Found 6 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50378137
(Ketek | TELITHROMYCIN)Show SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@H]2N(CCCCn3cnc(c3)-c3cccnc3)C(=O)O[C@]12C)OC |r| Show InChI InChI=1S/C43H65N5O10/c1-12-33-43(8)37(48(41(53)58-43)19-14-13-18-47-23-31(45-24-47)30-16-15-17-44-22-30)27(4)34(49)25(2)21-42(7,54-11)38(28(5)35(50)29(6)39(52)56-33)57-40-36(51)32(46(9)10)20-26(3)55-40/h15-17,22-29,32-33,36-38,40,51H,12-14,18-21H2,1-11H3/t25-,26-,27+,28+,29-,32+,33-,36-,37-,38-,40+,42-,43-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by patch-clamp assay |
J Med Chem 52: 7446-57 (2009)
Article DOI: 10.1021/jm900729s
BindingDB Entry DOI: 10.7270/Q2ST7QSP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50299106
(3-Descladinosyl-11,12-dideoxy-6-Omethyl-3-oxo-12,1...)Show SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(C3)[C@H](C)c3ccnc4ncccc34)C(=O)O[C@]12C |r| Show InChI InChI=1S/C43H63N5O10/c1-12-32-43(9)36(48(41(53)58-43)28-20-47(21-28)27(7)29-15-17-45-38-30(29)14-13-16-44-38)24(4)33(49)22(2)19-42(8,54)37(25(5)34(50)26(6)39(52)56-32)57-40-35(51)31(46(10)11)18-23(3)55-40/h13-17,22-28,31-32,35-37,40,51,54H,12,18-21H2,1-11H3/t22-,23-,24+,25+,26-,27-,31+,32-,35-,36-,37-,40+,42-,43-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by patch-clamp assay |
J Med Chem 52: 7446-57 (2009)
Article DOI: 10.1021/jm900729s
BindingDB Entry DOI: 10.7270/Q2ST7QSP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50299108
(3-Descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,...)Show SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(O)cnc5cccnc45)C3)C(=O)O[C@]12C |r| Show InChI InChI=1S/C42H61N5O11/c1-11-31-42(8)36(47(40(53)58-42)26-18-46(19-26)20-27-30(48)17-44-28-13-12-14-43-32(27)28)23(4)33(49)21(2)16-41(7,54)37(24(5)34(50)25(6)38(52)56-31)57-39-35(51)29(45(9)10)15-22(3)55-39/h12-14,17,21-26,29,31,35-37,39,48,51,54H,11,15-16,18-20H2,1-10H3/t21-,22-,23+,24+,25-,29+,31-,35-,36-,37-,39+,41-,42-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by patch-clamp assay |
J Med Chem 52: 7446-57 (2009)
Article DOI: 10.1021/jm900729s
BindingDB Entry DOI: 10.7270/Q2ST7QSP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50299105
(3-Descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,...)Show SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5ncccc45)C3)C(=O)O[C@]12C |r| Show InChI InChI=1S/C42H61N5O10/c1-11-31-42(8)35(47(40(52)57-42)28-20-46(21-28)19-27-14-16-44-37-29(27)13-12-15-43-37)24(4)32(48)22(2)18-41(7,53)36(25(5)33(49)26(6)38(51)55-31)56-39-34(50)30(45(9)10)17-23(3)54-39/h12-16,22-26,28,30-31,34-36,39,50,53H,11,17-21H2,1-10H3/t22-,23-,24+,25+,26-,30+,31-,34-,35-,36-,39+,41-,42-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by patch-clamp assay |
J Med Chem 52: 7446-57 (2009)
Article DOI: 10.1021/jm900729s
BindingDB Entry DOI: 10.7270/Q2ST7QSP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50299107
(3-Descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,...)Show SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4c(O)cnc5ncccc45)C3)C(=O)O[C@]12C |r| Show InChI InChI=1S/C42H61N5O11/c1-11-31-42(8)35(47(40(53)58-42)26-18-46(19-26)20-28-27-13-12-14-43-37(27)44-17-30(28)48)23(4)32(49)21(2)16-41(7,54)36(24(5)33(50)25(6)38(52)56-31)57-39-34(51)29(45(9)10)15-22(3)55-39/h12-14,17,21-26,29,31,34-36,39,48,51,54H,11,15-16,18-20H2,1-10H3/t21-,22-,23+,24+,25-,29+,31-,34-,35-,36-,39+,41-,42-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by patch-clamp assay |
J Med Chem 52: 7446-57 (2009)
Article DOI: 10.1021/jm900729s
BindingDB Entry DOI: 10.7270/Q2ST7QSP |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50299104
(3-Descladinosyl-11,12-dideoxy-6-O-methyl-3-oxo-12,...)Show SMILES CC[C@H]1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H]2N(C3CN(Cc4ccnc5cccnc45)C3)C(=O)O[C@]12C |r| Show InChI InChI=1S/C42H61N5O10/c1-11-31-42(8)36(47(40(52)57-42)28-20-46(21-28)19-27-14-16-43-29-13-12-15-44-32(27)29)24(4)33(48)22(2)18-41(7,53)37(25(5)34(49)26(6)38(51)55-31)56-39-35(50)30(45(9)10)17-23(3)54-39/h12-16,22-26,28,30-31,35-37,39,50,53H,11,17-21H2,1-10H3/t22-,23-,24+,25+,26-,30+,31-,35-,36-,37-,39+,41-,42-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.96E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research& Development
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by patch-clamp assay |
J Med Chem 52: 7446-57 (2009)
Article DOI: 10.1021/jm900729s
BindingDB Entry DOI: 10.7270/Q2ST7QSP |
More data for this
Ligand-Target Pair | |
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