Found 36 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Ephrin type-B receptor 1
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB1 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 2
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB2 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 2
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA2 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Ephrin type-A receptor 1
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA1 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 5
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA5 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 4
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA4 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 8
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA8 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 3
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB3 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 3
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA3 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299219
(8-(2-Methoxyphenyl)-1-methyl-7-o-methylphenyl-1H-i...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1C |(28.6,-45.77,;28.6,-44.23,;29.94,-43.46,;31.26,-44.23,;32.59,-43.46,;32.59,-41.92,;31.26,-41.16,;29.94,-41.93,;28.61,-41.16,;28.62,-39.62,;27.15,-39.13,;26.24,-40.38,;27.14,-41.63,;26.24,-42.87,;24.77,-42.4,;23.44,-43.16,;23.44,-44.7,;22.11,-42.39,;20.78,-43.17,;22.11,-40.85,;23.44,-40.08,;23.44,-38.54,;24.77,-40.85,;29.95,-38.84,;31.29,-39.61,;32.61,-38.83,;32.61,-37.29,;31.26,-36.53,;29.93,-37.31,;28.59,-36.55,)| Show InChI InChI=1S/C22H19N5O3/c1-13-8-4-5-9-14(13)16-12-26-18-19(25(2)22(29)24-20(18)28)23-21(26)27(16)15-10-6-7-11-17(15)30-3/h4-12H,1-3H3,(H,24,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299219
(8-(2-Methoxyphenyl)-1-methyl-7-o-methylphenyl-1H-i...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1C |(28.6,-45.77,;28.6,-44.23,;29.94,-43.46,;31.26,-44.23,;32.59,-43.46,;32.59,-41.92,;31.26,-41.16,;29.94,-41.93,;28.61,-41.16,;28.62,-39.62,;27.15,-39.13,;26.24,-40.38,;27.14,-41.63,;26.24,-42.87,;24.77,-42.4,;23.44,-43.16,;23.44,-44.7,;22.11,-42.39,;20.78,-43.17,;22.11,-40.85,;23.44,-40.08,;23.44,-38.54,;24.77,-40.85,;29.95,-38.84,;31.29,-39.61,;32.61,-38.83,;32.61,-37.29,;31.26,-36.53,;29.93,-37.31,;28.59,-36.55,)| Show InChI InChI=1S/C22H19N5O3/c1-13-8-4-5-9-14(13)16-12-26-18-19(25(2)22(29)24-20(18)28)23-21(26)27(16)15-10-6-7-11-17(15)30-3/h4-12H,1-3H3,(H,24,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299220
(8-(2-Methoxyphenyl)-1-methyl-7-m-hydroxyphenyl-1H-...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cccc(O)c1 |(15.4,-17.54,;15.41,-16,;16.74,-15.23,;18.07,-16,;19.4,-15.23,;19.39,-13.69,;18.06,-12.93,;16.75,-13.7,;15.42,-12.93,;15.42,-11.39,;13.96,-10.9,;13.05,-12.15,;13.95,-13.4,;13.05,-14.64,;11.58,-14.17,;10.25,-14.93,;10.25,-16.47,;8.92,-14.16,;7.59,-14.94,;8.92,-12.62,;10.25,-11.85,;10.25,-10.31,;11.58,-12.62,;16.75,-10.61,;16.74,-9.08,;18.06,-8.3,;19.41,-9.06,;19.42,-10.6,;20.76,-11.36,;18.09,-11.38,)| Show InChI InChI=1S/C21H17N5O4/c1-24-18-17(19(28)23-21(24)29)25-11-15(12-6-5-7-13(27)10-12)26(20(25)22-18)14-8-3-4-9-16(14)30-2/h3-11,27H,1-2H3,(H,23,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 213 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299221
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-4'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(O)cc1C |(-1.58,-43.46,;-1.58,-41.92,;-.25,-41.15,;1.08,-41.91,;2.41,-41.15,;2.41,-39.61,;1.08,-38.85,;-.24,-39.61,;-1.57,-38.85,;-1.56,-37.3,;-3.03,-36.82,;-3.94,-38.06,;-3.04,-39.32,;-3.94,-40.56,;-5.41,-40.08,;-6.74,-40.84,;-6.74,-42.38,;-8.07,-40.08,;-9.4,-40.85,;-8.07,-38.54,;-6.74,-37.76,;-6.74,-36.22,;-5.41,-38.54,;-.23,-36.52,;1.1,-37.29,;2.43,-36.52,;2.42,-34.97,;3.75,-34.19,;1.08,-34.21,;-.25,-34.99,;-1.59,-34.24,)| Show InChI InChI=1S/C22H19N5O4/c1-12-10-13(28)8-9-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 236 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299220
(8-(2-Methoxyphenyl)-1-methyl-7-m-hydroxyphenyl-1H-...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cccc(O)c1 |(15.4,-17.54,;15.41,-16,;16.74,-15.23,;18.07,-16,;19.4,-15.23,;19.39,-13.69,;18.06,-12.93,;16.75,-13.7,;15.42,-12.93,;15.42,-11.39,;13.96,-10.9,;13.05,-12.15,;13.95,-13.4,;13.05,-14.64,;11.58,-14.17,;10.25,-14.93,;10.25,-16.47,;8.92,-14.16,;7.59,-14.94,;8.92,-12.62,;10.25,-11.85,;10.25,-10.31,;11.58,-12.62,;16.75,-10.61,;16.74,-9.08,;18.06,-8.3,;19.41,-9.06,;19.42,-10.6,;20.76,-11.36,;18.09,-11.38,)| Show InChI InChI=1S/C21H17N5O4/c1-24-18-17(19(28)23-21(24)29)25-11-15(12-6-5-7-13(27)10-12)26(20(25)22-18)14-8-3-4-9-16(14)30-2/h3-11,27H,1-2H3,(H,23,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 368 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299222
(8-(Butyl)-1-methyl-7-p-hydroxyphenyl-1H-imidazo[2,...)Show SMILES CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(O)cc1 Show InChI InChI=1S/C18H19N5O3/c1-3-4-9-22-13(11-5-7-12(24)8-6-11)10-23-14-15(19-17(22)23)21(2)18(26)20-16(14)25/h5-8,10,24H,3-4,9H2,1-2H3,(H,20,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 558 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299223
(8-(Butyl)-1-methyl-7-m-hydroxyphenyl-1H-imidazo[2,...)Show SMILES CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cccc(O)c1 Show InChI InChI=1S/C18H19N5O3/c1-3-4-8-22-13(11-6-5-7-12(24)9-11)10-23-14-15(19-17(22)23)21(2)18(26)20-16(14)25/h5-7,9-10,24H,3-4,8H2,1-2H3,(H,20,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 691 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-A receptor 7
(Homo sapiens (Human)) | BDBM50299218
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| Show InChI InChI=1S/C22H19N5O4/c1-12-8-9-13(28)10-14(12)16-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(16)15-6-4-5-7-17(15)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphA7 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299224
(8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-3'-hydro...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cccc(O)c1C |(34.18,-29.88,;34.18,-28.34,;35.52,-27.58,;36.84,-28.34,;38.17,-27.58,;38.17,-26.03,;36.84,-25.27,;35.52,-26.04,;34.19,-25.27,;34.2,-23.73,;32.73,-23.25,;31.82,-24.49,;32.72,-25.74,;31.82,-26.99,;30.35,-26.51,;29.03,-27.27,;29.02,-28.81,;27.7,-26.51,;26.36,-27.28,;27.7,-24.97,;29.03,-24.19,;29.03,-22.65,;30.35,-24.97,;35.53,-22.95,;36.87,-23.72,;38.19,-22.94,;38.19,-21.4,;36.84,-20.64,;36.82,-19.1,;35.52,-21.42,;34.18,-20.66,)| Show InChI InChI=1S/C22H19N5O4/c1-12-13(7-6-9-16(12)28)15-11-26-18-19(25(2)22(30)24-20(18)29)23-21(26)27(15)14-8-4-5-10-17(14)31-3/h4-11,28H,1-3H3,(H,24,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299225
(8-(Butyl)-1-methyl-7-o-hydroxyphenyl-1H-imidazo[2,...)Show SMILES CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1O Show InChI InChI=1S/C18H19N5O3/c1-3-4-9-22-12(11-7-5-6-8-13(11)24)10-23-14-15(19-17(22)23)21(2)18(26)20-16(14)25/h5-8,10,24H,3-4,9H2,1-2H3,(H,20,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299226
(8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| Show InChI InChI=1S/C21H17N5O3/c1-24-18-17(19(27)23-21(24)28)25-12-15(13-8-4-3-5-9-13)26(20(25)22-18)14-10-6-7-11-16(14)29-2/h3-12H,1-2H3,(H,23,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299226
(8-(2-methoxyphenyl)-1-methyl-7-phenyl-1H-imidazo[1...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1 |(16.51,-2.42,;16.51,-.88,;17.85,-.11,;19.17,-.88,;20.5,-.11,;20.5,1.43,;19.17,2.19,;17.85,1.42,;16.52,2.19,;16.53,3.73,;15.06,4.22,;14.15,2.97,;15.05,1.72,;14.15,.48,;12.68,.95,;11.35,.19,;11.35,-1.35,;10.03,.96,;8.69,.18,;10.03,2.5,;11.35,3.27,;11.35,4.81,;12.68,2.5,;17.86,4.51,;19.2,3.74,;20.52,4.52,;20.52,6.06,;19.17,6.82,;17.84,6.04,)| Show InChI InChI=1S/C21H17N5O3/c1-24-18-17(19(27)23-21(24)28)25-12-15(13-8-4-3-5-9-13)26(20(25)22-18)14-10-6-7-11-16(14)29-2/h3-12H,1-2H3,(H,23,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299227
(8-(2-Methoxyphenyl)-1-methyl-7-(2',5'-dihydroxyphe...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1O |(34.54,-42.18,;34.55,-40.64,;35.88,-39.87,;37.21,-40.64,;38.54,-39.87,;38.53,-38.33,;37.21,-37.57,;35.89,-38.34,;34.56,-37.57,;34.57,-36.03,;33.1,-35.54,;32.19,-36.79,;33.09,-38.04,;32.19,-39.28,;30.72,-38.81,;29.39,-39.57,;29.39,-41.11,;28.06,-38.8,;26.73,-39.58,;28.06,-37.26,;29.39,-36.49,;29.39,-34.95,;30.72,-37.26,;35.89,-35.25,;37.23,-36.02,;38.56,-35.24,;39.9,-36,;38.55,-33.7,;37.2,-32.94,;35.88,-33.72,;34.54,-32.96,)| Show InChI InChI=1S/C21H17N5O5/c1-24-18-17(19(29)23-21(24)30)25-10-14(12-9-11(27)7-8-15(12)28)26(20(25)22-18)13-5-3-4-6-16(13)31-2/h3-10,27-28H,1-2H3,(H,23,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299228
(7-p-Fluorophenyl-8-(2-methoxyphenyl)-1H-imidazo[2,...)Show SMILES COc1ccccc1-n1c(cn2c1nc1[nH]c(=O)[nH]c(=O)c21)-c1ccc(F)cc1 |(17.88,-16.29,;17.89,-14.75,;19.22,-13.98,;20.55,-14.75,;21.88,-13.98,;21.87,-12.44,;20.55,-11.68,;19.23,-12.44,;17.9,-11.68,;17.91,-10.13,;16.44,-9.65,;15.53,-10.89,;16.43,-12.15,;15.53,-13.39,;14.06,-12.91,;12.73,-13.67,;11.4,-12.91,;10.07,-13.68,;11.4,-11.37,;12.73,-10.59,;12.73,-9.05,;14.06,-11.37,;19.23,-9.36,;20.57,-10.12,;21.9,-9.35,;21.89,-7.81,;23.22,-7.03,;20.54,-7.04,;19.22,-7.83,)| Show InChI InChI=1S/C20H14FN5O3/c1-29-15-5-3-2-4-13(15)26-14(11-6-8-12(21)9-7-11)10-25-16-17(23-20(25)26)22-19(28)24-18(16)27/h2-10H,1H3,(H2,22,24,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50234863
(8-(4-hydroxybutyl)-1-methyl-7-phenyl-1H-imidazo[1,...)Show SMILES Cn1c2nc3n(CCCCO)c(cn3c2c(=O)[nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C18H19N5O3/c1-21-15-14(16(25)20-18(21)26)23-11-13(12-7-3-2-4-8-12)22(17(23)19-15)9-5-6-10-24/h2-4,7-8,11,24H,5-6,9-10H2,1H3,(H,20,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 by [gamma33-P]ATP based assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50234863
(8-(4-hydroxybutyl)-1-methyl-7-phenyl-1H-imidazo[1,...)Show SMILES Cn1c2nc3n(CCCCO)c(cn3c2c(=O)[nH]c1=O)-c1ccccc1 Show InChI InChI=1S/C18H19N5O3/c1-21-15-14(16(25)20-18(21)26)23-11-13(12-7-3-2-4-8-12)22(17(23)19-15)9-5-6-10-24/h2-4,7-8,11,24H,5-6,9-10H2,1H3,(H,20,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299233
(1-Benzyl-7-p-fluorophenyl-8-(2-methoxyphenyl)-1H-i...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(Cc3ccccc3)c(=O)[nH]c(=O)c21)-c1ccc(F)cc1 |(.93,-16.47,;.93,-14.93,;2.27,-14.16,;3.59,-14.93,;4.92,-14.16,;4.92,-12.62,;3.59,-11.86,;2.27,-12.62,;.94,-11.86,;.95,-10.31,;-.52,-9.83,;-1.43,-11.07,;-.53,-12.33,;-1.43,-13.57,;-2.9,-13.09,;-4.22,-13.85,;-4.23,-15.39,;-5.56,-16.16,;-6.88,-15.39,;-8.22,-16.16,;-8.22,-17.7,;-6.88,-18.47,;-5.55,-17.69,;-5.55,-13.09,;-6.89,-13.86,;-5.55,-11.55,;-4.22,-10.77,;-4.22,-9.23,;-2.9,-11.55,;2.28,-9.54,;3.62,-10.3,;4.94,-9.53,;4.94,-7.98,;6.26,-7.21,;3.59,-7.22,;2.27,-8,)| Show InChI InChI=1S/C27H20FN5O3/c1-36-22-10-6-5-9-20(22)33-21(18-11-13-19(28)14-12-18)16-31-23-24(29-26(31)33)32(27(35)30-25(23)34)15-17-7-3-2-4-8-17/h2-14,16H,15H2,1H3,(H,30,34,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299235
(8-(Butyl)-1-methyl-7-p-methoxyphenyl-1H-imidazo[2,...)Show SMILES CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(OC)cc1 Show InChI InChI=1S/C19H21N5O3/c1-4-5-10-23-14(12-6-8-13(27-3)9-7-12)11-24-15-16(20-18(23)24)22(2)19(26)21-17(15)25/h6-9,11H,4-5,10H2,1-3H3,(H,21,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299232
(1-Benzyl-8-(2-methoxyphenyl)-7-phenyl-1H-imidazo[2...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(Cc3ccccc3)c(=O)[nH]c(=O)c21)-c1ccccc1 |(33.73,-2.65,;33.73,-1.11,;35.07,-.34,;36.4,-1.11,;37.73,-.34,;37.72,1.21,;36.39,1.96,;35.07,1.2,;33.74,1.97,;33.75,3.51,;32.29,3.99,;31.37,2.75,;32.27,1.5,;31.37,.25,;29.91,.73,;28.58,-.03,;28.57,-1.57,;27.24,-2.34,;25.92,-1.57,;24.58,-2.33,;24.58,-3.88,;25.92,-4.65,;27.25,-3.87,;27.25,.73,;25.91,-.04,;27.25,2.27,;28.58,3.05,;28.58,4.59,;29.91,2.27,;35.08,4.29,;36.42,3.52,;37.75,4.3,;37.74,5.84,;36.39,6.6,;35.07,5.82,)| Show InChI InChI=1S/C27H21N5O3/c1-35-22-15-9-8-14-20(22)32-21(19-12-6-3-7-13-19)17-30-23-24(28-26(30)32)31(27(34)29-25(23)33)16-18-10-4-2-5-11-18/h2-15,17H,16H2,1H3,(H,29,33,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299234
(8-(Butyl)-1-methyl-7-o-methoxyphenyl-1H-imidazo[2,...)Show SMILES CCCCn1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccccc1OC Show InChI InChI=1S/C19H21N5O3/c1-4-5-10-23-13(12-8-6-7-9-14(12)27-3)11-24-15-16(20-18(23)24)22(2)19(26)21-17(15)25/h6-9,11H,4-5,10H2,1-3H3,(H,21,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299236
(8-(2-Methoxyphenyl)-1-methyl-7-m-methylphenyl-1H-i...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cccc(C)c1 |(41.93,-45.89,;41.93,-44.35,;43.27,-43.58,;44.59,-44.34,;45.92,-43.58,;45.92,-42.04,;44.59,-41.28,;43.27,-42.04,;41.94,-41.28,;41.95,-39.73,;40.48,-39.25,;39.57,-40.49,;40.47,-41.75,;39.57,-42.99,;38.1,-42.51,;36.78,-43.27,;36.77,-44.81,;35.45,-42.51,;34.11,-43.28,;35.45,-40.97,;36.78,-40.19,;36.78,-38.65,;38.1,-40.97,;43.28,-38.95,;44.62,-39.72,;45.94,-38.95,;45.94,-37.4,;44.59,-36.64,;44.57,-35.1,;43.27,-37.42,)| Show InChI InChI=1S/C22H19N5O3/c1-13-7-6-8-14(11-13)16-12-26-18-19(25(2)22(29)24-20(18)28)23-21(26)27(16)15-9-4-5-10-17(15)30-3/h4-12H,1-3H3,(H,24,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299230
(8-(2-Methoxyphenyl)-1-methyl-7-p-cyanophenyl-1H-im...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(cc1)C#N |(17.13,-53.95,;17.13,-52.41,;18.47,-51.64,;19.79,-52.41,;21.13,-51.64,;21.12,-50.1,;19.79,-49.34,;18.47,-50.1,;17.14,-49.34,;17.15,-47.79,;15.69,-47.31,;14.77,-48.55,;15.67,-49.81,;14.77,-51.05,;13.31,-50.57,;11.98,-51.33,;11.98,-52.87,;10.65,-50.57,;9.32,-51.34,;10.65,-49.03,;11.98,-48.25,;11.98,-46.71,;13.31,-49.03,;18.48,-47.02,;19.82,-47.78,;21.15,-47.01,;21.14,-45.47,;19.79,-44.7,;18.47,-45.49,;22.46,-44.69,;23.79,-43.91,)| Show InChI InChI=1S/C22H16N6O3/c1-26-19-18(20(29)25-22(26)30)27-12-16(14-9-7-13(11-23)8-10-14)28(21(27)24-19)15-5-3-4-6-17(15)31-2/h3-10,12H,1-2H3,(H,25,29,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299237
(7-(Benzo[d][1,3]dioxol-5-yl)-8-(2-methoxyphenyl)-1...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc2OCOc2c1 |(11.46,-11.69,;11.42,-10.15,;12.74,-9.35,;14.09,-10.09,;15.4,-9.29,;15.37,-7.75,;14.02,-7.01,;12.7,-7.81,;11.29,-7.19,;11.28,-5.65,;9.82,-5.18,;8.92,-6.43,;9.83,-7.67,;8.93,-8.92,;7.46,-8.45,;6.13,-9.23,;6.14,-10.77,;4.8,-8.47,;3.47,-9.24,;4.79,-6.93,;6.12,-6.15,;6.11,-4.61,;7.46,-6.91,;12.61,-4.87,;13.95,-5.63,;15.28,-4.86,;15.27,-3.32,;16.41,-2.28,;15.77,-.88,;14.24,-1.05,;13.93,-2.56,;12.6,-3.33,)| Show InChI InChI=1S/C22H17N5O5/c1-25-19-18(20(28)24-22(25)29)26-10-14(12-7-8-16-17(9-12)32-11-31-16)27(21(26)23-19)13-5-3-4-6-15(13)30-2/h3-10H,11H2,1-2H3,(H,24,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299229
(8-(2-Methoxyphenyl)-1-methyl-7-p-nitrophenyl-1H-im...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(cc1)[N+]([O-])=O |(-.07,-54.79,;-.07,-53.25,;1.26,-52.48,;2.59,-53.25,;3.92,-52.48,;3.92,-50.94,;2.59,-50.18,;1.27,-50.94,;-.06,-50.18,;-.05,-48.63,;-1.52,-48.15,;-2.43,-49.39,;-1.53,-50.65,;-2.43,-51.89,;-3.9,-51.41,;-5.23,-52.17,;-5.23,-53.71,;-6.56,-51.41,;-7.89,-52.18,;-6.56,-49.87,;-5.23,-49.09,;-5.23,-47.55,;-3.9,-49.87,;1.28,-47.86,;2.61,-48.62,;3.94,-47.85,;3.93,-46.31,;2.59,-45.54,;1.26,-46.33,;5.26,-45.53,;6.6,-46.27,;5.24,-43.98,)| Show InChI InChI=1S/C21H16N6O5/c1-24-18-17(19(28)23-21(24)29)25-11-15(12-7-9-13(10-8-12)27(30)31)26(20(25)22-18)14-5-3-4-6-16(14)32-2/h3-11H,1-2H3,(H,23,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
Ephrin type-B receptor 4
(Homo sapiens (Human)) | BDBM50299231
(8-(2-Methoxyphenyl)-1-methyl-7-p-carboxyphenyl-1H-...)Show SMILES COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1ccc(cc1)C(O)=O |(34.47,-52.86,;34.47,-51.32,;35.8,-50.55,;37.13,-51.32,;38.46,-50.55,;38.46,-49.01,;37.13,-48.25,;35.81,-49.02,;34.48,-48.25,;34.49,-46.71,;33.02,-46.22,;32.11,-47.47,;33.01,-48.72,;32.11,-49.96,;30.64,-49.48,;29.31,-50.24,;29.31,-51.78,;27.98,-49.48,;26.65,-50.25,;27.98,-47.94,;29.31,-47.16,;29.31,-45.62,;30.64,-47.94,;35.82,-45.93,;37.15,-46.7,;38.48,-45.92,;38.47,-44.38,;37.13,-43.62,;35.8,-44.4,;39.8,-43.6,;41.14,-44.36,;39.79,-42.06,)| Show InChI InChI=1S/C22H17N5O5/c1-25-18-17(19(28)24-22(25)31)26-11-15(12-7-9-13(10-8-12)20(29)30)27(21(26)23-18)14-5-3-4-6-16(14)32-2/h3-11H,1-2H3,(H,29,30)(H,24,28,31) | PDB
MMDB
Reactome pathway
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Zurich
Curated by ChEMBL
| Assay Description
Inhibition of EphB4 assessed as blockade of synthetic substrate phosphorylation by FRET assay |
J Med Chem 52: 6433-46 (2009)
Article DOI: 10.1021/jm9009444
BindingDB Entry DOI: 10.7270/Q2BZ663G |
More data for this
Ligand-Target Pair | |
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