Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301016
(4-(2,4-Dichloro-5-methoxy-phenylamino)-7-[5-(1,1-d...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCS(=O)(=O)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O3S/c1-37-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-38(35,36)9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301015
(4-(2,4-Dichloro-5-methoxy-phenylamino)-7-[5-(1-oxo...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCS(=O)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2S/c1-36-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-37(35)9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301009
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCOCC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-36-9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM4552
(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) | PDB
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CHEMBL
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MCE
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PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301017
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-((dimet...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN(C)C)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C25H21Cl2N5O/c1-32(2)14-15-4-7-21(29-12-15)16-5-6-18-22(8-16)30-13-17(11-28)25(18)31-23-10-24(33-3)20(27)9-19(23)26/h4-10,12-13H,14H2,1-3H3,(H,30,31) | PDB
MMDB
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antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301013
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-((4-met...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCN(C)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H26Cl2N6O/c1-35-7-9-36(10-8-35)17-18-3-6-24(32-15-18)19-4-5-21-25(11-19)33-16-20(14-31)28(21)34-26-13-27(37-2)23(30)12-22(26)29/h3-6,11-13,15-16H,7-10,17H2,1-2H3,(H,33,34) | PDB
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PC cid
PC sid
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PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301014
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(thiomo...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCSCC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5OS/c1-35-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-36-9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301012
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(6-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCOCC3)nc2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-12-25(22(28)11-23(26)29)33-27-19(13-30)15-32-24-10-17(3-5-21(24)27)18-2-4-20(31-14-18)16-34-6-8-36-9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301019
(4-(2,4-dichlorophenylamino)-7-(5-((4-methylpiperaz...)Show SMILES CN1CCN(Cc2ccc(nc2)-c2ccc3c(Nc4ccc(Cl)cc4Cl)c(cnc3c2)C#N)CC1 Show InChI InChI=1S/C27H24Cl2N6/c1-34-8-10-35(11-9-34)17-18-2-6-24(31-15-18)19-3-5-22-26(12-19)32-16-20(14-30)27(22)33-25-7-4-21(28)13-23(25)29/h2-7,12-13,15-16H,8-11,17H2,1H3,(H,32,33) | PDB
MMDB
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301018
(7-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCN(C)CC3)cn2)C#N)cc(OC)c1OC Show InChI InChI=1S/C30H32N6O3/c1-35-9-11-36(12-10-35)19-20-5-8-25(32-17-20)21-6-7-24-26(13-21)33-18-22(16-31)29(24)34-23-14-27(37-2)30(39-4)28(15-23)38-3/h5-8,13-15,17-18H,9-12,19H2,1-4H3,(H,33,34) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301010
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(6-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cccc(CN3CCOCC3)n2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-13-25(21(28)12-22(26)29)33-27-18(14-30)15-31-24-11-17(5-6-20(24)27)23-4-2-3-19(32-23)16-34-7-9-36-10-8-34/h2-6,11-13,15H,7-10,16H2,1H3,(H,31,33) | PDB
MMDB
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301008
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cc(CN3CCOCC3)ccn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-13-25(21(28)12-22(26)29)33-27-19(14-30)15-32-24-11-18(2-3-20(24)27)23-10-17(4-5-31-23)16-34-6-8-36-9-7-34/h2-5,10-13,15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301011
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cncc(CN3CCOCC3)c2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-11-25(22(28)10-23(26)29)33-27-20(12-30)15-32-24-9-18(2-3-21(24)27)19-8-17(13-31-14-19)16-34-4-6-36-7-5-34/h2-3,8-11,13-15H,4-7,16H2,1H3,(H,32,33) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301013
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-((4-met...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCN(C)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H26Cl2N6O/c1-35-7-9-36(10-8-35)17-18-3-6-24(32-15-18)19-4-5-21-25(11-19)33-16-20(14-31)28(21)34-26-13-27(37-2)23(30)12-22(26)29/h3-6,11-13,15-16H,7-10,17H2,1-2H3,(H,33,34) | PDB
MMDB
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301015
(4-(2,4-Dichloro-5-methoxy-phenylamino)-7-[5-(1-oxo...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCS(=O)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2S/c1-36-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-37(35)9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM4552
(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) | PDB
MMDB
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CHEMBL
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Patents
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| DrugBank
Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301017
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-((dimet...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN(C)C)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C25H21Cl2N5O/c1-32(2)14-15-4-7-21(29-12-15)16-5-6-18-22(8-16)30-13-17(11-28)25(18)31-23-10-24(33-3)20(27)9-19(23)26/h4-10,12-13H,14H2,1-3H3,(H,30,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301020
(4-(2,4-dichloro-5-methoxyphenylamino)-6-(5-((4-met...)Show SMILES COc1cc(Nc2c(cnc3ccc(cc23)-c2ccc(CN3CCN(C)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H26Cl2N6O/c1-35-7-9-36(10-8-35)17-18-3-5-24(32-15-18)19-4-6-25-21(11-19)28(20(14-31)16-33-25)34-26-13-27(37-2)23(30)12-22(26)29/h3-6,11-13,15-16H,7-10,17H2,1-2H3,(H,33,34) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301016
(4-(2,4-Dichloro-5-methoxy-phenylamino)-7-[5-(1,1-d...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCS(=O)(=O)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O3S/c1-37-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-38(35,36)9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301009
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCOCC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-36-9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301014
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(thiomo...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCSCC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5OS/c1-35-26-12-25(21(28)11-22(26)29)33-27-19(13-30)15-32-24-10-18(3-4-20(24)27)23-5-2-17(14-31-23)16-34-6-8-36-9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301008
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(4-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cc(CN3CCOCC3)ccn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-13-25(21(28)12-22(26)29)33-27-19(14-30)15-32-24-11-18(2-3-20(24)27)23-10-17(4-5-31-23)16-34-6-8-36-9-7-34/h2-5,10-13,15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301012
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(6-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCOCC3)nc2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-12-25(22(28)11-23(26)29)33-27-19(13-30)15-32-24-10-17(3-5-21(24)27)18-2-4-20(31-14-18)16-34-6-8-36-9-7-34/h2-5,10-12,14-15H,6-9,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301018
(7-(5-((4-methylpiperazin-1-yl)methyl)pyridin-2-yl)...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ccc(CN3CCN(C)CC3)cn2)C#N)cc(OC)c1OC Show InChI InChI=1S/C30H32N6O3/c1-35-9-11-36(12-10-35)19-20-5-8-25(32-17-20)21-6-7-24-26(13-21)33-18-22(16-31)29(24)34-23-14-27(37-2)30(39-4)28(15-23)38-3/h5-8,13-15,17-18H,9-12,19H2,1-4H3,(H,33,34) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301019
(4-(2,4-dichlorophenylamino)-7-(5-((4-methylpiperaz...)Show SMILES CN1CCN(Cc2ccc(nc2)-c2ccc3c(Nc4ccc(Cl)cc4Cl)c(cnc3c2)C#N)CC1 Show InChI InChI=1S/C27H24Cl2N6/c1-34-8-10-35(11-9-34)17-18-2-6-24(31-15-18)19-3-5-22-26(12-19)32-16-20(14-30)27(22)33-25-7-4-21(28)13-23(25)29/h2-7,12-13,15-16H,8-11,17H2,1H3,(H,32,33) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301010
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(6-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cccc(CN3CCOCC3)n2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-13-25(21(28)12-22(26)29)33-27-18(14-30)15-31-24-11-17(5-6-20(24)27)23-4-2-3-19(32-23)16-34-7-9-36-10-8-34/h2-6,11-13,15H,7-10,16H2,1H3,(H,31,33) | PDB
MMDB
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UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301007
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(3-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ncccc2CN2CCOCC2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-25-13-24(21(28)12-22(25)29)33-27-19(14-30)15-32-23-11-17(4-5-20(23)27)26-18(3-2-6-31-26)16-34-7-9-36-10-8-34/h2-6,11-13,15H,7-10,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of Src |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301011
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(5-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2cncc(CN3CCOCC3)c2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-26-11-25(22(28)10-23(26)29)33-27-20(12-30)15-32-24-9-18(2-3-21(24)27)19-8-17(13-31-14-19)16-34-4-6-36-7-5-34/h2-3,8-11,13-15H,4-7,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301020
(4-(2,4-dichloro-5-methoxyphenylamino)-6-(5-((4-met...)Show SMILES COc1cc(Nc2c(cnc3ccc(cc23)-c2ccc(CN3CCN(C)CC3)cn2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C28H26Cl2N6O/c1-35-7-9-36(10-8-35)17-18-3-5-24(32-15-18)19-4-6-25-21(11-19)28(20(14-31)16-33-25)34-26-13-27(37-2)23(30)12-22(26)29/h3-6,11-13,15-16H,7-10,17H2,1-2H3,(H,33,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50301007
(4-(2,4-dichloro-5-methoxyphenylamino)-7-(3-(morpho...)Show SMILES COc1cc(Nc2c(cnc3cc(ccc23)-c2ncccc2CN2CCOCC2)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C27H23Cl2N5O2/c1-35-25-13-24(21(28)12-22(25)29)33-27-19(14-30)15-32-23-11-17(4-5-20(23)27)26-18(3-2-6-31-26)16-34-7-9-36-10-8-34/h2-6,11-13,15H,7-10,16H2,1H3,(H,32,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of human Src expressed in rat fibroblasts assessed as anchorage independent growth after 3 days |
Bioorg Med Chem Lett 19: 5071-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.043
BindingDB Entry DOI: 10.7270/Q27M081R |
More data for this
Ligand-Target Pair | |
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