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PubMed code 19864133

Compile data set for download or QSAR
Found 42 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415104
PNG
(CHEMBL570201)
Show SMILES Cc1cnc(c(C)c1)-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C18H23N3/c1-14-11-15(2)18(20-12-14)16-7-8-17(19-13-16)21-9-5-3-4-6-10-21/h7-8,11-13H,3-6,9-10H2,1-2H3
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n/an/an/an/a 1.26E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415117
PNG
(CHEMBL570415)
Show SMILES Clc1cccc(c1Cl)-c1cnc(N2CCCCCC2)c(c1)C#N
Show InChI InChI=1S/C18H17Cl2N3/c19-16-7-5-6-15(17(16)20)14-10-13(11-21)18(22-12-14)23-8-3-1-2-4-9-23/h5-7,10,12H,1-4,8-9H2
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415112
PNG
(CHEMBL569535)
Show SMILES CN(C)C(=O)c1cc(cnc1N1CCCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H23Cl2N3O/c1-24(2)20(26)16-12-14(15-8-7-9-17(21)18(15)22)13-23-19(16)25-10-5-3-4-6-11-25/h7-9,12-13H,3-6,10-11H2,1-2H3
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n/an/an/an/a 794n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415115
PNG
(CHEMBL583341)
Show SMILES FC(F)(F)c1cc(cnc1N1CCCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H17Cl2F3N2/c19-15-7-5-6-13(16(15)20)12-10-14(18(21,22)23)17(24-11-12)25-8-3-1-2-4-9-25/h5-7,10-11H,1-4,8-9H2
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n/an/an/an/a 6.31E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415118
PNG
(CHEMBL576919)
Show SMILES Fc1ccc(c(F)c1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H14F2N2O/c16-12-2-3-13(14(17)9-12)11-1-4-15(18-10-11)19-5-7-20-8-6-19/h1-4,9-10H,5-8H2
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415122
PNG
(CHEMBL577556)
Show SMILES Cc1c(Cl)cccc1-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C16H17ClN2O/c1-12-14(3-2-4-15(12)17)13-5-6-16(18-11-13)19-7-9-20-10-8-19/h2-6,11H,7-10H2,1H3
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n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415114
PNG
(CHEMBL583134)
Show SMILES FC(F)(F)c1cc(ncc1-c1cccc(Cl)c1Cl)N1CCCCCC1
Show InChI InChI=1S/C18H17Cl2F3N2/c19-15-7-5-6-12(17(15)20)13-11-24-16(10-14(13)18(21,22)23)25-8-3-1-2-4-9-25/h5-7,10-11H,1-4,8-9H2
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415115
PNG
(CHEMBL583341)
Show SMILES FC(F)(F)c1cc(cnc1N1CCCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H17Cl2F3N2/c19-15-7-5-6-13(16(15)20)12-10-14(18(21,22)23)17(24-11-12)25-8-3-1-2-4-9-25/h5-7,10-11H,1-4,8-9H2
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415102
PNG
(CHEMBL571334)
Show SMILES Cc1ccc(N)c(n1)-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C17H22N4/c1-13-6-8-15(18)17(20-13)14-7-9-16(19-12-14)21-10-4-2-3-5-11-21/h6-9,12H,2-5,10-11,18H2,1H3
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n/an/an/an/a 126n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415121
PNG
(CHEMBL570682)
Show SMILES Clc1ccc(Cl)c(c1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H14Cl2N2O/c16-12-2-3-14(17)13(9-12)11-1-4-15(18-10-11)19-5-7-20-8-6-19/h1-4,9-10H,5-8H2
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n/an/an/an/a 631n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415128
PNG
(CHEMBL569733)
Show SMILES Oc1ccc(O)n1-c1ccc(cn1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C15H10Cl2N2O2/c16-11-3-1-2-10(15(11)17)9-4-5-12(18-8-9)19-13(20)6-7-14(19)21/h1-8,20-21H
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n/an/an/an/a 3.98E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415107
PNG
(CHEMBL570640)
Show SMILES Clc1cccnc1-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C16H18ClN3/c17-14-6-5-9-18-16(14)13-7-8-15(19-12-13)20-10-3-1-2-4-11-20/h5-9,12H,1-4,10-11H2
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n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415108
PNG
(CHEMBL570457)
Show SMILES C1CCCN(CC1)c1ccc(cn1)-c1ccccn1
Show InChI InChI=1S/C16H19N3/c1-2-6-12-19(11-5-1)16-9-8-14(13-18-16)15-7-3-4-10-17-15/h3-4,7-10,13H,1-2,5-6,11-12H2
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415109
PNG
(CHEMBL570219)
Show SMILES Clc1cnc(c(Cl)c1)-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C16H17Cl2N3/c17-13-9-14(18)16(20-11-13)12-5-6-15(19-10-12)21-7-3-1-2-4-8-21/h5-6,9-11H,1-4,7-8H2
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n/an/an/an/a 316n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415111
PNG
(CHEMBL570683)
Show SMILES Clc1cccc(-c2cnc(N3CCCCCC3)c(c2)C(=O)N2CCOCC2)c1Cl
Show InChI InChI=1S/C22H25Cl2N3O2/c23-19-7-5-6-17(20(19)24)16-14-18(22(28)27-10-12-29-13-11-27)21(25-15-16)26-8-3-1-2-4-9-26/h5-7,14-15H,1-4,8-13H2
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n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415125
PNG
(CHEMBL571117)
Show SMILES Clc1ccc(cc1Cl)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H14Cl2N2O/c16-13-3-1-11(9-14(13)17)12-2-4-15(18-10-12)19-5-7-20-8-6-19/h1-4,9-10H,5-8H2
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n/an/an/an/a 3.98E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415127
PNG
(CHEMBL571746)
Show SMILES C[C@H]1CC[C@@H](C)N1c1ccc(cn1)-c1cccc(Cl)c1Cl |r|
Show InChI InChI=1S/C17H18Cl2N2/c1-11-6-7-12(2)21(11)16-9-8-13(10-20-16)14-4-3-5-15(18)17(14)19/h3-5,8-12H,6-7H2,1-2H3/t11-,12+
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n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415132
PNG
(CHEMBL570193)
Show SMILES CC1CC(C)CN(C1)c1ccc(cn1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H20Cl2N2/c1-12-8-13(2)11-22(10-12)17-7-6-14(9-21-17)15-4-3-5-16(19)18(15)20/h3-7,9,12-13H,8,10-11H2,1-2H3
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n/an/an/an/a 501n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415111
PNG
(CHEMBL570683)
Show SMILES Clc1cccc(-c2cnc(N3CCCCCC3)c(c2)C(=O)N2CCOCC2)c1Cl
Show InChI InChI=1S/C22H25Cl2N3O2/c23-19-7-5-6-17(20(19)24)16-14-18(22(28)27-10-12-29-13-11-27)21(25-15-16)26-8-3-1-2-4-9-26/h5-7,14-15H,1-4,8-13H2
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415101
PNG
(CHEMBL571338)
Show SMILES C1CCCN(CC1)c1ccc(cn1)-c1nccc2occc12
Show InChI InChI=1S/C18H19N3O/c1-2-4-11-21(10-3-1)17-6-5-14(13-20-17)18-15-8-12-22-16(15)7-9-19-18/h5-9,12-13H,1-4,10-11H2
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n/an/an/an/a 63.1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415114
PNG
(CHEMBL583134)
Show SMILES FC(F)(F)c1cc(ncc1-c1cccc(Cl)c1Cl)N1CCCCCC1
Show InChI InChI=1S/C18H17Cl2F3N2/c19-15-7-5-6-12(17(15)20)13-11-24-16(10-14(13)18(21,22)23)25-8-3-1-2-4-9-25/h5-7,10-11H,1-4,8-9H2
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n/an/an/an/a 2.51E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415116
PNG
(CHEMBL576087)
Show SMILES Clc1cccc(c1Cl)-c1cnc(cc1C#N)N1CCCCCC1
Show InChI InChI=1S/C18H17Cl2N3/c19-16-7-5-6-14(18(16)20)15-12-22-17(10-13(15)11-21)23-8-3-1-2-4-9-23/h5-7,10,12H,1-4,8-9H2
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415126
PNG
(CHEMBL571116)
Show SMILES CCCCNc1ccc(cn1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C15H16Cl2N2/c1-2-3-9-18-14-8-7-11(10-19-14)12-5-4-6-13(16)15(12)17/h4-8,10H,2-3,9H2,1H3,(H,18,19)
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n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415130
PNG
(CHEMBL570420)
Show SMILES Clc1cccc(c1Cl)-c1ccc(nc1)N1CCSCC1
Show InChI InChI=1S/C15H14Cl2N2S/c16-13-3-1-2-12(15(13)17)11-4-5-14(18-10-11)19-6-8-20-9-7-19/h1-5,10H,6-9H2
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n/an/an/an/a 158n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415133
PNG
(CHEMBL577347)
Show SMILES Clc1cccc(c1Cl)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H14Cl2N2O/c16-13-3-1-2-12(15(13)17)11-4-5-14(18-10-11)19-6-8-20-9-7-19/h1-5,10H,6-9H2
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n/an/an/an/a 79.4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415113
PNG
(CHEMBL571333)
Show SMILES OC(=O)c1cc(cnc1N1CCCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O2/c19-15-7-5-6-13(16(15)20)12-10-14(18(23)24)17(21-11-12)22-8-3-1-2-4-9-22/h5-7,10-11H,1-4,8-9H2,(H,23,24)
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415116
PNG
(CHEMBL576087)
Show SMILES Clc1cccc(c1Cl)-c1cnc(cc1C#N)N1CCCCCC1
Show InChI InChI=1S/C18H17Cl2N3/c19-16-7-5-6-14(18(16)20)15-12-22-17(10-13(15)11-21)23-8-3-1-2-4-9-23/h5-7,10,12H,1-4,8-9H2
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415134
PNG
(CHEMBL576079)
Show SMILES Clc1cccc(-c2ccc(nc2)N2CCCCCC2)c1Cl
Show InChI InChI=1S/C17H18Cl2N2/c18-15-7-5-6-14(17(15)19)13-8-9-16(20-12-13)21-10-3-1-2-4-11-21/h5-9,12H,1-4,10-11H2
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415105
PNG
(CHEMBL569734)
Show SMILES Cc1cccnc1-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C17H21N3/c1-14-7-6-10-18-17(14)15-8-9-16(19-13-15)20-11-4-2-3-5-12-20/h6-10,13H,2-5,11-12H2,1H3
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n/an/an/an/a 794n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415106
PNG
(CHEMBL570641)
Show SMILES N#Cc1cccnc1-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C17H18N4/c18-12-14-6-5-9-19-17(14)15-7-8-16(20-13-15)21-10-3-1-2-4-11-21/h5-9,13H,1-4,10-11H2
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n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415117
PNG
(CHEMBL570415)
Show SMILES Clc1cccc(c1Cl)-c1cnc(N2CCCCCC2)c(c1)C#N
Show InChI InChI=1S/C18H17Cl2N3/c19-16-7-5-6-15(17(16)20)14-10-13(11-21)18(22-12-14)23-8-3-1-2-4-9-23/h5-7,10,12H,1-4,8-9H2
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n/an/an/an/a 3.98E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415119
PNG
(CHEMBL571133)
Show SMILES Clc1ccc(c(Cl)c1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H14Cl2N2O/c16-12-2-3-13(14(17)9-12)11-1-4-15(18-10-11)19-5-7-20-8-6-19/h1-4,9-10H,5-8H2
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415120
PNG
(CHEMBL576709)
Show SMILES Fc1cccc(c1F)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H14F2N2O/c16-13-3-1-2-12(15(13)17)11-4-5-14(18-10-11)19-6-8-20-9-7-19/h1-5,10H,6-9H2
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n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415123
PNG
(CHEMBL577555)
Show SMILES Clc1ccccc1-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H15ClN2O/c16-14-4-2-1-3-13(14)12-5-6-15(17-11-12)18-7-9-19-10-8-18/h1-6,11H,7-10H2
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n/an/an/an/a 398n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415134
PNG
(CHEMBL576079)
Show SMILES Clc1cccc(-c2ccc(nc2)N2CCCCCC2)c1Cl
Show InChI InChI=1S/C17H18Cl2N2/c18-15-7-5-6-14(17(15)19)13-8-9-16(20-12-13)21-10-3-1-2-4-11-21/h5-9,12H,1-4,10-11H2
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n/an/an/an/a 39.8n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415124
PNG
(CHEMBL577348)
Show SMILES Clc1cccc(c1)-c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C15H15ClN2O/c16-14-3-1-2-12(10-14)13-4-5-15(17-11-13)18-6-8-19-9-7-18/h1-5,10-11H,6-9H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415129
PNG
(CHEMBL571745)
Show SMILES Clc1cccc(c1Cl)-c1ccc(nc1)N1CCCC1=O
Show InChI InChI=1S/C15H12Cl2N2O/c16-12-4-1-3-11(15(12)17)10-6-7-13(18-9-10)19-8-2-5-14(19)20/h1,3-4,6-7,9H,2,5,8H2
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n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415131
PNG
(CHEMBL569949)
Show SMILES Clc1cccc(c1Cl)-c1ccc(nc1)N1CCCOCC1
Show InChI InChI=1S/C16H16Cl2N2O/c17-14-4-1-3-13(16(14)18)12-5-6-15(19-11-12)20-7-2-9-21-10-8-20/h1,3-6,11H,2,7-10H2
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n/an/an/an/a 63.1n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415103
PNG
(CHEMBL570202)
Show SMILES Nc1cccnc1-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C16H20N4/c17-14-6-5-9-18-16(14)13-7-8-15(19-12-13)20-10-3-1-2-4-11-20/h5-9,12H,1-4,10-11,17H2
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415113
PNG
(CHEMBL571333)
Show SMILES OC(=O)c1cc(cnc1N1CCCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H18Cl2N2O2/c19-15-7-5-6-13(16(15)20)12-10-14(18(23)24)17(21-11-12)22-8-3-1-2-4-9-22/h5-7,10-11H,1-4,8-9H2,(H,23,24)
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n/an/an/an/a 1.58E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 1


(Homo sapiens (Human))
BDBM50415112
PNG
(CHEMBL569535)
Show SMILES CN(C)C(=O)c1cc(cnc1N1CCCCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H23Cl2N3O/c1-24(2)20(26)16-12-14(15-8-7-9-17(21)18(15)22)13-23-19(16)25-10-5-3-4-6-11-25/h7-9,12-13H,3-6,10-11H2,1-2H3
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n/an/an/an/a>3.16E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB1 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
Cannabinoid receptor 2


(Homo sapiens (Human))
BDBM50415110
PNG
(CHEMBL577986)
Show SMILES Clc1ccc(nc1)-c1ccc(nc1)N1CCCCCC1
Show InChI InChI=1S/C16H18ClN3/c17-14-6-7-15(18-12-14)13-5-8-16(19-11-13)20-9-3-1-2-4-10-20/h5-8,11-12H,1-4,9-10H2
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human CB2 receptor expressed in yeast cells


Bioorg Med Chem Lett 19: 6578-81 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.041
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%