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PubMed code 19736007

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302304
PNG
(1,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CC1CCCCC1(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-15-13-21-18(12-17(15)14-23-8-10-25-11-9-23)22-19(24)20(3)7-5-4-6-16(20)2/h12-13,16H,4-11,14H2,1-3H3,(H,21,22,24)
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 1.90n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302299
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C18H29N3O2/c1-5-6-18(3,4)17(22)20-16-11-15(14(2)12-19-16)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
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 5.30n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302303
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-3-20(7-5-4-6-8-20)19(24)22-18-13-17(16(2)14-21-18)15-23-9-11-25-12-10-23/h13-14H,3-12,15H2,1-2H3,(H,21,22,24)
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 7n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302295
PNG
(CHEMBL570792 | N-(5-ethyl-4-(morpholinomethyl)pyri...)
Show SMILES CCc1cnc(NC(=O)C(C)(C)CC)cc1CN1CCOCC1
Show InChI InChI=1S/C18H29N3O2/c1-5-14-12-19-16(20-17(22)18(3,4)6-2)11-15(14)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
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 7.90n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302302
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C19H29N3O2/c1-3-19(6-4-5-7-19)18(23)21-17-12-16(15(2)13-20-17)14-22-8-10-24-11-9-22/h12-13H,3-11,14H2,1-2H3,(H,20,21,23)
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 13n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302305
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C17H27N3O2/c1-5-17(3,4)16(21)19-15-10-14(13(2)11-18-15)12-20-6-8-22-9-7-20/h10-11H,5-9,12H2,1-4H3,(H,18,19,21)
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 24n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302301
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C18H27N3O2/c1-3-18(5-4-6-18)17(22)20-16-11-15(14(2)12-19-16)13-21-7-9-23-10-8-21/h11-12H,3-10,13H2,1-2H3,(H,19,20,22)
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 45n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302300
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C17H25N3O2/c1-3-17(4-5-17)16(21)19-15-10-14(13(2)11-18-15)12-20-6-8-22-9-7-20/h10-11H,3-9,12H2,1-2H3,(H,18,19,21)
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 63n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302294
PNG
(2,2-dimethyl-N-(6-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)cc(C)n1
Show InChI InChI=1S/C17H27N3O2/c1-5-17(3,4)16(21)19-15-11-14(10-13(2)18-15)12-20-6-8-22-9-7-20/h10-11H,5-9,12H2,1-4H3,(H,18,19,21)
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 67n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302298
PNG
(CHEMBL566456 | N-(5-methyl-4-(morpholinomethyl)pyr...)
Show SMILES Cc1cnc(NC(=O)C(C)(C)C)cc1CN1CCOCC1
Show InChI InChI=1S/C16H25N3O2/c1-12-10-17-14(18-15(20)16(2,3)4)9-13(12)11-19-5-7-21-8-6-19/h9-10H,5-8,11H2,1-4H3,(H,17,18,20)
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 81n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302296
PNG
(CHEMBL568157 | N-(5-cyano-4-(morpholinomethyl)pyri...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(cn1)C#N
Show InChI InChI=1S/C17H24N4O2/c1-4-17(2,3)16(22)20-15-9-13(14(10-18)11-19-15)12-21-5-7-23-8-6-21/h9,11H,4-8,12H2,1-3H3,(H,19,20,22)
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 100n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50301314
PNG
(2,2-dimethyl-N-(4-methyl-3-(morpholinomethyl)pheny...)
Show SMILES CCC(C)(C)C(=O)Nc1ccc(C)c(CN2CCOCC2)c1
Show InChI InChI=1S/C18H28N2O2/c1-5-18(3,4)17(21)19-16-7-6-14(2)15(12-16)13-20-8-10-22-11-9-20/h6-7,12H,5,8-11,13H2,1-4H3,(H,19,21)
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 120n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50301310
PNG
(CHEMBL567924 | N-(2,4-dimethyl-5-(morpholinomethyl...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cc1C
Show InChI InChI=1S/C19H30N2O2/c1-6-19(4,5)18(22)20-17-12-16(14(2)11-15(17)3)13-21-7-9-23-10-8-21/h11-12H,6-10,13H2,1-5H3,(H,20,22)
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 530n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302297
PNG
(CHEMBL572328 | N-(5-amino-4-(morpholinomethyl)pyri...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(N)cn1
Show InChI InChI=1S/C16H26N4O2/c1-4-16(2,3)15(21)19-14-9-12(13(17)10-18-14)11-20-5-7-22-8-6-20/h9-10H,4-8,11,17H2,1-3H3,(H,18,19,21)
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 870n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50302302
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C19H29N3O2/c1-3-19(6-4-5-7-19)18(23)21-17-12-16(15(2)13-20-17)14-22-8-10-24-11-9-22/h12-13H,3-11,14H2,1-2H3,(H,20,21,23)
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 1.10E+3n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB1 receptor after 120 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))		BDBM50302306
PNG
(2,2-dimethyl-N-(5-methyl-6-(morpholinomethyl)pyrid...)
Show SMILES CCC(C)(C)C(=O)Nc1ccc(C)c(CN2CCOCC2)n1
Show InChI InChI=1S/C17H27N3O2/c1-5-17(3,4)16(21)19-15-7-6-13(2)14(18-15)12-20-8-10-22-11-9-20/h6-7H,5,8-12H2,1-4H3,(H,18,19,21)
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 1.80E+3n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB2 receptor after 60 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50302299
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C18H29N3O2/c1-5-6-18(3,4)17(22)20-16-11-15(14(2)12-19-16)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
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 1.80E+3n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB1 receptor after 120 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50302304
PNG
(1,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CC1CCCCC1(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-15-13-21-18(12-17(15)14-23-8-10-25-11-9-23)22-19(24)20(3)7-5-4-6-16(20)2/h12-13,16H,4-11,14H2,1-3H3,(H,21,22,24)
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 2.50E+3n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB1 receptor after 120 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50302305
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C17H27N3O2/c1-5-17(3,4)16(21)19-15-10-14(13(2)11-18-15)12-20-6-8-22-9-7-20/h10-11H,5-9,12H2,1-4H3,(H,18,19,21)
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 3.80E+3n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB1 receptor after 120 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))		BDBM50302295
PNG
(CHEMBL570792 | N-(5-ethyl-4-(morpholinomethyl)pyri...)
Show SMILES CCc1cnc(NC(=O)C(C)(C)CC)cc1CN1CCOCC1
Show InChI InChI=1S/C18H29N3O2/c1-5-14-12-19-16(20-17(22)18(3,4)6-2)11-15(14)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
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 4.30E+3n/an/an/an/an/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Displacement of [3H]CP55960 from human cloned CB1 receptor after 120 mins by scintillation spectroscopy

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302304
PNG
(1,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CC1CCCCC1(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-15-13-21-18(12-17(15)14-23-8-10-25-11-9-23)22-19(24)20(3)7-5-4-6-16(20)2/h12-13,16H,4-11,14H2,1-3H3,(H,21,22,24)
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n/an/an/an/a 2.80n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302302
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C19H29N3O2/c1-3-19(6-4-5-7-19)18(23)21-17-12-16(15(2)13-20-17)14-22-8-10-24-11-9-22/h12-13H,3-11,14H2,1-2H3,(H,20,21,23)
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n/an/an/an/a 13n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302303
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCCCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C20H31N3O2/c1-3-20(7-5-4-6-8-20)19(24)22-18-13-17(16(2)14-21-18)15-23-9-11-25-12-10-23/h13-14H,3-12,15H2,1-2H3,(H,21,22,24)
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n/an/an/an/a 8.80n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302305
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C17H27N3O2/c1-5-17(3,4)16(21)19-15-10-14(13(2)11-18-15)12-20-6-8-22-9-7-20/h10-11H,5-9,12H2,1-4H3,(H,18,19,21)
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n/an/an/an/a 41n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302295
PNG
(CHEMBL570792 | N-(5-ethyl-4-(morpholinomethyl)pyri...)
Show SMILES CCc1cnc(NC(=O)C(C)(C)CC)cc1CN1CCOCC1
Show InChI InChI=1S/C18H29N3O2/c1-5-14-12-19-16(20-17(22)18(3,4)6-2)11-15(14)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
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n/an/an/an/a 9.60n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302296
PNG
(CHEMBL568157 | N-(5-cyano-4-(morpholinomethyl)pyri...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(cn1)C#N
Show InChI InChI=1S/C17H24N4O2/c1-4-17(2,3)16(22)20-15-9-13(14(10-18)11-19-15)12-21-5-7-23-8-6-21/h9,11H,4-8,12H2,1-3H3,(H,19,20,22)
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n/an/an/an/a 200n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302301
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CCC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C18H27N3O2/c1-3-18(5-4-6-18)17(22)20-16-11-15(14(2)12-19-16)13-21-7-9-23-10-8-21/h11-12H,3-10,13H2,1-2H3,(H,19,20,22)
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n/an/an/an/a 140n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302294
PNG
(2,2-dimethyl-N-(6-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)cc(C)n1
Show InChI InChI=1S/C17H27N3O2/c1-5-17(3,4)16(21)19-15-11-14(10-13(2)18-15)12-20-6-8-22-9-7-20/h10-11H,5-9,12H2,1-4H3,(H,18,19,21)
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n/an/an/an/a 260n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302298
PNG
(CHEMBL566456 | N-(5-methyl-4-(morpholinomethyl)pyr...)
Show SMILES Cc1cnc(NC(=O)C(C)(C)C)cc1CN1CCOCC1
Show InChI InChI=1S/C16H25N3O2/c1-12-10-17-14(18-15(20)16(2,3)4)9-13(12)11-19-5-7-21-8-6-19/h9-10H,5-8,11H2,1-4H3,(H,17,18,20)
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n/an/an/an/a 70n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302300
PNG
(1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-...)
Show SMILES CCC1(CC1)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C17H25N3O2/c1-3-17(4-5-17)16(21)19-15-10-14(13(2)11-18-15)12-20-6-8-22-9-7-20/h10-11H,3-9,12H2,1-2H3,(H,18,19,21)
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n/an/an/an/a 62n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Rattus norvegicus (Rat))		BDBM50302299
PNG
(2,2-dimethyl-N-(5-methyl-4-(morpholinomethyl)pyrid...)
Show SMILES CCCC(C)(C)C(=O)Nc1cc(CN2CCOCC2)c(C)cn1
Show InChI InChI=1S/C18H29N3O2/c1-5-6-18(3,4)17(22)20-16-11-15(14(2)12-19-16)13-21-7-9-23-10-8-21/h11-12H,5-10,13H2,1-4H3,(H,19,20,22)
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n/an/an/an/a 4.10n/an/an/an/a



Adolor Corporation

Curated by ChEMBL


Assay Description
Agonist activity at CB2 receptor in rat cerebellar membrane assessed as WIN 55212-2-stimulated [35S]GTPgammaS binding after 6 hrs by scintillation sp...

Bioorg Med Chem Lett 19: 5931-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.063
BindingDB Entry DOI: 10.7270/Q2HQ4001
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%