Affinity Data by PubMed id=19827080

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PubMed code 19827080

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84865 (5'-Deoxy-5'-thiodenosine scaffold, 14c) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.70E+5	n/a	n/a	n/a	7.6	25
University of Cambridge					Assay Description The dissociation constants and enthalpies was determined by isothermal titration calorimety.				Chembiochem 10: 2772-9 (2009) Checked by Author Article DOI: 10.1002/cbic.200900537 BindingDB Entry DOI: 10.7270/Q21J988R
University of Cambridge					More data for this Ligand-Target Pair
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84866 (5'-Deoxy-5'-thiodenosine scaffold, 18) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.40E+5	n/a	n/a	n/a	7.6	25
University of Cambridge					Assay Description The dissociation constants and enthalpies was determined by isothermal titration calorimety.				Chembiochem 10: 2772-9 (2009) Checked by Author Article DOI: 10.1002/cbic.200900537 BindingDB Entry DOI: 10.7270/Q21J988R
University of Cambridge					More data for this Ligand-Target Pair
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84862 (5'-Deoxy-5'-thiodenosine scaffold, 6) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	3.80E+5	n/a	n/a	n/a	7.6	25
University of Cambridge					Assay Description The dissociation constants and enthalpies was determined by isothermal titration calorimety.				Chembiochem 10: 2772-9 (2009) Checked by Author Article DOI: 10.1002/cbic.200900537 BindingDB Entry DOI: 10.7270/Q21J988R
University of Cambridge					More data for this Ligand-Target Pair				3D Structure (crystal)
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84863 (5'-Deoxy-5'-thiodenosine scaffold, 14a) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.10E+5	n/a	n/a	n/a	7.6	25
University of Cambridge					Assay Description The dissociation constants and enthalpies was determined by isothermal titration calorimety.				Chembiochem 10: 2772-9 (2009) Checked by Author Article DOI: 10.1002/cbic.200900537 BindingDB Entry DOI: 10.7270/Q21J988R
University of Cambridge					More data for this Ligand-Target Pair				3D Structure (crystal)
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84864 (5'-Deoxy-5'-thiodenosine scaffold, 14b) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	8.00E+4	n/a	n/a	n/a	7.6	25
University of Cambridge					Assay Description The dissociation constants and enthalpies was determined by isothermal titration calorimety.				Chembiochem 10: 2772-9 (2009) Checked by Author Article DOI: 10.1002/cbic.200900537 BindingDB Entry DOI: 10.7270/Q21J988R
University of Cambridge					More data for this Ligand-Target Pair

Found 5 hits of Isothermal Titration Calorimetry Data.
Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kJ/mole	-TΔS° kJ/mole	ΔH° kJ/mole	log K	pH	Temp °C
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84862 (5'-Deoxy-5'-thiodenosine scaffold, 6)	GoogleScholar PDB	CHEBI MMDB PC cid PC sid PDB		n/a	n/a	-93.8	n/a	7.60	25
University of Cambridge	BDBM84862 (5'-Deoxy-5'-thiodenosine scaffold, 6)	GoogleScholar PDB	CHEBI MMDB PC cid PC sid PDB		Chembiochem 10: 2772-9 (2009)
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84863 (5'-Deoxy-5'-thiodenosine scaffold, 14a)	GoogleScholar PDB	KEGG MMDB PC cid PC sid PDB		n/a	n/a	-59.9	n/a	7.60	25
University of Cambridge	BDBM84863 (5'-Deoxy-5'-thiodenosine scaffold, 14a)	GoogleScholar PDB	KEGG MMDB PC cid PC sid PDB		Chembiochem 10: 2772-9 (2009)
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84866 (5'-Deoxy-5'-thiodenosine scaffold, 18)	GoogleScholar PDB	PC cid PC sid		n/a	n/a	-125	n/a	7.60	25
University of Cambridge	BDBM84866 (5'-Deoxy-5'-thiodenosine scaffold, 18)	GoogleScholar PDB	PC cid PC sid		Chembiochem 10: 2772-9 (2009)
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84865 (5'-Deoxy-5'-thiodenosine scaffold, 14c)	GoogleScholar PDB	KEGG PC cid PC sid		n/a	n/a	-49.4	n/a	7.60	25
University of Cambridge	BDBM84865 (5'-Deoxy-5'-thiodenosine scaffold, 14c)	GoogleScholar PDB	KEGG PC cid PC sid		Chembiochem 10: 2772-9 (2009)
Pantothenate synthetase (Mycobacterium tuberculosis (strain ATCC 25618 / H3...)	BDBM84864 (5'-Deoxy-5'-thiodenosine scaffold, 14b)	GoogleScholar PDB	KEGG PC cid PC sid		n/a	n/a	-19	n/a	7.60	25
University of Cambridge	BDBM84864 (5'-Deoxy-5'-thiodenosine scaffold, 14b)	GoogleScholar PDB	KEGG PC cid PC sid		Chembiochem 10: 2772-9 (2009)

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Change energy units to:kcal/mole

* indicates data uncertainty>20%