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PubMed code 19877644

Compile data set for download or QSAR
Found 6 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM50299910
PNG
(4-(pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one...)
Show SMILES O=C1OC(\C=C\c2ccccc2)=N/C/1=C\c1cccnc1 |c:12|
Show InChI InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
PDB
MMDB

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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



PharmaDesign, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FGFR1


J Med Chem 52: 7323-7 (2009)


Article DOI: 10.1021/jm901191q
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase Sgk1


(Homo sapiens (Human))
BDBM50299910
PNG
(4-(pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one...)
Show SMILES O=C1OC(\C=C\c2ccccc2)=N/C/1=C\c1cccnc1 |c:12|
Show InChI InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



PharmaDesign, Inc.

Curated by ChEMBL


Assay Description
Inhibition of SGK1


J Med Chem 52: 7323-7 (2009)


Article DOI: 10.1021/jm901191q
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50299910
PNG
(4-(pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one...)
Show SMILES O=C1OC(\C=C\c2ccccc2)=N/C/1=C\c1cccnc1 |c:12|
Show InChI InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



PharmaDesign, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Erk2


J Med Chem 52: 7323-7 (2009)


Article DOI: 10.1021/jm901191q
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50299910
PNG
(4-(pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one...)
Show SMILES O=C1OC(\C=C\c2ccccc2)=N/C/1=C\c1cccnc1 |c:12|
Show InChI InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
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PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



PharmaDesign, Inc.

Curated by ChEMBL


Assay Description
Inhibition of KDR


J Med Chem 52: 7323-7 (2009)


Article DOI: 10.1021/jm901191q
More data for this
Ligand-Target Pair
Casein kinase I isoform delta


(Homo sapiens (Human))
BDBM50299910
PNG
(4-(pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one...)
Show SMILES O=C1OC(\C=C\c2ccccc2)=N/C/1=C\c1cccnc1 |c:12|
Show InChI InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
PDB

UniProtKB/SwissProt

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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



PharmaDesign, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CK1delta


J Med Chem 52: 7323-7 (2009)


Article DOI: 10.1021/jm901191q
More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM50299910
PNG
(4-(pyridin-3-ylmethylene)-2-styryloxazol-5(4H)-one...)
Show SMILES O=C1OC(\C=C\c2ccccc2)=N/C/1=C\c1cccnc1 |c:12|
Show InChI InChI=1S/C17H12N2O2/c20-17-15(11-14-7-4-10-18-12-14)19-16(21-17)9-8-13-5-2-1-3-6-13/h1-12H/b9-8+,15-11-
PDB
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



PharmaDesign, Inc.

Curated by ChEMBL


Assay Description
Inhibition of DYRK1R


J Med Chem 52: 7323-7 (2009)


Article DOI: 10.1021/jm901191q
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%