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PubMed code 19879134

Compile data set for download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 7n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 10n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 13n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 26n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 33n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 33n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin receptor


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 35n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EPHA2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312184
PNG
(1-(2-hydroxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES Oc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H20F3N7O2/c27-26(28,29)18-4-5-22(37)20(13-18)35-25(38)33-19-3-1-2-17(12-19)21-15-36-11-10-31-24(36)23(34-21)32-14-16-6-8-30-9-7-16/h1-13,15,37H,14H2,(H,32,34)(H2,33,35,38)
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n/an/a 37n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 37n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 37n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 49n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 50n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 50n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 50n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 62n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312187
PNG
(1-(2-chloro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES FC(F)(F)c1ccc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H19ClF3N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 66n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 67n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312200
PNG
(1-(3-(8-(methyl(pyridin-4-ylmethyl)amino)imidazo[1...)
Show SMILES CN(Cc1ccncc1)c1nc(cn2ccnc12)-c1cccc(NC(=O)Nc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H22F3N7O/c1-36(16-18-8-10-31-11-9-18)25-24-32-12-13-37(24)17-23(35-25)19-4-2-6-21(14-19)33-26(38)34-22-7-3-5-20(15-22)27(28,29)30/h2-15,17H,16H2,1H3,(H2,33,34,38)
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n/an/a 69n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Focal adhesion kinase 1/vascular endothelial growth factor receptor 3


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 71n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR3 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 75n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312178
PNG
(1-(5-chloro-2-methoxyphenyl)-3-(3-(8-(pyridin-4-yl...)
Show SMILES COc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22ClN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 77n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312175
PNG
(1-(2-methoxy-5-methylphenyl)-3-(3-(8-(pyridin-4-yl...)
Show SMILES COc1ccc(C)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C27H25N7O2/c1-18-6-7-24(36-2)22(14-18)33-27(35)31-21-5-3-4-20(15-21)23-17-34-13-12-29-26(34)25(32-23)30-16-19-8-10-28-11-9-19/h3-15,17H,16H2,1-2H3,(H,30,32)(H2,31,33,35)
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n/an/a 78n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312155
PNG
(1-(2-methoxy-5-(trifluoromethyl)phenyl)-3-(3-(8-(p...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O2/c1-39-23-6-5-19(27(28,29)30)14-21(23)36-26(38)34-20-4-2-3-18(13-20)22-16-37-12-11-32-25(37)24(35-22)33-15-17-7-9-31-10-8-17/h2-14,16H,15H2,1H3,(H,33,35)(H2,34,36,38)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 100n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312185
PNG
(1-(2,5-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1ccc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H19Cl2N7O/c26-18-4-5-20(27)21(13-18)33-25(35)31-19-3-1-2-17(12-19)22-15-34-11-10-29-24(34)23(32-22)30-14-16-6-8-28-9-7-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)
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n/an/a 101n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312201
PNG
(1-(3-(8-(pyridin-4-ylmethoxy)imidazo[1,2-a]pyrazin...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(OCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H19F3N6O2/c27-26(28,29)19-4-2-6-21(14-19)33-25(36)32-20-5-1-3-18(13-20)22-15-35-12-11-31-23(35)24(34-22)37-16-17-7-9-30-10-8-17/h1-15H,16H2,(H2,32,33,36)
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n/an/a 105n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312174
PNG
(1-(5-cyano-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C#N
Show InChI InChI=1S/C27H22N8O2/c1-37-24-6-5-19(15-28)13-22(24)34-27(36)32-21-4-2-3-20(14-21)23-17-35-12-11-30-26(35)25(33-23)31-16-18-7-9-29-10-8-18/h2-14,17H,16H2,1H3,(H,31,33)(H2,32,34,36)
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n/an/a 125n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312177
PNG
(1-(5-chloro-2-phenoxyphenyl)-3-(3-(8-(pyridin-4-yl...)
Show SMILES Clc1ccc(Oc2ccccc2)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C31H24ClN7O2/c32-23-9-10-28(41-25-7-2-1-3-8-25)26(18-23)38-31(40)36-24-6-4-5-22(17-24)27-20-39-16-15-34-30(39)29(37-27)35-19-21-11-13-33-14-12-21/h1-18,20H,19H2,(H,35,37)(H2,36,38,40)
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n/an/a 138n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312203
PNG
(1-(3-(8-(2-(pyridin-4-yl)ethylamino)imidazo[1,2-a]...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)20-4-2-6-22(16-20)35-26(38)34-21-5-1-3-19(15-21)23-17-37-14-13-33-25(37)24(36-23)32-12-9-18-7-10-31-11-8-18/h1-8,10-11,13-17H,9,12H2,(H,32,36)(H2,34,35,38)
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n/an/a 158n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312176
PNG
(1-(5-chloro-2-methylphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES Cc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22ClN7O/c1-17-5-6-20(27)14-22(17)33-26(35)31-21-4-2-3-19(13-21)23-16-34-12-11-29-25(34)24(32-23)30-15-18-7-9-28-10-8-18/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 160n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312197
PNG
(1-(3-chlorophenyl)-3-(3-(8-(pyridin-4-ylmethylamin...)
Show SMILES Clc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H20ClN7O/c26-19-4-2-6-21(14-19)31-25(34)30-20-5-1-3-18(13-20)22-16-33-12-11-28-24(33)23(32-22)29-15-17-7-9-27-10-8-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)
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n/an/a 165n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312169
PNG
(1-(5-bromo-2,4-dimethoxyphenyl)-3-(3-(8-(pyridin-4...)
Show SMILES COc1cc(OC)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Br
Show InChI InChI=1S/C27H24BrN7O3/c1-37-23-14-24(38-2)21(13-20(23)28)34-27(36)32-19-5-3-4-18(12-19)22-16-35-11-10-30-26(35)25(33-22)31-15-17-6-8-29-9-7-17/h3-14,16H,15H2,1-2H3,(H,31,33)(H2,32,34,36)
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n/an/a 206n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312167
PNG
(1-(2,4-diethoxy-5-(trifluoromethyl)phenyl)-3-(3-(8...)
Show SMILES CCOc1cc(OCC)c(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C30H28F3N7O3/c1-3-42-25-16-26(43-4-2)23(15-22(25)30(31,32)33)39-29(41)37-21-7-5-6-20(14-21)24-18-40-13-12-35-28(40)27(38-24)36-17-19-8-10-34-11-9-19/h5-16,18H,3-4,17H2,1-2H3,(H,36,38)(H2,37,39,41)
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n/an/a 211n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312196
PNG
(1-(3-bromophenyl)-3-(3-(8-(pyridin-4-ylmethylamino...)
Show SMILES Brc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H20BrN7O/c26-19-4-2-6-21(14-19)31-25(34)30-20-5-1-3-18(13-20)22-16-33-12-11-28-24(33)23(32-22)29-15-17-7-9-27-10-8-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)
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n/an/a 213n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM50312157
PNG
(1-(5-bromo-2-methoxyphenyl)-3-(3-(8-(pyridin-4-ylm...)
Show SMILES COc1ccc(Br)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H22BrN7O2/c1-36-23-6-5-19(27)14-21(23)33-26(35)31-20-4-2-3-18(13-20)22-16-34-12-11-29-25(34)24(32-22)30-15-17-7-9-28-10-8-17/h2-14,16H,15H2,1H3,(H,30,32)(H2,31,33,35)
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n/an/a 250n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Tie2 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312195
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES Cc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H23N7O/c1-18-4-2-6-21(14-18)30-26(34)31-22-7-3-5-20(15-22)23-17-33-13-12-28-25(33)24(32-23)29-16-19-8-10-27-11-9-19/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)
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n/an/a 300n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312156
PNG
(1-(2-fluoro-5-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-20-5-4-18(26(28,29)30)13-21(20)36-25(38)34-19-3-1-2-17(12-19)22-15-37-11-10-32-24(37)23(35-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,35)(H2,34,36,38)
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n/an/a 400n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312170
PNG
(1-(5-chloro-2,4-dimethoxyphenyl)-3-(3-(8-(pyridin-...)
Show SMILES COc1cc(OC)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl
Show InChI InChI=1S/C27H24ClN7O3/c1-37-23-14-24(38-2)21(13-20(23)28)34-27(36)32-19-5-3-4-18(12-19)22-16-35-11-10-30-26(35)25(33-22)31-15-17-6-8-29-9-7-17/h3-14,16H,15H2,1-2H3,(H,31,33)(H2,32,34,36)
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n/an/a 402n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312166
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES Clc1cc(Cl)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl
Show InChI InChI=1S/C25H18Cl3N7O/c26-18-11-20(28)21(12-19(18)27)34-25(36)32-17-3-1-2-16(10-17)22-14-35-9-8-30-24(35)23(33-22)31-13-15-4-6-29-7-5-15/h1-12,14H,13H2,(H,31,33)(H2,32,34,36)
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n/an/a 517n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312168
PNG
(1-(2,4-dimethoxy-5-(trifluoromethyl)phenyl)-3-(3-(...)
Show SMILES COc1cc(OC)c(cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O3/c1-40-23-14-24(41-2)21(13-20(23)28(29,30)31)37-27(39)35-19-5-3-4-18(12-19)22-16-38-11-10-33-26(38)25(36-22)34-15-17-6-8-32-9-7-17/h3-14,16H,15H2,1-2H3,(H,34,36)(H2,35,37,39)
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n/an/a 518n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312165
PNG
(CHEMBL1079795 | N-(3-(8-(pyridin-4-ylmethylamino)i...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H19F3N6O/c27-26(28,29)20-5-1-4-19(13-20)25(36)33-21-6-2-3-18(14-21)22-16-35-12-11-31-24(35)23(34-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,34)(H,33,36)
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n/an/a 744n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 1


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 747n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of VEGFR1 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312173
PNG
(1-(4-methyl-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O/c1-17-5-6-21(14-22(17)27(28,29)30)35-26(38)34-20-4-2-3-19(13-20)23-16-37-12-11-32-25(37)24(36-23)33-15-18-7-9-31-10-8-18/h2-14,16H,15H2,1H3,(H,33,36)(H2,34,35,38)
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n/an/a 810n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312172
PNG
(1-(4-fluoro-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES Fc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O/c27-21-5-4-19(13-20(21)26(28,29)30)35-25(38)34-18-3-1-2-17(12-18)22-15-37-11-10-32-24(37)23(36-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,36)(H2,34,35,38)
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n/an/a 850n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312186
PNG
(1-(2,5-dimethylphenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Cc1ccc(C)c(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H25N7O/c1-18-6-7-19(2)23(14-18)33-27(35)31-22-5-3-4-21(15-22)24-17-34-13-12-29-26(34)25(32-24)30-16-20-8-10-28-11-9-20/h3-15,17H,16H2,1-2H3,(H,30,32)(H2,31,33,35)
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n/an/a 938n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312179
PNG
(1-(2,6-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1cccc(Cl)c1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H19Cl2N7O/c26-19-5-2-6-20(27)22(19)33-25(35)31-18-4-1-3-17(13-18)21-15-34-12-11-29-24(34)23(32-21)30-14-16-7-9-28-10-8-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)
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n/an/a 1.00E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312171
PNG
(1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(3-(8-(py...)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)ccc1Cl
Show InChI InChI=1S/C26H19ClF3N7O/c27-21-5-4-19(13-20(21)26(28,29)30)35-25(38)34-18-3-1-2-17(12-18)22-15-37-11-10-32-24(37)23(36-22)33-14-16-6-8-31-9-7-16/h1-13,15H,14H2,(H,33,36)(H2,34,35,38)
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n/an/a 1.20E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312193
PNG
(1-(3-(methylthio)phenyl)-3-(3-(8-(pyridin-4-ylmeth...)
Show SMILES CSc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H23N7OS/c1-35-22-7-3-6-21(15-22)31-26(34)30-20-5-2-4-19(14-20)23-17-33-13-12-28-25(33)24(32-23)29-16-18-8-10-27-11-9-18/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)
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n/an/a 1.20E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312198
PNG
(1-(2-bromophenyl)-3-(3-(8-(pyridin-4-ylmethylamino...)
Show SMILES Brc1ccccc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H20BrN7O/c26-20-6-1-2-7-21(20)32-25(34)30-19-5-3-4-18(14-19)22-16-33-13-12-28-24(33)23(31-22)29-15-17-8-10-27-11-9-17/h1-14,16H,15H2,(H,29,31)(H2,30,32,34)
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n/an/a 1.70E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312194
PNG
(1-(3-methoxyphenyl)-3-(3-(8-(pyridin-4-ylmethylami...)
Show SMILES COc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H23N7O2/c1-35-22-7-3-6-21(15-22)31-26(34)30-20-5-2-4-19(14-20)23-17-33-13-12-28-25(33)24(32-23)29-16-18-8-10-27-11-9-18/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)
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n/an/a 1.70E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312180
PNG
(1-(3,5-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1cc(Cl)cc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C25H19Cl2N7O/c26-18-11-19(27)13-21(12-18)32-25(35)31-20-3-1-2-17(10-20)22-15-34-9-8-29-24(34)23(33-22)30-14-16-4-6-28-7-5-16/h1-13,15H,14H2,(H,30,33)(H2,31,32,35)
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n/an/a 1.80E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312192
PNG
(1-(3-cyanophenyl)-3-(3-(8-(pyridin-4-ylmethylamino...)
Show SMILES O=C(Nc1cccc(c1)C#N)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C26H20N8O/c27-15-19-3-1-5-21(13-19)31-26(35)32-22-6-2-4-20(14-22)23-17-34-12-11-29-25(34)24(33-23)30-16-18-7-9-28-10-8-18/h1-14,17H,16H2,(H,30,33)(H2,31,32,35)
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n/an/a 1.90E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312182
PNG
(1-(2,4-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c(Cl)c1
Show InChI InChI=1S/C25H19Cl2N7O/c26-18-4-5-21(20(27)13-18)33-25(35)31-19-3-1-2-17(12-19)22-15-34-11-10-29-24(34)23(32-22)30-14-16-6-8-28-9-7-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)
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n/an/a 1.90E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 2.00E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Flt3 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312163
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(CNC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)21-5-1-3-19(13-21)16-34-26(38)35-22-6-2-4-20(14-22)23-17-37-12-11-32-25(37)24(36-23)33-15-18-7-9-31-10-8-18/h1-14,17H,15-16H2,(H,33,36)(H2,34,35,38)
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n/an/a 2.10E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312164
PNG
(CHEMBL1079452 | N-(3-(8-(pyridin-4-ylmethylamino)i...)
Show SMILES FC(F)(F)c1cccc(CC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H21F3N6O/c28-27(29,30)21-5-1-3-19(13-21)14-24(37)34-22-6-2-4-20(15-22)23-17-36-12-11-32-26(36)25(35-23)33-16-18-7-9-31-10-8-18/h1-13,15,17H,14,16H2,(H,33,35)(H,34,37)
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n/an/a 2.40E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312181
PNG
(1-(3,4-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1Cl
Show InChI InChI=1S/C25H19Cl2N7O/c26-20-5-4-19(13-21(20)27)32-25(35)31-18-3-1-2-17(12-18)22-15-34-11-10-29-24(34)23(33-22)30-14-16-6-8-28-9-7-16/h1-13,15H,14H2,(H,30,33)(H2,31,32,35)
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n/an/a 2.50E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312199
PNG
(1-(2-chlorophenyl)-3-(3-(8-(pyridin-4-ylmethylamin...)
Show SMILES Clc1ccccc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H20ClN7O/c26-20-6-1-2-7-21(20)32-25(34)30-19-5-3-4-18(14-19)22-16-33-13-12-28-24(33)23(31-22)29-15-17-8-10-27-11-9-17/h1-14,16H,15H2,(H,29,31)(H2,30,32,34)
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n/an/a 2.90E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312189
PNG
(1-(4-chlorophenyl)-3-(3-(8-(pyridin-4-ylmethylamin...)
Show SMILES Clc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1
Show InChI InChI=1S/C25H20ClN7O/c26-19-4-6-20(7-5-19)30-25(34)31-21-3-1-2-18(14-21)22-16-33-13-12-28-24(33)23(32-22)29-15-17-8-10-27-11-9-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)
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n/an/a 4.60E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312202
PNG
(4-((6-(3-(3-(3-(trifluoromethyl)phenyl)ureido)phen...)
Show SMILES OC(=O)c1ccc(CNc2nc(cn3ccnc23)-c2cccc(NC(=O)Nc3cccc(c3)C(F)(F)F)c2)cc1
Show InChI InChI=1S/C28H21F3N6O3/c29-28(30,31)20-4-2-6-22(14-20)35-27(40)34-21-5-1-3-19(13-21)23-16-37-12-11-32-25(37)24(36-23)33-15-17-7-9-18(10-8-17)26(38)39/h1-14,16H,15H2,(H,33,36)(H,38,39)(H2,34,35,40)
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n/an/a 5.30E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312158
PNG
(1-(3-(8-aminoimidazo[1,2-a]pyrazin-6-yl)phenyl)-3-...)
Show SMILES COc1ccc(Cl)cc1NC(=O)Nc1cccc(c1)-c1cn2ccnc2c(N)n1
Show InChI InChI=1S/C20H17ClN6O2/c1-29-17-6-5-13(21)10-15(17)26-20(28)24-14-4-2-3-12(9-14)16-11-27-8-7-23-19(27)18(22)25-16/h2-11H,1H3,(H2,22,25)(H2,24,26,28)
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n/an/a 5.40E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312183
PNG
(1-(2,3-dichlorophenyl)-3-(3-(8-(pyridin-4-ylmethyl...)
Show SMILES Clc1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1Cl
Show InChI InChI=1S/C25H19Cl2N7O/c26-19-5-2-6-20(22(19)27)33-25(35)31-18-4-1-3-17(13-18)21-15-34-12-11-29-24(34)23(32-21)30-14-16-7-9-28-10-8-16/h1-13,15H,14H2,(H,30,32)(H2,31,33,35)
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n/an/a 5.70E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312154
PNG
(1-(5-chloro-2-methoxyphenyl)-3-(3-(8-(methylamino)...)
Show SMILES CNc1nc(cn2ccnc12)-c1cccc(NC(=O)Nc2cc(Cl)ccc2OC)c1
Show InChI InChI=1S/C21H19ClN6O2/c1-23-19-20-24-8-9-28(20)12-17(26-19)13-4-3-5-15(10-13)25-21(29)27-16-11-14(22)6-7-18(16)30-2/h3-12H,1-2H3,(H,23,26)(H2,25,27,29)
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n/an/a 5.70E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lyn


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 6.00E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Lyn after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312161
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)NCc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H22F3N7O/c28-27(29,30)21-5-2-6-22(14-21)35-26(38)34-16-19-3-1-4-20(13-19)23-17-37-12-11-32-25(37)24(36-23)33-15-18-7-9-31-10-8-18/h1-14,17H,15-16H2,(H,33,36)(H2,34,35,38)
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n/an/a 6.80E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312190
PNG
(1-(4-fluorophenyl)-3-(3-(8-(pyridin-4-ylmethylamin...)
Show SMILES Fc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1
Show InChI InChI=1S/C25H20FN7O/c26-19-4-6-20(7-5-19)30-25(34)31-21-3-1-2-18(14-21)22-16-33-13-12-28-24(33)23(32-22)29-15-17-8-10-27-11-9-17/h1-14,16H,15H2,(H,29,32)(H2,30,31,34)
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n/an/a 7.40E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 7.70E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 7.80E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Btk after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312151
PNG
(1-(3-(8-(pyridin-3-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3cccnc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-6-2-8-21(13-19)34-25(37)33-20-7-1-5-18(12-20)22-16-36-11-10-31-24(36)23(35-22)32-15-17-4-3-9-30-14-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 7.80E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312188
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES Cc1ccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)cc1
Show InChI InChI=1S/C26H23N7O/c1-18-5-7-21(8-6-18)30-26(34)31-22-4-2-3-20(15-22)23-17-33-14-13-28-25(33)24(32-23)29-16-19-9-11-27-12-10-19/h2-15,17H,16H2,1H3,(H,29,32)(H2,30,31,34)
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n/an/a 7.90E+3n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312191
PNG
(1-(3-phenoxyphenyl)-3-(3-(8-(pyridin-4-ylmethylami...)
Show SMILES O=C(Nc1cccc(Oc2ccccc2)c1)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C31H25N7O2/c39-31(36-25-8-5-11-27(19-25)40-26-9-2-1-3-10-26)35-24-7-4-6-23(18-24)28-21-38-17-16-33-30(38)29(37-28)34-20-22-12-14-32-15-13-22/h1-19,21H,20H2,(H,34,37)(H2,35,36,39)
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n/an/a 1.05E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312160
PNG
(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazi...)
Show SMILES FC(F)(F)c1cccc(CNC(=O)c2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C27H21F3N6O/c28-27(29,30)22-6-1-3-19(13-22)16-34-26(37)21-5-2-4-20(14-21)23-17-36-12-11-32-25(36)24(35-23)33-15-18-7-9-31-10-8-18/h1-14,17H,15-16H2,(H,33,35)(H,34,37)
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n/an/a 1.11E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 1.44E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Abl1 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312150
PNG
(1-(3-(8-(piperidin-4-ylmethylamino)imidazo[1,2-a]p...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCC3CCNCC3)n2)c1
Show InChI InChI=1S/C26H26F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-6,11-14,16-17,30H,7-10,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Protein kinase C theta type


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PKCtheta after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PKCbeta2 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
SRC


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Fyn after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CDK5 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Protein kinase C alpha type


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ZAP-70


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of ZAp70 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Src after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Syk after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Akt after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312159
PNG
(1-(4-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2ccc(cc2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-2-1-3-21(14-19)34-25(37)33-20-6-4-18(5-7-20)22-16-36-13-12-31-24(36)23(35-22)32-15-17-8-10-30-11-9-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GSK3-beta after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of LCK after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of FGFR4 after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Blk


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Blk after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312162
PNG
(CHEMBL1080872 | N-(3-(8-(pyridin-4-ylmethylamino)i...)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)Nc1cccc(c1)-c1cn2ccnc2c(NCc2ccncc2)n1
Show InChI InChI=1S/C25H19F3N6O2S/c26-25(27,28)19-4-2-6-21(14-19)37(35,36)33-20-5-1-3-18(13-20)22-16-34-12-11-30-24(34)23(32-22)31-15-17-7-9-29-10-8-17/h1-14,16,33H,15H2,(H,31,32)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Ephrin type-B receptor 4 (EphB4)


(Homo sapiens (Human))
BDBM50312152
PNG
(1-(3-(8-(benzylamino)imidazo[1,2-a]pyrazin-6-yl)ph...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccccc3)n2)c1
Show InChI InChI=1S/C27H21F3N6O/c28-27(29,30)20-9-5-11-22(15-20)34-26(37)33-21-10-4-8-19(14-21)23-17-36-13-12-31-25(36)24(35-23)32-16-18-6-2-1-3-7-18/h1-15,17H,16H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EphB4 autophosphorylation by cell based assay


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50312153
PNG
(1-(3-(8-(pyridin-4-ylmethylamino)imidazo[1,2-a]pyr...)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(c2)-c2cn3ccnc3c(NCc3ccncc3)n2)c1
Show InChI InChI=1S/C26H20F3N7O/c27-26(28,29)19-4-2-6-21(14-19)34-25(37)33-20-5-1-3-18(13-20)22-16-36-12-11-31-24(36)23(35-22)32-15-17-7-9-30-10-8-17/h1-14,16H,15H2,(H,32,35)(H2,33,34,37)
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n/an/a 5.00E+4n/an/an/an/an/an/a



CGI Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of IRK after 1 hr


Bioorg Med Chem Lett 19: 6991-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.10.037
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%