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PubMed code 19740658

Compile data set for download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302326
PNG
((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Show SMILES Cc1c(CN([C@@H]2CCNC2)S(C)(=O)=O)ccc2cc(F)ccc12 |r|
Show InChI InChI=1S/C17H21FN2O2S/c1-12-14(4-3-13-9-15(18)5-6-17(12)13)11-20(23(2,21)22)16-7-8-19-10-16/h3-6,9,16,19H,7-8,10-11H2,1-2H3/t16-/m1/s1
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PubMed
 1.60E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302327
PNG
(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C17H22N2O2S/c1-22(20,21)19(17-8-10-18-11-9-17)13-14-6-7-15-4-2-3-5-16(15)12-14/h2-7,12,17-18H,8-11,13H2,1H3
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 3.20E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302325
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m1/s1
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 4.20E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302320
PNG
((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m1/s1
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PubMed
 7.00E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302317
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C17H20N2O/c1-13(20)19(17-8-9-18-11-17)12-14-6-7-15-4-2-3-5-16(15)10-14/h2-7,10,17-18H,8-9,11-12H2,1H3/t17-/m1/s1
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 8.00E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302314
PNG
(CHEMBL578346 | N-cyclobutyl-N-(piperidin-4-yl)-2-n...)
Show SMILES O=C(N(C1CCC1)C1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H24N2O/c23-20(17-9-8-15-4-1-2-5-16(15)14-17)22(18-6-3-7-18)19-10-12-21-13-11-19/h1-2,4-5,8-9,14,18-19,21H,3,6-7,10-13H2
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302311
PNG
((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m0/s1
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 1.10E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302309
PNG
(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C19H24N2O/c1-2-19(22)21(18-9-11-20-12-10-18)14-15-7-8-16-5-3-4-6-17(16)13-15/h3-8,13,18,20H,2,9-12,14H2,1H3
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 1.20E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302313
PNG
(CHEMBL565638 | N-(piperidin-4-yl)-N-propyl-2-napht...)
Show SMILES CCCN(C1CCNCC1)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c1-2-13-21(18-9-11-20-12-10-18)19(22)17-8-7-15-5-3-4-6-16(15)14-17/h3-8,14,18,20H,2,9-13H2,1H3
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 1.27E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50302310
PNG
(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C18H22N2O/c1-14(21)20(18-8-10-19-11-9-18)13-15-6-7-16-4-2-3-5-17(16)12-15/h2-7,12,18-19H,8-11,13H2,1H3
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>2.00E+4n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302309
PNG
(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C19H24N2O/c1-2-19(22)21(18-9-11-20-12-10-18)14-15-7-8-16-5-3-4-6-17(16)13-15/h3-8,13,18,20H,2,9-12,14H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302318
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)p...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C18H22N2O/c1-2-18(21)20(17-9-10-19-12-17)13-14-7-8-15-5-3-4-6-16(15)11-14/h3-8,11,17,19H,2,9-10,12-13H2,1H3/t17-/m1/s1
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n/an/a 2.40n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302321
PNG
((S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302327
PNG
(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C17H22N2O2S/c1-22(20,21)19(17-8-10-18-11-9-17)13-14-6-7-15-4-2-3-5-16(15)12-14/h2-7,12,17-18H,8-11,13H2,1H3
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302311
PNG
((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302310
PNG
(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C18H22N2O/c1-14(21)20(18-8-10-19-11-9-18)13-15-6-7-16-4-2-3-5-17(16)12-15/h2-7,12,18-19H,8-11,13H2,1H3
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n/an/a 4.5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302326
PNG
((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Show SMILES Cc1c(CN([C@@H]2CCNC2)S(C)(=O)=O)ccc2cc(F)ccc12 |r|
Show InChI InChI=1S/C17H21FN2O2S/c1-12-14(4-3-13-9-15(18)5-6-17(12)13)11-20(23(2,21)22)16-7-8-19-10-16/h3-6,9,16,19H,7-8,10-11H2,1-2H3/t16-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302320
PNG
((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302317
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C17H20N2O/c1-13(20)19(17-8-9-18-11-17)12-14-6-7-15-4-2-3-5-16(15)10-14/h2-7,10,17-18H,8-9,11-12H2,1H3/t17-/m1/s1
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n/an/a 5.20n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50278564
PNG
(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Show SMILES C(OC1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C16H19NO/c1-2-4-15-11-13(5-6-14(15)3-1)12-18-16-7-9-17-10-8-16/h1-6,11,16-17H,7-10,12H2
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n/an/a 5.90n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302323
PNG
((R)-3,4-dichloro-N-isopropyl-2-methyl-N-(pyrrolidi...)
Show SMILES CC(C)N([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C15H20Cl2N2O/c1-9(2)19(11-6-7-18-8-11)15(20)12-4-5-13(16)14(17)10(12)3/h4-5,9,11,18H,6-8H2,1-3H3/t11-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302316
PNG
((R)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-naphthamide...)
Show SMILES O=C(N(C1CCC1)[C@@H]1CCNC1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H22N2O/c22-19(16-9-8-14-4-1-2-5-15(14)12-16)21(17-6-3-7-17)18-10-11-20-13-18/h1-2,4-5,8-9,12,17-18,20H,3,6-7,10-11,13H2/t18-/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302308
PNG
(CHEMBL567289 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES C(N(C1CCNCC1)c1ncccn1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H22N4/c1-2-5-18-14-16(6-7-17(18)4-1)15-24(19-8-12-21-13-9-19)20-22-10-3-11-23-20/h1-7,10-11,14,19,21H,8-9,12-13,15H2
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302314
PNG
(CHEMBL578346 | N-cyclobutyl-N-(piperidin-4-yl)-2-n...)
Show SMILES O=C(N(C1CCC1)C1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H24N2O/c23-20(17-9-8-15-4-1-2-5-16(15)14-17)22(18-6-3-7-18)19-10-12-21-13-11-19/h1-2,4-5,8-9,14,18-19,21H,3,6-7,10-13H2
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302322
PNG
((R)-3,4-dichloro-N-ethyl-2-methyl-N-(pyrrolidin-3-...)
Show SMILES CCN([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C14H18Cl2N2O/c1-3-18(10-6-7-17-8-10)14(19)11-4-5-12(15)13(16)9(11)2/h4-5,10,17H,3,6-8H2,1-2H3/t10-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302319
PNG
((R)-N-cyclopentyl-N-(pyrrolidin-3-yl)-2-naphthamid...)
Show SMILES O=C(N(C1CCCC1)[C@@H]1CCNC1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C20H24N2O/c23-20(17-10-9-15-5-1-2-6-16(15)13-17)22(18-7-3-4-8-18)19-11-12-21-14-19/h1-2,5-6,9-10,13,18-19,21H,3-4,7-8,11-12,14H2/t19-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302324
PNG
((S)-3,4-dichloro-2-methyl-N-neopentyl-N-(pyrrolidi...)
Show SMILES Cc1c(Cl)c(Cl)ccc1C(=O)N(CC(C)(C)C)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C17H24Cl2N2O/c1-11-13(5-6-14(18)15(11)19)16(22)21(10-17(2,3)4)12-7-8-20-9-12/h5-6,12,20H,7-10H2,1-4H3/t12-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302315
PNG
((R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide ...)
Show SMILES CC(C)N([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H22N2O/c1-13(2)20(17-9-10-19-12-17)18(21)16-8-7-14-5-3-4-6-15(14)11-16/h3-8,11,13,17,19H,9-10,12H2,1-2H3/t17-/m1/s1
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n/an/a 15n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302325
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302321
PNG
((S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302313
PNG
(CHEMBL565638 | N-(piperidin-4-yl)-N-propyl-2-napht...)
Show SMILES CCCN(C1CCNCC1)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c1-2-13-21(18-9-11-20-12-10-18)19(22)17-8-7-15-5-3-4-6-16(15)14-17/h3-8,14,18,20H,2,9-13H2,1H3
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n/an/a 28.3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302329
PNG
((R)-3,4-dichloro-N,2-dimethyl-N-(pyrrolidin-3-yl)b...)
Show SMILES CN([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C13H16Cl2N2O/c1-8-10(3-4-11(14)12(8)15)13(18)17(2)9-5-6-16-7-9/h3-4,9,16H,5-7H2,1-2H3/t9-/m1/s1
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n/an/a 58n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302318
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)p...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C18H22N2O/c1-2-18(21)20(17-9-10-19-12-17)13-14-7-8-15-5-3-4-6-16(15)11-14/h3-8,11,17,19H,2,9-10,12-13H2,1H3/t17-/m1/s1
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n/an/a 224n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302318
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)p...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C18H22N2O/c1-2-18(21)20(17-9-10-19-12-17)13-14-7-8-15-5-3-4-6-16(15)11-14/h3-8,11,17,19H,2,9-10,12-13H2,1H3/t17-/m1/s1
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n/an/a 266n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302309
PNG
(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C19H24N2O/c1-2-19(22)21(18-9-11-20-12-10-18)14-15-7-8-16-5-3-4-6-17(16)13-15/h3-8,13,18,20H,2,9-12,14H2,1H3
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n/an/a 339n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302324
PNG
((S)-3,4-dichloro-2-methyl-N-neopentyl-N-(pyrrolidi...)
Show SMILES Cc1c(Cl)c(Cl)ccc1C(=O)N(CC(C)(C)C)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C17H24Cl2N2O/c1-11-13(5-6-14(18)15(11)19)16(22)21(10-17(2,3)4)12-7-8-20-9-12/h5-6,12,20H,7-10H2,1-4H3/t12-/m0/s1
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n/an/a 357n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302311
PNG
((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m0/s1
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n/an/a 370n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302312
PNG
(CHEMBL577272 | N-(piperidin-4-yl)-2-naphthamide)
Show SMILES O=C(NC1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C16H18N2O/c19-16(18-15-7-9-17-10-8-15)14-6-5-12-3-1-2-4-13(12)11-14/h1-6,11,15,17H,7-10H2,(H,18,19)
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n/an/a>400n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Homo sapiens (Human))		BDBM50302328
PNG
((R)-3,4-dichloro-N-methyl-N-(pyrrolidin-3-yl)benza...)
Show SMILES CN([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C12H14Cl2N2O/c1-16(9-4-5-15-7-9)12(17)8-2-3-10(13)11(14)6-8/h2-3,6,9,15H,4-5,7H2,1H3/t9-/m1/s1
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n/an/a>400n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302319
PNG
((R)-N-cyclopentyl-N-(pyrrolidin-3-yl)-2-naphthamid...)
Show SMILES O=C(N(C1CCCC1)[C@@H]1CCNC1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C20H24N2O/c23-20(17-10-9-15-5-1-2-6-16(15)13-17)22(18-7-3-4-8-18)19-11-12-21-14-19/h1-2,5-6,9-10,13,18-19,21H,3-4,7-8,11-12,14H2/t19-/m1/s1
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n/an/a 677n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302317
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C17H20N2O/c1-13(20)19(17-8-9-18-11-17)12-14-6-7-15-4-2-3-5-16(15)10-14/h2-7,10,17-18H,8-9,11-12H2,1H3/t17-/m1/s1
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n/an/a 726n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302326
PNG
((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Show SMILES Cc1c(CN([C@@H]2CCNC2)S(C)(=O)=O)ccc2cc(F)ccc12 |r|
Show InChI InChI=1S/C17H21FN2O2S/c1-12-14(4-3-13-9-15(18)5-6-17(12)13)11-20(23(2,21)22)16-7-8-19-10-16/h3-6,9,16,19H,7-8,10-11H2,1-2H3/t16-/m1/s1
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n/an/a 735n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302321
PNG
((S)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m0/s1
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n/an/a 744n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302320
PNG
((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302308
PNG
(CHEMBL567289 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES C(N(C1CCNCC1)c1ncccn1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H22N4/c1-2-5-18-14-16(6-7-17(18)4-1)15-24(19-8-12-21-13-9-19)20-22-10-3-11-23-20/h1-7,10-11,14,19,21H,8-9,12-13,15H2
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302309
PNG
(CHEMBL567288 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CCC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C19H24N2O/c1-2-19(22)21(18-9-11-20-12-10-18)14-15-7-8-16-5-3-4-6-17(16)13-15/h3-8,13,18,20H,2,9-12,14H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302308
PNG
(CHEMBL567289 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES C(N(C1CCNCC1)c1ncccn1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H22N4/c1-2-5-18-14-16(6-7-17(18)4-1)15-24(19-8-12-21-13-9-19)20-22-10-3-11-23-20/h1-7,10-11,14,19,21H,8-9,12-13,15H2
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50278564
PNG
(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Show SMILES C(OC1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C16H19NO/c1-2-4-15-11-13(5-6-14(15)3-1)12-18-16-7-9-17-10-8-16/h1-6,11,16-17H,7-10,12H2
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n/an/a 1.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302310
PNG
(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C18H22N2O/c1-14(21)20(18-8-10-19-11-9-18)13-15-6-7-16-4-2-3-5-17(16)12-15/h2-7,12,18-19H,8-11,13H2,1H3
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302327
PNG
(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C17H22N2O2S/c1-22(20,21)19(17-8-10-18-11-9-17)13-14-6-7-15-4-2-3-5-16(15)12-14/h2-7,12,17-18H,8-11,13H2,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302311
PNG
((S)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m0/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302327
PNG
(CHEMBL568350 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C17H22N2O2S/c1-22(20,21)19(17-8-10-18-11-9-17)13-14-6-7-15-4-2-3-5-16(15)12-14/h2-7,12,17-18H,8-11,13H2,1H3
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n/an/a 4.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302323
PNG
((R)-3,4-dichloro-N-isopropyl-2-methyl-N-(pyrrolidi...)
Show SMILES CC(C)N([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C15H20Cl2N2O/c1-9(2)19(11-6-7-18-8-11)15(20)12-4-5-13(16)14(17)10(12)3/h4-5,9,11,18H,6-8H2,1-3H3/t11-/m1/s1
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n/an/a 5.70E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302316
PNG
((R)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-naphthamide...)
Show SMILES O=C(N(C1CCC1)[C@@H]1CCNC1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H22N2O/c22-19(16-9-8-14-4-1-2-5-15(14)12-16)21(17-6-3-7-17)18-10-11-20-13-18/h1-2,4-5,8-9,12,17-18,20H,3,6-7,10-11,13H2/t18-/m1/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302316
PNG
((R)-N-cyclobutyl-N-(pyrrolidin-3-yl)-2-naphthamide...)
Show SMILES O=C(N(C1CCC1)[C@@H]1CCNC1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H22N2O/c22-19(16-9-8-14-4-1-2-5-15(14)12-16)21(17-6-3-7-17)18-10-11-20-13-18/h1-2,4-5,8-9,12,17-18,20H,3,6-7,10-11,13H2/t18-/m1/s1
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n/an/a 6.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50278564
PNG
(CHEMBL471036 | Litoxetine | US9511061, Compound A)
Show SMILES C(OC1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C16H19NO/c1-2-4-15-11-13(5-6-14(15)3-1)12-18-16-7-9-17-10-8-16/h1-6,11,16-17H,7-10,12H2
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n/an/a 6.70E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302325
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302319
PNG
((R)-N-cyclopentyl-N-(pyrrolidin-3-yl)-2-naphthamid...)
Show SMILES O=C(N(C1CCCC1)[C@@H]1CCNC1)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C20H24N2O/c23-20(17-10-9-15-5-1-2-6-16(15)13-17)22(18-7-3-4-8-18)19-11-12-21-14-19/h1-2,5-6,9-10,13,18-19,21H,3-4,7-8,11-12,14H2/t19-/m1/s1
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n/an/a 7.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302315
PNG
((R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide ...)
Show SMILES CC(C)N([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H22N2O/c1-13(2)20(17-9-10-19-12-17)18(21)16-8-7-14-5-3-4-6-15(14)11-16/h3-8,11,13,17,19H,9-10,12H2,1-2H3/t17-/m1/s1
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n/an/a 7.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302310
PNG
(CHEMBL567944 | N-(naphthalen-2-ylmethyl)-N-(piperi...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)C1CCNCC1
Show InChI InChI=1S/C18H22N2O/c1-14(21)20(18-8-10-19-11-9-18)13-15-6-7-16-4-2-3-5-17(16)12-15/h2-7,12,18-19H,8-11,13H2,1H3
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n/an/a 8.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302320
PNG
((R)-N-isobutyl-N-(pyrrolidin-3-yl)-2-naphthamide |...)
Show SMILES CC(C)CN([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m1/s1
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n/an/a 9.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302317
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)a...)
Show SMILES CC(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C17H20N2O/c1-13(20)19(17-8-9-18-11-17)12-14-6-7-15-4-2-3-5-16(15)10-14/h2-7,10,17-18H,8-9,11-12H2,1H3/t17-/m1/s1
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n/an/a>1.20E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302315
PNG
((R)-N-isopropyl-N-(pyrrolidin-3-yl)-2-naphthamide ...)
Show SMILES CC(C)N([C@@H]1CCNC1)C(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C18H22N2O/c1-13(2)20(17-9-10-19-12-17)18(21)16-8-7-14-5-3-4-6-15(14)11-16/h3-8,11,13,17,19H,9-10,12H2,1-2H3/t17-/m1/s1
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n/an/a>1.40E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302322
PNG
((R)-3,4-dichloro-N-ethyl-2-methyl-N-(pyrrolidin-3-...)
Show SMILES CCN([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C14H18Cl2N2O/c1-3-18(10-6-7-17-8-10)14(19)11-4-5-12(15)13(16)9(11)2/h4-5,10,17H,3,6-8H2,1-2H3/t10-/m1/s1
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n/an/a 1.74E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302324
PNG
((S)-3,4-dichloro-2-methyl-N-neopentyl-N-(pyrrolidi...)
Show SMILES Cc1c(Cl)c(Cl)ccc1C(=O)N(CC(C)(C)C)[C@H]1CCNC1 |r|
Show InChI InChI=1S/C17H24Cl2N2O/c1-11-13(5-6-14(18)15(11)19)16(22)21(10-17(2,3)4)12-7-8-20-9-12/h5-6,12,20H,7-10H2,1-4H3/t12-/m0/s1
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n/an/a>2.80E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302326
PNG
((R)-N-((6-fluoro-1-methylnaphthalen-2-yl)methyl)-N...)
Show SMILES Cc1c(CN([C@@H]2CCNC2)S(C)(=O)=O)ccc2cc(F)ccc12 |r|
Show InChI InChI=1S/C17H21FN2O2S/c1-12-14(4-3-13-9-15(18)5-6-17(12)13)11-20(23(2,21)22)16-7-8-19-10-16/h3-6,9,16,19H,7-8,10-11H2,1-2H3/t16-/m1/s1
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n/an/a>2.80E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302313
PNG
(CHEMBL565638 | N-(piperidin-4-yl)-N-propyl-2-napht...)
Show SMILES CCCN(C1CCNCC1)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c1-2-13-21(18-9-11-20-12-10-18)19(22)17-8-7-15-5-3-4-6-16(15)14-17/h3-8,14,18,20H,2,9-13H2,1H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302313
PNG
(CHEMBL565638 | N-(piperidin-4-yl)-N-propyl-2-napht...)
Show SMILES CCCN(C1CCNCC1)C(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C19H24N2O/c1-2-13-21(18-9-11-20-12-10-18)19(22)17-8-7-15-5-3-4-6-16(15)14-17/h3-8,14,18,20H,2,9-13H2,1H3
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n/an/a>4.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302322
PNG
((R)-3,4-dichloro-N-ethyl-2-methyl-N-(pyrrolidin-3-...)
Show SMILES CCN([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C14H18Cl2N2O/c1-3-18(10-6-7-17-8-10)14(19)11-4-5-12(15)13(16)9(11)2/h4-5,10,17H,3,6-8H2,1-2H3/t10-/m1/s1
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n/an/a>4.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302323
PNG
((R)-3,4-dichloro-N-isopropyl-2-methyl-N-(pyrrolidi...)
Show SMILES CC(C)N([C@@H]1CCNC1)C(=O)c1ccc(Cl)c(Cl)c1C |r|
Show InChI InChI=1S/C15H20Cl2N2O/c1-9(2)19(11-6-7-18-8-11)15(20)12-4-5-13(16)14(17)10(12)3/h4-5,9,11,18H,6-8H2,1-3H3/t11-/m1/s1
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n/an/a>4.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302314
PNG
(CHEMBL578346 | N-cyclobutyl-N-(piperidin-4-yl)-2-n...)
Show SMILES O=C(N(C1CCC1)C1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H24N2O/c23-20(17-9-8-15-4-1-2-5-16(15)14-17)22(18-6-3-7-18)19-10-12-21-13-11-19/h1-2,4-5,8-9,14,18-19,21H,3,6-7,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent noradrenaline transporter


(Homo sapiens (Human))		BDBM50302314
PNG
(CHEMBL578346 | N-cyclobutyl-N-(piperidin-4-yl)-2-n...)
Show SMILES O=C(N(C1CCC1)C1CCNCC1)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H24N2O/c23-20(17-9-8-15-4-1-2-5-16(15)14-17)22(18-6-3-7-18)19-10-12-21-13-11-19/h1-2,4-5,8-9,14,18-19,21H,3,6-7,10-13H2
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n/an/a>4.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
Sodium-dependent dopamine transporter


(Homo sapiens (Human))		BDBM50302325
PNG
((R)-N-(naphthalen-2-ylmethyl)-N-(pyrrolidin-3-yl)m...)
Show SMILES CS(=O)(=O)N(Cc1ccc2ccccc2c1)[C@@H]1CCNC1 |r|
Show InChI InChI=1S/C16H20N2O2S/c1-21(19,20)18(16-8-9-17-11-16)12-13-6-7-14-4-2-3-5-15(14)10-13/h2-7,10,16-17H,8-9,11-12H2,1H3/t16-/m1/s1
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n/an/a>6.80E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting

Bioorg Med Chem Lett 19: 5893-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.066
BindingDB Entry DOI: 10.7270/Q28915Z6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%