Found 38 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300888
((S)-4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl...)Show SMILES CC(C)c1onc(c1-c1ccnc(N[C@@H](C)c2ccccc2)c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H24FN3O/c1-16(2)25-23(24(29-30-25)19-9-11-21(26)12-10-19)20-13-14-27-22(15-20)28-17(3)18-7-5-4-6-8-18/h4-17H,1-3H3,(H,27,28)/t17-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300885
(CHEMBL569551 | N-sec-butyl-4-(3-(4-fluorophenyl)-5...)Show SMILES CCC(C)Nc1cc(ccn1)-c1c(noc1C(C)C)-c1ccc(F)cc1 Show InChI InChI=1S/C21H24FN3O/c1-5-14(4)24-18-12-16(10-11-23-18)19-20(25-26-21(19)13(2)3)15-6-8-17(22)9-7-15/h6-14H,5H2,1-4H3,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300892
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1 Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+ | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300892
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1 Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+ | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM13531
(4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridy...)Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300886
(4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)-N-...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC2CCOCC2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H24FN3O2/c1-14(2)22-20(21(26-28-22)15-3-5-17(23)6-4-15)16-7-10-24-19(13-16)25-18-8-11-27-12-9-18/h3-7,10,13-14,18H,8-9,11-12H2,1-2H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform epsilon
(Homo sapiens (Human)) | BDBM50300884
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc(SC)[nH]c2-c2ccc(F)cc2)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O3S/c1-33-20-10-6-16(21(15-20)34-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)35-3)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1epsilon by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300890
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300890
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM13336
(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)Show SMILES CS(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50206421
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50206421
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300889
(CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropy...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O2/c1-11(2)19-17(14-8-9-21-16(10-14)22-12(3)24)18(23-25-19)13-4-6-15(20)7-5-13/h4-11H,1-3H3,(H,21,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50229971
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) | PDB MMDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta expressed in Escherichia coli using phosphorylated peptide TFRPRTSpSNASTIS as substrate |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300889
(CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropy...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O2/c1-11(2)19-17(14-8-9-21-16(10-14)22-12(3)24)18(23-25-19)13-4-6-15(20)7-5-13/h4-11H,1-3H3,(H,21,22,24) | PDB MMDB
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| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Rattus norvegicus (rat)) | BDBM50300891
((rac)-N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)C(C)Oc2ccccc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H24FN3O3/c1-16(2)25-23(24(30-33-25)18-9-11-20(27)12-10-18)19-13-14-28-22(15-19)29-26(31)17(3)32-21-7-5-4-6-8-21/h4-17H,1-3H3,(H,28,29,31) | PDB MMDB
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| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused rat CK1delta by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform epsilon
(Homo sapiens (Human)) | BDBM50300893
((E)-3-(2,4-Dimethoxy-phenyl)-N-(4-[5-(4-fluoro-phe...)Show SMILES COc1ccc(C=CC(=O)Nc2cc(ccn2)-c2nc([nH]c2-c2ccc(F)cc2)S(C)=O)c(OC)c1 |w:6.5| Show InChI InChI=1S/C26H23FN4O4S/c1-34-20-10-6-16(21(15-20)35-2)7-11-23(32)29-22-14-18(12-13-28-22)25-24(30-26(31-25)36(3)33)17-4-8-19(27)9-5-17/h4-15H,1-3H3,(H,30,31)(H,28,29,32) | PDB
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| Article PubMed
| n/a | n/a | 447 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1epsilon by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50206421
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300887
((R)-4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl...)Show SMILES CC(C)c1onc(c1-c1ccnc(N[C@H](C)c2ccccc2)c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H24FN3O/c1-16(2)25-23(24(29-30-25)19-9-11-21(26)12-10-19)20-13-14-27-22(15-20)28-17(3)18-7-5-4-6-8-18/h4-17H,1-3H3,(H,27,28)/t17-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 10
(Homo sapiens (Human)) | BDBM50206421
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of JNK3 by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300889
(CHEMBL585533 | N-(4-(3-(4-fluorophenyl)-5-isopropy...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(C)=O)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C19H18FN3O2/c1-11(2)19-17(14-8-9-21-16(10-14)22-12(3)24)18(23-25-19)13-4-6-15(20)7-5-13/h4-11H,1-3H3,(H,21,22,24) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300891
((rac)-N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)C(C)Oc2ccccc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H24FN3O3/c1-16(2)25-23(24(30-33-25)18-9-11-20(27)12-10-18)19-13-14-28-22(15-19)29-26(31)17(3)32-21-7-5-4-6-8-21/h4-17H,1-3H3,(H,28,29,31) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300891
((rac)-N-(4-(3-(4-fluorophenyl)-5-isopropylisoxazol...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)C(C)Oc2ccccc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C26H24FN3O3/c1-16(2)25-23(24(30-33-25)18-9-11-20(27)12-10-18)19-13-14-28-22(15-19)29-26(31)17(3)32-21-7-5-4-6-8-21/h4-17H,1-3H3,(H,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50263829
(3-(2,4,6-Trimethoxybenzylidene)indolin-2-one | 3-[...)Show InChI InChI=1S/C18H17NO4/c1-21-11-8-16(22-2)14(17(9-11)23-3)10-13-12-6-4-5-7-15(12)19-18(13)20/h4-10H,1-3H3,(H,19,20)/b13-10+ | PDB
UniProtKB/SwissProt
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CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of human CK1delta |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50206421
(3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)iso...)Show InChI InChI=1S/C17H15FN2O/c1-11(2)17-15(12-7-9-19-10-8-12)16(20-21-17)13-3-5-14(18)6-4-13/h3-11H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of JNK2 by Cherenkov counting in presence of 20 uM ATP |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300890
(2-(4-fluorophenyl)-N-(4-(3-(4-fluorophenyl)-5-isop...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C25H21F2N3O2/c1-15(2)25-23(24(30-32-25)17-5-9-20(27)10-6-17)18-11-12-28-21(14-18)29-22(31)13-16-3-7-19(26)8-4-16/h3-12,14-15H,13H2,1-2H3,(H,28,29,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300888
((S)-4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl...)Show SMILES CC(C)c1onc(c1-c1ccnc(N[C@@H](C)c2ccccc2)c1)-c1ccc(F)cc1 |r| Show InChI InChI=1S/C25H24FN3O/c1-16(2)25-23(24(29-30-25)19-9-11-21(26)12-10-19)20-13-14-27-22(15-20)28-17(3)18-7-5-4-6-8-18/h4-17H,1-3H3,(H,27,28)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50206423
(4-(5-(4-fluorophenyl)-3-isopropylisoxazol-4-yl)pyr...)Show InChI InChI=1S/C17H15FN2O/c1-11(2)16-15(12-7-9-19-10-8-12)17(21-20-16)13-3-5-14(18)6-4-13/h3-11H,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Casein kinase I isoform delta
(Homo sapiens (Human)) | BDBM50300886
(4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)-N-...)Show SMILES CC(C)c1onc(c1-c1ccnc(NC2CCOCC2)c1)-c1ccc(F)cc1 Show InChI InChI=1S/C22H24FN3O2/c1-14(2)22-20(21(26-28-22)15-3-5-17(23)6-4-15)16-7-10-24-19(13-16)25-18-8-11-27-12-9-18/h3-7,10,13-14,18H,8-9,11-12H2,1-2H3,(H,24,25) | PDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of recombinant CK1delta kinase domain by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50300892
((E)-3-(2,4-dimethoxyphenyl)-N-(4-(3-(4-fluoropheny...)Show SMILES COc1ccc(\C=C\C(=O)Nc2cc(ccn2)-c2c(noc2C(C)C)-c2ccc(F)cc2)c(OC)c1 Show InChI InChI=1S/C28H26FN3O4/c1-17(2)28-26(27(32-36-28)19-5-9-21(29)10-6-19)20-13-14-30-24(15-20)31-25(33)12-8-18-7-11-22(34-3)16-23(18)35-4/h5-17H,1-4H3,(H,30,31,33)/b12-8+ | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by Cherenkov counting |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50229971
(4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-...)Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccc2OCCOc2c1)-c1ccccn1 Show InChI InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard-Karls-University
Curated by ChEMBL
| Assay Description Inhibition of GST-fused human p38alpha expressed in Escherichia coli |
J Med Chem 52: 7618-30 (2009)
Article DOI: 10.1021/jm9005127 BindingDB Entry DOI: 10.7270/Q28K7961 |
More data for this Ligand-Target Pair | |