BindingDB logo
myBDB logout

PubMed code 19682896

Compile data set for download or QSAR
Found 49 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301693
PNG
(5-(5-((4-(dimethylamino)piperidin-1-yl)methyl)fura...)
Show SMILES CN(C)C1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H30N6O/c1-18-23-6-9-30-26(23)5-4-25(18)31-27-20(13-28)14-29-15-24(27)19-12-22(34-17-19)16-33-10-7-21(8-11-33)32(2)3/h4-6,9,12,14-15,17,21,30H,7-8,10-11,16H2,1-3H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301694
PNG
(5-(5-((4-isopropylpiperazin-1-yl)methyl)furan-3-yl...)
Show SMILES CC(C)N1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H30N6O/c1-18(2)33-10-8-32(9-11-33)16-22-12-20(17-34-22)24-15-29-14-21(13-28)27(24)31-25-4-5-26-23(19(25)3)6-7-30-26/h4-7,12,14-15,17-18,30H,8-11,16H2,1-3H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301679
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpip...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H28N6/c1-19-23-8-9-30-26(23)7-6-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-4-20(14-21)18-33-12-10-32(2)11-13-33/h3-9,14,16-17,30H,10-13,18H2,1-2H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301695
PNG
(5-(5-((4-cyclopentylpiperazin-1-yl)methyl)furan-3-...)
Show SMILES Cc1c(Nc2c(cncc2-c2coc(CN3CCN(CC3)C3CCCC3)c2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C29H32N6O/c1-20-25-8-9-32-28(25)7-6-27(20)33-29-22(15-30)16-31-17-26(29)21-14-24(36-19-21)18-34-10-12-35(13-11-34)23-4-2-3-5-23/h6-9,14,16-17,19,23,32H,2-5,10-13,18H2,1H3,(H,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301685
PNG
(1-((4-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2cc(cs2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2S/c1-4-22-7-5-10-28(25-17-26(32-20-25)19-31-15-13-30(3)14-16-31)29(22)18-24-12-11-23-8-6-9-27(23)21(24)2/h1,5-7,9-12,17,20H,8,13-16,18-19H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301678
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpip...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H28N6/c1-19-23-9-10-30-26(23)8-7-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-20(4-6-21)18-33-13-11-32(2)12-14-33/h3-10,16-17,30H,11-14,18H2,1-2H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301684
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)
Show SMILES CN1CCN(Cc2ccc(s2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C25H26N6S/c1-17-20-7-8-28-23(20)5-4-22(17)29-25-18(13-26)14-27-15-21(25)24-6-3-19(32-24)16-31-11-9-30(2)10-12-31/h3-8,14-15,28H,9-12,16H2,1-2H3,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301676
PNG
(5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Show SMILES CN(C)Cc1cccc(c1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H23N5/c1-16-20-9-10-27-23(20)8-7-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-5-17(11-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 6.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301689
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(thiomorpholi...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCSCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H23N5OS/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(30-23)15-29-8-10-31-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301688
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinome...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H23N5O2/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(31-23)15-29-8-10-30-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.80n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301693
PNG
(5-(5-((4-(dimethylamino)piperidin-1-yl)methyl)fura...)
Show SMILES CN(C)C1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H30N6O/c1-18-23-6-9-30-26(23)5-4-25(18)31-27-20(13-28)14-29-15-24(27)19-12-22(34-17-19)16-33-10-7-21(8-11-33)32(2)3/h4-6,9,12,14-15,17,21,30H,7-8,10-11,16H2,1-3H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.20n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301675
PNG
(5-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H23N5/c1-16-20-10-11-27-23(20)9-8-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-17(5-7-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.40n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301680
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinome...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C26H25N5O/c1-18-22-8-9-29-25(22)7-6-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-19(3-5-20)17-31-10-12-32-13-11-31/h2-9,15-16,29H,10-13,17H2,1H3,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301685
PNG
(1-((4-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2cc(cs2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2S/c1-4-22-7-5-10-28(25-17-26(32-20-25)19-31-15-13-30(3)14-16-31)29(22)18-24-12-11-23-8-6-9-27(23)21(24)2/h1,5-7,9-12,17,20H,8,13-16,18-19H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C, epsilon


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of PKCepsilon by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301687
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)
Show SMILES CN1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C25H26N6O/c1-17-21-5-6-28-24(21)4-3-23(17)29-25-19(12-26)13-27-14-22(25)18-11-20(32-16-18)15-31-9-7-30(2)8-10-31/h3-6,11,13-14,16,28H,7-10,15H2,1-2H3,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301694
PNG
(5-(5-((4-isopropylpiperazin-1-yl)methyl)furan-3-yl...)
Show SMILES CC(C)N1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H30N6O/c1-18(2)33-10-8-32(9-11-33)16-22-12-20(17-34-22)24-15-29-14-21(13-28)27(24)31-25-4-5-26-23(19(25)3)6-7-30-26/h4-7,12,14-15,17-18,30H,8-11,16H2,1-3H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301695
PNG
(5-(5-((4-cyclopentylpiperazin-1-yl)methyl)furan-3-...)
Show SMILES Cc1c(Nc2c(cncc2-c2coc(CN3CCN(CC3)C3CCCC3)c2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C29H32N6O/c1-20-25-8-9-32-28(25)7-6-27(20)33-29-22(15-30)16-31-17-26(29)21-14-24(36-19-21)18-34-10-12-35(13-11-34)23-4-2-3-5-23/h6-9,14,16-17,19,23,32H,2-5,10-13,18H2,1H3,(H,31,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301679
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-((4-methylpip...)
Show SMILES CN1CCN(Cc2cccc(c2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H28N6/c1-19-23-8-9-30-26(23)7-6-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-4-20(14-21)18-33-12-10-32(2)11-13-33/h3-9,14,16-17,30H,10-13,18H2,1-2H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301681
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(morpholinome...)
Show SMILES Cc1c(Nc2c(cncc2-c2cccc(CN3CCOCC3)c2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C26H25N5O/c1-18-22-7-8-29-25(22)6-5-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-3-19(13-20)17-31-9-11-32-12-10-31/h2-8,13,15-16,29H,9-12,17H2,1H3,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301678
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-((4-methylpip...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C27H28N6/c1-19-23-9-10-30-26(23)8-7-25(19)31-27-22(15-28)16-29-17-24(27)21-5-3-20(4-6-21)18-33-13-11-32(2)12-14-33/h3-10,16-17,30H,11-14,18H2,1-2H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301676
PNG
(5-(3-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Show SMILES CN(C)Cc1cccc(c1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H23N5/c1-16-20-9-10-27-23(20)8-7-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-5-17(11-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301691
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H23N5O/c1-16-19-8-9-27-22(19)6-5-21(16)28-24-17(12-25)13-26-14-20(24)23-7-4-18(30-23)15-29-10-2-3-11-29/h4-9,13-14,27H,2-3,10-11,15H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 35n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301687
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)
Show SMILES CN1CCN(Cc2cc(co2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C25H26N6O/c1-17-21-5-6-28-24(21)4-3-23(17)29-25-19(12-26)13-27-14-22(25)18-11-20(32-16-18)15-31-9-7-30(2)8-10-31/h3-6,11,13-14,16,28H,7-10,15H2,1-2H3,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301682
PNG
(4-(4-methyl-1H-indol-5-ylamino)-6'-((4-methylpiper...)
Show SMILES CN1CCN(Cc2ccc(cn2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C26H27N7/c1-18-22-7-8-29-25(22)6-5-24(18)31-26-20(13-27)14-28-16-23(26)19-3-4-21(30-15-19)17-33-11-9-32(2)10-12-33/h3-8,14-16,29H,9-12,17H2,1-2H3,(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301690
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperidin-1-...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C25H25N5O/c1-17-20-9-10-28-23(20)7-6-22(17)29-25-18(13-26)14-27-15-21(25)24-8-5-19(31-24)16-30-11-3-2-4-12-30/h5-10,14-15,28H,2-4,11-12,16H2,1H3,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 41n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301692
PNG
(5-(5-((diethylamino)methyl)furan-2-yl)-4-(4-methyl...)
Show SMILES CCN(CC)Cc1ccc(o1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H25N5O/c1-4-29(5-2)15-18-6-9-23(30-18)20-14-26-13-17(12-25)24(20)28-21-7-8-22-19(16(21)3)10-11-27-22/h6-11,13-14,27H,4-5,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 42n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301684
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-((4-methylpip...)
Show SMILES CN1CCN(Cc2ccc(s2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C25H26N6S/c1-17-20-7-8-28-23(20)5-4-22(17)29-25-18(13-26)14-27-15-21(25)24-6-3-19(32-24)16-31-11-9-30(2)10-12-31/h3-8,14-15,28H,9-12,16H2,1-2H3,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 50n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301675
PNG
(5-(4-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Show SMILES CN(C)Cc1ccc(cc1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H23N5/c1-16-20-10-11-27-23(20)9-8-22(16)28-24-19(12-25)13-26-14-21(24)18-6-4-17(5-7-18)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 58n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301680
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(4-(morpholinome...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)cc2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C26H25N5O/c1-18-22-8-9-29-25(22)7-6-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-19(3-5-20)17-31-10-12-32-13-11-31/h2-9,15-16,29H,10-13,17H2,1H3,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 70n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301681
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(morpholinome...)
Show SMILES Cc1c(Nc2c(cncc2-c2cccc(CN3CCOCC3)c2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C26H25N5O/c1-18-22-7-8-29-25(22)6-5-24(18)30-26-21(14-27)15-28-16-23(26)20-4-2-3-19(13-20)17-31-9-11-32-12-10-31/h2-8,13,15-16,29H,9-12,17H2,1H3,(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 84n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301688
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(morpholinome...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCOCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H23N5O2/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(31-23)15-29-8-10-30-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 86n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301689
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(thiomorpholi...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCSCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H23N5OS/c1-16-19-6-7-27-22(19)4-3-21(16)28-24-17(12-25)13-26-14-20(24)23-5-2-18(30-23)15-29-8-10-31-11-9-29/h2-7,13-14,27H,8-11,15H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 94n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C, eta


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of PKCeta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301692
PNG
(5-(5-((diethylamino)methyl)furan-2-yl)-4-(4-methyl...)
Show SMILES CCN(CC)Cc1ccc(o1)-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H25N5O/c1-4-29(5-2)15-18-6-9-23(30-18)20-14-26-13-17(12-25)24(20)28-21-7-8-22-19(16(21)3)10-11-27-22/h6-11,13-14,27H,4-5,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301683
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5'-((4-methylpiper...)
Show SMILES CN1CCN(Cc2cncc(c2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C26H27N7/c1-18-22-5-6-30-25(22)4-3-24(18)31-26-21(12-27)15-29-16-23(26)20-11-19(13-28-14-20)17-33-9-7-32(2)8-10-33/h3-6,11,13-16,30H,7-10,17H2,1-2H3,(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50301677
PNG
(5-(2-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Show SMILES CN(C)Cc1ccccc1-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H23N5/c1-16-19-10-11-27-23(19)9-8-22(16)28-24-18(12-25)13-26-14-21(24)20-7-5-4-6-17(20)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCtheta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301682
PNG
(4-(4-methyl-1H-indol-5-ylamino)-6'-((4-methylpiper...)
Show SMILES CN1CCN(Cc2ccc(cn2)-c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)CC1
Show InChI InChI=1S/C26H27N7/c1-18-22-7-8-29-25(22)6-5-24(18)31-26-20(13-27)14-28-16-23(26)19-3-4-21(30-15-19)17-33-11-9-32(2)10-12-33/h3-8,14-16,29H,9-12,17H2,1-2H3,(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 250n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301691
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(pyrrolidin-1...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C24H23N5O/c1-16-19-8-9-27-22(19)6-5-21(16)28-24-17(12-25)13-26-14-20(24)23-7-4-18(30-23)15-29-10-2-3-11-29/h4-9,13-14,27H,2-3,10-11,15H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301690
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(5-(piperidin-1-...)
Show SMILES Cc1c(Nc2c(cncc2-c2ccc(CN3CCCCC3)o2)C#N)ccc2[nH]ccc12
Show InChI InChI=1S/C25H25N5O/c1-17-20-9-10-28-23(20)7-6-22(17)29-25-18(13-26)14-27-15-21(25)24-8-5-19(31-24)16-30-11-3-2-4-12-30/h5-10,14-15,28H,2-4,11-12,16H2,1H3,(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 390n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Lck


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50301677
PNG
(5-(2-((dimethylamino)methyl)phenyl)-4-(4-methyl-1H...)
Show SMILES CN(C)Cc1ccccc1-c1cncc(C#N)c1Nc1ccc2[nH]ccc2c1C
Show InChI InChI=1S/C24H23N5/c1-16-19-10-11-27-23(19)9-8-22(16)28-24-18(12-25)13-26-14-21(24)20-7-5-4-6-17(20)15-29(2)3/h4-11,13-14,27H,15H2,1-3H3,(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.40E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of human PKCdelta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
MAP kinase-activated protein kinase 2


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of MK2


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of Lyn


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Rho-associated protein kinase 1


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of ROCK1


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50301686
PNG
(1-((5-(3-ethynyl-2-((4-methyl-1H-inden-5-yl)methyl...)
Show SMILES CN1CCN(Cc2ccc(o2)-c2cccc(C#C)c2Cc2ccc3CC=Cc3c2C)CC1 |c:27|
Show InChI InChI=1S/C29H30N2O/c1-4-22-7-5-10-27(28(22)19-24-12-11-23-8-6-9-26(23)21(24)2)29-14-13-25(32-29)20-31-17-15-30(3)16-18-31/h1,5-7,9-14H,8,15-20H2,2-3H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of PKCzeta by IMAP kinase assay


Bioorg Med Chem Lett 19: 5423-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.109
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%