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PubMed code 19713110

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302101
PNG
(3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1
Show InChI InChI=1S/C21H22N4O4/c1-4-25(13-9-6-5-7-10-13)23-17-16(19(27)20(17)28)22-15-12-8-11-14(18(15)26)21(29)24(2)3/h5-12,22-23,26H,4H2,1-3H3
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110n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302098
PNG
(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Show SMILES CCN(CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C17H22N4O4/c1-5-21(6-2)19-13-12(15(23)16(13)24)18-11-9-7-8-10(14(11)22)17(25)20(3)4/h7-9,18-19,22H,5-6H2,1-4H3
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120n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302104
PNG
(3-(2-(2-ethyl-2-(pyridin-2-yl)hydrazinyl)-3,4-diox...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccn1
Show InChI InChI=1S/C20H21N5O4/c1-4-25(14-10-5-6-11-21-14)23-16-15(18(27)19(16)28)22-13-9-7-8-12(17(13)26)20(29)24(2)3/h5-11,22-23,26H,4H2,1-3H3
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130n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302103
PNG
(3-(2-(2-ethyl-2-(4-methoxyphenyl)hydrazinyl)-3,4-d...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C22H24N4O5/c1-5-26(13-9-11-14(31-4)12-10-13)24-18-17(20(28)21(18)29)23-16-8-6-7-15(19(16)27)22(30)25(2)3/h6-12,23-24,27H,5H2,1-4H3
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180n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302106
PNG
(3-(2-(2-ethyl-2-(4-fluorobenzoyl)hydrazinyl)-3,4-d...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN4O5/c1-4-27(21(31)12-8-10-13(23)11-9-12)25-17-16(19(29)20(17)30)24-15-7-5-6-14(18(15)28)22(32)26(2)3/h5-11,24-25,28H,4H2,1-3H3
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260n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302100
PNG
(3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)=O
Show InChI InChI=1S/C17H20N4O5/c1-5-21(9(2)22)19-13-12(15(24)16(13)25)18-11-8-6-7-10(14(11)23)17(26)20(3)4/h6-8,18-19,23H,5H2,1-4H3
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320n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302102
PNG
(3-(2-(2-ethyl-2-(4-fluorophenyl)hydrazinyl)-3,4-di...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN4O4/c1-4-26(13-10-8-12(22)9-11-13)24-17-16(19(28)20(17)29)23-15-7-5-6-14(18(15)27)21(30)25(2)3/h5-11,23-24,27H,4H2,1-3H3
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550n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302101
PNG
(3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1
Show InChI InChI=1S/C21H22N4O4/c1-4-25(13-9-6-5-7-10-13)23-17-16(19(27)20(17)28)22-15-12-8-11-14(18(15)26)21(29)24(2)3/h5-12,22-23,26H,4H2,1-3H3
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4.10E+3n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302104
PNG
(3-(2-(2-ethyl-2-(pyridin-2-yl)hydrazinyl)-3,4-diox...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccn1
Show InChI InChI=1S/C20H21N5O4/c1-4-25(14-10-5-6-11-21-14)23-16-15(18(27)19(16)28)22-13-9-7-8-12(17(13)26)20(29)24(2)3/h5-11,22-23,26H,4H2,1-3H3
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5.20E+3n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302103
PNG
(3-(2-(2-ethyl-2-(4-methoxyphenyl)hydrazinyl)-3,4-d...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C22H24N4O5/c1-5-26(13-9-11-14(31-4)12-10-13)24-18-17(20(28)21(18)29)23-16-8-6-7-15(19(16)27)22(30)25(2)3/h6-12,23-24,27H,5H2,1-4H3
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6.50E+3n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302105
PNG
(3-(2-(2-ethyl-2-(4-fluorobenzyl)hydrazinyl)-3,4-di...)
Show SMILES CCN(Cc1ccc(F)cc1)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C22H23FN4O4/c1-4-27(12-13-8-10-14(23)11-9-13)25-18-17(20(29)21(18)30)24-16-7-5-6-15(19(16)28)22(31)26(2)3/h5-11,24-25,28H,4,12H2,1-3H3
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7.20E+3n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302098
PNG
(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Show SMILES CCN(CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C17H22N4O4/c1-5-21(6-2)19-13-12(15(23)16(13)24)18-11-9-7-8-10(14(11)22)17(25)20(3)4/h7-9,18-19,22H,5-6H2,1-4H3
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9.70E+3n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302106
PNG
(3-(2-(2-ethyl-2-(4-fluorobenzoyl)hydrazinyl)-3,4-d...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN4O5/c1-4-27(21(31)12-8-10-13(23)11-9-12)25-17-16(19(29)20(17)30)24-15-7-5-6-14(18(15)28)22(32)26(2)3/h5-11,24-25,28H,4H2,1-3H3
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>1.20E+4n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302105
PNG
(3-(2-(2-ethyl-2-(4-fluorobenzyl)hydrazinyl)-3,4-di...)
Show SMILES CCN(Cc1ccc(F)cc1)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C22H23FN4O4/c1-4-27(12-13-8-10-14(23)11-9-13)25-18-17(20(29)21(18)30)24-16-7-5-6-15(19(16)28)22(31)26(2)3/h5-11,24-25,28H,4,12H2,1-3H3
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>1.20E+4n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302100
PNG
(3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)=O
Show InChI InChI=1S/C17H20N4O5/c1-5-21(9(2)22)19-13-12(15(24)16(13)25)18-11-8-6-7-10(14(11)23)17(26)20(3)4/h6-8,18-19,23H,5H2,1-4H3
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>1.20E+4n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Chemokine receptor type 1 (CXCR1)


(Homo sapiens (Human))
BDBM50302102
PNG
(3-(2-(2-ethyl-2-(4-fluorophenyl)hydrazinyl)-3,4-di...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN4O4/c1-4-26(13-10-8-12(22)9-11-13)24-17-16(19(28)20(17)29)23-15-7-5-6-14(18(15)27)21(30)25(2)3/h5-11,23-24,27H,4H2,1-3H3
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>1.20E+4n/an/an/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR1 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302098
PNG
(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Show SMILES CCN(CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C17H22N4O4/c1-5-21(6-2)19-13-12(15(23)16(13)24)18-11-9-7-8-10(14(11)22)17(25)20(3)4/h7-9,18-19,22H,5-6H2,1-4H3
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n/an/a 46n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302101
PNG
(3-(2-(2-ethyl-2-phenylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccc1
Show InChI InChI=1S/C21H22N4O4/c1-4-25(13-9-6-5-7-10-13)23-17-16(19(27)20(17)28)22-15-12-8-11-14(18(15)26)21(29)24(2)3/h5-12,22-23,26H,4H2,1-3H3
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n/an/a 54n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302104
PNG
(3-(2-(2-ethyl-2-(pyridin-2-yl)hydrazinyl)-3,4-diox...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccccn1
Show InChI InChI=1S/C20H21N5O4/c1-4-25(14-10-5-6-11-21-14)23-16-15(18(27)19(16)28)22-13-9-7-8-12(17(13)26)20(29)24(2)3/h5-11,22-23,26H,4H2,1-3H3
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n/an/a 75n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302103
PNG
(3-(2-(2-ethyl-2-(4-methoxyphenyl)hydrazinyl)-3,4-d...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(OC)cc1
Show InChI InChI=1S/C22H24N4O5/c1-5-26(13-9-11-14(31-4)12-10-13)24-18-17(20(28)21(18)29)23-16-8-6-7-15(19(16)27)22(30)25(2)3/h6-12,23-24,27H,5H2,1-4H3
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UniChem
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302102
PNG
(3-(2-(2-ethyl-2-(4-fluorophenyl)hydrazinyl)-3,4-di...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H21FN4O4/c1-4-26(13-10-8-12(22)9-11-13)24-17-16(19(28)20(17)29)23-15-7-5-6-14(18(15)27)21(30)25(2)3/h5-11,23-24,27H,4H2,1-3H3
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UniChem
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n/an/a 840n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302106
PNG
(3-(2-(2-ethyl-2-(4-fluorobenzoyl)hydrazinyl)-3,4-d...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(=O)c1ccc(F)cc1
Show InChI InChI=1S/C22H21FN4O5/c1-4-27(21(31)12-8-10-13(23)11-9-12)25-17-16(19(29)20(17)30)24-15-7-5-6-14(18(15)28)22(32)26(2)3/h5-11,24-25,28H,4H2,1-3H3
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n/an/a 840n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302100
PNG
(3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)=O
Show InChI InChI=1S/C17H20N4O5/c1-5-21(9(2)22)19-13-12(15(24)16(13)25)18-11-8-6-7-10(14(11)23)17(26)20(3)4/h6-8,18-19,23H,5H2,1-4H3
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n/an/a 1.25E+3n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302098
PNG
(3-(2-(2,2-diethylhydrazinyl)-3,4-dioxocyclobut-1-e...)
Show SMILES CCN(CC)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C17H22N4O4/c1-5-21(6-2)19-13-12(15(23)16(13)24)18-11-9-7-8-10(14(11)22)17(25)20(3)4/h7-9,18-19,22H,5-6H2,1-4H3
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n/an/a 1.86E+3n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302100
PNG
(3-(2-(2-acetyl-2-ethylhydrazinyl)-3,4-dioxocyclobu...)
Show SMILES CCN(Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O)C(C)=O
Show InChI InChI=1S/C17H20N4O5/c1-5-21(9(2)22)19-13-12(15(24)16(13)25)18-11-8-6-7-10(14(11)23)17(26)20(3)4/h6-8,18-19,23H,5H2,1-4H3
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n/an/a 3.29E+3n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302099
PNG
(3-(2-(2-ethylhydrazinyl)-3,4-dioxocyclobut-1-enyla...)
Show SMILES CCNNc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C15H18N4O4/c1-4-16-18-11-10(13(21)14(11)22)17-9-7-5-6-8(12(9)20)15(23)19(2)3/h5-7,16-18,20H,4H2,1-3H3
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n/an/a 5.49E+3n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Displacement of [125I]IL-8 from human CXCR2 expressed in mouse BaF3 cells by liquid scintillation counting


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR2


(Homo sapiens (Human))
BDBM50302105
PNG
(3-(2-(2-ethyl-2-(4-fluorobenzyl)hydrazinyl)-3,4-di...)
Show SMILES CCN(Cc1ccc(F)cc1)Nc1c(Nc2cccc(C(=O)N(C)C)c2O)c(=O)c1=O
Show InChI InChI=1S/C22H23FN4O4/c1-4-27(12-13-8-10-14(23)11-9-13)25-18-17(20(29)21(18)30)24-16-7-5-6-15(19(16)28)22(31)26(2)3/h5-11,24-25,28H,4,12H2,1-3H3
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n/an/a 6.34E+3n/an/an/an/an/an/a



WuXi PharmaTech Co. Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at CXCR2 expressed in CHO cells assessed as inhibition of IL-8-induced chemotaxis


Bioorg Med Chem Lett 19: 5741-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.014
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%