Found 44 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35616
(pyrazolo pyrimidine, 5v)Show SMILES O=C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C28H28N8O2/c37-28(21-2-1-8-29-17-21)35-10-6-22(7-11-35)36-27-23(18-31-36)26(34-12-14-38-15-13-34)32-25(33-27)20-3-4-24-19(16-20)5-9-30-24/h1-5,8-9,16-18,22,30H,6-7,10-15H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35598
(pyrazolo pyrimidine, 5c)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3ccccc3)c2n1 Show InChI InChI=1S/C27H28N6O3/c34-22-8-4-7-20(17-22)24-29-25(31-13-15-36-16-14-31)23-18-28-33(26(23)30-24)21-9-11-32(12-10-21)27(35)19-5-2-1-3-6-19/h1-8,17-18,21,34H,9-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35599
(pyrazolo pyrimidine, 5d)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3cccnc3)c2n1 Show InChI InChI=1S/C26H27N7O3/c34-21-5-1-3-18(15-21)23-29-24(31-11-13-36-14-12-31)22-17-28-33(25(22)30-23)20-6-9-32(10-7-20)26(35)19-4-2-8-27-16-19/h1-5,8,15-17,20,34H,6-7,9-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35615
(pyrazolo pyrimidine, 5u)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C28H30N8O/c1-2-20(17-29-8-1)19-34-10-6-23(7-11-34)36-28-24(18-31-36)27(35-12-14-37-15-13-35)32-26(33-28)22-3-4-25-21(16-22)5-9-30-25/h1-5,8-9,16-18,23,30H,6-7,10-15,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35572
(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1 Show InChI InChI=1S/C26H29N7O2/c34-22-5-1-4-20(15-22)24-29-25(32-11-13-35-14-12-32)23-17-28-33(26(23)30-24)21-6-9-31(10-7-21)18-19-3-2-8-27-16-19/h1-5,8,15-17,21,34H,6-7,9-14,18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35596
(pyrazolo pyrimidine, 5a)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCNCC3)c2n1 Show InChI InChI=1S/C20H24N6O2/c27-16-3-1-2-14(12-16)18-23-19(25-8-10-28-11-9-25)17-13-22-26(20(17)24-18)15-4-6-21-7-5-15/h1-3,12-13,15,21,27H,4-11H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35572
(JMC527081 Compound 5f | pyrazolo pyrimidine, 1)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4cccnc4)CC3)c2n1 Show InChI InChI=1S/C26H29N7O2/c34-22-5-1-4-20(15-22)24-29-25(32-11-13-35-14-12-32)23-17-28-33(26(23)30-24)21-6-9-31(10-7-21)18-19-3-2-8-27-16-19/h1-5,8,15-17,21,34H,6-7,9-14,18H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35597
(pyrazolo pyrimidine, 5b)Show SMILES CC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccc(O)c1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3/c1-15(29)26-7-5-17(6-8-26)28-22-19(14-23-28)21(27-9-11-31-12-10-27)24-20(25-22)16-3-2-4-18(30)13-16/h2-4,13-14,17,30H,5-12H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35598
(pyrazolo pyrimidine, 5c)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3ccccc3)c2n1 Show InChI InChI=1S/C27H28N6O3/c34-22-8-4-7-20(17-22)24-29-25(31-13-15-36-16-14-31)23-18-28-33(26(23)30-24)21-9-11-32(12-10-21)27(35)19-5-2-1-3-6-19/h1-8,17-18,21,34H,9-16H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35597
(pyrazolo pyrimidine, 5b)Show SMILES CC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccc(O)c1)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3/c1-15(29)26-7-5-17(6-8-26)28-22-19(14-23-28)21(27-9-11-31-12-10-27)24-20(25-22)16-3-2-4-18(30)13-16/h2-4,13-14,17,30H,5-12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35600
(pyrazolo pyrimidine, 5e)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-4-7-21(17-23)25-29-26(32-13-15-35-16-14-32)24-18-28-33(27(24)30-25)22-9-11-31(12-10-22)19-20-5-2-1-3-6-20/h1-8,17-18,22,34H,9-16,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 78 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35599
(pyrazolo pyrimidine, 5d)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)c3cccnc3)c2n1 Show InChI InChI=1S/C26H27N7O3/c34-21-5-1-3-18(15-21)23-29-24(31-11-13-36-14-12-31)22-17-28-33(25(22)30-23)20-6-9-32(10-7-20)26(35)19-4-2-8-27-16-19/h1-5,8,15-17,20,34H,6-7,9-14H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35610
(pyrazolo pyrimidine, 5p)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-4-21(5-3-1)20-34-12-9-24(10-13-34)36-29-25(19-31-36)28(35-14-16-37-17-15-35)32-27(33-29)23-6-7-26-22(18-23)8-11-30-26/h1-8,11,18-19,24,30H,9-10,12-17,20H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 88 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35605
(pyrazolo pyrimidine, 5k)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cnc2ccccc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C30H31N7O/c1-2-6-22(7-3-1)21-35-12-10-25(11-13-35)37-30-26(20-32-37)29(36-14-16-38-17-15-36)33-28(34-30)24-18-23-8-4-5-9-27(23)31-19-24/h1-9,18-20,25H,10-17,21H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35608
(pyrazolo pyrimidine, 5n)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cc2ccccc2[nH]1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-6-21(7-3-1)20-34-12-10-23(11-13-34)36-29-24(19-30-36)28(35-14-16-37-17-15-35)32-27(33-29)26-18-22-8-4-5-9-25(22)31-26/h1-9,18-19,23,31H,10-17,20H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35609
(pyrazolo pyrimidine, 5o)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccc2[nH]ccc12)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-5-21(6-3-1)20-34-13-10-22(11-14-34)36-29-25(19-31-36)28(35-15-17-37-18-16-35)32-27(33-29)24-7-4-8-26-23(24)9-12-30-26/h1-9,12,19,22,30H,10-11,13-18,20H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 145 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35602
(pyrazolo pyrimidine, 5h)Show SMILES Oc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-6-21(7-9-23)25-29-26(32-14-16-35-17-15-32)24-18-28-33(27(24)30-25)22-10-12-31(13-11-22)19-20-4-2-1-3-5-20/h1-9,18,22,34H,10-17,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35614
(pyrazolo pyrimidine, 5t)Show SMILES C1CC(CCN1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1 Show InChI InChI=1S/C22H25N7O/c1-2-19-15(3-8-24-19)13-16(1)20-26-21(28-9-11-30-12-10-28)18-14-25-29(22(18)27-20)17-4-6-23-7-5-17/h1-3,8,13-14,17,23-24H,4-7,9-12H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35607
(pyrazolo pyrimidine, 5m)Show SMILES O=c1[nH]c2ccc(cc2[nH]1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C28H30N8O2/c37-28-30-23-7-6-20(16-24(23)31-28)25-32-26(35-12-14-38-15-13-35)22-17-29-36(27(22)33-25)21-8-10-34(11-9-21)18-19-4-2-1-3-5-19/h1-7,16-17,21H,8-15,18H2,(H2,30,31,37) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 195 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35596
(pyrazolo pyrimidine, 5a)Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2cnn(C3CCNCC3)c2n1 Show InChI InChI=1S/C20H24N6O2/c27-16-3-1-2-14(12-16)18-23-19(25-8-10-28-11-9-25)17-13-22-26(20(17)24-18)15-4-6-21-7-5-15/h1-3,12-13,15,21,27H,4-11H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 215 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35611
(pyrazolo pyrimidine, 5q)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2cc[nH]c2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-4-21(5-3-1)20-34-12-9-24(10-13-34)36-29-25(19-31-36)28(35-14-16-37-17-15-35)32-27(33-29)23-7-6-22-8-11-30-26(22)18-23/h1-8,11,18-19,24,30H,9-10,12-17,20H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35609
(pyrazolo pyrimidine, 5o)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccc2[nH]ccc12)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-5-21(6-3-1)20-34-13-10-22(11-14-34)36-29-25(19-31-36)28(35-15-17-37-18-16-35)32-27(33-29)24-7-4-8-26-23(24)9-12-30-26/h1-9,12,19,22,30H,10-11,13-18,20H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35603
(pyrazolo pyrimidine, 5i)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccnc1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H29N7O/c1-2-5-20(6-3-1)19-31-11-8-22(9-12-31)33-26-23(18-28-33)25(32-13-15-34-16-14-32)29-24(30-26)21-7-4-10-27-17-21/h1-7,10,17-18,22H,8-9,11-16,19H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35612
(pyrazolo pyrimidine, 5r)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccc2cc[nH]c12)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-5-21(6-3-1)20-34-13-10-23(11-14-34)36-29-25(19-31-36)28(35-15-17-37-18-16-35)32-27(33-29)24-8-4-7-22-9-12-30-26(22)24/h1-9,12,19,23,30H,10-11,13-18,20H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35606
(pyrazolo pyrimidine, 5l)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2ncccc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C30H31N7O/c1-2-5-22(6-3-1)21-35-13-10-25(11-14-35)37-30-26(20-32-37)29(36-15-17-38-18-16-36)33-28(34-30)24-8-9-27-23(19-24)7-4-12-31-27/h1-9,12,19-20,25H,10-11,13-18,21H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 466 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35612
(pyrazolo pyrimidine, 5r)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccc2cc[nH]c12)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-5-21(6-3-1)20-34-13-10-23(11-14-34)36-29-25(19-31-36)28(35-15-17-37-18-16-35)32-27(33-29)24-8-4-7-22-9-12-30-26(22)24/h1-9,12,19,23,30H,10-11,13-18,20H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35613
(pyrazolo pyrimidine, 5s)Show SMILES Cn1ccc2cc(ccc12)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C30H33N7O/c1-34-12-9-23-19-24(7-8-27(23)34)28-32-29(36-15-17-38-18-16-36)26-20-31-37(30(26)33-28)25-10-13-35(14-11-25)21-22-5-3-2-4-6-22/h2-9,12,19-20,25H,10-11,13-18,21H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 575 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35603
(pyrazolo pyrimidine, 5i)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cccnc1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H29N7O/c1-2-5-20(6-3-1)19-31-11-8-22(9-12-31)33-26-23(18-28-33)25(32-13-15-34-16-14-32)29-24(30-26)21-7-4-10-27-17-21/h1-7,10,17-18,22H,8-9,11-16,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 695 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35602
(pyrazolo pyrimidine, 5h)Show SMILES Oc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-23-8-6-21(7-9-23)25-29-26(32-14-16-35-17-15-32)24-18-28-33(27(24)30-25)22-10-12-31(13-11-22)19-20-4-2-1-3-5-20/h1-9,18,22,34H,10-17,19H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 720 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35610
(pyrazolo pyrimidine, 5p)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-4-21(5-3-1)20-34-12-9-24(10-13-34)36-29-25(19-31-36)28(35-14-16-37-17-15-35)32-27(33-29)23-6-7-26-22(18-23)8-11-30-26/h1-8,11,18-19,24,30H,9-10,12-17,20H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35608
(pyrazolo pyrimidine, 5n)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cc2ccccc2[nH]1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-6-21(7-3-1)20-34-12-10-23(11-13-34)36-29-24(19-30-36)28(35-14-16-37-17-15-35)32-27(33-29)26-18-22-8-4-5-9-25(22)31-26/h1-9,18-19,23,31H,10-17,20H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35601
(pyrazolo pyrimidine, 5g)Show SMILES Oc1ccccc1-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-24-9-5-4-8-22(24)25-29-26(32-14-16-35-17-15-32)23-18-28-33(27(23)30-25)21-10-12-31(13-11-21)19-20-6-2-1-3-7-20/h1-9,18,21,34H,10-17,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35611
(pyrazolo pyrimidine, 5q)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2cc[nH]c2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C29H31N7O/c1-2-4-21(5-3-1)20-34-12-9-24(10-13-34)36-29-25(19-31-36)28(35-14-16-37-17-15-35)32-27(33-29)23-7-6-22-8-11-30-26(22)18-23/h1-8,11,18-19,24,30H,9-10,12-17,20H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35614
(pyrazolo pyrimidine, 5t)Show SMILES C1CC(CCN1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1 Show InChI InChI=1S/C22H25N7O/c1-2-19-15(3-8-24-19)13-16(1)20-26-21(28-9-11-30-12-10-28)18-14-25-29(22(18)27-20)17-4-6-23-7-5-17/h1-3,8,13-14,17,23-24H,4-7,9-12H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35615
(pyrazolo pyrimidine, 5u)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C28H30N8O/c1-2-20(17-29-8-1)19-34-10-6-23(7-11-34)36-28-24(18-31-36)27(35-12-14-37-15-13-35)32-26(33-28)22-3-4-25-21(16-22)5-9-30-25/h1-5,8-9,16-18,23,30H,6-7,10-15,19H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.96E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35604
(pyrazolo pyrimidine, 5j)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccncc1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H29N7O/c1-2-4-20(5-3-1)19-31-12-8-22(9-13-31)33-26-23(18-28-33)25(32-14-16-34-17-15-32)29-24(30-26)21-6-10-27-11-7-21/h1-7,10-11,18,22H,8-9,12-17,19H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.77E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35601
(pyrazolo pyrimidine, 5g)Show SMILES Oc1ccccc1-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C27H30N6O2/c34-24-9-5-4-8-22(24)25-29-26(32-14-16-35-17-15-32)23-18-28-33(27(23)30-25)21-10-12-31(13-11-21)19-20-6-2-1-3-7-20/h1-9,18,21,34H,10-17,19H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.57E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35607
(pyrazolo pyrimidine, 5m)Show SMILES O=c1[nH]c2ccc(cc2[nH]1)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C28H30N8O2/c37-28-30-23-7-6-20(16-24(23)31-28)25-32-26(35-12-14-38-15-13-35)22-17-29-36(27(22)33-25)21-8-10-34(11-9-21)18-19-4-2-1-3-5-19/h1-7,16-17,21H,8-15,18H2,(H2,30,31,37) | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.39E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35613
(pyrazolo pyrimidine, 5s)Show SMILES Cn1ccc2cc(ccc12)-c1nc(N2CCOCC2)c2cnn(C3CCN(Cc4ccccc4)CC3)c2n1 Show InChI InChI=1S/C30H33N7O/c1-34-12-9-23-19-24(7-8-27(23)34)28-32-29(36-15-17-38-18-16-36)26-20-31-37(30(26)33-28)25-10-13-35(14-11-25)21-22-5-3-2-4-6-22/h2-9,12,19-20,25H,10-11,13-18,21H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.19E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35616
(pyrazolo pyrimidine, 5v)Show SMILES O=C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2[nH]ccc2c1)N1CCOCC1)c1cccnc1 Show InChI InChI=1S/C28H28N8O2/c37-28(21-2-1-8-29-17-21)35-10-6-22(7-11-35)36-27-23(18-31-36)26(34-12-14-38-15-13-34)32-25(33-27)20-3-4-24-19(16-20)5-9-30-24/h1-5,8-9,16-18,22,30H,6-7,10-15H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.87E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35606
(pyrazolo pyrimidine, 5l)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc2ncccc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C30H31N7O/c1-2-5-22(6-3-1)21-35-13-10-25(11-14-35)37-30-26(20-32-37)29(36-15-17-38-18-16-36)33-28(34-30)24-8-9-27-23(19-24)7-4-12-31-27/h1-9,12,19-20,25H,10-11,13-18,21H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.95E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM35605
(pyrazolo pyrimidine, 5k)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1cnc2ccccc2c1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C30H31N7O/c1-2-6-22(7-3-1)21-35-12-10-25(11-13-35)37-30-26(20-32-37)29(36-14-16-38-17-15-36)33-28(34-30)24-18-23-8-4-5-9-27(23)31-19-24/h1-9,18-20,25H,10-17,21H2 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | 25 |
Wyeth Research
| Assay Description
Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay. |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase mTOR
(Homo sapiens (Human)) | BDBM35604
(pyrazolo pyrimidine, 5j)Show SMILES C(N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccncc1)N1CCOCC1)c1ccccc1 Show InChI InChI=1S/C26H29N7O/c1-2-4-20(5-3-1)19-31-12-8-22(9-13-31)33-26-23(18-28-33)25(32-14-16-34-17-15-32)29-24(30-26)21-6-10-27-11-7-21/h1-7,10-11,18,22H,8-9,12-17,19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | 7.4 | 23 |
Wyeth Research
| Assay Description
The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ... |
J Med Chem 52: 7081-9 (2009)
Article DOI: 10.1021/jm9012642
BindingDB Entry DOI: 10.7270/Q2NS0S73 |
More data for this
Ligand-Target Pair | |
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