Found 4 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50302943
(4-(4-fluorophenyl)-5-(4-pyridyl)-1-(ethynyl)-2-(bu...)Show InChI InChI=1S/C20H14FN3O/c1-2-24-18(5-3-4-14-25)23-19(15-6-8-17(21)9-7-15)20(24)16-10-12-22-13-11-16/h1,6-13,25H,4,14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Austin
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by FRET assay |
Bioorg Med Chem Lett 19: 6293-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.094 BindingDB Entry DOI: 10.7270/Q25B02JM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Homo sapiens (Human)) | BDBM50302944
(2-(4-Fluorophenyl)-3(4-pyridinyl)-5-chloro-7-ethan...)Show SMILES OCCc1cc(Cl)n2c(c(nc2c1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H15ClFN3O/c21-17-11-13(7-10-26)12-18-24-19(14-1-3-16(22)4-2-14)20(25(17)18)15-5-8-23-9-6-15/h1-6,8-9,11-12,26H,7,10H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Austin
Curated by ChEMBL
| Assay Description Inhibition of p38alpha by FRET assay |
Bioorg Med Chem Lett 19: 6293-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.094 BindingDB Entry DOI: 10.7270/Q25B02JM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 4
(Homo sapiens (Human)) | BDBM50302943
(4-(4-fluorophenyl)-5-(4-pyridyl)-1-(ethynyl)-2-(bu...)Show InChI InChI=1S/C20H14FN3O/c1-2-24-18(5-3-4-14-25)23-19(15-6-8-17(21)9-7-15)20(24)16-10-12-22-13-11-16/h1,6-13,25H,4,14H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Austin
Curated by ChEMBL
| Assay Description Inhibition of human MAP4K4 by FRET assay |
Bioorg Med Chem Lett 19: 6293-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.094 BindingDB Entry DOI: 10.7270/Q25B02JM |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11
(Homo sapiens (Human)) | BDBM50302943
(4-(4-fluorophenyl)-5-(4-pyridyl)-1-(ethynyl)-2-(bu...)Show InChI InChI=1S/C20H14FN3O/c1-2-24-18(5-3-4-14-25)23-19(15-6-8-17(21)9-7-15)20(24)16-10-12-22-13-11-16/h1,6-13,25H,4,14H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Austin
Curated by ChEMBL
| Assay Description Inhibition of p38beta by FRET assay |
Bioorg Med Chem Lett 19: 6293-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.09.094 BindingDB Entry DOI: 10.7270/Q25B02JM |
More data for this Ligand-Target Pair | |