)15-12-7-2-1-3-8-12/h1-9,15H,10H2,(H,16,17)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295273
PNG
(3-(2-(2-(2,6-dichlorophenylamino)phenyl)propanamid...)
Show SMILES CC(C(=O)NCCC[N+](C)(C)C)c1ccccc1Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H27Cl2N3O/c1-15(21(27)24-13-8-14-26(2,3)4)16-9-5-6-12-19(16)25-20-17(22)10-7-11-18(20)23/h5-7,9-12,15,25H,8,13-14H2,1-4H3/p+1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295286
PNG
(2-(3-benzoylphenyl)acetic acid | CHEMBL561718)
Show SMILES OC(=O)Cc1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C15H12O3/c16-14(17)10-11-5-4-8-13(9-11)15(18)12-6-2-1-3-7-12/h1-9H,10H2,(H,16,17)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295285
PNG
((4-Isobutyl-phenyl)-acetic acid | 2-(4-isobutylphe...)
Show SMILES CC(C)Cc1ccc(CC(O)=O)cc1
Show InChI InChI=1S/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295280
PNG
((2-Phenoxy-phenyl)-acetic acid | 2-(2-phenoxypheny...)
Show SMILES OC(=O)Cc1ccccc1Oc1ccccc1
Show InChI InChI=1S/C14H12O3/c15-14(16)10-11-6-4-5-9-13(11)17-12-7-2-1-3-8-12/h1-9H,10H2,(H,15,16)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295284
PNG
(2-(2-(2,6-dichlorobenzyl)phenyl)acetic acid | CHEM...)
Show SMILES OC(=O)Cc1ccccc1Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C15H12Cl2O2/c16-13-6-3-7-14(17)12(13)8-10-4-1-2-5-11(10)9-15(18)19/h1-7H,8-9H2,(H,18,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295279
PNG
(2-(2-(2,6-difluorophenylamino)phenyl)acetic acid |...)
Show SMILES OC(=O)Cc1ccccc1Nc1c(F)cccc1F
Show InChI InChI=1S/C14H11F2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
Interleukin-8


(Homo sapiens (Human))		BDBM50295278
PNG
(2-(2-(o-tolylamino)phenyl)acetic acid | CHEMBL5524...)
Show SMILES Cc1ccccc1Nc1ccccc1CC(O)=O
Show InChI InChI=1S/C15H15NO2/c1-11-6-2-4-8-13(11)16-14-9-5-3-7-12(14)10-15(17)18/h2-9,16H,10H2,1H3,(H,17,18)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Grupo Uriach

Curated by ChEMBL


Assay Description
Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay

Bioorg Med Chem Lett 19: 4026-30 (2009)


Article DOI: 10.1016/j.bmcl.2009.06.027
BindingDB Entry DOI: 10.7270/Q2V124TW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%