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PubMed code 19773175

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304523
PNG
(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(N)n1
Show InChI InChI=1S/C16H20Cl2N6/c1-23-5-7-24(8-6-23)15-9-14(21-16(19)22-15)20-10-11-12(17)3-2-4-13(11)18/h2-4,9H,5-8,10H2,1H3,(H3,19,20,21,22)
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12n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM22566
PNG
(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Show SMILES CN1CCN(CC1)C(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C14H16ClN3O/c1-17-4-6-18(7-5-17)14(19)13-9-10-8-11(15)2-3-12(10)16-13/h2-3,8-9,16H,4-7H2,1H3
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14n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304524
PNG
(CHEMBL594721 | N4-(2-Chlorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2Cl)nc(N)n1
Show InChI InChI=1S/C16H21ClN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-4-2-3-5-13(12)17/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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18n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304525
PNG
(CHEMBL594731 | N4-(2-Methylbenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2C)nc(N)n1
Show InChI InChI=1S/C17H24N6/c1-13-5-3-4-6-14(13)12-19-15-11-16(21-17(18)20-15)23-9-7-22(2)8-10-23/h3-6,11H,7-10,12H2,1-2H3,(H3,18,19,20,21)
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25n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304528
PNG
(CHEMBL593103 | N4-(4-Fluorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(F)cc2)nc(N)n1
Show InChI InChI=1S/C16H21FN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-2-4-13(17)5-3-12/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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46n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304526
PNG
(CHEMBL594022 | N4-(4-Chlorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(Cl)cc2)nc(N)n1
Show InChI InChI=1S/C16H21ClN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-2-4-13(17)5-3-12/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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71n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304527
PNG
(CHEMBL492677 | N4-Benzyl-6-(4-methylpiperazin-1-yl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2)nc(N)n1
Show InChI InChI=1S/C16H22N6/c1-21-7-9-22(10-8-21)15-11-14(19-16(17)20-15)18-12-13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3,(H3,17,18,19,20)
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98n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304503
PNG
(4-(3,4-Dihydroisoquinolin-2(1H)-yl)-6-(4-methylpip...)
Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)N1CCc2ccccc2C1
Show InChI InChI=1S/C18H24N6/c1-22-8-10-23(11-9-22)16-12-17(21-18(19)20-16)24-7-6-14-4-2-3-5-15(14)13-24/h2-5,12H,6-11,13H2,1H3,(H2,19,20,21)
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146n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304529
PNG
(CHEMBL595215 | N4-(3,4-Dichlorobenzyl)-6-(4-methyl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(Cl)c(Cl)c2)nc(N)n1
Show InChI InChI=1S/C16H20Cl2N6/c1-23-4-6-24(7-5-23)15-9-14(21-16(19)22-15)20-10-11-2-3-12(17)13(18)8-11/h2-3,8-9H,4-7,10H2,1H3,(H3,19,20,21,22)
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150n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304530
PNG
(CHEMBL609161 | N4-(4-Methylbenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(C)cc2)nc(N)n1
Show InChI InChI=1S/C17H24N6/c1-13-3-5-14(6-4-13)12-19-15-11-16(21-17(18)20-15)23-9-7-22(2)8-10-23/h3-6,11H,7-10,12H2,1-2H3,(H3,18,19,20,21)
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205n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304500
PNG
(4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(O)cc2)nc(N)n1
Show InChI InChI=1S/C16H22N6O/c1-21-6-8-22(9-7-21)15-10-14(19-16(17)20-15)18-11-12-2-4-13(23)5-3-12/h2-5,10,23H,6-9,11H2,1H3,(H3,17,18,19,20)
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237n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304502
PNG
(4-(isoindolin-2-yl)-6-(4-methylpiperazin-1-yl)pyri...)
Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)N1Cc2ccccc2C1
Show InChI InChI=1S/C17H22N6/c1-21-6-8-22(9-7-21)15-10-16(20-17(18)19-15)23-11-13-4-2-3-5-14(13)12-23/h2-5,10H,6-9,11-12H2,1H3,(H2,18,19,20)
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248n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304505
PNG
(CHEMBL594949 | N4-(3-Methylbenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2cccc(C)c2)nc(N)n1
Show InChI InChI=1S/C17H24N6/c1-13-4-3-5-14(10-13)12-19-15-11-16(21-17(18)20-15)23-8-6-22(2)7-9-23/h3-5,10-11H,6-9,12H2,1-2H3,(H3,18,19,20,21)
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282n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304501
PNG
(6-(4-Methylpiperazin-1-yl)pyrimidine-2,4-diamine |...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(N)n1
Show InChI InChI=1S/C9H16N6/c1-14-2-4-15(5-3-14)8-6-7(10)12-9(11)13-8/h6H,2-5H2,1H3,(H4,10,11,12,13)
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290n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304531
PNG
(CHEMBL595639 | N4-(3-Chlorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2cccc(Cl)c2)nc(N)n1
Show InChI InChI=1S/C16H21ClN6/c1-22-5-7-23(8-6-22)15-10-14(20-16(18)21-15)19-11-12-3-2-4-13(17)9-12/h2-4,9-10H,5-8,11H2,1H3,(H3,18,19,20,21)
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290n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304504
PNG
(4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(cc2)C#N)nc(N)n1
Show InChI InChI=1S/C17H21N7/c1-23-6-8-24(9-7-23)16-10-15(21-17(19)22-16)20-12-14-4-2-13(11-18)3-5-14/h2-5,10H,6-9,12H2,1H3,(H3,19,20,21,22)
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341n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304507
PNG
(CHEMBL596562 | N-Benzyl-6-(4-methylpiperazin-1-yl)...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2)ncn1
Show InChI InChI=1S/C16H21N5/c1-20-7-9-21(10-8-20)16-11-15(18-13-19-16)17-12-14-5-3-2-4-6-14/h2-6,11,13H,7-10,12H2,1H3,(H,17,18,19)
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417n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304506
PNG
(6-(4-Methylpiperazin-1-yl)-N4-(3-nitrobenzyl)pyrim...)
Show SMILES CN1CCN(CC1)c1cc(NCc2cccc(c2)[N+]([O-])=O)nc(N)n1
Show InChI InChI=1S/C16H21N7O2/c1-21-5-7-22(8-6-21)15-10-14(19-16(17)20-15)18-11-12-3-2-4-13(9-12)23(24)25/h2-4,9-10H,5-8,11H2,1H3,(H3,17,18,19,20)
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538n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304509
PNG
(CHEMBL608717 | N4-(4-Methoxybenzyl)-6-(4-methylpip...)
Show SMILES COc1ccc(CNc2cc(nc(N)n2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C17H24N6O/c1-22-7-9-23(10-8-22)16-11-15(20-17(18)21-16)19-12-13-3-5-14(24-2)6-4-13/h3-6,11H,7-10,12H2,1-2H3,(H3,18,19,20,21)
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542n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304508
PNG
(CHEMBL593551 | N4-(Biphenyl-4-ylmethyl)-6-(4-methy...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(cc2)-c2ccccc2)nc(N)n1
Show InChI InChI=1S/C22H26N6/c1-27-11-13-28(14-12-27)21-15-20(25-22(23)26-21)24-16-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3,(H3,23,24,25,26)
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716n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50304523
PNG
(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(N)n1
Show InChI InChI=1S/C16H20Cl2N6/c1-23-5-7-24(8-6-23)15-9-14(21-16(19)22-15)20-10-11-12(17)3-2-4-13(11)18/h2-4,9H,5-8,10H2,1H3,(H3,19,20,21,22)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50304525
PNG
(CHEMBL594731 | N4-(2-Methylbenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2C)nc(N)n1
Show InChI InChI=1S/C17H24N6/c1-13-5-3-4-6-14(13)12-19-15-11-16(21-17(18)20-15)23-9-7-22(2)8-10-23/h3-6,11H,7-10,12H2,1-2H3,(H3,18,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50304524
PNG
(CHEMBL594721 | N4-(2-Chlorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2Cl)nc(N)n1
Show InChI InChI=1S/C16H21ClN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-4-2-3-5-13(12)17/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50304528
PNG
(CHEMBL593103 | N4-(4-Fluorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(F)cc2)nc(N)n1
Show InChI InChI=1S/C16H21FN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-2-4-13(17)5-3-12/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50304528
PNG
(CHEMBL593103 | N4-(4-Fluorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(F)cc2)nc(N)n1
Show InChI InChI=1S/C16H21FN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-2-4-13(17)5-3-12/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H2 Receptor


(Homo sapiens (Human))
BDBM50304524
PNG
(CHEMBL594721 | N4-(2-Chlorobenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2Cl)nc(N)n1
Show InChI InChI=1S/C16H21ClN6/c1-22-6-8-23(9-7-22)15-10-14(20-16(18)21-15)19-11-12-4-2-3-5-13(12)17/h2-5,10H,6-9,11H2,1H3,(H3,18,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]tiotidine from GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50304523
PNG
(CHEMBL595180 | N4-(2,6-Dichlorobenzyl)-6-(4-methyl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2c(Cl)cccc2Cl)nc(N)n1
Show InChI InChI=1S/C16H20Cl2N6/c1-23-5-7-24(8-6-23)15-9-14(21-16(19)22-15)20-10-11-12(17)3-2-4-13(11)18/h2-4,9H,5-8,10H2,1H3,(H3,19,20,21,22)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Homo sapiens (Human))
BDBM50304525
PNG
(CHEMBL594731 | N4-(2-Methylbenzyl)-6-(4-methylpipe...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccccc2C)nc(N)n1
Show InChI InChI=1S/C17H24N6/c1-13-5-3-4-6-14(13)12-19-15-11-16(21-17(18)20-15)23-9-7-22(2)8-10-23/h3-6,11H,7-10,12H2,1-2H3,(H3,18,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in Sf9 cells co-expressing RGS4


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304519
PNG
(6-(4-Methylpiperazin-1-yl)-N4-(4-(trifluoromethyl)...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(cc2)C(F)(F)F)nc(N)n1
Show InChI InChI=1S/C17H21F3N6/c1-25-6-8-26(9-7-25)15-10-14(23-16(21)24-15)22-11-12-2-4-13(5-3-12)17(18,19)20/h2-5,10H,6-9,11H2,1H3,(H3,21,22,23,24)
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1.20E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304521
PNG
(CHEMBL610626 | N4-(4-Isopropylbenzyl)-6-(4-methylp...)
Show SMILES CC(C)c1ccc(CNc2cc(nc(N)n2)N2CCN(C)CC2)cc1
Show InChI InChI=1S/C19H28N6/c1-14(2)16-6-4-15(5-7-16)13-21-17-12-18(23-19(20)22-17)25-10-8-24(3)9-11-25/h4-7,12,14H,8-11,13H2,1-3H3,(H3,20,21,22,23)
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2.20E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304517
PNG
(4-(Benzyloxy)-6-(4-methylpiperazin-1-yl)pyrimidin-...)
Show SMILES CN1CCN(CC1)c1cc(OCc2ccccc2)nc(N)n1
Show InChI InChI=1S/C16H21N5O/c1-20-7-9-21(10-8-20)14-11-15(19-16(17)18-14)22-12-13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3,(H2,17,18,19)
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2.50E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304520
PNG
(CHEMBL608864 | N4-(4-tert-Butylbenzyl)-6-(4-methyl...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(cc2)C(C)(C)C)nc(N)n1
Show InChI InChI=1S/C20H30N6/c1-20(2,3)16-7-5-15(6-8-16)14-22-17-13-18(24-19(21)23-17)26-11-9-25(4)10-12-26/h5-8,13H,9-12,14H2,1-4H3,(H3,21,22,23,24)
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3.40E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304510
PNG
(3-(4-chlorobenzyl)-7-(4-methylpiperazin-1-yl)-3H-[...)
Show SMILES CN1CCN(CC1)c1ncnc2n(Cc3ccc(Cl)cc3)nnc12
Show InChI InChI=1S/C16H18ClN7/c1-22-6-8-23(9-7-22)15-14-16(19-11-18-15)24(21-20-14)10-12-2-4-13(17)5-3-12/h2-5,11H,6-10H2,1H3
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3.50E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304511
PNG
(6-ethyl-4-(4-methylpiperazin-1-yl)thieno[2,3-d]pyr...)
Show SMILES CCc1cc2c(ncnc2s1)N1CCN(C)CC1
Show InChI InChI=1S/C13H18N4S/c1-3-10-8-11-12(14-9-15-13(11)18-10)17-6-4-16(2)5-7-17/h8-9H,3-7H2,1-2H3
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6.60E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304515
PNG
(9-Benzyl-6-(4-methylpiperazin-1-yl)-9H-purin-2-ami...)
Show SMILES CN1CCN(CC1)c1nc(N)nc2n(Cc3ccccc3)cnc12
Show InChI InChI=1S/C17H21N7/c1-22-7-9-23(10-8-22)15-14-16(21-17(18)20-15)24(12-19-14)11-13-5-3-2-4-6-13/h2-6,12H,7-11H2,1H3,(H2,18,20,21)
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8.10E+3n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304518
PNG
(4-(Benzylthio)-6-(4-methylpiperazin-1-yl)pyrimidin...)
Show SMILES CN1CCN(CC1)c1cc(SCc2ccccc2)nc(N)n1
Show InChI InChI=1S/C16H21N5S/c1-20-7-9-21(10-8-20)14-11-15(19-16(17)18-14)22-12-13-5-3-2-4-6-13/h2-6,11H,7-10,12H2,1H3,(H2,17,18,19)
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1.37E+4n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304513
PNG
(9-benzyl-6-(4-methylpiperazin-1-yl)-9H-purine | CH...)
Show SMILES CN1CCN(CC1)c1ncnc2n(Cc3ccccc3)cnc12
Show InChI InChI=1S/C17H20N6/c1-21-7-9-22(10-8-21)16-15-17(19-12-18-16)23(13-20-15)11-14-5-3-2-4-6-14/h2-6,12-13H,7-11H2,1H3
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1.43E+4n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304514
PNG
(6-(4-Methylpiperazin-1-yl)-9H-purin-2-amine | CHEM...)
Show SMILES CN1CCN(CC1)c1nc(N)nc2nc[nH]c12
Show InChI InChI=1S/C10H15N7/c1-16-2-4-17(5-3-16)9-7-8(13-6-12-7)14-10(11)15-9/h6H,2-5H2,1H3,(H3,11,12,13,14,15)
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1.56E+4n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304512
PNG
(6-(4-methylpiperazin-1-yl)-9Hpurine | CHEMBL594152)
Show SMILES CN1CCN(CC1)c1ncnc2nc[nH]c12
Show InChI InChI=1S/C10H14N6/c1-15-2-4-16(5-3-15)10-8-9(12-6-11-8)13-7-14-10/h6-7H,2-5H2,1H3,(H,11,12,13,14)
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1.84E+4n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304516
PNG
(1-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)-4-methy...)
Show SMILES CN1CCN(Cc2cn(Cc3ccccc3)nn2)CC1
Show InChI InChI=1S/C15H21N5/c1-18-7-9-19(10-8-18)12-15-13-20(17-16-15)11-14-5-3-2-4-6-14/h2-6,13H,7-12H2,1H3
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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
3.50E+4n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50304522
PNG
(4-((2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-...)
Show SMILES CN1CCN(CC1)c1cc(NCc2ccc(cc2)C(O)=O)nc(N)n1
Show InChI InChI=1S/C17H22N6O2/c1-22-6-8-23(9-7-22)15-10-14(20-17(18)21-15)19-11-12-2-4-13(5-3-12)16(24)25/h2-5,10H,6-9,11H2,1H3,(H,24,25)(H3,18,19,20,21)
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PC cid
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UniChem
Article
PubMed
3.77E+5n/an/an/an/an/an/an/an/a



Johann Wolfgang Goethe-University

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human histamine H4 receptor expressed in Sf9 cells co-expressing Galphai2 and Gbeta1gamma2


Bioorg Med Chem 17: 7186-96 (2009)


Article DOI: 10.1016/j.bmc.2009.08.059
BindingDB Entry DOI: 10.7270/Q2416X4F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%