Affinity Data by PubMed id=19628397

PubMed code 19628397

Found 3 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as cGMP hydrolysis after 60 mins by fluorescence polarization assay using tetramethylrhodamine-tagged ...				Bioorg Med Chem 17: 5974-82 (2009) Article DOI: 10.1016/j.bmc.2009.06.063 BindingDB Entry DOI: 10.7270/Q2125SRW
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM15296 (6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...) Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	1.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as cAMP hydrolysis after 60 mins by fluorescence polarization assay using fluorescein-tagged cAMP as s...				Bioorg Med Chem 17: 5974-82 (2009) Article DOI: 10.1016/j.bmc.2009.06.063 BindingDB Entry DOI: 10.7270/Q2125SRW
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Homo sapiens (Human))	BDBM50300897 (6-(4-Bromophenyl)-4-(2-ethoxyphenyl)-2-imino-1,2-d...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo Curated by ChEMBL					Assay Description Inhibition of human recombinant PDE3A assessed as cGMP hydrolysis after 60 mins by fluorescence polarization assay using tetramethylrhodamine-tagged ...				Bioorg Med Chem 17: 5974-82 (2009) Article DOI: 10.1016/j.bmc.2009.06.063 BindingDB Entry DOI: 10.7270/Q2125SRW
German University in Cairo Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%