Found 17 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311970
(1-(3-(5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-met...)Show SMILES Cn1cnc(c1-c1cc2c(N)ncnc2s1)-c1cccc(NC(=O)Nc2cc(ccc2F)C(F)(F)F)c1 Show InChI InChI=1S/C24H17F4N7OS/c1-35-11-32-19(20(35)18-9-15-21(29)30-10-31-22(15)37-18)12-3-2-4-14(7-12)33-23(36)34-17-8-13(24(26,27)28)5-6-16(17)25/h2-11H,1H3,(H2,29,30,31)(H2,33,34,36) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311971
(1-(3-(5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-met...)Show SMILES Cc1cc(NC(=O)Nc2cccc(c2)-c2ncn(C)c2-c2cc3c(N)ncnc3s2)on1 Show InChI InChI=1S/C21H18N8O2S/c1-11-6-16(31-28-11)27-21(30)26-13-5-3-4-12(7-13)17-18(29(2)10-25-17)15-8-14-19(22)23-9-24-20(14)32-15/h3-10H,1-2H3,(H2,22,23,24)(H2,26,27,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 340 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311976
((R)-2-(4-phenyl-1-((tetrahydrofuran-2-yl)methyl)-1...)Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1C[C@H]1CCCO1)-c1ccccc1 |r| Show InChI InChI=1S/C19H18N6OS/c20-17-15-18(22-10-21-17)27-19(24-15)16-14(12-5-2-1-3-6-12)23-11-25(16)9-13-7-4-8-26-13/h1-3,5-6,10-11,13H,4,7-9H2,(H2,20,21,22)/t13-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311977
(2-(1-(2-morpholinobenzyl)-4-phenyl-1H-imidazol-5-y...)Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1Cc1ccccc1N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C25H23N7OS/c26-23-21-24(28-15-27-23)34-25(30-21)22-20(17-6-2-1-3-7-17)29-16-32(22)14-18-8-4-5-9-19(18)31-10-12-33-13-11-31/h1-9,15-16H,10-14H2,(H2,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311975
(2-(1-isobutyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5...)Show InChI InChI=1S/C18H18N6S/c1-11(2)8-24-10-22-13(12-6-4-3-5-7-12)15(24)18-23-14-16(19)20-9-21-17(14)25-18/h3-7,9-11H,8H2,1-2H3,(H2,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311974
(2-(1-(cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl)...)Show SMILES Nc1ncnc2sc(nc12)-c1c(ncn1CC1CCCCC1)-c1ccccc1 Show InChI InChI=1S/C21H22N6S/c22-19-17-20(24-12-23-19)28-21(26-17)18-16(15-9-5-2-6-10-15)25-13-27(18)11-14-7-3-1-4-8-14/h2,5-6,9-10,12-14H,1,3-4,7-8,11H2,(H2,22,23,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
Similars
| MMDB
PDB
Article
PubMed
| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311968
(6-(1-methyl-4-(3-(p-tolylthio)phenyl)-1H-imidazol-...)Show SMILES Cc1ccc(Sc2cccc(c2)-c2ncn(C)c2-c2cc3c(N)ncnc3s2)cc1 Show InChI InChI=1S/C23H19N5S2/c1-14-6-8-16(9-7-14)29-17-5-3-4-15(10-17)20-21(28(2)13-27-20)19-11-18-22(24)25-12-26-23(18)30-19/h3-13H,1-2H3,(H2,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311969
(1-(3-(5-(4-aminothieno[2,3-d]pyrimidin-6-yl)-1-met...)Show SMILES Cn1cnc(c1-c1cc2c(N)ncnc2s1)-c1cccc(NC(=O)Nc2ccccc2)c1 Show InChI InChI=1S/C23H19N7OS/c1-30-13-27-19(20(30)18-11-17-21(24)25-12-26-22(17)32-18)14-6-5-9-16(10-14)29-23(31)28-15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26)(H2,28,29,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311973
(2-(1-ethyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4-...)Show InChI InChI=1S/C16H14N6S/c1-2-22-9-20-11(10-6-4-3-5-7-10)13(22)16-21-12-14(17)18-8-19-15(12)23-16/h3-9H,2H2,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 phosphorylation by cell based assay |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of FLt |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of FLt |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50311967
(6-(1-methyl-4-phenyl-1H-imidazol-5-yl)thieno[2,3-d...)Show InChI InChI=1S/C16H13N5S/c1-21-9-20-13(10-5-3-2-4-6-10)14(21)12-7-11-15(17)18-8-19-16(11)22-12/h2-9H,1H3,(H2,17,18,19) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of Tie-2 |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50311972
(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)thiazolo[5,4...)Show InChI InChI=1S/C15H12N6S/c1-21-8-19-10(9-5-3-2-4-6-9)12(21)15-20-11-13(16)17-7-18-14(11)22-15/h2-8H,1H3,(H2,16,17,18) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 19: 6670-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.001
BindingDB Entry DOI: 10.7270/Q2FN16BJ |
More data for this
Ligand-Target Pair | |
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