Affinity Data by PubMed id=19856955

PubMed code 19856955

Found 2 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50312003 (CHEMBL1079947 \| Lorneic acid A) Show SMILES CCCC\C=C\c1cc(C)ccc1\C=C\CC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					Assay Description Inhibition of human platelet PDE5 assessed as [3H]cGMP to [3H]GMP conversion pretreated 15 mins before substrate addition measured after 20 mins				J Nat Prod 72: 2046-8 (2009) Article DOI: 10.1021/np900353y BindingDB Entry DOI: 10.7270/Q22F7NM9
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM50312004 (CHEMBL1079948 \| Lorneic acid B) Show SMILES CCCCCC(O)c1cc(C)ccc1\C=C\CC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.71E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					Assay Description Inhibition of human platelet PDE5 assessed as [3H]cGMP to [3H]GMP conversion pretreated 15 mins before substrate addition measured after 20 mins				J Nat Prod 72: 2046-8 (2009) Article DOI: 10.1021/np900353y BindingDB Entry DOI: 10.7270/Q22F7NM9
Nippon Suisan Kaisha, Ltd Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%